UA94586C2 - N-ацильные производные аминокислот, способ их получения, фармацевтическая композиция и их применение как противоаллергических, противовоспалительных и гиполипидемических средств - Google Patents
N-ацильные производные аминокислот, способ их получения, фармацевтическая композиция и их применение как противоаллергических, противовоспалительных и гиполипидемических средствInfo
- Publication number
- UA94586C2 UA94586C2 UAA200800495A UAA200800495A UA94586C2 UA 94586 C2 UA94586 C2 UA 94586C2 UA A200800495 A UAA200800495 A UA A200800495A UA A200800495 A UAA200800495 A UA A200800495A UA 94586 C2 UA94586 C2 UA 94586C2
- Authority
- UA
- Ukraine
- Prior art keywords
- allergic
- inflammatory
- antiallergic
- hypolipidemic agents
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000003266 anti-allergic effect Effects 0.000 title abstract 2
- 239000002260 anti-inflammatory agent Substances 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 239000003524 antilipemic agent Substances 0.000 title abstract 2
- 239000000043 antiallergic agent Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 2
- 206010037660 Pyrexia Diseases 0.000 abstract 2
- 208000026935 allergic disease Diseases 0.000 abstract 2
- 230000000172 allergic effect Effects 0.000 abstract 2
- 201000010105 allergic rhinitis Diseases 0.000 abstract 2
- 206010058284 Allergy to arthropod sting Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 abstract 1
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 208000000501 Lipidoses Diseases 0.000 abstract 1
- 206010024585 Lipidosis Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 206010039094 Rhinitis perennial Diseases 0.000 abstract 1
- 208000036284 Rhinitis seasonal Diseases 0.000 abstract 1
- 208000024780 Urticaria Diseases 0.000 abstract 1
- 208000002205 allergic conjunctivitis Diseases 0.000 abstract 1
- 208000030961 allergic reaction Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 230000002052 anaphylactic effect Effects 0.000 abstract 1
- 230000002804 anti-anaphylactic effect Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000024998 atopic conjunctivitis Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 abstract 1
- 208000022719 perennial allergic rhinitis Diseases 0.000 abstract 1
- 239000008196 pharmacological composition Substances 0.000 abstract 1
- 230000002685 pulmonary effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000017022 seasonal allergic rhinitis Diseases 0.000 abstract 1
- 230000001932 seasonal effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2005118635/04A RU2335495C2 (ru) | 2005-06-15 | 2005-06-15 | N-ацильные производные аминокислот, их фармацевтически приемлевые соли, фармацевтическая композиция и применение в качестве гиполипидемических средств |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA94586C2 true UA94586C2 (ru) | 2011-05-25 |
Family
ID=37502176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200800495A UA94586C2 (ru) | 2005-06-15 | 2006-06-15 | N-ацильные производные аминокислот, способ их получения, фармацевтическая композиция и их применение как противоаллергических, противовоспалительных и гиполипидемических средств |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8940780B2 (enExample) |
| EP (1) | EP1905763B1 (enExample) |
| JP (2) | JP2008543830A (enExample) |
| KR (1) | KR101402855B1 (enExample) |
| CN (1) | CN101243053B (enExample) |
| CA (1) | CA2612324C (enExample) |
| EA (1) | EA013057B1 (enExample) |
| RU (1) | RU2335495C2 (enExample) |
| UA (1) | UA94586C2 (enExample) |
| WO (1) | WO2006135280A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2373934C1 (ru) * | 2008-03-19 | 2009-11-27 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Применение производных глутаровой кислоты или их фармацевтически приемлемых солей в качестве противоаритмических средств |
| US9464306B2 (en) * | 2008-10-29 | 2016-10-11 | Kaneka Corporation | Method for producing L-amino acid |
| WO2010064958A2 (ru) * | 2008-12-01 | 2010-06-10 | Закрытое Акционерное Общество "Мастерклон" | Ингибиторы протеинкиназы с, обладающие противовоспалительным, противоаллергическим и противоастматическим действием |
| UA115431C2 (uk) * | 2011-10-11 | 2017-11-10 | Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" | Застосування глутарилгістаміну для лікування захворювань дихальних шляхів |
| CN102757388B (zh) * | 2012-07-04 | 2015-05-20 | 四川百利药业有限责任公司 | 一种高纯度英加韦林的制备方法 |
| RU2518314C2 (ru) * | 2012-08-30 | 2014-06-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Способ и средство активации irf-3 для лечения и профилактики заболеваний, вызываемых (+) phk-содержащими вирусами |
| CA3316609A1 (en) * | 2013-03-15 | 2026-08-05 | Modular Genetics, Inc. | Generation of acyl amino acids |
| RU2665688C2 (ru) * | 2013-04-12 | 2018-09-04 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения |
| CN103288741B (zh) * | 2013-05-24 | 2015-09-30 | 华南农业大学 | 一种组胺半抗原、人工抗原、抗体及其制备方法与应用 |
| CA2920488C (en) * | 2013-08-05 | 2022-04-26 | Mannkind Corporation | Insufflation apparatus and methods |
| RU2628800C2 (ru) * | 2014-03-12 | 2017-08-22 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Амидные соединения, способы получения, применение в качестве средств для лечения и профилактики заболеваний, вызываемых рнк-содержащими вирусами |
| CN104119277B (zh) * | 2014-07-16 | 2016-08-17 | 华南农业大学 | 一种直接针对组胺的半抗原、人工抗原、抗体及其制备方法与应用 |
| CN104230833B (zh) * | 2014-10-07 | 2016-01-20 | 张远强 | 含腈基的四氮唑乙酸类化合物、其制备方法及用途 |
| US11371066B2 (en) | 2015-07-13 | 2022-06-28 | Modular Genetics, Inc. | Generation of acyl alcohols |
| RU2665638C1 (ru) * | 2017-05-24 | 2018-09-03 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Амидное соединение и его применение в качестве средства для лечения и профилактики заболеваний, вызываемых рнк-содержащими вирусами |
| CN110031583B (zh) * | 2018-12-29 | 2022-01-18 | 浙江工业大学 | 分离测定n-琥珀酰色氨酸对映异构体的液相色谱方法 |
| CN114340612A (zh) * | 2019-05-24 | 2022-04-12 | 斯特姆德公司 | 包含n-酰基氨基酸作为有效成分的用于预防或治疗哮喘、鼻炎或结膜炎的组合物 |
| BR112021023536A2 (pt) * | 2019-05-24 | 2022-02-01 | Stemdr Inc | Composição para prevenir ou tratar asma, rinite ou conjuntivite, compreendendo n-acilaminoácido como ingrediente ativo |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2117199C (en) | 1991-09-09 | 2004-12-28 | Jurgen Michaelis | Method for the treatment of the complications and pathology of diabetes |
| RU2141483C1 (ru) * | 1997-07-04 | 1999-11-20 | Небольсин Владимир Евгеньевич | Производные пептидов или их фармацевтически приемлемые соли, способ их получения, применение и фармацевтическая композиция |
| RU2217196C2 (ru) * | 2002-02-28 | 2003-11-27 | Небольсин Владимир Евгеньевич | Способ индукции дифференцировки клеток |
-
2005
- 2005-06-15 RU RU2005118635/04A patent/RU2335495C2/ru active
-
2006
- 2006-06-15 EP EP06757984.7A patent/EP1905763B1/en not_active Expired - Lifetime
- 2006-06-15 EA EA200800054A patent/EA013057B1/ru not_active IP Right Cessation
- 2006-06-15 US US11/917,598 patent/US8940780B2/en not_active Expired - Fee Related
- 2006-06-15 CN CN2006800296822A patent/CN101243053B/zh not_active Expired - Fee Related
- 2006-06-15 WO PCT/RU2006/000311 patent/WO2006135280A1/ru not_active Ceased
- 2006-06-15 JP JP2008516776A patent/JP2008543830A/ja not_active Withdrawn
- 2006-06-15 KR KR1020087001210A patent/KR101402855B1/ko not_active Expired - Fee Related
- 2006-06-15 UA UAA200800495A patent/UA94586C2/ru unknown
- 2006-06-15 CA CA2612324A patent/CA2612324C/en not_active Expired - Fee Related
-
2010
- 2010-04-21 US US12/764,515 patent/US8318950B2/en not_active Expired - Fee Related
-
2013
- 2013-04-10 JP JP2013082349A patent/JP5836995B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN101243053B (zh) | 2012-08-08 |
| US20080319040A1 (en) | 2008-12-25 |
| EP1905763A4 (en) | 2008-08-27 |
| EA013057B1 (ru) | 2010-02-26 |
| US8318950B2 (en) | 2012-11-27 |
| JP2008543830A (ja) | 2008-12-04 |
| JP5836995B2 (ja) | 2015-12-24 |
| RU2005118635A (ru) | 2006-11-20 |
| KR20080039872A (ko) | 2008-05-07 |
| EA200800054A1 (ru) | 2008-06-30 |
| US20100267962A1 (en) | 2010-10-21 |
| CA2612324C (en) | 2014-12-30 |
| CA2612324A1 (en) | 2006-12-21 |
| JP2013151551A (ja) | 2013-08-08 |
| US8940780B2 (en) | 2015-01-27 |
| RU2335495C2 (ru) | 2008-10-10 |
| CN101243053A (zh) | 2008-08-13 |
| EP1905763A1 (en) | 2008-04-02 |
| KR101402855B1 (ko) | 2014-06-03 |
| WO2006135280A1 (en) | 2006-12-21 |
| EP1905763B1 (en) | 2019-05-08 |
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