JP2022536017A - 精神障害、行動障害、認知障害を処置する方法 - Google Patents
精神障害、行動障害、認知障害を処置する方法 Download PDFInfo
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- JP2022536017A JP2022536017A JP2021558496A JP2021558496A JP2022536017A JP 2022536017 A JP2022536017 A JP 2022536017A JP 2021558496 A JP2021558496 A JP 2021558496A JP 2021558496 A JP2021558496 A JP 2021558496A JP 2022536017 A JP2022536017 A JP 2022536017A
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- azelastine
- acid
- disease
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- acceptable salt
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Abstract
Description
[001] 本発明は、実用医学の分野、すなわち、中枢神経系への様々な起源の器質的損傷の場合の精神的、行動的、又は認知的な障害の症状を軽減する向神経性作用を示す医薬組成物の使用に関する。
[002] アルツハイマー病(AD)は進行性の慢性神経変性疾患であり、通常はゆっくりと始まり、時間の経過とともに徐々に悪化する。ADは、高齢者の認知症の最も一般的な原因である。認知症とは、人の日常生活及び活動に支障をきたす程度の、認知機能(思考、記憶、及び推論)及び行動能力の喪失である。初期の段階では記憶喪失は軽度であるが、後期のADでは、個人は会話を継続し、その環境に反応する能力を失う。未処置の場合、ADは最終的に死に至る。進行の速度は様々であるが、診断後の典型的な平均余命は3~9年である。
[009] 本発明は、精神障害、行動障害、認知障害を処置するために、患者にアゼラスチン又はアゼラスチンの薬学的に許容される塩を投与する方法の発見を含む。
[0015] 本発明の発明者らは、驚くべきことに、より高い経口投与量のアゼラスチン又はアゼラスチンの薬学的に許容される塩が、精神障害、行動障害、認知障害に罹患している患者を処置するのに適していることを見出した。
[0018] 本明細書で使用される場合、以下の語及び句は、それらが使用される文脈が別の意味を示す場合を除いて、一般に、以下に記載される意味を有することを意図している。
[0037] 体重51キログラムで6年間後期アルツハイマー病と診断されている80歳の女性患者は、歩行及び物探しなどの日常活動、並びにパーソナルケアに24時間の補助が必要であり、女性の発話はほんの数語に制限されていた。女性は就寝前に1日1回12mgのアゼラスチンHClで処置される前は、周囲のことをほとんど意識していなかった。女性は就寝前に1日1回12mgのアゼラスチンHClで6週間処置した後、軽度の補助を伴って家の中を歩行することができた。12週間の処置の後、女性は1分を超えて話し、家での活動を知り、家での日常活動について質問することができた。6ヶ月の処置後、女性は、何ができるかに関して、処置前にできたことと比較して、全く異なっており、活発に人と話すことができ、日常活動及びパーソナルケアのための補助を必要としなかった。その結果、女性のMMSEスコアも同様に改善することが予想されたであろう。女性の体重は、6ヶ月の処置後に3キログラム増加した。
[0039] 83歳、体重49キログラムの女性が中~後期アルツハイマー病と診断された。女性は起こったばかりのことを思い出せず、自分で取り戻したいものを見つけることができなかったため、女性の日常活動は制限されていた。女性は就寝前に1日1回12mgのアゼラスチンHClの処置を開始する前は、パーソナルケアを含む女性の日常活動のほとんどに補助を必要としていた。6週間の処置の後、女性は自分が回収しようとしているものをいくつか見つけることができたという兆候を示し始めた。3ヶ月の処置の後、女性が日常活動やパーソナルケアについて必要とした補助は少しだけであり、ほとんどを自分で行うことができた。女性のMMSEスコアも同様に改善することが予想されたであろう。女性の体重は、6ヶ月の処置後に2.5キログラム増加した。
[0041] Sucher NJ, Lipton SA, Dreyer EB. Molecular basis of glutamate toxicity in retinal ganglion cells. Vision Res. 1997;37(24):3483-3493.
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Claims (12)
- 精神障害、行動障害、又は認知障害に罹患している患者を処置する方法であって、前記方法が、アゼラスチン又はアゼラスチンの薬学的に許容される塩を含む、有効量の医薬組成物を投与することを含む、方法。
- 前記医薬組成物が、経口製剤である、請求項1に記載の方法。
- 前記医薬組成物が、約4mg~約40mgの前記アゼラスチン又は前記アゼラスチンの薬学的に許容される塩を含む、請求項1に記載の方法。
- 前記アゼラスチンの薬学的に許容される塩が、アゼラスチン塩酸塩である、請求項1に記載の方法。
- 前記医薬組成物が、約4mg~約20mgの前記アゼラスチン又は前記アゼラスチンの薬学的に許容される塩を含む、請求項1に記載の方法。
- 前記医薬組成物が、約8mg~約16mgの前記アゼラスチン又は前記アゼラスチンの薬学的に許容される塩を含む、請求項1に記載の方法。
- 前記経口製剤が、固体又は液体の形態である、請求項2に記載の方法。
- 前記精神障害、行動障害、又は認知障害が、アルツハイマー病、血管性認知症、パーキンソン病、ハンチントン病、前頭側頭型認知症、外傷性脳損傷、大脳皮質基底核変性症、若しくはパーキンソン病、又はそれらの任意の組み合わせである、請求項1に記載の方法。
- 前記精神障害、行動障害、又は認知障害が、アルツハイマー病である、請求項1に記載の方法。
- アルツハイマー病に罹患している患者を処置する方法であって、約8mg~約16mgのアゼラスチン塩酸塩の1日有効量を、それを必要とする患者に経口投与することを含む、方法。
- 患者の記憶、言語、推論、及び/又は時間の段取りが改善されるように、アゼラスチン又はアゼラスチンの薬学的に許容される塩を含む、有効量の医薬組成物を投与することを含む、アルツハイマー病に罹患している患者を処置する方法。
- 前記有効量の前記医薬組成物が、約8mg~約16mgの前記アゼラスチン又は前記アゼラスチンの薬学的に許容される塩を含む、請求項11に記載の方法。
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US11690849B2 (en) | 2019-04-12 | 2023-07-04 | LA PharmaTech Inc. | Method of treating dementia |
US11744833B2 (en) | 2019-04-12 | 2023-09-05 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treatment of insomnia |
US11938139B2 (en) | 2019-04-12 | 2024-03-26 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for anxiety, depression and other psychiatric disorders |
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US11389458B2 (en) | 2019-04-12 | 2022-07-19 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treating parkinson's and huntington's disease |
US10639314B1 (en) | 2019-04-30 | 2020-05-05 | LA PharmaTech Inc. | Method of treating Alzheimer's disease |
US10966989B2 (en) | 2019-04-12 | 2021-04-06 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treating mental, behavioral, cognitive disorders |
US11318144B2 (en) | 2019-04-12 | 2022-05-03 | LA PharmaTech Inc. | Compositions and methods for treating Alzheimer's disease and Parkinson's disease |
US11351179B1 (en) | 2021-08-05 | 2022-06-07 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treatment of psychiatric disorders |
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US7355042B2 (en) * | 2001-10-16 | 2008-04-08 | Hypnion, Inc. | Treatment of CNS disorders using CNS target modulators |
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US11690849B2 (en) | 2019-04-12 | 2023-07-04 | LA PharmaTech Inc. | Method of treating dementia |
US11744833B2 (en) | 2019-04-12 | 2023-09-05 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treatment of insomnia |
US11938139B2 (en) | 2019-04-12 | 2024-03-26 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for anxiety, depression and other psychiatric disorders |
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