JP2009120598A5 - - Google Patents

Download PDF

Info

Publication number
JP2009120598A5
JP2009120598A5 JP2008273676A JP2008273676A JP2009120598A5 JP 2009120598 A5 JP2009120598 A5 JP 2009120598A5 JP 2008273676 A JP2008273676 A JP 2008273676A JP 2008273676 A JP2008273676 A JP 2008273676A JP 2009120598 A5 JP2009120598 A5 JP 2009120598A5
Authority
JP
Japan
Prior art keywords
group
pharmaceutically acceptable
solvate
acceptable salt
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008273676A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009120598A (ja
JP4568779B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority to JP2008273676A priority Critical patent/JP4568779B2/ja
Priority claimed from JP2008273676A external-priority patent/JP4568779B2/ja
Publication of JP2009120598A publication Critical patent/JP2009120598A/ja
Publication of JP2009120598A5 publication Critical patent/JP2009120598A5/ja
Application granted granted Critical
Publication of JP4568779B2 publication Critical patent/JP4568779B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2008273676A 2007-10-26 2008-10-24 スピロ環化合物及びその医薬用途 Expired - Fee Related JP4568779B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008273676A JP4568779B2 (ja) 2007-10-26 2008-10-24 スピロ環化合物及びその医薬用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007279697 2007-10-26
JP2008273676A JP4568779B2 (ja) 2007-10-26 2008-10-24 スピロ環化合物及びその医薬用途

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010165678A Division JP2010270137A (ja) 2007-10-26 2010-07-23 スピロ環化合物及びその医薬用途

Publications (3)

Publication Number Publication Date
JP2009120598A JP2009120598A (ja) 2009-06-04
JP2009120598A5 true JP2009120598A5 (https=) 2010-04-22
JP4568779B2 JP4568779B2 (ja) 2010-10-27

Family

ID=40579581

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2008273676A Expired - Fee Related JP4568779B2 (ja) 2007-10-26 2008-10-24 スピロ環化合物及びその医薬用途
JP2010165678A Pending JP2010270137A (ja) 2007-10-26 2010-07-23 スピロ環化合物及びその医薬用途
JP2014158380A Pending JP2014221829A (ja) 2007-10-26 2014-08-04 スピロ環化合物及びその医薬用途
JP2016001396A Ceased JP2016102130A (ja) 2007-10-26 2016-01-06 スピロ環化合物及びその医薬用途
JP2017049246A Pending JP2017132787A (ja) 2007-10-26 2017-03-14 スピロ環化合物及びその医薬用途

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2010165678A Pending JP2010270137A (ja) 2007-10-26 2010-07-23 スピロ環化合物及びその医薬用途
JP2014158380A Pending JP2014221829A (ja) 2007-10-26 2014-08-04 スピロ環化合物及びその医薬用途
JP2016001396A Ceased JP2016102130A (ja) 2007-10-26 2016-01-06 スピロ環化合物及びその医薬用途
JP2017049246A Pending JP2017132787A (ja) 2007-10-26 2017-03-14 スピロ環化合物及びその医薬用途

Country Status (29)

Country Link
US (3) US8299296B2 (https=)
EP (3) EP2508503A1 (https=)
JP (5) JP4568779B2 (https=)
KR (1) KR101565622B1 (https=)
CN (1) CN101835737B (https=)
AR (1) AR071055A1 (https=)
AU (1) AU2008314933B2 (https=)
BR (1) BRPI0818687A2 (https=)
CA (1) CA2704013C (https=)
CL (1) CL2008003153A1 (https=)
CO (1) CO6321230A2 (https=)
CY (1) CY1113352T1 (https=)
DK (1) DK2202216T3 (https=)
ES (1) ES2386596T3 (https=)
HR (1) HRP20120696T1 (https=)
IL (1) IL205283A (https=)
ME (1) ME02338B (https=)
MX (1) MX2010004435A (https=)
MY (1) MY148469A (https=)
NZ (1) NZ584161A (https=)
PE (1) PE20091014A1 (https=)
PL (1) PL2202216T3 (https=)
PT (1) PT2202216E (https=)
RS (1) RS52474B (https=)
RU (1) RU2490250C2 (https=)
SI (1) SI2202216T1 (https=)
TW (1) TWI421070B (https=)
WO (1) WO2009054479A1 (https=)
ZA (1) ZA201002305B (https=)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101679908B (zh) * 2007-06-11 2012-10-24 奇华顿股份有限公司 有机化合物
BRPI0818687A2 (pt) * 2007-10-26 2017-05-02 Japan Tobacco Inc composto espiro, o sal deste farmaceuticamente aceitavél ou o solvato deste, composição farmacêutica, medicamento agonista de gpr40, agente promotor da secreção de insulina ou um agente hipoglicêmico, uso do composto espíro, o sal deste farmaceuticamente aceitavél ou o solvato deste, e, métodos para a ativação de gpr40, para promover secreção de insulina ou diminuir o nível de glicose sanguínea, e para tratar ou prevenir uma doença.
KR20110027657A (ko) * 2008-06-25 2011-03-16 다이이찌 산쿄 가부시키가이샤 카르복실산 화합물
HRP20130486T1 (en) * 2009-06-29 2013-06-30 Merz Pharma Gmbh & Co. Kgaa Method of preparing neramexane
EP2448911A1 (en) 2009-06-29 2012-05-09 Merz Pharma GmbH & Co. KGaA Method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane
WO2011000540A1 (en) * 2009-06-29 2011-01-06 Merz Pharma Gmbh & Co. Kgaa Method of preparing 3,3,5,5-tetramethylcyclohexanone
EP2289881A1 (de) * 2009-08-06 2011-03-02 Boehringer Ingelheim International GmbH Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen
AR078522A1 (es) 2009-10-15 2011-11-16 Lilly Co Eli Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis
AR078948A1 (es) * 2009-11-30 2011-12-14 Lilly Co Eli Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes
CN104710381A (zh) 2009-12-25 2015-06-17 持田制药株式会社 新的3-羟基-5-芳基异噻唑衍生物
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
JP5809157B2 (ja) 2010-10-08 2015-11-10 持田製薬株式会社 環状アミド誘導体
AP3531A (en) 2011-02-01 2016-01-13 Boehringer Ingelheim Int 9-[4-(3-chlor-2-fluor-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one dimaleate, use thereof as a drug, and production thereof
RU2013152631A (ru) 2011-04-27 2015-06-10 Мотида Фармасьютикал Ко., Лтд. Новое 3-гидроксиизотиазол-1-окидное производное
JPWO2012147516A1 (ja) 2011-04-28 2014-07-28 持田製薬株式会社 環状アミド誘導体
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2014012859A1 (en) 2012-07-19 2014-01-23 Boehringer Ingelheim International Gmbh Fumaric acid salt of 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy- chinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one, its use as medicament and the preparation thereof
US20150297573A1 (en) 2012-10-24 2015-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING Beta-CELL SURVIVAL
TWI692469B (zh) 2012-11-09 2020-05-01 南韓商Ｌｇ化學股份有限公司 Ｇｐｒ４０受體促效劑，製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物
RS55363B1 (sr) 2012-11-16 2017-03-31 Bristol Myers Squibb Co Dihidropirazolni gpr40 modulatori
KR101569522B1 (ko) 2013-04-18 2015-11-17 현대약품 주식회사 신규한 3-(4-(벤질옥시)페닐)헥스-4-이노익 산 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물
EP3076959B1 (en) 2013-12-04 2018-07-04 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
WO2015119899A1 (en) 2014-02-06 2015-08-13 Merck Sharp & Dohme Corp. Antidiabetic compounds
AU2015220427B2 (en) 2014-02-19 2017-09-21 Piramal Enterprises Limited Compounds for use as GPR120 agonists
AU2015293541B2 (en) 2014-07-25 2019-11-21 Piramal Enterprises Limited Substituted phenyl alkanoic acid compounds as GPR120 agonists and uses thereof
EP3191463B1 (en) 2014-09-11 2019-10-30 Piramal Enterprises Limited Fused heterocyclic compounds as gpr120 agonists
US10426818B2 (en) 2015-03-24 2019-10-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method and pharmaceutical composition for use in the treatment of diabetes
WO2018181847A1 (ja) * 2017-03-31 2018-10-04 武田薬品工業株式会社 芳香環化合物
BR102018007822A2 (pt) 2017-04-20 2018-11-06 Gilead Sciences, Inc. composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição
CR20200347A (es) 2018-02-13 2020-09-23 Gilead Sciences Inc Inhibidores pd-1/pd-l1
TWI712412B (zh) 2018-04-19 2020-12-11 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
SG11202012425QA (en) 2018-07-13 2021-01-28 Gilead Sciences Inc Pd-1/pd-l1 inhibitors
WO2020086556A1 (en) 2018-10-24 2020-04-30 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
KR20220150270A (ko) 2019-10-07 2022-11-10 칼리오페, 인크. Gpr119 효능제
TW202140440A (zh) 2020-02-28 2021-11-01 美商克力歐普股份有限公司 Gpr40激動劑
WO2021236617A1 (en) 2020-05-19 2021-11-25 Kallyope, Inc. Ampk activators
CN116390925A (zh) 2020-06-26 2023-07-04 卡尔优普公司 Ampk活化剂
CN115181023B (zh) * 2022-05-17 2023-07-28 东华理工大学 螺环活性增塑剂及其制备方法
WO2025037230A1 (en) * 2023-08-11 2025-02-20 Life Code Limited Compositions, agents and preparations for promoting hair growth and/or mitigating hair loss

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4331179A1 (de) * 1993-09-14 1995-03-16 Hoechst Schering Agrevo Gmbh Substituierte Pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide
GB9927056D0 (en) * 1999-11-17 2000-01-12 Karobio Ab Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders
EP1411110B1 (en) * 2002-10-14 2007-08-22 Firmenich Sa Spiro compounds as perfuming ingredients
JP4594611B2 (ja) * 2002-11-08 2010-12-08 武田薬品工業株式会社 受容体機能調節剤
CA2505322A1 (en) * 2002-11-08 2004-05-21 Takeda Pharmaceutical Company Limited Receptor function regulator
EP1630152A4 (en) * 2003-05-30 2009-09-23 Takeda Pharmaceutical CONDENSED CYCLIC COMPOUND
WO2005051373A1 (ja) * 2003-11-26 2005-06-09 Takeda Pharmaceutical Company Limited 受容体機能調節剤
AU2004309271A1 (en) * 2003-12-25 2005-07-14 Takeda Pharmaceutical Company Limited 3-(4-benzyloxyphenyl)propanoic acid derivatives
JP4074616B2 (ja) * 2003-12-25 2008-04-09 武田薬品工業株式会社 ３−（４−ベンジルオキシフェニル）プロパン酸誘導体
CA2558585C (en) 2004-02-27 2010-10-12 Amgen Inc. Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
US7517910B2 (en) * 2004-03-30 2009-04-14 Takeda Pharmaceutical Company Limited Alkoxyphenylpropanoic acid derivatives
JP2007284350A (ja) * 2004-07-27 2007-11-01 Takeda Chem Ind Ltd 糖尿病治療剤
US7465804B2 (en) * 2005-05-20 2008-12-16 Amgen Inc. Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
EP1924546A1 (en) * 2005-09-14 2008-05-28 Amgen, Inc Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
CA2662242C (en) * 2006-09-07 2012-06-12 Amgen Inc. Benzo-fused compounds for use in treating metabolic disorders
EP2064193A1 (en) 2006-09-07 2009-06-03 Amgen, Inc Heterocyclic gpr40 modulators
BRPI0818687A2 (pt) * 2007-10-26 2017-05-02 Japan Tobacco Inc composto espiro, o sal deste farmaceuticamente aceitavél ou o solvato deste, composição farmacêutica, medicamento agonista de gpr40, agente promotor da secreção de insulina ou um agente hipoglicêmico, uso do composto espíro, o sal deste farmaceuticamente aceitavél ou o solvato deste, e, métodos para a ativação de gpr40, para promover secreção de insulina ou diminuir o nível de glicose sanguínea, e para tratar ou prevenir uma doença.
KR20110027657A (ko) 2008-06-25 2011-03-16 다이이찌 산쿄 가부시키가이샤 카르복실산 화합물

Similar Documents

Publication Publication Date Title
JP2009120598A5 (https=)
RU2490250C2 (ru) Спиросоединения и их фармацевтическое применение
JP2012512907A5 (https=)
WO2007125405A3 (en) Substituted 2-amino-fused heterocyclic compounds
WO2009010416A3 (en) Inhibitors of 11b-hydroxysteroid dehydrogenase
NZ602754A (en) Substituted 1,3-benzothiazepines useful in treating metabolic disorders
JP2010524932A5 (https=)
JP2013510123A5 (https=)
EP1857457A3 (en) Benzimidazole derivative and its use as AII receptor antagonist
EP3404029A3 (en) Pyrimido-pyridazinone compounds and methods and use thereof
JP2018511647A5 (https=)
RU2009138600A (ru) Амиды диазабициклоалканов, селективные в отношении ацетилхолинового подтипа никотиновых рецепторов
PH12014502448A1 (en) Pharmaceutical combinations for the treatment of metabolic disorders
DE602006009095D1 (en) Diacylglycerol-acyltransferase-hemmer
WO2011045232A3 (en) Neuropeptide-2 receptor (y-2r) agonists
WO2010052144A3 (en) Neuropeptide-2-receptor (y-2r) agonists and uses thereof
EA201391525A1 (ru) Гликозидные производные и их применение для лечения диабета
ATE528306T1 (de) Benzoxazepin-verbindungen, ihre herstellung und verwendung
MX2011013648A (es) Nuevos compuestos, composiciones farmaceuticas y metodos relacionados con ellos.
JP2013537240A5 (https=)
JP2017522304A5 (https=)
WO2008098978A3 (en) Benzofuran compounds useful in the treatment of conditions mediated by the action of pge2 at the ep1 receptor
RU2012150501A (ru) Противораковые стероидные лактоны, ненасыщенные в положении 7(8)
AU2025213600A1 (en) Nurr1 receptor modulators
WO2014087307A3 (en) Compositions and methods for the treatment of metabolic syndrome and diabetes