JP2009106767A - 皮膚の療法emr治療を行う方法及び装置 - Google Patents
皮膚の療法emr治療を行う方法及び装置 Download PDFInfo
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Abstract
【解決手段】治療部分Vと全容積との比率は、0.1%乃至90%の犯意内で変化するが、50%以下であることが好ましい。波長を含む色々な技術を利用して放射線が集中させる深さを制御することができ、また、適宜な光学系212を提供して印加された放射線222を1つ又は2つ以上の治療部分Vの選んだ組み合わせに対し並列に又は直列に集中させることができる。
【選択図】図22
Description
アンダーソン・RR(Anderson RR)、パリシエ・J(Parrish J.)のサイエンス、1983;220:524−526の選択的光熱療法;パルス状放射線の選択的吸収による精密顕微鏡外科手術(Selective Photothermolysis;Precise microsurgery by selective absorption of the pulsed radiation)
図1Bは、複数のターゲット部分に対し平行に放射線を供給するときに使用するのに適した光学要素配列を含む更に別の光学系の頂面図である。
図2Bは、複数のターゲット部分に対し平行に放射線を供給するのに適した更に別のレンズ配列の側面図である。
図3Bは、複数のターゲット部分に対し平行に放射線を供給するのに適した更に別のレンズ配列の側面図である。
図4Bは、複数のターゲット部分に対し平行に放射線を供給するのに適した更に別のフレネルレンズ配列の側面図である。
図5Bは、複数のターゲット部分に対し平行に放射線を供給するときに使用するのに適した更に別のホログラフィックレンズ配列の側面図である。
図7Bは、その幾つかが複数のターゲット部分に対し線状焦点を提供するのに適した筒形レンズの別のマトリックス配列の頂面図である。
図8Bは、複数のターゲット部分に対し平行に放射線を提供するのに適したマトリックス筒形レンズ系の更に別の層の断面図又は側面図である。
図9Bは、図9の更に別の断面側面図である。
図14Bは、連続的なターゲット部分を移動させるべく図10乃至図13の配列と共に使用するのに適した偏向器システムの側面図である。
図15Bは、連続的なターゲット部分を移動させるべく図10乃至図13の配列と共に使用するのに適した別の偏向器システムの側面図である。
6 主要レンズ面
7 二次的面
8 屈折性材料
10 平坦面
11 入射ビーム、平行化初期ビーム
12 焦点
13 主要面
14 二次的平面
15 レンズ片
16 浸漬材料
17 フレネルレンズ面、フレネル面の中心
18 フレネルレンズ面、フレネル面のリング
19 ホログラフィックレンズ面
20 ホログラフィック材料
22 勾配レンズ
23 主要平坦面
24 二次的平坦面
25 筒形レンズ
26 筒形レンズの長さ
27 筒形レンズの直径
28 線状焦点
29 半筒形レンズ
30 主要作用光学面
31 二次的光学作用面
32 筒形レンズ、主要層レンズ
33、34 面
35 筒形レンズ、二次的レンズ
36、37 面
38 角度ビームスプリッタ
39 中心点、集束点
40 偏心点、集束点
41、42 屈折面、光学面
43 対物レンズ
44、45 光学面
46、49 対物レンズ
50、51 光学面
53 光学的平坦面
54 板
55 光学的平坦面
57 面
58 レンズ
62 走査ミラー
63 光学軸、ビーム
64 法線
65 光源、光ファイバ
66 ビーム
67 走査ミラー
68 光学面
70 走査レンズ
71 光軸
72 方向、屈折した光軸
73 偏心位置
74、75 面
76 レンズ
77 位置
79、80 光学面
81 単一のレンズ
82、83 光学面
84 レンズ
85 光学面
87 レンズ
88、89 面
90 単一のレンズ
93、96、99、102、105 レンズ
106 対物レンズ
200 患者の皮膚
202 表皮部分
204 真皮
206 真皮−表皮(DE)接合部
208 システム
210 EMR光源
212 光学系、システム、光学装置
214 ターゲット部分、治療部分、照射部分、損傷部分
215 冷却要素
216 検出器
218 光学装置、制御装置
220 皮膚領域
222 放射線ビーム、集束ビーム
θ 角度
A 領域
V ターゲット容積、治療容積
d 患者の皮膚の深さ
f 角度
2f 角度
f1 角度
s 方向
Claims (30)
- 患者の皮膚(200)内の所定容積部分(V)を治療する装置において、
放射線源(210)と、
該源(210)からの放射線(11)が印加される光学系(5、8、15−20、22、25、26、32、35、43、46、49、52、58、61、70、76、81、84、87、90、93、96、99、102、105、106)であって、光学系(5、8・・・105、106)が列状の光学要素を備え、
該列状の光学要素が、前記源(210)から受け取った放射線(11)を容積部分(V)内の三次元的に照射された複数の治療部分(214)内に集中させ、該列状の光学要素は、照射された複数の治療部分(214)が、互いに分離離間して形成されるような形態とされた装置。 - 請求項1に記載の装置において、
前記照射された複数の治療部分(214)が、容積部分(V)に対して約4%乃至50%、好ましくは約10%乃至50%の比率である、装置。 - 患者の皮膚(200)内の所定容積部分(V)を治療する装置において、
放射線源(210)と、
該源(210)からの放射線(11)が印加される光学系(5、8、15−20、22、25、26、32、35、43、46、49、52、58、61、70、76、81、84、87、90、93、96、99、102、105、106)であって、
該光学系(5、8・・・105、106)が、前記放射線(11)を容積部分(V)内の複数の三次元的治療部分(214)を照射するように該容積部分(V)内に集中させることにより、照射された複数の治療部分(214)が、互いに分離離間して形成され、
前記光学系(5、8・・・105、106)が、少なくとも1つの収束構成要素(81、90)と、該収束構成要素(81、90)を動かして放射線(11)を連続的な治療部分(214)に収束させ得るように該収束構成要素(81、90)に結合された位置決め機構を備える、装置。 - 請求項1又は2に記載の装置において、
前記光学要素(8、25、29、30)の各々が、前記源(210)から受け取った放射線(11)を、所定の長さ及び厚さを有する複数の狭小なストリップ(214)内に集中させ、前記要素(8、25、29、30)の幾つかに対応する該狭小なストリップ(214)は、前記要素(8、25、29、30)の他のものに対応する該狭小なストリップ(214)に対して選んだ角度となる、装置。 - 請求項1乃至4の何れかに記載の装置において、
光学系(5、8・・・105、106)が、放射線(11)を容積部分(V)内に集中させ、照射された治療部分(214)が、選んだ寸法及び厚さの円筒体、球状体、楕円体、中実な矩形体又は平面の形状とされる、装置。 - 請求項1又は2に記載の装置において、
光学系(5、8・・・105、106)が、源(210)からの放射線(11)を同時に、光学要素の少なくとも複数のものに印加する、装置。 - 請求項1又は2に記載の装置において、
前記光学要素の各々が、前記源(210)から受け取った放射線(11)を、所定の長さ及び厚さを有する複数の収束線(28)内に集中させ、光学要素(8、25、29、30)の幾つかからの前記収束線(28)が、その他の光学要素からの放射線の収束線(28)に対して選んだ角度にある、装置。 - 請求項1又は2に記載の装置において、
光学系(5、8・・・105、106)が、N>1である、N個の治療部分(214)に対し放射線(11)を同時に連続的に収束させ得るように光学要素に印加された放射線(11)を走査する走査ミラー(62、67)又は走査レンズ(70)を更に備える、装置。 - 請求項1乃至4の何れかに記載の装置において、
患者の皮膚表面(202)の一部分を選んだ温度まで冷却する機構(215)と、放射線(11)を印加する前又は放射線(11)を印加する間、患者の皮膚(200)を選んだ時間、予め冷却する機構(215)を選択的に作動させる制御装置(218)とを更に備える、装置。 - 請求項9に記載の装置において、
前記機構(215)及び制御装置(218)が、皮膚表面(202)から皮膚(200)の下方の深さまで伸びる患者の皮膚(200)の一部分を通常の体温以下の温度まで予め冷却する、装置。 - 請求項9に記載の装置において、
前記機構(215)及び制御装置(218)が、皮膚表面(202)から皮膚(200)の下方の深さまで伸びる患者の皮膚(200)を冷却し得るようにある温度及びある時間、皮膚(200)を冷却し、これにより治療部分(214)の各々が冷却した皮膚(200)により取り巻かれる、装置。 - 請求項1乃至4の何れかに記載の装置において、
放射線源(210)が、約800nmないし約1850nmの範囲又は約2100nmないし2300nmの範囲の波長を有する放射線(11)を発生させる、装置。 - 請求項1乃至4の何れかに記載の装置において、
放射線源(210)が、約800nmないし約1850nmの範囲又は約2150nmないし2300nmの範囲の波長を有する放射線(11)を発生させる、装置。 - 請求項1乃至4の何れかに記載の装置において、
放射線源(210)が、約900nmないし約1300nmの範囲又は約1550nmないし約1820の範囲又は約2150ないし2250nmの範囲の波長を有する放射線(11)を発生させる、装置。 - 請求項1乃至4の何れかに記載の装置において、
放射線源(210)が、約900nmないし約1250nmの範囲又は約1650ないし1750nmの範囲の波長を有する放射線(11)を発生させる、装置。 - 請求項1乃至4の何れかに記載の装置において、
放射線源(210)が、約900nmないし1230nmの範囲の波長を有する放射線(11)を発生させる、装置。 - 請求項1乃至4の何れかに記載の装置において、
放射線源(210)が、約1050ないし1220nmの範囲の波長を有する放射線(11)を発生させる、装置。 - 請求項1乃至4の何れかに記載の装置において、
光学系(5、8・・・105、106)が、深さ座標に配置された治療部分(214)内のエネルギの集中を最大にし得るように、少なくとも深さ座標の下方の皮膚(200)の深さまで放射線(11)を収束させる、装置。 - 請求項1乃至18の何れかつに記載の装置において、
容積部分(V)と患者の皮膚(200)内の該容積部分(V)の上方部分との少なくとも一方の状態を検出する検出器(216)を更に備え、
光学系(5、8・・・105、106)が、該検出器(216)に応答して作動し、放射線(11)が集中される容積部分(V)の治療部分(214)を制御する、装置。 - 請求項19に記載の装置において、
検出器(216)の出力を受け取り且つ、該出力に応答して源(210)のパワー輪郭外形(profile)を制御する制御装置(218)を更に備える、装置。 - 請求項20に記載の装置において、
制御装置(218)が、検出器(216)の出力に応答して光学系(5、8・・・105、106)の焦点深さを制御する、装置。 - 請求項19に記載の装置において、
制御装置(218)が、放射線(11)が任意の所定の時間にて集中される1つ又はより多数の治療部分(214)を決定し得るように検出器(216)の出力に応答して走査装置(62、67、70)を制御する、装置。 - 請求項3に記載の装置において、
前記照射された複数の治療部分(214)が、容積部分(V)に対して約4%乃至50%、好ましくは約10%乃至50%の比率である、装置。 - 請求項3に記載の装置において、
前記少なくとも1つの収束構成要素(81、90)は、調節可能の深さ収束構成要素である、装置。 - 請求項24に記載の装置において、
前記少なくとも1つの調節可能の深さ収束構成要素(81、90)はズームレンズを備え、該ズームレンズは、前記源に連結されて放射線を受け取り且つ光学軸線に沿って移動可能であり且つ放射線を空間的に分離された治療部分内に集中させ、
該空間的に分離された治療部分の少なくとも幾つかは、該容積部分内で異なった深さに配置されている、装置。 - 請求項1乃至4の何れかに記載の装置において、
マイクロレンズ系(5、6)を更に備える、装置。 - 請求項1乃至4の何れかに記載の装置において、
列状のフレネルレンズ(17、18)を更に備える、装置。 - 請求項1乃至4の何れかに記載の装置において、
1つ又はより多数の勾配レンズ(22)を更に備える、装置。 - 請求項1乃至4の何れかに記載の装置において、
光学系(5、8・・・105、106)の収束要素が列状の筒形レンズ(25、29、32、35)を備える、装置。 - 請求項1乃至4の何れかに記載の装置において、
2列の筒形レンズ(32、35)を更に備え、
一方の列におけるレンズが他方の列におけるレンズに対して直交状態に配置される、装置。
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