JP2015515475A5 - - Google Patents
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- Publication number
- JP2015515475A5 JP2015515475A5 JP2015504706A JP2015504706A JP2015515475A5 JP 2015515475 A5 JP2015515475 A5 JP 2015515475A5 JP 2015504706 A JP2015504706 A JP 2015504706A JP 2015504706 A JP2015504706 A JP 2015504706A JP 2015515475 A5 JP2015515475 A5 JP 2015515475A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- amount
- pridopidine
- tetrabenazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 29
- YGKUEOZJFIXDGI-UHFFFAOYSA-N pridopidine Chemical compound C1CN(CCC)CCC1C1=CC=CC(S(C)(=O)=O)=C1 YGKUEOZJFIXDGI-UHFFFAOYSA-N 0.000 claims 14
- 229950003764 pridopidine Drugs 0.000 claims 14
- MKJIEFSOBYUXJB-HOCLYGCPSA-N (3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one Chemical compound C1CN2C[C@H](CC(C)C)C(=O)C[C@H]2C2=C1C=C(OC)C(OC)=C2 MKJIEFSOBYUXJB-HOCLYGCPSA-N 0.000 claims 13
- 229960005333 tetrabenazine Drugs 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 208000016285 Movement disease Diseases 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 4
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 3
- 208000023105 Huntington disease Diseases 0.000 claims 3
- 208000000323 Tourette Syndrome Diseases 0.000 claims 3
- 208000016620 Tourette disease Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 208000012661 Dyskinesia Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 230000003111 delayed effect Effects 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 208000019505 Deglutition disease Diseases 0.000 claims 1
- 208000027089 Parkinsonian disease Diseases 0.000 claims 1
- 206010034010 Parkinsonism Diseases 0.000 claims 1
- 208000001431 Psychomotor Agitation Diseases 0.000 claims 1
- 206010038743 Restlessness Diseases 0.000 claims 1
- 206010039897 Sedation Diseases 0.000 claims 1
- 208000032140 Sleepiness Diseases 0.000 claims 1
- 206010041349 Somnolence Diseases 0.000 claims 1
- 206010043118 Tardive Dyskinesia Diseases 0.000 claims 1
- 238000011374 additional therapy Methods 0.000 claims 1
- 238000013019 agitation Methods 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 238000002648 combination therapy Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 230000003340 mental effect Effects 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 230000036280 sedation Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261620203P | 2012-04-04 | 2012-04-04 | |
| US61/620,203 | 2012-04-04 | ||
| US201261625192P | 2012-04-17 | 2012-04-17 | |
| US61/625,192 | 2012-04-17 | ||
| US201361783730P | 2013-03-14 | 2013-03-14 | |
| US61/783,730 | 2013-03-14 | ||
| PCT/US2013/035124 WO2013152105A1 (en) | 2012-04-04 | 2013-04-03 | Pharmaceutical compositions for combination therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015515475A JP2015515475A (ja) | 2015-05-28 |
| JP2015515475A5 true JP2015515475A5 (https=) | 2016-05-26 |
| JP6177875B2 JP6177875B2 (ja) | 2017-08-09 |
Family
ID=49292803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015504706A Active JP6177875B2 (ja) | 2012-04-04 | 2013-04-03 | 併用療法のための医薬組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20130267552A1 (https=) |
| EP (1) | EP2844346B1 (https=) |
| JP (1) | JP6177875B2 (https=) |
| KR (1) | KR20150013476A (https=) |
| CN (1) | CN104470585A (https=) |
| AU (1) | AU2013243461A1 (https=) |
| BR (1) | BR112014024672A8 (https=) |
| CA (1) | CA2869145A1 (https=) |
| EA (1) | EA027748B1 (https=) |
| ES (1) | ES2776678T3 (https=) |
| HK (1) | HK1206297A1 (https=) |
| IL (1) | IL234831B (https=) |
| MX (1) | MX2014011971A (https=) |
| NZ (1) | NZ630560A (https=) |
| WO (1) | WO2013152105A1 (https=) |
| ZA (1) | ZA201407726B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| CN101711236B (zh) * | 2007-04-12 | 2012-10-31 | Nsab神经研究瑞典公司分公司 | 表现出改善的心血管副作用特性的多巴胺受体稳定剂/调节剂的n-氧化物和/或二-n-氧化物衍生物 |
| JP2013536825A (ja) | 2010-09-03 | 2013-09-26 | イバックス・インターナショナル・ゲーエムベーハー | ドパミン作動性安定化剤として有用なプリドピジンの重水素化類似体 |
| BR112014005389A8 (pt) | 2011-09-07 | 2018-04-03 | Ivax Int Gmbh | Sal cloridrato de 4- (3-metanossulfonil-fenil) -1- propil-piperidina em uma forma cristalina, composição farmacêutica compreendendo o mesmo e usos do dito sal |
| TWI579272B (zh) | 2011-12-08 | 2017-04-21 | 梯瓦製藥國際有限責任公司 | 普多比啶（ｐｒｉｄｏｐｉｄｉｎｅ）之氫溴酸鹽 |
| US11090297B2 (en) | 2013-06-21 | 2021-08-17 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating huntington's disease |
| HK1221646A1 (zh) | 2013-06-21 | 2017-06-09 | Teva Pharmaceuticals International Gmbh | 高剂量普利多匹定用於治疗亨廷顿舞蹈症的用途 |
| MX377576B (es) * | 2014-01-22 | 2025-03-04 | Prilenia Neurotherapeutics Ltd | Formulaciones de pridopidina de liberación modificada. |
| TWI831128B (zh) * | 2014-04-25 | 2024-02-01 | 日商中外製藥股份有限公司 | 以高用量含有４環性化合物的製劑 |
| TW201613859A (en) | 2014-06-30 | 2016-04-16 | Teva Pharma | Analogs of PRIDOPIDINE, their preparation and use |
| MX2017008136A (es) | 2014-12-22 | 2018-03-06 | Teva Pharmaceuticals Int Gmbh | Sal de l-tartrato de pridopidina. |
| JP6887952B2 (ja) | 2015-02-25 | 2021-06-16 | プリレニア ニューロセラピューティクス リミテッド | 認知機能を改善するため、およびアルツハイマー病を治療するためのプリドピジンの使用 |
| US11471449B2 (en) | 2015-02-25 | 2022-10-18 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine to improve cognitive function and for treating Alzheimer's disease |
| AR105434A1 (es) | 2015-07-22 | 2017-10-04 | Teva Pharmaceuticals Int Gmbh | Proceso para preparar pridopidina |
| JP7034488B2 (ja) | 2016-02-24 | 2022-03-14 | プリレニア・ニューロセラピューティクス・エルティーディー | プリドピジンを使用する神経変性眼疾患の治療 |
| EP4516356A3 (en) | 2016-08-24 | 2025-05-14 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine for treating functional decline |
| CA3035099C (en) | 2016-08-24 | 2023-01-17 | Prilenia Therapeutics Development Ltd. | Use of pridopidine for treating dystonias |
| US12102627B2 (en) | 2016-09-16 | 2024-10-01 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine for treating rett syndrome |
| HUE058314T2 (hu) | 2016-09-16 | 2022-07-28 | Prilenia Neurotherapeutics Ltd | Pridopidin alkalmazása Rett-szindróma kezelésére |
| CA3050700C (en) | 2017-01-20 | 2023-10-03 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine for the treatment of fragile x syndrome |
| WO2019010491A1 (en) * | 2017-07-07 | 2019-01-10 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | COMBINATIONS OF MEDICINES FOR THE PROTECTION AGAINST THE DEATH OF NEURONAL CELLS |
| EP3664787B1 (en) | 2017-07-20 | 2022-07-20 | Neurolixis | Use of selective serotonin 5-ht1a receptor agonists for treating side-effects of vmat inhibitors |
| SI4154882T1 (sl) | 2017-08-14 | 2026-01-30 | Prilenia Neurotherapeutics Ltd. | Zdravljenje amiotrofične lateralne skleroze s pridopidinom |
| CA3073568A1 (en) | 2017-08-30 | 2019-03-07 | Prilenia Neurotherapeutics Ltd. | High concentration dosage forms of pridopidine |
| JP2020533296A (ja) * | 2017-09-08 | 2020-11-19 | プリレニア ニューロセラピューティクス リミテッド | 薬物誘発性ジスキネジアを治療するためのプリドピジン |
| WO2020110128A1 (en) * | 2018-11-29 | 2020-06-04 | Prilenia Neurotherapeutics Ltd. | Combination of pridopidine and an additional therapeutic agent for treating drug induced dyskinesia |
| US12036213B2 (en) | 2017-09-08 | 2024-07-16 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating drug induced dyskinesias |
| DE102019101015A1 (de) * | 2018-01-17 | 2019-07-18 | Hirschmann Car Communication Gmbh | Ein von einem Empfangssystem abgesetztes LTE-Modul |
| CA3097189A1 (en) * | 2018-04-25 | 2019-10-31 | Shinkei Therapeutics Llc | Tetrabenazine transdermal delivery device |
| CN113395964A (zh) | 2019-02-04 | 2021-09-14 | 普瑞尼亚神经治疗有限公司 | 用于帕金森氏病和与帕金森症相关的其它疾病的低剂量普利多匹定 |
| CA3176917A1 (en) * | 2020-05-04 | 2021-11-11 | Prilenia Neurotherapeutics Ltd. | Treatment of viral infection, disease or disorder using a selective s1r agonist |
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| JP2013536825A (ja) | 2010-09-03 | 2013-09-26 | イバックス・インターナショナル・ゲーエムベーハー | ドパミン作動性安定化剤として有用なプリドピジンの重水素化類似体 |
| BR112014005389A8 (pt) | 2011-09-07 | 2018-04-03 | Ivax Int Gmbh | Sal cloridrato de 4- (3-metanossulfonil-fenil) -1- propil-piperidina em uma forma cristalina, composição farmacêutica compreendendo o mesmo e usos do dito sal |
| TWI579272B (zh) | 2011-12-08 | 2017-04-21 | 梯瓦製藥國際有限責任公司 | 普多比啶（ｐｒｉｄｏｐｉｄｉｎｅ）之氫溴酸鹽 |
-
2013
- 2013-04-03 AU AU2013243461A patent/AU2013243461A1/en not_active Abandoned
- 2013-04-03 NZ NZ630560A patent/NZ630560A/en not_active IP Right Cessation
- 2013-04-03 BR BR112014024672A patent/BR112014024672A8/pt active Search and Examination
- 2013-04-03 JP JP2015504706A patent/JP6177875B2/ja active Active
- 2013-04-03 KR KR1020147030277A patent/KR20150013476A/ko not_active Withdrawn
- 2013-04-03 MX MX2014011971A patent/MX2014011971A/es unknown
- 2013-04-03 EP EP13772325.0A patent/EP2844346B1/en active Active
- 2013-04-03 US US13/856,254 patent/US20130267552A1/en not_active Abandoned
- 2013-04-03 CA CA 2869145 patent/CA2869145A1/en not_active Abandoned
- 2013-04-03 ES ES13772325T patent/ES2776678T3/es active Active
- 2013-04-03 WO PCT/US2013/035124 patent/WO2013152105A1/en not_active Ceased
- 2013-04-03 HK HK15106790.2A patent/HK1206297A1/xx unknown
- 2013-04-03 EA EA201491819A patent/EA027748B1/ru active IP Right Revival
- 2013-04-03 CN CN201380018981.6A patent/CN104470585A/zh active Pending
-
2014
- 2014-09-23 IL IL234831A patent/IL234831B/en active IP Right Grant
- 2014-10-23 ZA ZA2014/07726A patent/ZA201407726B/en unknown
-
2017
- 2017-06-02 US US15/612,779 patent/US20170266170A1/en not_active Abandoned
-
2018
- 2018-11-28 US US16/203,182 patent/US11207308B2/en active Active
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