ATE417834T1 - N-oxide als prodrugs von piperazin- und piperidinderivaten - Google Patents

N-oxide als prodrugs von piperazin- und piperidinderivaten

Info

Publication number
ATE417834T1
ATE417834T1 AT06778284T AT06778284T ATE417834T1 AT E417834 T1 ATE417834 T1 AT E417834T1 AT 06778284 T AT06778284 T AT 06778284T AT 06778284 T AT06778284 T AT 06778284T AT E417834 T1 ATE417834 T1 AT E417834T1
Authority
AT
Austria
Prior art keywords
art
relates
disease
manufacture
disclosed
Prior art date
Application number
AT06778284T
Other languages
English (en)
Inventor
Theodorus Koopman
Hendrik Koster
Amsterdam Peter Van
Roelof Feenstra
Marinus Verhage
Andrew Mccreary
Mayke Hesselink
Scharrenburg Gustaaf Van
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Application granted granted Critical
Publication of ATE417834T1 publication Critical patent/ATE417834T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24—Oxygen atoms
AT06778284T 2005-08-22 2006-08-21 N-oxide als prodrugs von piperazin- und piperidinderivaten ATE417834T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70982105P 2005-08-22 2005-08-22
EP05107671 2005-08-22

Publications (1)

Publication Number Publication Date
ATE417834T1 true ATE417834T1 (de) 2009-01-15

Family

ID=39246895

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06778284T ATE417834T1 (de) 2005-08-22 2006-08-21 N-oxide als prodrugs von piperazin- und piperidinderivaten

Country Status (17)

Country Link
EP (1) EP1919883B1 (de)
JP (1) JP2009504799A (de)
KR (1) KR20080046205A (de)
AT (1) ATE417834T1 (de)
AU (1) AU2006283882B2 (de)
CA (1) CA2621158A1 (de)
DE (1) DE602006004363D1 (de)
DK (1) DK1919883T3 (de)
ES (1) ES2318783T3 (de)
HR (1) HRP20090143T3 (de)
IL (1) IL188903A0 (de)
NO (1) NO20081435L (de)
PL (1) PL1919883T3 (de)
PT (1) PT1919883E (de)
RU (1) RU2394821C2 (de)
SI (1) SI1919883T1 (de)
WO (1) WO2007023141A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7423040B2 (en) 2005-02-18 2008-09-09 Irene Eijgendaal Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same
US7964604B2 (en) 2005-02-18 2011-06-21 Solvay Pharmaceuticals B.V. Bifeprunox mesylate maintenance dose compositions and methods for using the same
US7786126B2 (en) 2006-06-16 2010-08-31 Solvay Pharmaceuticals B.V. Combination preparations comprising SLV308 and a dopamine agonist
CA2654719A1 (en) * 2006-06-16 2007-12-21 Solvay Pharmaceuticals B.V. Combination preparations comprising slv308 and a l-dopa
AU2007291235A1 (en) 2006-08-31 2008-03-06 H. Lundbeck A/S Bifeprunox doses for treating schizophrenia
AU2008239841B2 (en) * 2007-04-12 2013-07-18 Teva Pharmaceuticals International Gmbh N-oxide and/or di-N-oxide derivatives of dopamine receptor stabilizers/modulators displaying improved cardiovascular side-effects profiles
MX2010007703A (es) * 2008-01-15 2010-09-14 Abbott Healthcare Products Bv Derivados de bifeprunox.
WO2011023796A1 (en) 2009-08-31 2011-03-03 Abbott Healthcare Products B.V. Bifeprunox for treating addiction
CA2856749A1 (en) 2011-12-08 2013-06-13 IVAX International GmbH The hydrobromide salt of pridopidine
US20130267552A1 (en) 2012-04-04 2013-10-10 IVAX International GmbH Pharmaceutical compositions for combination therapy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE503170A (de) * 1975-09-02
SK285119B6 (sk) * 1996-03-29 2006-06-01 Duphar International Research B. V. Piperazínové a piperidínové zlúčeniny, spôsob ich prípravy, farmaceutické kompozície, ktoré ich obsahujú, a ich použitie
UA71590C2 (en) * 1998-11-13 2004-12-15 Duphar Int Res Piperazine and piperidine derivatives
RU2261250C2 (ru) * 2000-05-12 2005-09-27 Солвей Фармасьютикалс Б.В. Соединения пиперазина и пиперидина
CN1330646C (zh) * 2002-01-16 2007-08-08 詹森药业有限公司 普卢卡必利－n－氧化物

Also Published As

Publication number Publication date
PL1919883T3 (pl) 2009-06-30
PT1919883E (pt) 2009-03-26
RU2394821C2 (ru) 2010-07-20
ES2318783T3 (es) 2009-05-01
JP2009504799A (ja) 2009-02-05
DK1919883T3 (da) 2009-04-14
KR20080046205A (ko) 2008-05-26
NO20081435L (no) 2008-05-16
DE602006004363D1 (de) 2009-01-29
IL188903A0 (en) 2008-04-13
CA2621158A1 (en) 2007-03-01
RU2008110945A (ru) 2009-09-27
EP1919883B1 (de) 2008-12-17
AU2006283882A1 (en) 2007-03-01
SI1919883T1 (sl) 2009-04-30
HRP20090143T3 (en) 2009-04-30
EP1919883A1 (de) 2008-05-14
WO2007023141A1 (en) 2007-03-01
AU2006283882B2 (en) 2011-06-23

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