JP2008546731A5 - - Google Patents
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- Publication number
- JP2008546731A5 JP2008546731A5 JP2008517430A JP2008517430A JP2008546731A5 JP 2008546731 A5 JP2008546731 A5 JP 2008546731A5 JP 2008517430 A JP2008517430 A JP 2008517430A JP 2008517430 A JP2008517430 A JP 2008517430A JP 2008546731 A5 JP2008546731 A5 JP 2008546731A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- compound
- formula
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0512844.2A GB0512844D0 (en) | 2005-06-23 | 2005-06-23 | Organic compounds |
| PCT/EP2006/006083 WO2006136442A1 (en) | 2005-06-23 | 2006-06-23 | Pyrimidine derivatives for the treatment op gaba b mediated nervous system disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008546731A JP2008546731A (ja) | 2008-12-25 |
| JP2008546731A5 true JP2008546731A5 (enExample) | 2009-08-06 |
Family
ID=34856051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008517430A Pending JP2008546731A (ja) | 2005-06-23 | 2006-06-23 | Ｇａｂａｂ仲介神経系障害の処置のためのピリミジン誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20100179127A1 (enExample) |
| EP (1) | EP1896428A1 (enExample) |
| JP (1) | JP2008546731A (enExample) |
| KR (1) | KR20080017382A (enExample) |
| CN (1) | CN101193868A (enExample) |
| AU (1) | AU2006261122A1 (enExample) |
| BR (1) | BRPI0613394A2 (enExample) |
| CA (1) | CA2610742A1 (enExample) |
| GB (1) | GB0512844D0 (enExample) |
| MX (1) | MX2007016395A (enExample) |
| RU (1) | RU2008101525A (enExample) |
| WO (1) | WO2006136442A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8389534B2 (en) | 2008-05-19 | 2013-03-05 | The University Of Tennessee Research Foundation | Pyrimidine non-classical cannabinoid compounds and related methods of use |
| JP2011520975A (ja) | 2008-05-19 | 2011-07-21 | ユニヴァーシティ オブ テネシー リサーチ ファウンデーション，ザ | ピリミジンの非古典的カンナビノイド化合物及び関連する使用方法 |
| JP5674661B2 (ja) * | 2008-08-20 | 2015-02-25 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | エチニル置換ピリジンおよびピリミジン誘導体ならびにそれらのウイルス感染の治療における使用 |
| AU2009282574B2 (en) * | 2008-08-20 | 2014-08-21 | Merck Sharp & Dohme Corp. | Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
| WO2010022126A1 (en) | 2008-08-20 | 2010-02-25 | Schering Corporation | Azo-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
| US8697694B2 (en) | 2008-08-20 | 2014-04-15 | Merck Sharp & Dohme Corp. | Substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
| WO2010045377A2 (en) * | 2008-10-14 | 2010-04-22 | University Of Tennessee Research Foundation, The | Pyrimidine non-classical cannabinoid compounds and related methods of use |
| US8389536B2 (en) * | 2009-10-27 | 2013-03-05 | Hoffmann-La Roche Inc. | Positive allosteric modulators (PAM) |
| WO2012059932A1 (en) | 2010-11-01 | 2012-05-10 | Aurigene Discovery Technologies Limited | 2, 4 -diaminopyrimidine derivatives as protein kinase inhibitors |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| CZ305457B6 (cs) * | 2011-02-28 | 2015-09-30 | Ústav organické chemie a biochemie, Akademie věd ČR v. v. i. | Pyrimidinové sloučeniny inhibující tvorbu oxidu dusnatého a prostaglandinu E2, způsob výroby a použití |
| SG10201604682VA (en) | 2011-06-10 | 2016-07-28 | Merck Patent Gmbh | Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity |
| US9221809B2 (en) * | 2011-10-31 | 2015-12-29 | Merck Sharp & Dohme Corp. | Aminopyrimidinones as interleukin receptor-associated kinase inhibitors |
| HUE042374T2 (hu) | 2012-06-13 | 2019-06-28 | Incyte Holdings Corp | Szubsztituált triciklusos vegyületek mint FGFR inhibitorok |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| US9637505B2 (en) | 2013-03-15 | 2017-05-02 | Dow Agrosciences Llc | 4-amino-6-(heterocyclic)picolinates and 6-amino-2-(heterocyclic)pyrimidine-4-carboxylates and their use as herbicides |
| MX2015012947A (es) | 2013-03-15 | 2016-06-02 | Dow Agrosciences Llc | 4-amino-6-(heterociclico) picolinatos y 6-amino-2-(heterociclico) pirimidina-4-carboxilatos y su uso como herbicidas. |
| CN105377830B (zh) * | 2013-03-15 | 2018-04-13 | 美国陶氏益农公司 | 4‑氨基‑6‑(杂环基)吡啶‑2‑甲酸酯和6‑氨基‑2‑(杂环基)嘧啶‑4‑羧酸酯以及它们作为除草剂的用途 |
| KR102469849B1 (ko) | 2013-04-19 | 2022-11-23 | 인사이트 홀딩스 코포레이션 | Fgfr 저해제로서 이환식 헤테로사이클 |
| TW201623257A (zh) | 2014-05-09 | 2016-07-01 | 奧利安公司 | 藥理活性之喹唑啉二酮衍生物 |
| TWI689252B (zh) | 2014-09-15 | 2020-04-01 | 美商陶氏農業科學公司 | 源自於施用吡啶羧酸除草劑與乙醯乳酸合成酶（ａｌｓ）抑制劑的協同性雜草控制 |
| TWI689251B (zh) | 2014-09-15 | 2020-04-01 | 美商陶氏農業科學公司 | 源自於施用吡啶羧酸除草劑與合成生長素除草劑及/或生長素轉運抑制劑的協同性雜草控制 |
| TWI685302B (zh) | 2014-09-15 | 2020-02-21 | 美商陶氏農業科學公司 | 包含吡啶羧酸除草劑之安全的除草組成物 |
| TWI694770B (zh) | 2014-09-15 | 2020-06-01 | 美商陶氏農業科學公司 | 包含吡啶羧酸除草劑之安全的除草組成物（二） |
| TWI698178B (zh) | 2014-09-15 | 2020-07-11 | 美商陶氏農業科學公司 | 源自於施用吡啶羧酸除草劑與光系統ii抑制劑的協同性雜草控制 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| AU2016219822B2 (en) | 2015-02-20 | 2020-07-09 | Incyte Holdings Corporation | Bicyclic heterocycles as FGFR inhibitors |
| HRP20231547T1 (hr) | 2015-11-17 | 2024-03-15 | Merck Patent Gmbh | Postupci liječenja multiple skleroze primjenom spojeva pirimidina i piridina s aktivnošću inhibicije btk |
| HU231058B1 (hu) | 2017-03-13 | 2020-04-28 | Richter Gedeon Nyrt. | Gyógyászatilag hatékony aliciklusos-szubsztituált pirazolo[1,5-a]pirimidin származékok |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| EP3788046B1 (en) | 2018-05-04 | 2025-12-10 | Incyte Corporation | Salts of an fgfr inhibitor |
| EP4309737A3 (en) | 2018-05-04 | 2024-03-27 | Incyte Corporation | Solid forms of an fgfr inhibitor and processes for preparing the same |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021076602A1 (en) | 2019-10-14 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| JP7720840B2 (ja) | 2019-12-04 | 2025-08-08 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての三環式複素環 |
| KR20220131900A (ko) | 2019-12-04 | 2022-09-29 | 인사이트 코포레이션 | Fgfr 억제제의 유도체 |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| MX2023001444A (es) | 2020-08-05 | 2023-03-08 | Richter Gedeon Nyrt | Derivados de pirazolo[1,5-a]pirimidina sustituidos con heterociclicos farmacologicamente activos. |
| CA3215903A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| EP4352059A1 (en) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| WO2022261159A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH560197A5 (en) * | 1971-05-17 | 1975-03-27 | Ciba Geigy Ag | 2-alkylthio-4,6-bis (subst amino)-5-nitropyrimidines - - herbicides |
| CH558137A (de) * | 1971-05-17 | 1975-01-31 | Ciba Geigy Ag | Mittel zur beeinflussung des pflanzenwachstums. |
| CH574206A5 (enExample) * | 1972-11-16 | 1976-04-15 | Ciba Geigy Ag | |
| DE2341925A1 (de) * | 1973-08-20 | 1975-03-06 | Thomae Gmbh Dr K | Neue pyrimidinderivate und verfahren zu ihrer herstellung |
| CH595061A5 (enExample) * | 1974-05-10 | 1978-01-31 | Ciba Geigy Ag | |
| CH617833A5 (enExample) * | 1975-07-07 | 1980-06-30 | Ciba Geigy Ag | |
| SE9904129D0 (sv) * | 1999-11-15 | 1999-11-15 | Astra Pharma Prod | Novel compounds |
| ATE303367T1 (de) * | 2000-06-13 | 2005-09-15 | 5 phenyl substituierte 2-(cyanoamino)-pyrimidine als fungizide | |
| SE0004099D0 (sv) * | 2000-11-09 | 2000-11-09 | Astrazeneca Ab | Novel compounds |
| GB0206860D0 (en) * | 2002-03-22 | 2002-05-01 | Glaxo Group Ltd | Compounds |
| MXPA05007503A (es) * | 2003-01-17 | 2005-09-21 | Warner Lambert Co | Heterociclicos 2-aminopiridina sustituidos como inhibidores de proliferacion celular. |
| US20090036448A1 (en) * | 2004-03-30 | 2009-02-05 | Taisho Pharmecutical Co., Ltd. | Pyrimidine derivatives and methods of treatment related to the use thereof |
-
2005
- 2005-06-23 GB GBGB0512844.2A patent/GB0512844D0/en not_active Ceased
-
2006
- 2006-06-23 CA CA002610742A patent/CA2610742A1/en not_active Abandoned
- 2006-06-23 WO PCT/EP2006/006083 patent/WO2006136442A1/en not_active Ceased
- 2006-06-23 RU RU2008101525/04A patent/RU2008101525A/ru not_active Application Discontinuation
- 2006-06-23 AU AU2006261122A patent/AU2006261122A1/en not_active Abandoned
- 2006-06-23 CN CNA2006800207941A patent/CN101193868A/zh active Pending
- 2006-06-23 JP JP2008517430A patent/JP2008546731A/ja active Pending
- 2006-06-23 US US11/993,630 patent/US20100179127A1/en not_active Abandoned
- 2006-06-23 EP EP06762168A patent/EP1896428A1/en not_active Withdrawn
- 2006-06-23 KR KR1020077029918A patent/KR20080017382A/ko not_active Withdrawn
- 2006-06-23 BR BRPI0613394-0A patent/BRPI0613394A2/pt not_active IP Right Cessation
- 2006-06-23 MX MX2007016395A patent/MX2007016395A/es not_active Application Discontinuation
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