JP2009298705A - 口腔用組成物 - Google Patents
口腔用組成物 Download PDFInfo
- Publication number
- JP2009298705A JP2009298705A JP2008152271A JP2008152271A JP2009298705A JP 2009298705 A JP2009298705 A JP 2009298705A JP 2008152271 A JP2008152271 A JP 2008152271A JP 2008152271 A JP2008152271 A JP 2008152271A JP 2009298705 A JP2009298705 A JP 2009298705A
- Authority
- JP
- Japan
- Prior art keywords
- quaternary ammonium
- composition
- betaine
- oral cavity
- oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 56
- 125000001453 quaternary ammonium group Chemical group 0.000 claims abstract description 34
- 210000000214 mouth Anatomy 0.000 claims abstract description 28
- 239000002280 amphoteric surfactant Substances 0.000 claims abstract description 21
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 17
- 229960003237 betaine Drugs 0.000 claims description 31
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 30
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 30
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 22
- 239000000194 fatty acid Substances 0.000 claims description 22
- 229930195729 fatty acid Natural products 0.000 claims description 22
- 150000004665 fatty acids Chemical class 0.000 claims description 16
- 239000000551 dentifrice Substances 0.000 claims description 13
- 239000007787 solid Substances 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 12
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 229940034610 toothpaste Drugs 0.000 claims description 7
- 239000000606 toothpaste Substances 0.000 claims description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 5
- 238000013329 compounding Methods 0.000 claims description 5
- 229940041667 oral paste Drugs 0.000 claims description 3
- 230000003020 moisturizing effect Effects 0.000 claims description 2
- 125000005313 fatty acid group Chemical group 0.000 claims 2
- 230000007794 irritation Effects 0.000 abstract description 19
- 239000003899 bactericide agent Substances 0.000 abstract description 10
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 8
- 244000005700 microbiome Species 0.000 abstract description 7
- 230000001954 sterilising effect Effects 0.000 abstract description 7
- 238000010348 incorporation Methods 0.000 abstract description 2
- 230000001629 suppression Effects 0.000 abstract 1
- -1 polyethylene Polymers 0.000 description 28
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 17
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- 239000003205 fragrance Substances 0.000 description 11
- 239000004615 ingredient Substances 0.000 description 9
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 238000011156 evaluation Methods 0.000 description 7
- 239000000796 flavoring agent Substances 0.000 description 7
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- 238000000034 method Methods 0.000 description 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 6
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 6
- 239000011230 binding agent Substances 0.000 description 5
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- 239000000049 pigment Substances 0.000 description 5
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- 150000003839 salts Chemical class 0.000 description 5
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- 235000019658 bitter taste Nutrition 0.000 description 4
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 4
- 239000004359 castor oil Substances 0.000 description 4
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- 238000000576 coating method Methods 0.000 description 4
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 4
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- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 description 4
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- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 4
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 4
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 4
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- 235000010447 xylitol Nutrition 0.000 description 4
- 229960002675 xylitol Drugs 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 235000019482 Palm oil Nutrition 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000001721 carbon Chemical class 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
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- 239000006260 foam Substances 0.000 description 3
- 235000003599 food sweetener Nutrition 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 229960002216 methylparaben Drugs 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000002540 palm oil Substances 0.000 description 3
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 3
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- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
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- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 2
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 2
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 2
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Landscapes
- Cosmetics (AREA)
Abstract
【解決手段】オルガノシリコン第四級アンモニウムを含有する口腔用組成物に、非イオン性界面活性剤、およびベタイン型両性界面活性剤を配合することにより、口腔内微生物の殺菌、除去効果を発揮しつつ、オルガノシリコン第四級アンモニウム由来の刺激を抑制することができる。
【選択図】なし
Description
項1.オルガノシリコン第四級アンモニウムを固定化した水不溶性固体、非イオン性界面活性剤、およびベタイン型両性界面活性剤を配合したことを特徴とする口腔用組成物。
項2.非イオン性界面活性剤の配合量が0.01〜15重量%である項1に記載の口腔用組成物。
項3.ベタイン型両性界面活性剤の配合量が0.0001〜3重量%である項1または2に記載の口腔用組成物。
項4.(A)非イオン性界面活性剤と(B)ベタイン型両性界面活性剤の配合比率が、(A):(B)=1000:1〜1:10である項1〜3に記載の口腔用組成物。
項5.ベタイン型両性界面活性剤が、脂肪酸アミドプロピルベタインである項1〜4に記載の口腔用組成物。
項6.脂肪酸アミドプロピルベタインの脂肪酸部分のアルキル基の炭素数がC8〜C18である項5に記載の口腔用組成物。
項7.練歯磨剤、潤性歯磨剤、ジェル状歯磨剤、口腔用パスタ剤である項1〜6に記載の口腔用組成物。
本発明においては、殺菌剤としてオルガノシリコン第四級アンモニウムを固定化して用いる。本発明に用いるオルガノシリコン第四級アンモニウム塩は化学式:R1 3N+R2SiR3 nX3-n・Y-で示される公知の化合物で、通常、アルコール溶液として市販されている。前記の式中、Xはハロゲン原子、アルコキシ基、アシル基などの加水分解可能な基を表わし、Yは塩素または臭素を表わす。R1は炭素原子数が1〜22の1価の脂肪族炭化水素基であり、特に3つのR1のうちの2つがメチル基で、他の1つが炭素原子数が8〜22のアルキル基であることが好ましい。R2は2価の炭化水素基であり、特に炭素原子数が2〜4のアルキレン基または式:−CH2CH2NHCH2CH2−で表わされるものが好ましい。R3はメチル基のような低級アルキル基、フェニル基またはCF3CH2CH2基である。nは0、1または2を表わし、好ましくは0である。
以上のようなオルガノシリコン第四級アンモニウムのうち、本発明では、特に以下の式で表わされるものが好ましい。
成分 配合量
オルガノシリコン第四級アンモニウム固定化無水ケイ酸 10.0
ラウリルグルコシド 2.0
ヤシ油脂肪酸アミドプロピルベタイン 1.0
歯磨用リン酸水素カルシウム 5.0
結晶セルロース 1.0
ヒドロキシエチルセルロース 1.0
トラネキサム酸 0.1
酢酸トコフェロール 0.1
モノフルオロリン酸ナトリウム 0.7
濃グリセリン 10.0
ソルビット液 30.0
酸化チタン 0.3
安息香酸ナトリウム 0.1
キシリトール 10.0
香料 0.8
精製水 残部
合計 100.0
刺激性評価結果 5.0
成分 配合量
オルガノシリコン第四級アンモニウム固定化リン酸水素カルシウム 20.0
ポリオキシエチレン(60)硬化ヒマシ油 0.5
2−アルキル−N−カルボキシメチル−N−
ヒドロキシエチルイミダゾリニウムベタイン 0.1
無水ケイ酸 3.0
カルボキシメチルセルロースナトリウム 1.0
塩化セチルピリジニウム 0.1
トリクロサン 0.1
フッ化ナトリウム 0.2
プロピレングリコール 3.0
グリセリン 30.0
酸化チタン 0.2
モノオレイン酸ポリオキシソルビタン(20EO) 0.5
ステビアエキス 0.01
香料 0.9
精製水 残部
合計 100.0
刺激性評価結果 4.8
成分 配合量
オルガノシリコン第四級アンモニウム固定化カルシウム 5.0
ショ糖脂肪酸エステル 0.8
ラウリルベタイン 0.3
研磨性沈降シリカ 5.0
ジェランガム 1.0
塩化O−[2−ヒドロキシ−3−(トリメチルアンモニオ)プロピル]
ヒドロキシエチルセルロース 0.3
塩酸ピリドキシン 0.05
ラウロイルサルコシンナトリウム 0.5
ニコチン酸トコフェロール 0.2
アラントイン 0.02
1,3−ブチレングリコール 1.0
グリセリン 10.0
酸化チタン 0.3
メチルパラベン 0.2
還元パラチノース 5.0
香料 0.7
精製水 残部
合計 100.0
刺激性評価結果 4.4
成分 配合量
オルガノシリコン第四級アンモニウム固定化無水ケイ酸 2.0
ラウリルグルコシド 2.0
ヤシ油脂肪酸アミドプロピルベタイン 0.03
歯磨用リン酸水素カルシウム 10.0
結晶セルロース 2.0
トラネキサム酸 0.1
酢酸トコフェロール 0.1
モノフルオロリン酸ナトリウム 0.7
ソルビット液 30.0
酸化チタン 0.3
安息香酸ナトリウム 0.1
キシリトール 10.0
香料 0.8
精製水 残部
合計 100.0
刺激性評価結果 5.0
成分 配合量
オルガノシリコン第四級アンモニウム固定化セルロース 1.0
ポリオキシエチレンモノラウレート(Tween 20) 0.5
ミリスチン酸アミドプロピルベタイン 0.01
研磨性沈降シリカ 10.0
キサンタンガム 0.2
イソプロピルメチルフェノール 0.02
グリチルリチン酸ジカリウム 0.05
硝酸カリウム 3.0
トラネキサム酸 0.05
ラウリル硫酸ナトリウム 0.5
ポリエチレングリコール 2.0
グリセリン 30.0
酸化チタン 0.2
メチルパラベン 0.2
キシリトール 2.0
香料 0.9
精製水 残部
合計 100.0
刺激性評価結果 4.4
Claims (7)
- オルガノシリコン第四級アンモニウムを固定化した水不溶性固体、非イオン性界面活性剤、およびベタイン型両性界面活性剤を配合したことを特徴とする口腔用組成物。
- 非イオン性界面活性剤の配合量が0.01〜15重量%である請求項1に記載の口腔用組成物。
- ベタイン型両性界面活性剤の配合量が0.0001〜3重量%である請求項1または2に記載の口腔用組成物。
- (A)非イオン性界面活性剤と(B)ベタイン型両性界面活性剤の配合比率が、(A):(B)=1000:1〜1:10である請求項1〜3に記載の口腔用組成物。
- ベタイン型両性界面活性剤が、脂肪酸アミドプロピルベタインである請求項1〜4に記載の口腔用組成物。
- 脂肪酸アミドプロピルベタインの脂肪酸部分のアルキル基の炭素数がC8〜C18である請求項5に記載の口腔用組成物。
- 練歯磨剤、潤性歯磨剤、ジェル状歯磨剤、口腔用パスタ剤である請求項1〜6に記載の口腔用組成物。
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2013067568A (ja) * | 2011-09-21 | 2013-04-18 | Lion Corp | 歯磨剤組成物 |
JP2018043982A (ja) * | 2016-09-07 | 2018-03-22 | 第一三共ヘルスケア株式会社 | カチオン性殺菌剤、未修飾シリカ、及びベタイン系界面活性剤を含む口腔用組成物 |
JP2019006751A (ja) * | 2017-06-28 | 2019-01-17 | サンスター株式会社 | 口腔用組成物 |
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JPH0624947A (ja) * | 1992-07-06 | 1994-02-01 | Sunstar Inc | 口腔用組成物 |
JPH0665036A (ja) * | 1992-06-19 | 1994-03-08 | Sunstar Inc | 口腔用組成物 |
JPH1087457A (ja) * | 1996-09-14 | 1998-04-07 | Sunstar Inc | 口腔用組成物 |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH0665036A (ja) * | 1992-06-19 | 1994-03-08 | Sunstar Inc | 口腔用組成物 |
JPH0624947A (ja) * | 1992-07-06 | 1994-02-01 | Sunstar Inc | 口腔用組成物 |
JPH1087457A (ja) * | 1996-09-14 | 1998-04-07 | Sunstar Inc | 口腔用組成物 |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013067568A (ja) * | 2011-09-21 | 2013-04-18 | Lion Corp | 歯磨剤組成物 |
JP2018043982A (ja) * | 2016-09-07 | 2018-03-22 | 第一三共ヘルスケア株式会社 | カチオン性殺菌剤、未修飾シリカ、及びベタイン系界面活性剤を含む口腔用組成物 |
JP7032889B2 (ja) | 2016-09-07 | 2022-03-09 | 第一三共ヘルスケア株式会社 | カチオン性殺菌剤、未修飾シリカ、及びベタイン系界面活性剤を含む口腔用組成物 |
JP2019006751A (ja) * | 2017-06-28 | 2019-01-17 | サンスター株式会社 | 口腔用組成物 |
JP7034612B2 (ja) | 2017-06-28 | 2022-03-14 | サンスター株式会社 | 口腔用組成物 |
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