HRP20090143T3 - N-oxides as prodrugs of piperazine&piperidine derivatives - Google Patents
N-oxides as prodrugs of piperazine&piperidine derivativesInfo
- Publication number
- HRP20090143T3 HRP20090143T3 HR20090143T HRP20090143T HRP20090143T3 HR P20090143 T3 HRP20090143 T3 HR P20090143T3 HR 20090143 T HR20090143 T HR 20090143T HR P20090143 T HRP20090143 T HR P20090143T HR P20090143 T3 HRP20090143 T3 HR P20090143T3
- Authority
- HR
- Croatia
- Prior art keywords
- art
- relates
- disease
- manufacture
- disclosed
- Prior art date
Links
- 150000001204 N-oxides Chemical class 0.000 title abstract 2
- 150000004885 piperazines Chemical class 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 230000009286 beneficial effect Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010003805 Autism Diseases 0.000 abstract 1
- 208000020706 Autistic disease Diseases 0.000 abstract 1
- 206010012335 Dependence Diseases 0.000 abstract 1
- 208000011688 Generalised anxiety disease Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000020114 Schizophrenia and other psychotic disease Diseases 0.000 abstract 1
- 208000012886 Vertigo Diseases 0.000 abstract 1
- 230000016571 aggressive behavior Effects 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000019771 cognition Effects 0.000 abstract 1
- 235000019788 craving Nutrition 0.000 abstract 1
- 208000029364 generalized anxiety disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
- 231100000889 vertigo Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/24—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70982105P | 2005-08-22 | 2005-08-22 | |
| EP05107671 | 2005-08-22 | ||
| PCT/EP2006/065477 WO2007023141A1 (en) | 2005-08-22 | 2006-08-21 | N-oxides as prodrugs of piperazine & piperidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20090143T3 true HRP20090143T3 (en) | 2009-04-30 |
Family
ID=39246895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20090143T HRP20090143T3 (en) | 2005-08-22 | 2009-03-10 | N-oxides as prodrugs of piperazine&piperidine derivatives |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1919883B1 (de) |
| JP (1) | JP2009504799A (de) |
| KR (1) | KR20080046205A (de) |
| AT (1) | ATE417834T1 (de) |
| AU (1) | AU2006283882B2 (de) |
| CA (1) | CA2621158A1 (de) |
| DE (1) | DE602006004363D1 (de) |
| DK (1) | DK1919883T3 (de) |
| ES (1) | ES2318783T3 (de) |
| HR (1) | HRP20090143T3 (de) |
| IL (1) | IL188903A0 (de) |
| NO (1) | NO20081435L (de) |
| PL (1) | PL1919883T3 (de) |
| PT (1) | PT1919883E (de) |
| RU (1) | RU2394821C2 (de) |
| SI (1) | SI1919883T1 (de) |
| WO (1) | WO2007023141A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7423040B2 (en) | 2005-02-18 | 2008-09-09 | Irene Eijgendaal | Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same |
| US7964604B2 (en) | 2005-02-18 | 2011-06-21 | Solvay Pharmaceuticals B.V. | Bifeprunox mesylate maintenance dose compositions and methods for using the same |
| US7786126B2 (en) | 2006-06-16 | 2010-08-31 | Solvay Pharmaceuticals B.V. | Combination preparations comprising SLV308 and a dopamine agonist |
| MY148457A (en) * | 2006-06-16 | 2013-04-30 | Solvay Pharm Bv | Combination preparations comprising slv308 and a dopamine agonist |
| CA2661800A1 (en) | 2006-08-31 | 2008-03-06 | Solvay Pharmaceuticals B.V. | Bifeprunox doses for treating schizophrenia |
| WO2008127188A1 (en) * | 2007-04-12 | 2008-10-23 | Allbay Ab | N-oxide and/or di-n-oxide derivatives of dopamine receptor stabilizers/modulators displaying improved cardiovascular side-effects profiles |
| AU2009204851A1 (en) * | 2008-01-15 | 2009-07-23 | Abbott Healthcare Products B.V. | Bifeprunox derivatives |
| WO2011023796A1 (en) | 2009-08-31 | 2011-03-03 | Abbott Healthcare Products B.V. | Bifeprunox for treating addiction |
| EP2787997A4 (de) | 2011-12-08 | 2015-05-27 | Ivax Int Gmbh | Hydrobromidsalz von pridopidin |
| JP6177875B2 (ja) | 2012-04-04 | 2017-08-09 | テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハーＴｅｖａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ ＧｍｂＨ | 併用療法のための医薬組成物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE503170A (de) * | 1975-09-02 | |||
| EP0889889B1 (de) * | 1996-03-29 | 2006-09-20 | Duphar International Research B.V | Piperazin- und piperidin- derivate |
| UA71590C2 (en) * | 1998-11-13 | 2004-12-15 | Duphar Int Res | Piperazine and piperidine derivatives |
| CA2405971C (en) * | 2000-05-12 | 2010-03-30 | Solvay Pharmaceuticals B.V. | New piperazine and piperidine compounds |
| US20050085510A1 (en) * | 2002-01-16 | 2005-04-21 | Telefonaktiebolaget Lm Ericsson (Publ) | Prucalopride-n-oxide |
-
2006
- 2006-08-21 PT PT06778284T patent/PT1919883E/pt unknown
- 2006-08-21 KR KR1020087006996A patent/KR20080046205A/ko not_active Application Discontinuation
- 2006-08-21 RU RU2008110945/04A patent/RU2394821C2/ru not_active IP Right Cessation
- 2006-08-21 AU AU2006283882A patent/AU2006283882B2/en not_active Ceased
- 2006-08-21 DK DK06778284T patent/DK1919883T3/da active
- 2006-08-21 AT AT06778284T patent/ATE417834T1/de active
- 2006-08-21 ES ES06778284T patent/ES2318783T3/es active Active
- 2006-08-21 DE DE602006004363T patent/DE602006004363D1/de active Active
- 2006-08-21 SI SI200630214T patent/SI1919883T1/sl unknown
- 2006-08-21 JP JP2008527453A patent/JP2009504799A/ja active Pending
- 2006-08-21 EP EP06778284A patent/EP1919883B1/de active Active
- 2006-08-21 WO PCT/EP2006/065477 patent/WO2007023141A1/en active Application Filing
- 2006-08-21 CA CA002621158A patent/CA2621158A1/en not_active Abandoned
- 2006-08-21 PL PL06778284T patent/PL1919883T3/pl unknown
-
2008
- 2008-01-21 IL IL188903A patent/IL188903A0/en unknown
- 2008-03-19 NO NO20081435A patent/NO20081435L/no not_active Application Discontinuation
-
2009
- 2009-03-10 HR HR20090143T patent/HRP20090143T3/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2621158A1 (en) | 2007-03-01 |
| AU2006283882A1 (en) | 2007-03-01 |
| PL1919883T3 (pl) | 2009-06-30 |
| RU2008110945A (ru) | 2009-09-27 |
| EP1919883A1 (de) | 2008-05-14 |
| ES2318783T3 (es) | 2009-05-01 |
| NO20081435L (no) | 2008-05-16 |
| SI1919883T1 (sl) | 2009-04-30 |
| WO2007023141A1 (en) | 2007-03-01 |
| PT1919883E (pt) | 2009-03-26 |
| AU2006283882B2 (en) | 2011-06-23 |
| JP2009504799A (ja) | 2009-02-05 |
| IL188903A0 (en) | 2008-04-13 |
| KR20080046205A (ko) | 2008-05-26 |
| DK1919883T3 (da) | 2009-04-14 |
| EP1919883B1 (de) | 2008-12-17 |
| RU2394821C2 (ru) | 2010-07-20 |
| DE602006004363D1 (de) | 2009-01-29 |
| ATE417834T1 (de) | 2009-01-15 |
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