NO20081435L - N-oksider som prodroger for piperazin- og piperidinderivater - Google Patents
N-oksider som prodroger for piperazin- og piperidinderivaterInfo
- Publication number
- NO20081435L NO20081435L NO20081435A NO20081435A NO20081435L NO 20081435 L NO20081435 L NO 20081435L NO 20081435 A NO20081435 A NO 20081435A NO 20081435 A NO20081435 A NO 20081435A NO 20081435 L NO20081435 L NO 20081435L
- Authority
- NO
- Norway
- Prior art keywords
- art
- relates
- disease
- manufacture
- disclosed
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/24—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Det beskrives N-oksider av visse piperazin og piperidin derivater og metoder for fremstilling av disse forbindelser. Det beskrives videre anvendelse av forbindelser som beskrevet her for fremstilling av et medikament som gir en fordelaktig virkning der en fordelaktig virkning er beskrevet her eller åpenbar for fagmannen fra beskrivelse og den generelle kunnskap. Det beskrives videre anvendelse av en forbindelse ifølge oppfinnelsen for fremstilling av et medikament for terapi eller prevensjon av en sykdom eller tilstand. Mer spesielt beskrives det en ny anvendelse for behandling av en sykdom eller tilstand som beskrevet her eller som er åpenbar for fagmannen. I utførelsesformer av oppfinnelsen er spesifikke forbindelser som beskrevet her nyttige for fremstilling av et medikament som er nyttig ved terapi av CNS forstyrrelser og særlig terapi av angstforstyrrelser inkludert generaliserte angstforstyrrelser og panisk forstyrrelse, obsessiv kompulsiv forstyrrelse, aggresjon, addiksjon (inkludert behov), depresjon, autisme, vertigo, schizofreni og andre psykotiske forstyrrelser, Parkinsons sykdom og forstyrrelser i forbindelse med kognisjon og hukommelse. Forbindelsene har den generelle formel der symbolene har den betydning som er gitt i beskrivelsen.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70982105P | 2005-08-22 | 2005-08-22 | |
| EP05107671 | 2005-08-22 | ||
| PCT/EP2006/065477 WO2007023141A1 (en) | 2005-08-22 | 2006-08-21 | N-oxides as prodrugs of piperazine & piperidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20081435L true NO20081435L (no) | 2008-05-16 |
Family
ID=39246895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20081435A NO20081435L (no) | 2005-08-22 | 2008-03-19 | N-oksider som prodroger for piperazin- og piperidinderivater |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1919883B1 (no) |
| JP (1) | JP2009504799A (no) |
| KR (1) | KR20080046205A (no) |
| AT (1) | ATE417834T1 (no) |
| AU (1) | AU2006283882B2 (no) |
| CA (1) | CA2621158A1 (no) |
| DE (1) | DE602006004363D1 (no) |
| DK (1) | DK1919883T3 (no) |
| ES (1) | ES2318783T3 (no) |
| HR (1) | HRP20090143T3 (no) |
| IL (1) | IL188903A0 (no) |
| NO (1) | NO20081435L (no) |
| PL (1) | PL1919883T3 (no) |
| PT (1) | PT1919883E (no) |
| RU (1) | RU2394821C2 (no) |
| SI (1) | SI1919883T1 (no) |
| WO (1) | WO2007023141A1 (no) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7423040B2 (en) | 2005-02-18 | 2008-09-09 | Irene Eijgendaal | Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same |
| US7964604B2 (en) | 2005-02-18 | 2011-06-21 | Solvay Pharmaceuticals B.V. | Bifeprunox mesylate maintenance dose compositions and methods for using the same |
| US7786126B2 (en) | 2006-06-16 | 2010-08-31 | Solvay Pharmaceuticals B.V. | Combination preparations comprising SLV308 and a dopamine agonist |
| AU2007259255A1 (en) * | 2006-06-16 | 2007-12-21 | Solvay Pharmaceuticals B.V. | Combination preparations comprising SLV308 and a L-DOPA |
| AU2007291234A1 (en) | 2006-08-31 | 2008-03-06 | Solvay Pharmaceuticals B.V. | Titration schedule for bifeprunox for treating schizophrenia and kits for use therein |
| EP2146961B1 (en) | 2007-04-12 | 2014-01-29 | IVAX International GmbH | N-oxide and/or di-n-oxide derivatives of dopamine receptor stabilizers/modulators displaying improved cardiovascular side-effects profiles |
| US20110105523A1 (en) * | 2008-01-15 | 2011-05-05 | Van Stuivenberg Herman H | Bifeprunox derivatives |
| WO2011023796A1 (en) | 2009-08-31 | 2011-03-03 | Abbott Healthcare Products B.V. | Bifeprunox for treating addiction |
| WO2013086425A1 (en) | 2011-12-08 | 2013-06-13 | IVAX International GmbH | The hydrobromide salt of pridopidine |
| CA2869145A1 (en) | 2012-04-04 | 2013-10-10 | IVAX International GmbH | Pharmaceutical compositions for combination therapy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE503170A (no) * | 1975-09-02 | |||
| PT889889E (pt) * | 1996-03-29 | 2007-01-31 | Duphar Int Res | Composto de piperazina e piperidina |
| UA71590C2 (en) * | 1998-11-13 | 2004-12-15 | Duphar Int Res | Piperazine and piperidine derivatives |
| PL198857B1 (pl) * | 2000-05-12 | 2008-07-31 | Solvay Pharm Bv | Nowe związki piperazynowe i piperydynowe, sposób wytwarzania nowych związków piperazynowych i piperydynowych, kompozycja farmaceutyczna zawierająca te związki oraz zastosowanie tych związków |
| KR101023433B1 (ko) * | 2002-01-16 | 2011-03-25 | 얀센 파마슈티카 엔.브이. | 프루칼로프리드-ｎ-옥사이드 |
-
2006
- 2006-08-21 KR KR1020087006996A patent/KR20080046205A/ko not_active Application Discontinuation
- 2006-08-21 RU RU2008110945/04A patent/RU2394821C2/ru not_active IP Right Cessation
- 2006-08-21 JP JP2008527453A patent/JP2009504799A/ja active Pending
- 2006-08-21 AU AU2006283882A patent/AU2006283882B2/en not_active Ceased
- 2006-08-21 EP EP06778284A patent/EP1919883B1/en active Active
- 2006-08-21 ES ES06778284T patent/ES2318783T3/es active Active
- 2006-08-21 DE DE602006004363T patent/DE602006004363D1/de active Active
- 2006-08-21 AT AT06778284T patent/ATE417834T1/de active
- 2006-08-21 WO PCT/EP2006/065477 patent/WO2007023141A1/en active Application Filing
- 2006-08-21 PT PT06778284T patent/PT1919883E/pt unknown
- 2006-08-21 CA CA002621158A patent/CA2621158A1/en not_active Abandoned
- 2006-08-21 DK DK06778284T patent/DK1919883T3/da active
- 2006-08-21 SI SI200630214T patent/SI1919883T1/sl unknown
- 2006-08-21 PL PL06778284T patent/PL1919883T3/pl unknown
-
2008
- 2008-01-21 IL IL188903A patent/IL188903A0/en unknown
- 2008-03-19 NO NO20081435A patent/NO20081435L/no not_active Application Discontinuation
-
2009
- 2009-03-10 HR HR20090143T patent/HRP20090143T3/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1919883B1 (en) | 2008-12-17 |
| DK1919883T3 (da) | 2009-04-14 |
| SI1919883T1 (sl) | 2009-04-30 |
| WO2007023141A1 (en) | 2007-03-01 |
| AU2006283882A1 (en) | 2007-03-01 |
| RU2008110945A (ru) | 2009-09-27 |
| RU2394821C2 (ru) | 2010-07-20 |
| PL1919883T3 (pl) | 2009-06-30 |
| IL188903A0 (en) | 2008-04-13 |
| JP2009504799A (ja) | 2009-02-05 |
| HRP20090143T3 (en) | 2009-04-30 |
| PT1919883E (pt) | 2009-03-26 |
| AU2006283882B2 (en) | 2011-06-23 |
| CA2621158A1 (en) | 2007-03-01 |
| DE602006004363D1 (de) | 2009-01-29 |
| KR20080046205A (ko) | 2008-05-26 |
| EP1919883A1 (en) | 2008-05-14 |
| ATE417834T1 (de) | 2009-01-15 |
| ES2318783T3 (es) | 2009-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |