JP2009500353A5 - - Google Patents
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- JP2009500353A5 JP2009500353A5 JP2008519691A JP2008519691A JP2009500353A5 JP 2009500353 A5 JP2009500353 A5 JP 2009500353A5 JP 2008519691 A JP2008519691 A JP 2008519691A JP 2008519691 A JP2008519691 A JP 2008519691A JP 2009500353 A5 JP2009500353 A5 JP 2009500353A5
- Authority
- JP
- Japan
- Prior art keywords
- taqman
- rna
- sample
- seq
- applied biosystems
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69576705P | 2005-06-30 | 2005-06-30 | |
| US60/695,767 | 2005-06-30 | ||
| US11/478,337 | 2006-06-28 | ||
| US11/478,337 US7608592B2 (en) | 2005-06-30 | 2006-06-28 | HCV inhibitors |
| PCT/US2006/025996 WO2007005838A2 (en) | 2005-06-30 | 2006-06-29 | Hcv inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012111958A Division JP2012176973A (ja) | 2005-06-30 | 2012-05-15 | Hcvインヒビター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009500353A JP2009500353A (ja) | 2009-01-08 |
| JP2009500353A5 true JP2009500353A5 (enExample) | 2009-06-04 |
| JP5368089B2 JP5368089B2 (ja) | 2013-12-18 |
Family
ID=37605137
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008519691A Expired - Fee Related JP5368089B2 (ja) | 2005-06-30 | 2006-06-29 | Hcvインヒビター |
| JP2012111958A Pending JP2012176973A (ja) | 2005-06-30 | 2012-05-15 | Hcvインヒビター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012111958A Pending JP2012176973A (ja) | 2005-06-30 | 2012-05-15 | Hcvインヒビター |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7608592B2 (enExample) |
| EP (2) | EP1906945B1 (enExample) |
| JP (2) | JP5368089B2 (enExample) |
| KR (1) | KR101369872B1 (enExample) |
| AU (1) | AU2006265632B2 (enExample) |
| BR (1) | BRPI0612104A8 (enExample) |
| CA (1) | CA2613112C (enExample) |
| EA (1) | EA015415B1 (enExample) |
| ES (1) | ES2552712T3 (enExample) |
| IL (1) | IL188207A (enExample) |
| MX (1) | MX2007016324A (enExample) |
| NO (1) | NO20080540L (enExample) |
| NZ (1) | NZ564257A (enExample) |
| WO (1) | WO2007005838A2 (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003007697A (ja) * | 2001-06-21 | 2003-01-10 | Hitachi Kokusai Electric Inc | 半導体装置の製造方法、基板処理方法および基板処理装置 |
| US7608592B2 (en) * | 2005-06-30 | 2009-10-27 | Virobay, Inc. | HCV inhibitors |
| GEP20105124B (en) | 2005-07-25 | 2010-11-25 | Array Biopharma Inc | Novel macrocyclic inhibitors of hepatitis c virus replication |
| UA93990C2 (ru) * | 2005-10-11 | 2011-03-25 | Интермюн, Инк. | Соединения и способ ингибирования репликации вируса гепатита c |
| WO2007133865A2 (en) | 2006-04-11 | 2007-11-22 | Novartis Ag | Hcv/hiv inhibitors an their uses |
| KR20090024834A (ko) * | 2006-07-05 | 2009-03-09 | 인터뮨, 인크. | C형 간염 바이러스 복제의 신규 억제제 |
| EP2374812B1 (en) | 2006-07-13 | 2015-04-15 | Achillion Pharmaceuticals, Inc. | 4-amino-4-oxobutanoyl Peptides as Inhibitors of Viral Replication |
| US20080161254A1 (en) * | 2007-01-03 | 2008-07-03 | Virobay, Inc. | Hcv inhibitors |
| CA2679377A1 (en) | 2007-02-26 | 2008-09-04 | Achillion Pharmaceuticals, Inc. | Tertiary amine substituted peptides useful as inhibitors of hcv replication |
| US20090155209A1 (en) * | 2007-05-03 | 2009-06-18 | Blatt Lawrence M | Novel macrocyclic inhibitors of hepatitis c virus replication |
| AP2009005057A0 (en) | 2007-05-10 | 2009-12-31 | Array Biopharma Inc | Novel peptide inhibitors of hepatitis c virus replication |
| JP5095824B2 (ja) | 2007-10-10 | 2012-12-12 | ノバルティス アーゲー | スピロピロリジン類およびhcvおよびhiv感染に対するその使用 |
| CN104557861A (zh) | 2007-12-21 | 2015-04-29 | 阿维拉制药公司 | Hcv蛋白酶抑制剂和其用途 |
| TWI487522B (zh) * | 2007-12-21 | 2015-06-11 | 賽基艾維洛米斯研究股份有限公司 | Hcv蛋白酶抑制劑及其用途(一) |
| US8293705B2 (en) | 2007-12-21 | 2012-10-23 | Avila Therapeutics, Inc. | HCV protease inhibitors and uses thereof |
| US8309685B2 (en) | 2007-12-21 | 2012-11-13 | Celgene Avilomics Research, Inc. | HCV protease inhibitors and uses thereof |
| EA201001262A1 (ru) | 2008-02-07 | 2011-04-29 | Вайробей, Инк. | Ингибиторы катепсина в |
| US8431733B2 (en) * | 2008-03-12 | 2013-04-30 | Virobay, Inc. | Process for the preparation of (3S)-3-amino-N-cyclopropyl-2-hydroxyalkanamide derivatives |
| KR20110005869A (ko) * | 2008-04-15 | 2011-01-19 | 인터뮨, 인크. | C형 간염 바이러스 복제의 신규한 마크로사이클릭 억제제 |
| US8188137B2 (en) | 2008-08-15 | 2012-05-29 | Avila Therapeutics, Inc. | HCV protease inhibitors and uses thereof |
| UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
| JP5723783B2 (ja) | 2008-12-10 | 2015-05-27 | アキリオン ファーマシューティカルズ,インコーポレーテッド | ウイルス複製の阻害剤としての新しい4−アミノ−4−オキソブタノイルペプチド |
| AR075584A1 (es) * | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
| US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
| CA2775697A1 (en) * | 2009-09-28 | 2011-03-31 | Intermune, Inc. | Cyclic peptide inhibitors of hepatitis c virus replication |
| UA113501C2 (xx) | 2010-11-03 | 2017-02-10 | Пестицидні композиції і пов'язані з ними способи | |
| EP2658858A4 (en) | 2010-12-30 | 2014-06-25 | Enanta Pharm Inc | MACROCYCLIC INHIBITORS OF HEPATITIS C SERINE PROTEASE PHENANTHRIDINE |
| MX2013007677A (es) | 2010-12-30 | 2013-07-30 | Abbvie Inc | Inhibidores macrociclicos de serina proteasa de hepatitis. |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| CA2852688C (en) | 2011-10-26 | 2021-06-29 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| US9282739B2 (en) | 2012-04-27 | 2016-03-15 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| HK1209590A1 (en) | 2012-04-27 | 2016-04-08 | 陶氏益农公司 | Pesticidal compositions and processes related thereto |
| US9708288B2 (en) | 2012-04-27 | 2017-07-18 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
| US9115175B2 (en) | 2013-03-14 | 2015-08-25 | Achillion Pharmaceuticals, Inc. | Processes for Producing sovaprevir |
| AU2014227849A1 (en) | 2013-03-15 | 2015-10-01 | Achillion Pharmaceuticals, Inc. | Sovaprevir polymorphs and methods of manufacture thereof |
| WO2014145507A1 (en) | 2013-03-15 | 2014-09-18 | Achillion Pharmaceuticals, Inc. | A process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof |
| WO2014145600A1 (en) | 2013-03-15 | 2014-09-18 | Achillion Pharmaceuticals, Inc. | Ach-0142684 sodium salt polymorphs, composition including the same, and method of manufacture thereof |
| CA2925873A1 (en) | 2013-10-17 | 2015-04-23 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| JP2016536296A (ja) | 2013-10-17 | 2016-11-24 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除性化合物の製造方法 |
| WO2015058028A1 (en) | 2013-10-17 | 2015-04-23 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| EP3057431A4 (en) | 2013-10-17 | 2017-04-05 | Dow AgroSciences LLC | Processes for the preparation of pesticidal compounds |
| MX2016004946A (es) | 2013-10-17 | 2016-06-28 | Dow Agrosciences Llc | Procesos para la preparacion de compuestos plaguicidas. |
| WO2015058024A1 (en) | 2013-10-17 | 2015-04-23 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| KR20160075565A (ko) | 2013-10-17 | 2016-06-29 | 다우 아그로사이언시즈 엘엘씨 | 살충성 화합물의 제조 방법 |
| US9137998B2 (en) | 2013-10-22 | 2015-09-22 | Dow Agrosciences Llc | Pesticidal compositions and related methods |
| CN105658064A (zh) | 2013-10-22 | 2016-06-08 | 美国陶氏益农公司 | 协同杀虫组合物和相关方法 |
| AR098092A1 (es) | 2013-10-22 | 2016-05-04 | Dow Agrosciences Llc | Composiciones plaguicidas sinérgicas y los métodos relacionados |
| KR20160074634A (ko) | 2013-10-22 | 2016-06-28 | 다우 아그로사이언시즈 엘엘씨 | 상승작용적 살충 조성물 및 관련 방법 |
| US9282740B2 (en) | 2013-10-22 | 2016-03-15 | Dow Agrosciences Llc | Synergistic pesticidal compositions and related methods |
| MX2016005306A (es) | 2013-10-22 | 2016-08-12 | Dow Agrosciences Llc | Composiciones pesticidas sinergicas y metodos relacionados. |
| MX2016005304A (es) | 2013-10-22 | 2017-03-01 | Dow Agrosciences Llc | Composiciones pesticidas sinergicas y metodos relacionados. |
| RU2656391C2 (ru) | 2013-10-22 | 2018-06-05 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Пестицидные композиции и связанные с ними способы |
| RU2016119368A (ru) | 2013-10-22 | 2017-11-28 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Синергетические пестицидные композиции и связанные с ними способы |
| TW201519786A (zh) | 2013-10-22 | 2015-06-01 | 陶氏農業科學公司 | 殺蟲組成物及相關方法(一) |
| KR20160074640A (ko) | 2013-10-22 | 2016-06-28 | 다우 아그로사이언시즈 엘엘씨 | 살충 조성물 및 관련 방법 |
| MX2016005317A (es) | 2013-10-22 | 2016-08-12 | Dow Agrosciences Llc | Composiciones pesticidas y metodos relacionados. |
| JP2016536307A (ja) | 2013-10-22 | 2016-11-24 | ダウ アグロサイエンシィズ エルエルシー | 農薬組成物および関連する方法 |
| AR098099A1 (es) | 2013-10-22 | 2016-05-04 | Dow Agrosciences Llc | Composiciones plaguicidas sinérgicas y los métodos relacionados |
| JP2016535733A (ja) | 2013-10-22 | 2016-11-17 | ダウ アグロサイエンシィズ エルエルシー | 相乗的有害生物防除組成物および関連する方法 |
| RU2016119560A (ru) | 2013-10-22 | 2017-11-28 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Синергетические пестицидные композиции и относящиеся к ним способы |
| RU2016119576A (ru) | 2013-10-22 | 2017-11-28 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Синергетические пестицидные композиции и связанные с ними способы |
| WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
| ES2883023T3 (es) | 2014-05-28 | 2021-12-03 | Agensys Inc | Derivados de péptidos de dolaproína-dolaisoleuina citotóxicos para el tratamiento del cáncer |
| AR098110A1 (es) | 2014-07-31 | 2016-05-04 | Dow Agrosciences Llc | Proceso para la preparación de 3-(3-cloro-1h-pirazol-1-il)piridina |
| US9029555B1 (en) | 2014-07-31 | 2015-05-12 | Dow Agrosciences Llc | Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine |
| CN106470976A (zh) | 2014-07-31 | 2017-03-01 | 美国陶氏益农公司 | 制备3‑(3‑氯‑1h‑吡唑‑1‑基)吡啶的方法 |
| BR112017002735A2 (pt) | 2014-08-19 | 2017-12-19 | Dow Agrosciences Llc | processo para a preparação de 3-(3-cloro-1h-pirazol-1-il)piridina |
| KR20170058388A (ko) | 2014-09-12 | 2017-05-26 | 다우 아그로사이언시즈 엘엘씨 | 3-(3-클로로-1h-피라졸-1-일)피리딘의 제조 방법 |
| JP7164521B2 (ja) | 2016-06-21 | 2022-11-01 | オリオン・オフサルモロジー・エルエルシー | 炭素環式プロリンアミド誘導体 |
| MX392422B (es) | 2016-06-21 | 2025-03-24 | Orion Ophthalmology LLC | Derivados de prolinamida heterociclica |
| WO2018125817A1 (en) | 2016-12-29 | 2018-07-05 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| CN110139853B (zh) | 2016-12-29 | 2023-06-16 | 美国陶氏益农公司 | 用于制备杀有害生物化合物的方法 |
| EP3972963A1 (en) | 2019-05-21 | 2022-03-30 | Bayer Aktiengesellschaft | Identification and use of kras inhibitors |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA79749C2 (en) * | 1996-10-18 | 2007-07-25 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
| EP1136498A1 (en) | 1996-10-18 | 2001-09-26 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus NS3 protease |
| HUP0100287A3 (en) | 1997-11-11 | 2003-04-28 | Pfizer Prod Inc | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents |
| US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| US6404397B1 (en) | 1998-08-10 | 2002-06-11 | Raytheon Company | Compact all-weather electromagnetic imaging system |
| US6608027B1 (en) | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
| UA74546C2 (en) | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
| WO2001040262A1 (en) | 1999-12-03 | 2001-06-07 | Bristol-Myers Squibb Pharma Company | Alpha-ketoamide inhibitors of hepatitis c virus ns3 protease |
| CN1498224A (zh) * | 2000-07-21 | 2004-05-19 | ���鹫˾ | 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽 |
| US7244721B2 (en) * | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| US6846806B2 (en) | 2000-10-23 | 2005-01-25 | Bristol-Myers Squibb Company | Peptide inhibitors of Hepatitis C virus NS3 protein |
| CA2369970A1 (en) | 2002-02-01 | 2003-08-01 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis c inhibitor tri-peptides |
| EP1408031A1 (en) | 2002-10-09 | 2004-04-14 | 3 D Gene Pharma | Pyrolidine derivatives useful in treatment of hepatitis C virus infection |
| EP2143727B1 (en) | 2003-04-18 | 2015-01-21 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
| DE602004010137T2 (de) * | 2003-05-21 | 2008-09-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verbindungen als hepatitis c inhibitoren |
| US7398790B2 (en) * | 2003-08-22 | 2008-07-15 | Glatz Ag | Extension arm for a free arm parasol, pivotably arranged on a carrier |
| TWI359147B (en) | 2003-09-05 | 2012-03-01 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv n |
| AU2004274051A1 (en) | 2003-09-22 | 2005-03-31 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
| JP4682155B2 (ja) | 2004-01-21 | 2011-05-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | C型肝炎ウイルスに対して活性な大環状ペプチド |
| TW200536528A (en) | 2004-02-27 | 2005-11-16 | Schering Corp | Novel inhibitors of hepatitis C virus NS3 protease |
| MXPA06013404A (es) * | 2004-05-20 | 2007-01-23 | Schering Corp | Prolinas sustituidas como inhibidores de serina proteasa ns3 de virus de hepatitis c. |
| EP1805187A1 (en) | 2004-10-21 | 2007-07-11 | Pfizer, Inc. | Inhibitors of hepatitis c virus protease, and compositions and treatments using the same |
| US7608592B2 (en) * | 2005-06-30 | 2009-10-27 | Virobay, Inc. | HCV inhibitors |
| EP1915382A2 (en) * | 2005-08-01 | 2008-04-30 | Phenomix Corporation | Hepatitis c serine protease inhibitors and uses therefor |
| JP2009524681A (ja) * | 2006-01-27 | 2009-07-02 | フェノミックス コーポレーション | C型肝炎ウイルスセリンプロテアーゼインヒビターおよびそのための使用 |
-
2006
- 2006-06-28 US US11/478,337 patent/US7608592B2/en active Active
- 2006-06-29 NZ NZ564257A patent/NZ564257A/en not_active IP Right Cessation
- 2006-06-29 WO PCT/US2006/025996 patent/WO2007005838A2/en not_active Ceased
- 2006-06-29 AU AU2006265632A patent/AU2006265632B2/en not_active Ceased
- 2006-06-29 EP EP06774467.2A patent/EP1906945B1/en active Active
- 2006-06-29 EA EA200800178A patent/EA015415B1/ru not_active IP Right Cessation
- 2006-06-29 CA CA2613112A patent/CA2613112C/en not_active Expired - Fee Related
- 2006-06-29 MX MX2007016324A patent/MX2007016324A/es active IP Right Grant
- 2006-06-29 JP JP2008519691A patent/JP5368089B2/ja not_active Expired - Fee Related
- 2006-06-29 EP EP11190816.6A patent/EP2431379A3/en not_active Withdrawn
- 2006-06-29 ES ES06774467.2T patent/ES2552712T3/es active Active
- 2006-06-29 BR BRPI0612104A patent/BRPI0612104A8/pt active Search and Examination
- 2006-06-29 KR KR1020077031049A patent/KR101369872B1/ko not_active Expired - Fee Related
-
2007
- 2007-12-18 IL IL188207A patent/IL188207A/en not_active IP Right Cessation
-
2008
- 2008-01-29 NO NO20080540A patent/NO20080540L/no not_active Application Discontinuation
-
2009
- 2009-10-23 US US12/605,271 patent/US8518874B2/en active Active
-
2012
- 2012-05-15 JP JP2012111958A patent/JP2012176973A/ja active Pending
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