JP2008543830A - アミノ酸のｎ−アシル誘導体、その製法、薬理組成物および抗−アレルギー性、抗−炎症性および抗−脂血性薬剤としてのその使用 - Google Patents

アミノ酸のｎ−アシル誘導体、その製法、薬理組成物および抗−アレルギー性、抗−炎症性および抗−脂血性薬剤としてのその使用 Download PDF

Info

Publication number
JP2008543830A
JP2008543830A JP2008516776A JP2008516776A JP2008543830A JP 2008543830 A JP2008543830 A JP 2008543830A JP 2008516776 A JP2008516776 A JP 2008516776A JP 2008516776 A JP2008516776 A JP 2008516776A JP 2008543830 A JP2008543830 A JP 2008543830A
Authority
JP
Japan
Prior art keywords
allergic
general formula
salt
group
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2008516776A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008543830A5 (enExample
Inventor
ウラディミル エフゲニエヴィッチ ネボルシン
タティアナ アレクサンドロフナ クロモヴァ
ガリナ アレクサンドロフナ ゼルツキナ
ヴィオレッタ レオニドフナ コヴァレヴァ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2008543830A publication Critical patent/JP2008543830A/ja
Publication of JP2008543830A5 publication Critical patent/JP2008543830A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2008516776A 2005-06-15 2006-06-15 アミノ酸のｎ−アシル誘導体、その製法、薬理組成物および抗−アレルギー性、抗−炎症性および抗−脂血性薬剤としてのその使用 Withdrawn JP2008543830A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2005118635/04A RU2335495C2 (ru) 2005-06-15 2005-06-15 N-ацильные производные аминокислот, их фармацевтически приемлевые соли, фармацевтическая композиция и применение в качестве гиполипидемических средств
PCT/RU2006/000311 WO2006135280A1 (en) 2005-06-15 2006-06-15 N-acylic aminoacid derivatives. method for the production thereof, pharmacological composition and the use in the form of anti-allergic, anti-inflammatory and hypolipidemic agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013082349A Division JP5836995B2 (ja) 2005-06-15 2013-04-10 アミノ酸のｎ−アシル誘導体、その製法、薬理組成物および抗−アレルギー性、抗−炎症性および抗−脂血性薬剤としてのその使用

Publications (2)

Publication Number Publication Date
JP2008543830A true JP2008543830A (ja) 2008-12-04
JP2008543830A5 JP2008543830A5 (enExample) 2013-01-24

Family

ID=37502176

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008516776A Withdrawn JP2008543830A (ja) 2005-06-15 2006-06-15 アミノ酸のｎ−アシル誘導体、その製法、薬理組成物および抗−アレルギー性、抗−炎症性および抗−脂血性薬剤としてのその使用
JP2013082349A Expired - Fee Related JP5836995B2 (ja) 2005-06-15 2013-04-10 アミノ酸のｎ−アシル誘導体、その製法、薬理組成物および抗−アレルギー性、抗−炎症性および抗−脂血性薬剤としてのその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013082349A Expired - Fee Related JP5836995B2 (ja) 2005-06-15 2013-04-10 アミノ酸のｎ−アシル誘導体、その製法、薬理組成物および抗−アレルギー性、抗−炎症性および抗−脂血性薬剤としてのその使用

Country Status (10)

Country Link
US (2) US8940780B2 (enExample)
EP (1) EP1905763B1 (enExample)
JP (2) JP2008543830A (enExample)
KR (1) KR101402855B1 (enExample)
CN (1) CN101243053B (enExample)
CA (1) CA2612324C (enExample)
EA (1) EA013057B1 (enExample)
RU (1) RU2335495C2 (enExample)
UA (1) UA94586C2 (enExample)
WO (1) WO2006135280A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016530930A (ja) * 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
JP2018203749A (ja) * 2014-03-12 2018-12-27 オブシェストヴォ エス オグラニケノイ オトヴェツヴェノスチュ “ファーメンタープライゼズ” Ｒｎａおよび／またはｄｎａ含有ウイルスにより引き起こされる疾患と合併症の治療および予防のための薬剤としてのアミド化合物、およびその使用
JP2022534083A (ja) * 2019-05-24 2022-07-27 ステムディーアール インク． Ｎ－アシル－アミノ酸を有効成分として含む喘息、鼻炎又は結膜炎の予防又は治療用組成物

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2373934C1 (ru) * 2008-03-19 2009-11-27 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Применение производных глутаровой кислоты или их фармацевтически приемлемых солей в качестве противоаритмических средств
US9464306B2 (en) * 2008-10-29 2016-10-11 Kaneka Corporation Method for producing L-amino acid
WO2010064958A2 (ru) * 2008-12-01 2010-06-10 Закрытое Акционерное Общество "Мастерклон" Ингибиторы протеинкиназы с, обладающие противовоспалительным, противоаллергическим и противоастматическим действием
UA115431C2 (uk) * 2011-10-11 2017-11-10 Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" Застосування глутарилгістаміну для лікування захворювань дихальних шляхів
CN102757388B (zh) * 2012-07-04 2015-05-20 四川百利药业有限责任公司 一种高纯度英加韦林的制备方法
RU2518314C2 (ru) * 2012-08-30 2014-06-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Способ и средство активации irf-3 для лечения и профилактики заболеваний, вызываемых (+) phk-содержащими вирусами
CA3316609A1 (en) * 2013-03-15 2026-08-05 Modular Genetics, Inc. Generation of acyl amino acids
RU2665688C2 (ru) * 2013-04-12 2018-09-04 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения
CN103288741B (zh) * 2013-05-24 2015-09-30 华南农业大学 一种组胺半抗原、人工抗原、抗体及其制备方法与应用
CN104119277B (zh) * 2014-07-16 2016-08-17 华南农业大学 一种直接针对组胺的半抗原、人工抗原、抗体及其制备方法与应用
CN104230833B (zh) * 2014-10-07 2016-01-20 张远强 含腈基的四氮唑乙酸类化合物、其制备方法及用途
US11371066B2 (en) 2015-07-13 2022-06-28 Modular Genetics, Inc. Generation of acyl alcohols
RU2665638C1 (ru) * 2017-05-24 2018-09-03 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Амидное соединение и его применение в качестве средства для лечения и профилактики заболеваний, вызываемых рнк-содержащими вирусами
CN110031583B (zh) * 2018-12-29 2022-01-18 浙江工业大学 分离测定n-琥珀酰色氨酸对映异构体的液相色谱方法
CN114340612A (zh) * 2019-05-24 2022-04-12 斯特姆德公司 包含n-酰基氨基酸作为有效成分的用于预防或治疗哮喘、鼻炎或结膜炎的组合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1020179A2 (en) * 1997-07-04 2000-07-19 Vladimir Evgenievich Nebolsin Peptide derivatives or pharmaceutically acceptable salts thereof, method for producing the same, use of said derivatives and pharmaceutical composition
WO2003072124A1 (en) * 2002-02-28 2003-09-04 Vladimir Evgenievich Nebolsin Induction method for cell differentiation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2117199C (en) 1991-09-09 2004-12-28 Jurgen Michaelis Method for the treatment of the complications and pathology of diabetes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1020179A2 (en) * 1997-07-04 2000-07-19 Vladimir Evgenievich Nebolsin Peptide derivatives or pharmaceutically acceptable salts thereof, method for producing the same, use of said derivatives and pharmaceutical composition
WO2003072124A1 (en) * 2002-02-28 2003-09-04 Vladimir Evgenievich Nebolsin Induction method for cell differentiation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ADVANCED SYNTHESIS & CATALYSIS, vol. Vol.345, No.6-7, JPN6012025673, 2003, pages 783 - 789, ISSN: 0002229332 *
BIOCHEMISTRY, vol. 16, no. 25, JPN6012025674, 1977, pages 5484 - 5491, ISSN: 0002229333 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016530930A (ja) * 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
JP2018203749A (ja) * 2014-03-12 2018-12-27 オブシェストヴォ エス オグラニケノイ オトヴェツヴェノスチュ “ファーメンタープライゼズ” Ｒｎａおよび／またはｄｎａ含有ウイルスにより引き起こされる疾患と合併症の治療および予防のための薬剤としてのアミド化合物、およびその使用
JP2022534083A (ja) * 2019-05-24 2022-07-27 ステムディーアール インク． Ｎ－アシル－アミノ酸を有効成分として含む喘息、鼻炎又は結膜炎の予防又は治療用組成物
JP7264540B2 (ja) 2019-05-24 2023-04-25 ステムディーアール インク． Ｎ－アシル－アミノ酸を有効成分として含む喘息、鼻炎又は結膜炎の予防又は治療用組成物

Also Published As

Publication number Publication date
CN101243053B (zh) 2012-08-08
US20080319040A1 (en) 2008-12-25
EP1905763A4 (en) 2008-08-27
EA013057B1 (ru) 2010-02-26
US8318950B2 (en) 2012-11-27
JP5836995B2 (ja) 2015-12-24
RU2005118635A (ru) 2006-11-20
UA94586C2 (ru) 2011-05-25
KR20080039872A (ko) 2008-05-07
EA200800054A1 (ru) 2008-06-30
US20100267962A1 (en) 2010-10-21
CA2612324C (en) 2014-12-30
CA2612324A1 (en) 2006-12-21
JP2013151551A (ja) 2013-08-08
US8940780B2 (en) 2015-01-27
RU2335495C2 (ru) 2008-10-10
CN101243053A (zh) 2008-08-13
EP1905763A1 (en) 2008-04-02
KR101402855B1 (ko) 2014-06-03
WO2006135280A1 (en) 2006-12-21
EP1905763B1 (en) 2019-05-08

Similar Documents

Publication Publication Date Title
JP5836995B2 (ja) アミノ酸のｎ−アシル誘導体、その製法、薬理組成物および抗−アレルギー性、抗−炎症性および抗−脂血性薬剤としてのその使用
RU2412934C2 (ru) Применение антагонистов crth2 в терапии
JP2009530362A (ja) Ｃｒｔｈ２アンタゴニスト活性を有する塩
JP2001520998A (ja) インドールｓＰＬＡ２阻害剤のモルホリノ−Ｎ−エチルエステルプロドラッグ
JP2003507327A (ja) 化学化合物
JPH0347167A (ja) メバロノラクトンの複素環同族体
JP2006056894A (ja) 置換イソキノリン−３−カルボキサミド、その製法および薬剤としてのその使用
AU2009330131B2 (en) Compounds and methods for the treatment of pain and other diseases
CA2576727C (fr) Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
KR20010071197A (ko) ｓＰＬＡ2 억제제 에스테르
JP2001520991A (ja) インドールｓＰＬＡ２阻害剤のＮ，Ｎ−ジエチルグリコールアミドエステルプロドラッグ
JPH0615533B2 (ja) ピラジン誘導体およびこれを含有する血小板凝集抑制剤
JP4564669B2 (ja) インドールｓＰＬＡ２インヒビターのモルホリノ−Ｎ−エチルエステル誘導体
KR20040063992A (ko) 디-프롤린으로의 전구약물
RU2406727C2 (ru) Фармацевтическая композиция, содержащая n-ацильные производные аминокислот, и их применение в качестве противоаллергических, антианафилактических и противовоспалительных средств
RU2378284C2 (ru) Способы получения n-ацильных производных аминокислот (варианты)
HK1118816A (en) N-acylic aminoacid derivatives. method for the production thereof, pharmacological composition and the use in the form of anti-allergic, anti-inflammatory and hypolipidemic agents
WO2025171382A1 (en) Indole amino ketone histone deacetylase inhibitors and uses thereof
CN115819349A (zh) 一种吡唑类化合物及其制备方法和应用
Paolini et al. Preparation of isoindoline derivatives for use as AMPK activators
CN1180065A (zh) 一种抗过敏、抗哮喘和抗炎症的新药
HK1076100B (en) Prodrugs to d-prolines
CN1190095A (zh) 一种具5－脂加氧酶抑制活性的新色酮衍生物

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090605

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120521

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120821

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120828

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121121

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20121121

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20121210

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130410

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130424

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130522

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20130528

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20130705

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20131227

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140108

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141118

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20141121

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20150217