JP2009501230A5 - - Google Patents
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- Publication number
- JP2009501230A5 JP2009501230A5 JP2008521556A JP2008521556A JP2009501230A5 JP 2009501230 A5 JP2009501230 A5 JP 2009501230A5 JP 2008521556 A JP2008521556 A JP 2008521556A JP 2008521556 A JP2008521556 A JP 2008521556A JP 2009501230 A5 JP2009501230 A5 JP 2009501230A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- composition
- subject
- administered
- camptothecin compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 37
- 241000700605 Viruses Species 0.000 claims 32
- -1 camptothecin compound Chemical class 0.000 claims 27
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 22
- 229940127093 camptothecin Drugs 0.000 claims 22
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 22
- 241000711404 Avian avulavirus 1 Species 0.000 claims 12
- WAVYAFBQOXCGSZ-UHFFFAOYSA-N 2-fluoropyrimidine Chemical compound FC1=NC=CC=N1 WAVYAFBQOXCGSZ-UHFFFAOYSA-N 0.000 claims 8
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 6
- 241000712079 Measles morbillivirus Species 0.000 claims 6
- 241000700562 Myxoma virus Species 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 241000709664 Picornaviridae Species 0.000 claims 6
- 241000711975 Vesicular stomatitis virus Species 0.000 claims 6
- 208000035269 cancer or benign tumor Diseases 0.000 claims 6
- 229960002949 fluorouracil Drugs 0.000 claims 6
- 229960004768 irinotecan Drugs 0.000 claims 6
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 6
- 241000712461 unidentified influenza virus Species 0.000 claims 6
- 241000710960 Sindbis virus Species 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- PAEZRCINULFAGO-OAQYLSRUSA-N (R)-homocamptothecin Chemical compound CC[C@@]1(O)CC(=O)OCC(C2=O)=C1C=C1N2CC2=CC3=CC=CC=C3N=C21 PAEZRCINULFAGO-OAQYLSRUSA-N 0.000 claims 2
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims 2
- FUXVKZWTXQUGMW-FQEVSTJZSA-N 9-Aminocamptothecin Chemical compound C1=CC(N)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 FUXVKZWTXQUGMW-FQEVSTJZSA-N 0.000 claims 2
- ZVYVPGLRVWUPMP-FYSMJZIKSA-N exatecan Chemical compound C1C[C@H](N)C2=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC3=CC(F)=C(C)C1=C32 ZVYVPGLRVWUPMP-FYSMJZIKSA-N 0.000 claims 2
- 229950009429 exatecan Drugs 0.000 claims 2
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims 2
- 235000008191 folinic acid Nutrition 0.000 claims 2
- 239000011672 folinic acid Substances 0.000 claims 2
- 238000001802 infusion Methods 0.000 claims 2
- 229960001691 leucovorin Drugs 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical compound C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 claims 2
- 229950009213 rubitecan Drugs 0.000 claims 2
- 229960000303 topotecan Drugs 0.000 claims 2
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 2
- 231100000331 toxic Toxicity 0.000 claims 2
- 230000002588 toxic effect Effects 0.000 claims 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69919505P | 2005-07-14 | 2005-07-14 | |
| US60/699,195 | 2005-07-14 | ||
| PCT/US2006/027018 WO2007011601A2 (en) | 2005-07-14 | 2006-07-12 | Cancer treatment using viruses, fluoropyrimidines and camptothecins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009501230A JP2009501230A (ja) | 2009-01-15 |
| JP2009501230A5 true JP2009501230A5 (https=) | 2009-08-06 |
| JP5190958B2 JP5190958B2 (ja) | 2013-04-24 |
Family
ID=37669342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008521556A Expired - Fee Related JP5190958B2 (ja) | 2005-07-14 | 2006-07-12 | ウイルス、フルオロピリミジンおよびカンプトテシンを使用した癌の処置 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7767200B2 (https=) |
| EP (1) | EP1907015B1 (https=) |
| JP (1) | JP5190958B2 (https=) |
| KR (1) | KR20080039344A (https=) |
| CN (1) | CN101400368B (https=) |
| AT (1) | ATE540698T1 (https=) |
| AU (1) | AU2006270297B2 (https=) |
| CA (1) | CA2612949C (https=) |
| IL (1) | IL186730A0 (https=) |
| MX (1) | MX2007015407A (https=) |
| NZ (1) | NZ562951A (https=) |
| RU (1) | RU2435586C2 (https=) |
| WO (1) | WO2007011601A2 (https=) |
| ZA (1) | ZA200708840B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070207149A1 (en) | 2004-04-27 | 2007-09-06 | Wellstat Biologics Corporation | Cancer treatment using viruses and camptothecins |
| US7900230B2 (en) * | 2005-04-01 | 2011-03-01 | The Directv Group, Inc. | Intelligent two-way switching network |
| US8019275B2 (en) | 2005-10-12 | 2011-09-13 | The Directv Group, Inc. | Band upconverter approach to KA/KU signal distribution |
| US7991348B2 (en) | 2005-10-12 | 2011-08-02 | The Directv Group, Inc. | Triple band combining approach to satellite signal distribution |
| JP5748656B2 (ja) * | 2008-05-22 | 2015-07-15 | ジェ イル ファーマシューティカル カンパニー リミテッド | 過剰増殖細胞の腫瘍抑制因子に基づいた腫瘍崩壊ウイルスに対する感受性を判定する方法 |
| ES2380289T3 (es) | 2009-11-30 | 2012-05-10 | United Cancer Research Institute | Nuevo clon del virus de la enfermedad de Newcastle, su fabricación y aplicación en el tratamiento médico del cáncer |
| RU2496873C1 (ru) * | 2012-06-04 | 2013-10-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет" (НГУ) | ШТАММ ЭНТЕРОВИРУСА КОКСАКИ В6, СЕЛЕКТИВНО ИНФИЦИРУЮЩИЙ И ЛИЗИРУЮЩИЙ ОПУХОЛЕВЫЕ КЛЕТКИ ЧЕЛОВЕКА in vitro |
| CN112704683A (zh) * | 2020-12-30 | 2021-04-27 | 烟台大学 | 一种新型喜树碱衍生物及其制备抗肿瘤药物的应用 |
| CN112773812A (zh) * | 2020-12-30 | 2021-05-11 | 烟台大学 | 新型喜树碱衍生物制备抗肿瘤药物的应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| US5004758A (en) | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
| CA2161671A1 (en) * | 1993-04-30 | 1994-11-10 | Robert M. Lorence | Methods of treating and detecting cancer using viruses |
| US6638762B1 (en) | 1994-11-28 | 2003-10-28 | Genetic Therapy, Inc. | Tissue-vectors specific replication and gene expression |
| JPH11513390A (ja) * | 1995-10-06 | 1999-11-16 | アーチ デベロップメント コーポレイション | 細胞殺傷のウイルス増強のための方法および組成物 |
| JP3499246B2 (ja) | 1995-11-02 | 2004-02-23 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | カンプトテシン誘導体の製造法 |
| GB9600438D0 (en) | 1996-01-10 | 1996-03-13 | Pharmacia Spa | Hexacyclic camptothecin analogues, and process for preparing them |
| GB9601779D0 (en) | 1996-01-30 | 1996-04-03 | Pharmacia Spa | 9, 10 Disubstituted camptothecin derivatives |
| GB9702807D0 (en) | 1997-02-12 | 1997-04-02 | Pharmacia & Upjohn Spa | Alkynyl-substituted camptothecins and process for their preparation |
| GB9715821D0 (en) | 1997-07-25 | 1997-10-01 | Pharmacia & Upjohn Spa | Amidino-camptothecin derivatives |
| GB9721069D0 (en) | 1997-10-03 | 1997-12-03 | Pharmacia & Upjohn Spa | Polymeric derivatives of camptothecin |
| GB9721070D0 (en) | 1997-10-03 | 1997-12-03 | Pharmacia & Upjohn Spa | Bioactive derivatives of camptothecin |
| US20030044384A1 (en) | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
| HUP0103314A3 (en) | 1998-08-05 | 2002-07-29 | Aventis Pharma Sa | Use of camptothecin derivatives, with reduced gastrointestinal toxicity |
| EP1044977B1 (en) | 1999-03-09 | 2002-05-02 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Camptothecin derivatives having antitumor activity |
| US6428968B1 (en) | 1999-03-15 | 2002-08-06 | The Trustees Of The University Of Pennsylvania | Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject |
| IL145899A0 (en) * | 1999-04-15 | 2002-07-25 | Pro Virus Inc | Treatment of neoplasms with viruses |
| AU4564200A (en) | 1999-04-29 | 2000-11-17 | Aventis Pharma S.A. | Method for treating cancer using camptothecin derivatives and 5-fluorouracil |
| CA2369491C (en) | 2000-02-02 | 2008-09-02 | Yasufumi Kaneda | Virus envelope vector for gene transfer |
| WO2001064194A2 (en) | 2000-02-29 | 2001-09-07 | Janssen Pharmaceutica N.V. | Farnesyl protein transferase inhibitor combinations with camptothecin compounds |
| HUP0204562A2 (hu) | 2000-03-17 | 2003-04-28 | Cell Therapeutics, Inc. | Poliglutaminsav-kamptotecin konjugátumok, eljárás előállításukra és ilyen konjugátumokat tartalmazó gyógyászati készítmények |
| US6911200B2 (en) | 2000-03-24 | 2005-06-28 | Cell Genesys, Inc. | Methods of treating neoplasia with combination of target-cell specific adenovirus, chemotherapy and radiation |
| GB0008928D0 (en) | 2000-04-11 | 2000-05-31 | Pharmacia & Upjohn Spa | A method of administering an antitumour compound |
| AU6814601A (en) | 2000-06-01 | 2001-12-11 | Sloan Kettering Inst Cancer | Use of mutant herpes viruses and anticancer agents in the treatment of cancer |
| AR035227A1 (es) | 2001-02-20 | 2004-05-05 | Oncolytics Biotech Inc | Uso de un agente quimioterapeutico para la manufactura de un medicamento para la sensibilizacion de celulas neoplasicas resistentes a agentes quimioterapeuticos con reovirus |
| US7348003B2 (en) * | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
| WO2003014338A1 (en) | 2001-08-02 | 2003-02-20 | Anges Mg, Inc. | Process for producing inactivated virus envelope |
| WO2005113013A2 (en) | 2004-05-20 | 2005-12-01 | Theravir Management L.P. | Compositions of ndv and methods of use thereof for treatment of cancer |
| US7615209B2 (en) | 2001-09-12 | 2009-11-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions of NDV and methods of use thereof for treatment of cancer |
| IL145397A0 (en) | 2001-09-12 | 2002-06-30 | Yissum Res Dev Co | Compositions and methods for treatment of cancer |
| TW200306314A (en) | 2002-04-16 | 2003-11-16 | Tanabe Seiyaku Co | Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation |
| US6593334B1 (en) | 2002-05-02 | 2003-07-15 | The University Of North Carolina At Chapel Hill | Camptothecin-taxoid conjugates as antimitotic and antitumor agents |
| ITRM20020306A1 (it) | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Esteri in posizione 20 di camptotecine. |
| WO2003101998A1 (en) | 2002-06-03 | 2003-12-11 | California Pacific Medical Center | Nitrogen-based homo-camptothecin derivatives |
| AU2003243397A1 (en) | 2002-06-03 | 2003-12-19 | California Pacific Medical Center | Homo-camptothecin derivatives |
| US20050220818A1 (en) | 2002-06-21 | 2005-10-06 | Wellstat Biologics Corporation | Administration of therapeutic viruses |
| US6759416B2 (en) | 2002-08-06 | 2004-07-06 | Panorama Research, Inc. | Anticancer conjugates of camptothecin and unsaturated fatty acids |
| CA2501701A1 (en) * | 2002-11-01 | 2004-05-13 | Genomidea Inc. | Chemotherapeutic agent-incorporated pharmaceutical preparation |
| US7329638B2 (en) * | 2003-04-30 | 2008-02-12 | The Regents Of The University Of Michigan | Drug delivery compositions |
| WO2005051433A1 (en) * | 2003-11-25 | 2005-06-09 | United Cancer Research Institute | Method for treating human tumor cells with a newcastle disease virus strain and a chemotherapeutic agent |
| US20070207149A1 (en) * | 2004-04-27 | 2007-09-06 | Wellstat Biologics Corporation | Cancer treatment using viruses and camptothecins |
| MXPA06013902A (es) | 2004-05-28 | 2007-01-26 | Pfizer Prod Inc | Procedimiento para tratar el crecimiento de celulas anormal. |
-
2006
- 2006-07-12 US US11/913,362 patent/US7767200B2/en active Active
- 2006-07-12 MX MX2007015407A patent/MX2007015407A/es active IP Right Grant
- 2006-07-12 KR KR1020077030035A patent/KR20080039344A/ko not_active Ceased
- 2006-07-12 CN CN2006800198745A patent/CN101400368B/zh not_active Expired - Fee Related
- 2006-07-12 CA CA2612949A patent/CA2612949C/en not_active Expired - Fee Related
- 2006-07-12 JP JP2008521556A patent/JP5190958B2/ja not_active Expired - Fee Related
- 2006-07-12 AU AU2006270297A patent/AU2006270297B2/en not_active Ceased
- 2006-07-12 EP EP06774644A patent/EP1907015B1/en not_active Not-in-force
- 2006-07-12 WO PCT/US2006/027018 patent/WO2007011601A2/en not_active Ceased
- 2006-07-12 RU RU2008105603/15A patent/RU2435586C2/ru not_active IP Right Cessation
- 2006-07-12 NZ NZ562951A patent/NZ562951A/en not_active IP Right Cessation
- 2006-07-12 AT AT06774644T patent/ATE540698T1/de active
-
2007
- 2007-10-16 ZA ZA200708840A patent/ZA200708840B/xx unknown
- 2007-10-17 IL IL186730A patent/IL186730A0/en not_active IP Right Cessation
-
2010
- 2010-07-20 US US12/839,829 patent/US20110117060A1/en not_active Abandoned
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