BR112015008552A2 - material cristalino, composição farmacêutica, e, processo para a preparação de um material cristalino - Google Patents
material cristalino, composição farmacêutica, e, processo para a preparação de um material cristalinoInfo
- Publication number
- BR112015008552A2 BR112015008552A2 BR112015008552A BR112015008552A BR112015008552A2 BR 112015008552 A2 BR112015008552 A2 BR 112015008552A2 BR 112015008552 A BR112015008552 A BR 112015008552A BR 112015008552 A BR112015008552 A BR 112015008552A BR 112015008552 A2 BR112015008552 A2 BR 112015008552A2
- Authority
- BR
- Brazil
- Prior art keywords
- crystalline material
- pharmaceutical composition
- crystalline
- carboxylic acid
- preparation
- Prior art date
Links
- 239000002178 crystalline material Substances 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- 239000005536 L01XE08 - Nilotinib Substances 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 150000001733 carboxylic acid esters Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 abstract 1
- 229960001346 nilotinib Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
- C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
- C07C309/35—Naphthalene sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
- C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
- C07C65/10—Salicylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1 / 1 resumo âmaterial cristalino, composiãão farmacãutica, e, processo para a preparaãão de um material cristalinoâ a presente invenã§ã£o refere-se a materiais cristalinos compreendendo nilotinibe e um ã¡cido carboxãlico, ã©ster de ã¡cido carboxãlico, amida de ã¡cido carboxãlico ou ã¡cido sulfã´nico como um formador de cocristal, e a composiã§ãµes farmacãªuticas que compreendem os referidos materiais. a invenã§ã£o tambã©m se refere a processos para preparar os referidos materiais cristalinos e a mã©todos de utilizaã§ã£o dessas matã©rias cristalinas para o tratamento de uma condiã§ã£o de doenã§a em que a inibiã§ã£o da tirosina quinase ã© benã©fica.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261715865P | 2012-10-19 | 2012-10-19 | |
EP12189264 | 2012-10-19 | ||
EP13167657 | 2013-05-14 | ||
PCT/EP2013/071580 WO2014060449A1 (en) | 2012-10-19 | 2013-10-16 | Multicomponent crystalline system comprising nilotinib and selected co-crystal formers |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015008552A2 true BR112015008552A2 (pt) | 2017-07-04 |
Family
ID=50487597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015008552A BR112015008552A2 (pt) | 2012-10-19 | 2013-10-16 | material cristalino, composição farmacêutica, e, processo para a preparação de um material cristalino |
Country Status (11)
Country | Link |
---|---|
US (1) | US9567317B2 (pt) |
EP (1) | EP2909191B1 (pt) |
JP (2) | JP2015534967A (pt) |
KR (1) | KR20150068483A (pt) |
CN (1) | CN104736531A (pt) |
AU (1) | AU2013333953B2 (pt) |
BR (1) | BR112015008552A2 (pt) |
CA (1) | CA2887540A1 (pt) |
MX (1) | MX2015004947A (pt) |
RU (1) | RU2652121C2 (pt) |
WO (1) | WO2014060449A1 (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013510113A (ja) | 2009-11-06 | 2013-03-21 | ビーエーエスエフ ソシエタス・ヨーロピア | 4−ヒドロキシ安息香酸及び選択された殺有害生物剤の結晶複合体 |
WO2013189910A1 (en) | 2012-06-22 | 2013-12-27 | Basf Se | Multicomponent crystals comprising imatinib mesilate and selected co-crystal formers |
US9290452B2 (en) | 2012-08-06 | 2016-03-22 | Basf Se | Multicomponent crystalline system comprising deferasirox and isonicotinamide and a process for the preparation thereof |
CN105377842A (zh) | 2013-07-25 | 2016-03-02 | 巴斯夫欧洲公司 | 呈无定形形式的达沙替尼的盐 |
CA2917183C (en) | 2013-07-25 | 2019-01-29 | Basf Se | Salts of dasatinib in crystalline form |
DK3166932T3 (en) | 2014-07-08 | 2018-10-01 | Basf Agro Bv | PROCEDURE FOR PREPARING SUBSTITUTED OXIRANES AND TRIAZOLES |
CA2964198C (en) | 2014-10-16 | 2023-03-14 | Apotex Inc. | Solid forms of nilotinib hydrochloride |
US9603937B2 (en) * | 2015-03-09 | 2017-03-28 | Theaprin Pharmaceuticals Inc. | Platform drug delivery system utilizing crystal engineering and theanine dissolution |
WO2016180642A1 (en) | 2015-05-08 | 2016-11-17 | BASF Agro B.V. | A process for the preparation of terpinolene epoxide |
DK3294700T3 (da) | 2015-05-08 | 2020-04-14 | Basf Agro Bv | Fremgangsmåde til fremstilling af limonen-4-ol |
ES2814499T3 (es) * | 2016-03-14 | 2021-03-29 | Pliva Hrvatska D O O | Formas en estado sólido de sales de Nilotinib |
DK3472138T3 (da) | 2016-06-15 | 2020-11-23 | Basf Agro Bv | Fremgangsmåde til epoxidering af en tetrasubstitueret alken |
KR20190017926A (ko) | 2016-06-15 | 2019-02-20 | 바스프 아그로 비.브이. | 사치환된 알켄의 에폭시화 방법 |
AU2019285066B2 (en) | 2018-06-15 | 2024-06-13 | Handa Pharmaceuticals, Inc. | Kinase inhibitor salts and compositions thereof |
CN113402575B (zh) * | 2021-06-18 | 2022-04-22 | 邦泰生物工程(深圳)有限公司 | 一种制备烟酰胺单核苷酸共晶体的方法 |
AU2022292092A1 (en) | 2021-06-19 | 2024-02-01 | Helm Ag | Granulate composition comprising nilotinib |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0215676D0 (en) * | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
EP1596869B1 (en) | 2003-01-21 | 2014-06-04 | New Form Pharmaceuticals Inc. | Novel cocrystallization |
GT200600315A (es) * | 2005-07-20 | 2007-03-19 | Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida | |
GT200600316A (es) | 2005-07-20 | 2007-04-02 | Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida. | |
EP2262793B1 (en) | 2008-11-05 | 2012-10-03 | Teva Pharmaceutical Industries Ltd. | Nilotinib hci crystalline forms |
CZ20098A3 (cs) * | 2009-01-13 | 2010-07-21 | Zentiva, K.S. | Lékové formy inhibitoru tyrosinových kináz |
WO2011086541A1 (en) | 2010-01-15 | 2011-07-21 | Generics [Uk] Limited | Novel polymorph of nilotinib monohydrochloride monohydrate |
JP5894153B2 (ja) | 2010-06-21 | 2016-03-23 | テバ ファーマシューティカル インダストリーズ リミティド | ニロチニブ塩及びそれらの結晶性形態 |
CN102453024B (zh) * | 2010-10-27 | 2014-09-03 | 浙江九洲药业股份有限公司 | 一种尼罗替尼盐酸盐晶型及其制备方法 |
US9249108B2 (en) | 2010-11-22 | 2016-02-02 | Basf Se | Multicomponent system of rosuvastatin calcium salt and sorbitol |
WO2012143308A1 (en) | 2011-04-18 | 2012-10-26 | Basf Se | Multicomponent crystalline system of rosuvastatin calcium salt and vanillin |
CA2841655A1 (en) | 2011-07-26 | 2013-01-31 | Basf Se | Multicomponent crystalline system of ezetimibe and proline |
MX2014002068A (es) | 2011-08-30 | 2014-05-30 | Basf Se | Co - cristales de ciprodinilo y ditianon. |
US20150087657A1 (en) | 2011-12-06 | 2015-03-26 | Basf Se | Multicomponent crystalline system of voriconazole with fumaric acid |
BR112014016137B1 (pt) | 2011-12-30 | 2021-02-09 | Basf Se | forma cristalina não solvatada, monossolvato de tolueno cristalino, solvato de acetona cristalino, composição, processo para a preparação do monossolvato de tolueno cristalino, processo para a preparação de uma forma cristalina não solvatada, processo para a preparação do solvato de acetona cristalino, método para obter o solvato de acetona cristalino, uso de uma forma cristalina, e, método para produzir um catalisador de metal de transição |
US8796481B2 (en) | 2011-12-30 | 2014-08-05 | Basf Se | Crystalline solvate and non-solvated forms of 6,6′-[[3,3′,5,5′-tetrakis(1,1-dimethylethyl)-[1,1′biphenyl]-2,2′-diyl]bis(oxy)]bis-dibenzo [d,f] [1,3,2]-dioxaphosphepine |
WO2013143927A1 (en) | 2012-03-29 | 2013-10-03 | Basf Se | Co-crystals of dicamba and a co-crystal former b |
CN104334549B (zh) | 2012-05-25 | 2017-03-22 | 巴斯夫欧洲公司 | 1,5‑二甲基‑6‑硫代‑3‑(2,2,7‑三氟‑3‑氧代‑4‑(丙‑2‑炔基)‑3,4‑二氢‑2H‑苯并[b][1,4]噁嗪‑6‑基)‑1,3,5‑三嗪烷‑2,4‑二酮的晶型A |
WO2013174694A1 (en) | 2012-05-25 | 2013-11-28 | Basf Se | Crystalline form b of 1,5-dimethyl-6-thioxo-3-(2,2,7-trifluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2h-benzo[b][1,4]oxazin-6-yl)-1,3,5-triazinane-2,4-dione |
ES2637829T3 (es) | 2012-06-15 | 2017-10-17 | Basf Se | Cristales multicomponentes que comprenden dasatinib y agentes de formación de cocristales seleccionados |
WO2013189910A1 (en) | 2012-06-22 | 2013-12-27 | Basf Se | Multicomponent crystals comprising imatinib mesilate and selected co-crystal formers |
US9290452B2 (en) | 2012-08-06 | 2016-03-22 | Basf Se | Multicomponent crystalline system comprising deferasirox and isonicotinamide and a process for the preparation thereof |
-
2013
- 2013-10-16 AU AU2013333953A patent/AU2013333953B2/en not_active Ceased
- 2013-10-16 CN CN201380054044.6A patent/CN104736531A/zh active Pending
- 2013-10-16 CA CA2887540A patent/CA2887540A1/en not_active Abandoned
- 2013-10-16 EP EP13783008.9A patent/EP2909191B1/en not_active Not-in-force
- 2013-10-16 US US14/433,147 patent/US9567317B2/en not_active Expired - Fee Related
- 2013-10-16 WO PCT/EP2013/071580 patent/WO2014060449A1/en active Application Filing
- 2013-10-16 BR BR112015008552A patent/BR112015008552A2/pt not_active IP Right Cessation
- 2013-10-16 RU RU2015118436A patent/RU2652121C2/ru not_active IP Right Cessation
- 2013-10-16 KR KR1020157012700A patent/KR20150068483A/ko not_active Application Discontinuation
- 2013-10-16 MX MX2015004947A patent/MX2015004947A/es unknown
- 2013-10-16 JP JP2015537234A patent/JP2015534967A/ja active Pending
-
2018
- 2018-01-31 JP JP2018014833A patent/JP2018065876A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
RU2652121C2 (ru) | 2018-04-25 |
AU2013333953B2 (en) | 2017-08-31 |
US20150246901A1 (en) | 2015-09-03 |
EP2909191A1 (en) | 2015-08-26 |
WO2014060449A1 (en) | 2014-04-24 |
KR20150068483A (ko) | 2015-06-19 |
JP2015534967A (ja) | 2015-12-07 |
CN104736531A (zh) | 2015-06-24 |
EP2909191B1 (en) | 2019-03-20 |
US9567317B2 (en) | 2017-02-14 |
AU2013333953A1 (en) | 2015-04-30 |
JP2018065876A (ja) | 2018-04-26 |
CA2887540A1 (en) | 2014-04-24 |
RU2015118436A (ru) | 2016-12-10 |
MX2015004947A (es) | 2016-02-22 |
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