JP2009502795A5 - - Google Patents
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- Publication number
- JP2009502795A5 JP2009502795A5 JP2008522899A JP2008522899A JP2009502795A5 JP 2009502795 A5 JP2009502795 A5 JP 2009502795A5 JP 2008522899 A JP2008522899 A JP 2008522899A JP 2008522899 A JP2008522899 A JP 2008522899A JP 2009502795 A5 JP2009502795 A5 JP 2009502795A5
- Authority
- JP
- Japan
- Prior art keywords
- substantially pure
- crystalline form
- pure crystalline
- methyl
- ray powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000634 powder X-ray diffraction Methods 0.000 claims 14
- HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 claims 7
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 150000004682 monohydrates Chemical class 0.000 claims 2
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 150000004683 dihydrates Chemical class 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70140505P | 2005-07-20 | 2005-07-20 | |
| US60/701,405 | 2005-07-20 | ||
| US71621405P | 2005-09-12 | 2005-09-12 | |
| US60/716,214 | 2005-09-12 | ||
| PCT/US2006/027875 WO2007015870A2 (en) | 2005-07-20 | 2006-07-18 | Crystalline forms of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012231108A Division JP5798101B2 (ja) | 2005-07-20 | 2012-10-18 | ４−メチル−ｎ−［３−（４−メチル−イミダゾール−１−イル）−５−トリフルオロメチル−フェニル］−３−（４−ピリジン−３−イル−ピリミジン−２−イルアミノ）−ベンズアミドの結晶形態 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502795A JP2009502795A (ja) | 2009-01-29 |
| JP2009502795A5 true JP2009502795A5 (enExample) | 2009-09-03 |
| JP5289948B2 JP5289948B2 (ja) | 2013-09-11 |
Family
ID=37451227
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008522899A Active JP5289948B2 (ja) | 2005-07-20 | 2006-07-18 | ４−メチル−ｎ−［３−（４−メチル−イミダゾール−１−イル）−５−トリフルオロメチル−フェニル］−３−（４−ピリジン−３−イル−ピリミジン−２−イルアミノ）−ベンズアミドの結晶形態 |
| JP2012231108A Active JP5798101B2 (ja) | 2005-07-20 | 2012-10-18 | ４−メチル−ｎ−［３−（４−メチル−イミダゾール−１−イル）−５−トリフルオロメチル−フェニル］−３−（４−ピリジン−３−イル−ピリミジン−２−イルアミノ）−ベンズアミドの結晶形態 |
| JP2014159022A Pending JP2014221831A (ja) | 2005-07-20 | 2014-08-04 | ４−メチル−ｎ−［３−（４−メチル−イミダゾール−１−イル）−５−トリフルオロメチル−フェニル］−３−（４−ピリジン−３−イル−ピリミジン−２−イルアミノ）−ベンズアミドの結晶形態 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012231108A Active JP5798101B2 (ja) | 2005-07-20 | 2012-10-18 | ４−メチル−ｎ−［３−（４−メチル−イミダゾール−１−イル）−５−トリフルオロメチル−フェニル］−３−（４−ピリジン−３−イル−ピリミジン−２−イルアミノ）−ベンズアミドの結晶形態 |
| JP2014159022A Pending JP2014221831A (ja) | 2005-07-20 | 2014-08-04 | ４−メチル−ｎ−［３−（４−メチル−イミダゾール−１−イル）−５−トリフルオロメチル−フェニル］−３−（４−ピリジン−３−イル−ピリミジン−２−イルアミノ）−ベンズアミドの結晶形態 |
Country Status (42)
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GT200600315A (es) | 2005-07-20 | 2007-03-19 | Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida | |
| GT200600316A (es) * | 2005-07-20 | 2007-04-02 | Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida. | |
| MX2008012903A (es) * | 2006-04-07 | 2008-10-13 | Novartis Ag | Uso de inhibidores de c-src en combinacion con un compuesto de pirimidilaminobenzamida para el tratamiento de la leucemia. |
| EP1923053A1 (en) | 2006-09-27 | 2008-05-21 | Novartis AG | Pharmaceutical compositions comprising nilotinib or its salt |
| EP2240172B1 (en) | 2007-12-21 | 2014-03-19 | Novartis AG | Combination of nilotinib and chlorambucil for the treatment of chronic lymphocytic leukemia |
| EP2305667A3 (en) | 2008-07-17 | 2011-05-11 | Teva Pharmaceutical Industries Ltd. | Nilotinib intermediates and preparation thereof |
| CN102203084B (zh) * | 2008-11-05 | 2014-10-29 | 特瓦制药工业有限公司 | 盐酸尼洛替尼晶型 |
| EP2186514B1 (en) | 2008-11-14 | 2016-06-29 | Kinki University | Treatment of Malignant Peripheral Nerve Sheath Tumors |
| EP2403492A1 (en) | 2009-03-06 | 2012-01-11 | Novartis AG | Use of pyrimidylaminobenzamide derivatives for the treatment of disorders mediated by the leucine zipper- and sterile alpha motif-containing kinase (zak) |
| TW201102068A (en) | 2009-06-02 | 2011-01-16 | Novartis Ag | Treatment of ophthalmologic disorders mediated by alpha-carbonic anhydrase isoforms |
| PH12012500797A1 (en) | 2009-10-23 | 2012-11-26 | Novartis Ag | Method of treating proliferative disorders and other pathological conditions mediated by bcr-abl, c-kit, ddr1, ddr2 or pdgf-r kinase activity |
| JO3634B1 (ar) | 2009-11-17 | 2020-08-27 | Novartis Ag | طريقة لعلاج اضطرابات تكاثرية وحالات مرضية أخرى متوسطة بنشاط كيناز bcr-abl، c-kit، ddr1، ddr2، أو pdgf-r |
| IN2010KO00035A (enExample) * | 2010-01-15 | 2016-09-02 | ||
| JP2013525296A (ja) | 2010-04-16 | 2013-06-20 | ノバルティス アーゲー | 内分泌療法抵抗性乳癌の処置 |
| EP2382976A1 (en) | 2010-04-30 | 2011-11-02 | Hiroshima University | Use of pdgf-r inhibitors for the treatment of lymph node metastasis of gastric cancer |
| US8937082B2 (en) | 2010-06-21 | 2015-01-20 | Teva Pharmaceutical Industries Ltd. | Nilotinib salts and crystalline forms thereof |
| CN102453024B (zh) * | 2010-10-27 | 2014-09-03 | 浙江九洲药业股份有限公司 | 一种尼罗替尼盐酸盐晶型及其制备方法 |
| EP2648519A4 (en) * | 2010-11-26 | 2014-04-30 | Hetero Research Foundation | NEW POLYMORPH OF NILOTINIB HYDROCHLORIDE |
| AR086913A1 (es) * | 2011-06-14 | 2014-01-29 | Novartis Ag | 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida amorfa, forma de dosificacion que la contiene y metodo para prepararlas |
| WO2013063003A1 (en) | 2011-10-28 | 2013-05-02 | Novartis Ag | Method of treating gastrointestinal stromal tumors |
| EP2770999A1 (en) | 2011-10-28 | 2014-09-03 | Novartis AG | Method of treating gastrointestinal stromal tumors |
| CA2855503A1 (en) | 2011-11-14 | 2013-05-23 | Novartis Ag | Immediate release 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-[5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide formulation |
| EP2626355B1 (en) * | 2012-02-09 | 2016-02-03 | Natco Pharma Limited | Process for the preparation of nilotinib hydrochloride |
| GB2514285B (en) | 2012-02-13 | 2018-07-18 | Grindeks Jsc | Intermediates for a novel process of preparing imatinib and related tyrosine kinase inhibitors |
| US9061028B2 (en) | 2012-02-15 | 2015-06-23 | Natco Pharma Limited | Process for the preparation of Nilotinib |
| BR112015000349A2 (pt) | 2012-07-11 | 2017-06-27 | Novartis Ag | método de tratamento de tumores estromais gastrointestinais |
| EP2906554A4 (en) * | 2012-10-15 | 2016-06-29 | Apotex Inc | SOLID FORMS OF NILOTINIB HYDROCHLORIDE |
| BR112015008552A2 (pt) * | 2012-10-19 | 2017-07-04 | Basf Se | material cristalino, composição farmacêutica, e, processo para a preparação de um material cristalino |
| HUE054212T2 (hu) * | 2013-02-21 | 2021-08-30 | Pfizer | Szelektív CDK4/6 inhibitor szilárd formái |
| EP2792360A1 (en) | 2013-04-18 | 2014-10-22 | IP Gesellschaft für Management mbH | (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV |
| JP2016522182A (ja) | 2013-04-24 | 2016-07-28 | ドクター レディズ ラボラトリーズ リミテッド | ニロチニブ塩酸塩の多形形態 |
| RU2551359C9 (ru) * | 2013-11-28 | 2021-08-20 | Общество с ограниченной ответственностью "Мамонт Фарм" | Наноразмерная слабо закристаллизованная модификация 4-метил-N-[3-(4-метилимидазол-1-ил)-5-(трифторметил)фенил]-3-[(4-пиридин-3-илпиримидин-2-ил)амино]бензамида гидрохлорида моногидрата, способ ее получения и фармацевтическая композиция на ее основе |
| WO2015092624A1 (en) | 2013-12-16 | 2015-06-25 | Ranbaxy Laboratories Limited | Nilotinib mono-oxalate and its crystalline form |
| EP3177610A4 (en) | 2014-08-08 | 2018-01-10 | Dr. Reddy's Laboratories Ltd. | Process for the preparation of polymorphic forms of nilotinib |
| WO2016058081A1 (en) * | 2014-10-16 | 2016-04-21 | Apotex Inc. | Solid forms of nilotinib hydrochloride |
| WO2017129694A1 (en) | 2016-01-26 | 2017-08-03 | Farma Grs, D.O.O. | Nilotinib dinitrate (v) and crystalline forms thereof |
| WO2017149550A1 (en) * | 2016-03-02 | 2017-09-08 | Msn Laboratories Private Limited | Amorphous form of 4-methyl-n-[3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-benzamide |
| SMT202000563T1 (it) | 2016-03-14 | 2020-11-10 | Pliva Hrvatska D O O | Forem allo stato solido di sali di nilotinib |
| CN106496193A (zh) * | 2016-09-13 | 2017-03-15 | 福格森（武汉）生物科技股份有限公司 | 一种高纯度尼罗替尼的制备方法 |
| EP3404025B1 (en) | 2017-05-16 | 2019-12-04 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of pure nilotinib and its salt |
| CZ2017821A3 (cs) | 2017-12-20 | 2019-07-03 | Zentiva, K.S. | Léková forma obsahující krystalický nilotinib |
| CN113292537B (zh) | 2018-06-15 | 2024-04-05 | 汉达癌症医药责任有限公司 | 激酶抑制剂的盐类及其组合物 |
| JP2020007240A (ja) * | 2018-07-04 | 2020-01-16 | 住友化学株式会社 | ベンズアミド化合物の製造方法 |
| US12065426B2 (en) | 2018-11-05 | 2024-08-20 | Laurus Labs Limited | Crystalline form of nilotinib hydrochloride, process for its preparation and pharmaceutical composition containing the same |
| EP4096791A1 (en) | 2020-01-31 | 2022-12-07 | Nanocopoeia LLC | Amorphous nilotinib microparticles and uses thereof |
| IL297776A (en) | 2020-04-30 | 2022-12-01 | Nanocopoeia Llc | Orally disintegrating tablets containing an amorphous solid dispersion of nalotinib |
| CN114133378B (zh) * | 2020-09-04 | 2023-08-15 | 成都苑东生物制药股份有限公司 | 一种盐酸尼洛替尼共晶及其制备方法 |
| MX2023003556A (es) | 2020-09-29 | 2023-06-13 | Shenzhen Pharmacin Co Ltd | Composiciones farmaceuticas. |
| WO2022263510A1 (en) | 2021-06-19 | 2022-12-22 | Helm Ag | Granulate composition comprising nilotinib |
| EP4122452A1 (en) | 2021-07-23 | 2023-01-25 | KRKA, d.d., Novo mesto | Pharmaceutical composition comprising nilotinib and method of manufacturing the same |
| CN113788817A (zh) * | 2021-09-27 | 2021-12-14 | 南京海润医药有限公司 | 一种尼罗替尼半盐酸盐一水合物晶型及其制备方法 |
| EP4260848A1 (en) | 2022-04-11 | 2023-10-18 | Lotus Pharmaceutical Co., Ltd. | Pharmaceutical composition for solid dosage form containing nilotinib and process for its preparation |
| CN116102540B (zh) * | 2023-01-05 | 2025-03-25 | 浙江工业大学 | 两种尼洛替尼游离碱新晶型及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US701406A (en) | 1901-07-16 | 1902-06-03 | Thomas K Jones | Cut-off-valve mechanism. |
| US701405A (en) | 1902-02-17 | 1902-06-03 | Archibald White Maconochie | Ejecting device for stamping-machines. |
| GB0215676D0 (en) * | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| GB0325031D0 (en) * | 2003-10-27 | 2003-12-03 | Novartis Ag | Organic compounds |
| SI1686997T1 (sl) * | 2003-11-18 | 2009-08-31 | Novartis Ag | Inhibitorji mutantne oblike KIT |
| GT200600316A (es) * | 2005-07-20 | 2007-04-02 | Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida. | |
| GT200600315A (es) | 2005-07-20 | 2007-03-19 | Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida |
-
2006
- 2006-07-14 GT GT200600315A patent/GT200600315A/es unknown
- 2006-07-18 KR KR1020137016680A patent/KR20130077915A/ko not_active Ceased
- 2006-07-18 MX MX2008000899A patent/MX2008000899A/es active IP Right Grant
- 2006-07-18 US US11/995,906 patent/US8343984B2/en active Active
- 2006-07-18 CN CN2011102583896A patent/CN102358736A/zh active Pending
- 2006-07-18 PT PT101739563T patent/PT2284167T/pt unknown
- 2006-07-18 PL PL10173956T patent/PL2284167T5/pl unknown
- 2006-07-18 EA EA201000145A patent/EA016856B1/ru not_active IP Right Cessation
- 2006-07-18 DK DK06800109.8T patent/DK1912973T3/da active
- 2006-07-18 WO PCT/US2006/027875 patent/WO2007015870A2/en not_active Ceased
- 2006-07-18 AU AU2006276204A patent/AU2006276204A1/en not_active Abandoned
- 2006-07-18 SG SG201005165-4A patent/SG163620A1/en unknown
- 2006-07-18 PL PL06800109T patent/PL1912973T3/pl unknown
- 2006-07-18 SI SI200632162T patent/SI2284167T2/sl unknown
- 2006-07-18 PT PT06800109T patent/PT1912973E/pt unknown
- 2006-07-18 SI SI200631365T patent/SI1912973T1/sl unknown
- 2006-07-18 EA EA200800201A patent/EA013464B1/ru not_active IP Right Cessation
- 2006-07-18 KR KR1020087001457A patent/KR101651288B1/ko active Active
- 2006-07-18 NI NI200800017A patent/NI200800017A/es unknown
- 2006-07-18 EP EP12160544.8A patent/EP2543665A3/en not_active Withdrawn
- 2006-07-18 SM SM200800011T patent/SMAP200800011A/it unknown
- 2006-07-18 ES ES06800109T patent/ES2386974T3/es active Active
- 2006-07-18 RS RS20170384A patent/RS55929B2/sr unknown
- 2006-07-18 EP EP12160493.8A patent/EP2535337B1/en active Active
- 2006-07-18 AR ARP060103070A patent/AR054846A1/es unknown
- 2006-07-18 EP EP06800109A patent/EP1912973B1/en not_active Revoked
- 2006-07-18 CN CN201310349258.8A patent/CN103804356A/zh active Pending
- 2006-07-18 UA UAA200800629A patent/UA94234C2/uk unknown
- 2006-07-18 BR BRPI0613615-0A patent/BRPI0613615B1/pt active IP Right Grant
- 2006-07-18 EP EP10173964A patent/EP2284168A3/en not_active Withdrawn
- 2006-07-18 GE GEAP200610480A patent/GEP20115302B/en unknown
- 2006-07-18 LT LTEP10173956.3T patent/LT2284167T/lt unknown
- 2006-07-18 JP JP2008522899A patent/JP5289948B2/ja active Active
- 2006-07-18 HR HRP20120573TT patent/HRP20120573T1/hr unknown
- 2006-07-18 ES ES12160493.8T patent/ES2648288T3/es active Active
- 2006-07-18 CA CA2614334A patent/CA2614334C/en active Active
- 2006-07-18 KR KR1020137016681A patent/KR20130085444A/ko not_active Ceased
- 2006-07-18 MY MYPI20063404A patent/MY148554A/en unknown
- 2006-07-18 HU HUE10173956A patent/HUE031791T2/en unknown
- 2006-07-18 ES ES10173956T patent/ES2623608T5/es active Active
- 2006-07-18 EP EP10173956.3A patent/EP2284167B2/en active Active
- 2006-07-18 DK DK10173956.3T patent/DK2284167T4/da active
- 2006-07-18 NZ NZ564409A patent/NZ564409A/en unknown
- 2006-07-19 TW TW095126415A patent/TWI406661B/zh active
- 2006-07-19 PE PE2006000870A patent/PE20070214A1/es not_active Application Discontinuation
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2007
- 2007-12-17 IL IL188189A patent/IL188189A0/en unknown
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2008
- 2008-01-09 MA MA30566A patent/MA29626B1/fr unknown
- 2008-01-11 CR CR9657A patent/CR9657A/es not_active Application Discontinuation
- 2008-01-17 CU CU2008000006A patent/CU23916B1/es active IP Right Grant
- 2008-01-18 EC EC2008008119A patent/ECSP088119A/es unknown
- 2008-01-18 TN TNP2008000029A patent/TNSN08029A1/en unknown
- 2008-02-14 NO NO20080820A patent/NO341930B1/no unknown
- 2008-02-26 HN HN2008000311A patent/HN2008000311A/es unknown
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2011
- 2011-05-04 AU AU2011202047A patent/AU2011202047A1/en not_active Withdrawn
- 2011-08-15 IL IL214659A patent/IL214659A0/en unknown
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2012
- 2012-03-09 AU AU2012201453A patent/AU2012201453C1/en active Active
- 2012-08-03 US US13/565,913 patent/US8415363B2/en active Active
- 2012-08-24 CY CY20121100769T patent/CY1113076T1/el unknown
- 2012-10-18 JP JP2012231108A patent/JP5798101B2/ja active Active
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2013
- 2013-02-22 US US13/774,433 patent/US8829015B2/en active Active
- 2013-07-26 PH PH12013501590A patent/PH12013501590A1/en unknown
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2014
- 2014-08-01 US US14/449,446 patent/US20140343087A1/en not_active Abandoned
- 2014-08-04 JP JP2014159022A patent/JP2014221831A/ja active Pending
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2016
- 2016-03-17 JO JOP/2016/0047A patent/JO3308B1/ar active
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2017
- 2017-04-24 HR HRP20170634TT patent/HRP20170634T4/hr unknown
- 2017-04-26 CY CY20171100471T patent/CY1119624T1/el unknown
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