BR112015008552A2 - material cristalino, composição farmacêutica, e, processo para a preparação de um material cristalino - Google Patents

material cristalino, composição farmacêutica, e, processo para a preparação de um material cristalino

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Publication number
BR112015008552A2
BR112015008552A2 BR112015008552A BR112015008552A BR112015008552A2 BR 112015008552 A2 BR112015008552 A2 BR 112015008552A2 BR 112015008552 A BR112015008552 A BR 112015008552A BR 112015008552 A BR112015008552 A BR 112015008552A BR 112015008552 A2 BR112015008552 A2 BR 112015008552A2
Authority
BR
Brazil
Prior art keywords
crystalline material
pharmaceutical composition
crystalline
carboxylic acid
preparation
Prior art date
Application number
BR112015008552A
Other languages
English (en)
Inventor
Hafner Andreas
Salvador Beate
Rödel Eva
Blatter Fritz
Vossen Marcus
Szelagiewicz Martin
Chiodo Tiziana
Hintermann Tobias
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of BR112015008552A2 publication Critical patent/BR112015008552A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
    • C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
    • C07C309/35—Naphthalene sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
    • C07C65/10—Salicylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1 / 1 resumo “material cristalino, composiã‡ãƒo farmacãšutica, e, processo para a preparaã‡ãƒo de um material cristalino” a presente invenã§ã£o refere-se a materiais cristalinos compreendendo nilotinibe e um ã¡cido carboxã­lico, ã©ster de ã¡cido carboxã­lico, amida de ã¡cido carboxã­lico ou ã¡cido sulfã´nico como um formador de cocristal, e a composiã§ãµes farmacãªuticas que compreendem os referidos materiais. a invenã§ã£o tambã©m se refere a processos para preparar os referidos materiais cristalinos e a mã©todos de utilizaã§ã£o dessas matã©rias cristalinas para o tratamento de uma condiã§ã£o de doenã§a em que a inibiã§ã£o da tirosina quinase ã© benã©fica.
BR112015008552A 2012-10-19 2013-10-16 material cristalino, composição farmacêutica, e, processo para a preparação de um material cristalino BR112015008552A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261715865P 2012-10-19 2012-10-19
EP12189264 2012-10-19
EP13167657 2013-05-14
PCT/EP2013/071580 WO2014060449A1 (en) 2012-10-19 2013-10-16 Multicomponent crystalline system comprising nilotinib and selected co-crystal formers

Publications (1)

Publication Number Publication Date
BR112015008552A2 true BR112015008552A2 (pt) 2017-07-04

Family

ID=50487597

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015008552A BR112015008552A2 (pt) 2012-10-19 2013-10-16 material cristalino, composição farmacêutica, e, processo para a preparação de um material cristalino

Country Status (11)

Country Link
US (1) US9567317B2 (pt)
EP (1) EP2909191B1 (pt)
JP (2) JP2015534967A (pt)
KR (1) KR20150068483A (pt)
CN (1) CN104736531A (pt)
AU (1) AU2013333953B2 (pt)
BR (1) BR112015008552A2 (pt)
CA (1) CA2887540A1 (pt)
MX (1) MX2015004947A (pt)
RU (1) RU2652121C2 (pt)
WO (1) WO2014060449A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9173391B2 (en) 2009-11-06 2015-11-03 Basf Se Crystalline complexes of 4-hydroxy benzoic acid and selected pesticides
CA2877030A1 (en) 2012-06-22 2013-12-27 Basf Se Multicomponent crystals comprising imatinib mesilate and selected co-crystal formers
ES2598168T3 (es) 2012-08-06 2017-01-25 Basf Se Sistema cristalino de múltiples componentes que comprende deferasirox e isonicotinamida y procedimiento para la preparación del mismo
AU2014295144B2 (en) 2013-07-25 2017-06-15 Basf Se Salts of Dasatinib in crystalline form
US9884857B2 (en) 2013-07-25 2018-02-06 Basf Se Salts of dasatinib in amorphous form
BR112017000304B1 (pt) 2014-07-08 2021-06-29 BASF Agro B.V. Processo para a preparação dos compostos de fórmula ii
CA2964198C (en) 2014-10-16 2023-03-14 Apotex Inc. Solid forms of nilotinib hydrochloride
US9603937B2 (en) * 2015-03-09 2017-03-28 Theaprin Pharmaceuticals Inc. Platform drug delivery system utilizing crystal engineering and theanine dissolution
WO2016180642A1 (en) 2015-05-08 2016-11-17 BASF Agro B.V. A process for the preparation of terpinolene epoxide
EP3294700B1 (en) 2015-05-08 2020-01-29 BASF Agro B.V. A process for the preparation of limonene-4-ol
LT3430004T (lt) 2016-03-14 2020-11-25 Pliva Hrvatska D.O.O. Nilotinibo druskų kietosios būsenos formos
WO2017215929A1 (en) 2016-06-15 2017-12-21 BASF Agro B.V. Process for the epoxidation of a tetrasubstituted alkene
WO2017215928A1 (en) 2016-06-15 2017-12-21 BASF Agro B.V. Process for the epoxidation of a tetrasubstituted alkene
CN116808044A (zh) 2018-06-15 2023-09-29 汉达癌症医药责任有限公司 激酶抑制剂的盐类及其组合物
CN113402575B (zh) * 2021-06-18 2022-04-22 邦泰生物工程(深圳)有限公司 一种制备烟酰胺单核苷酸共晶体的方法
CA3224750A1 (en) 2021-06-19 2022-12-22 Helm Ag Granulate composition comprising nilotinib

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
JP5069905B2 (ja) * 2003-01-21 2012-11-07 アプテュイト （ウエスト ラファイエット）、エルエルシー 新規な共結晶化
GT200600316A (es) * 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
GT200600315A (es) * 2005-07-20 2007-03-19 Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida
PL2262793T3 (pl) 2008-11-05 2013-01-31 Teva Pharma Formy krystaliczne nilotynibu HCL
CZ20098A3 (cs) 2009-01-13 2010-07-21 Zentiva, K.S. Lékové formy inhibitoru tyrosinových kináz
WO2011086541A1 (en) * 2010-01-15 2011-07-21 Generics [Uk] Limited Novel polymorph of nilotinib monohydrochloride monohydrate
WO2011163222A1 (en) 2010-06-21 2011-12-29 Teva Pharmaceutical Industries Ltd. Nilotinib salts and crystalline forms thereof
CN102453024B (zh) * 2010-10-27 2014-09-03 浙江九洲药业股份有限公司 一种尼罗替尼盐酸盐晶型及其制备方法
EP2643305A1 (en) 2010-11-22 2013-10-02 Basf Se Multicomponent system of rosuvastatin calcium salt and sorbitol
CA2832343A1 (en) 2011-04-18 2012-10-26 Basf Se Multicomponent crystalline system of rosuvastatin calcium salt and vanillin
US20140155371A1 (en) 2011-07-26 2014-06-05 Basf Se Multicomponent crystalline system of ezetimibe and proline
PE20141533A1 (es) 2011-08-30 2014-11-14 Basf Se Cocristales de cyprodinil y dithianon
WO2013084130A1 (en) 2011-12-06 2013-06-13 Basf Se Multicomponent crystalline system of voriconazole with fumaric acid
US8796481B2 (en) 2011-12-30 2014-08-05 Basf Se Crystalline solvate and non-solvated forms of 6,6′-[[3,3′,5,5′-tetrakis(1,1-dimethylethyl)-[1,1′biphenyl]-2,2′-diyl]bis(oxy)]bis-dibenzo [d,f] [1,3,2]-dioxaphosphepine
EP2797937B1 (en) 2011-12-30 2022-08-31 Basf Se Non-solvated crystalline form of 6,6'-[[3,3',5,5'-tetrakis(1,1-dimethylethyl)-[1,1'-biphenyl]-2,2'-diyl]bis(oxy)]bis-dibenzo [d,f][1,3,2]-dioxaphosphepine
US20150065347A1 (en) 2012-03-29 2015-03-05 Basf Se Co-crystals of dicamba and a co-crystal former b
UA116887C2 (uk) 2012-05-25 2018-05-25 Басф Се КРИСТАЛІЧНА ФОРМА В 1,5-ДИМЕТИЛ-6-ТІОКСО-3-(2,2,7-ТРИФТОР-3-ОКСО-4-(ПРОП-2-ІНІЛ)-3,4-ДИГІДРО-2H-БЕНЗО[b][1,4]ОКСАЗИН-6-ІЛ)-1,3,5-ТРИАЗИНАН-2,4-ДІОНУ
CA2871315C (en) 2012-05-25 2020-11-03 Basf Se Crystalline form a of 1,5-dimethyl-6-thioxo-3-(2,2,7-trifluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2h-benzo[b][1,4]oxazin-6-yl)-1,3,5-triazinane-2,4-dione
MX347429B (es) 2012-06-15 2017-04-26 Basf Se Cristales de múltiples componentes que comprenden dasatinib y formadores de cocristales seleccionados.
CA2877030A1 (en) 2012-06-22 2013-12-27 Basf Se Multicomponent crystals comprising imatinib mesilate and selected co-crystal formers
ES2598168T3 (es) 2012-08-06 2017-01-25 Basf Se Sistema cristalino de múltiples componentes que comprende deferasirox e isonicotinamida y procedimiento para la preparación del mismo

Also Published As

Publication number Publication date
JP2015534967A (ja) 2015-12-07
AU2013333953A1 (en) 2015-04-30
CA2887540A1 (en) 2014-04-24
US9567317B2 (en) 2017-02-14
AU2013333953B2 (en) 2017-08-31
WO2014060449A1 (en) 2014-04-24
CN104736531A (zh) 2015-06-24
RU2015118436A (ru) 2016-12-10
JP2018065876A (ja) 2018-04-26
US20150246901A1 (en) 2015-09-03
RU2652121C2 (ru) 2018-04-25
EP2909191B1 (en) 2019-03-20
KR20150068483A (ko) 2015-06-19
MX2015004947A (es) 2016-02-22
EP2909191A1 (en) 2015-08-26

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
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B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2599 DE 27-10-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.