UA94586C2 - N-ацильные производные аминокислот, способ их получения, фармацевтическая композиция и их применение как противоаллергических, противовоспалительных и гиполипидемических средств - Google Patents
N-ацильные производные аминокислот, способ их получения, фармацевтическая композиция и их применение как противоаллергических, противовоспалительных и гиполипидемических средствInfo
- Publication number
- UA94586C2 UA94586C2 UAA200800495A UAA200800495A UA94586C2 UA 94586 C2 UA94586 C2 UA 94586C2 UA A200800495 A UAA200800495 A UA A200800495A UA A200800495 A UAA200800495 A UA A200800495A UA 94586 C2 UA94586 C2 UA 94586C2
- Authority
- UA
- Ukraine
- Prior art keywords
- allergic
- inflammatory
- antiallergic
- hypolipidemic agents
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Otolaryngology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Данное изобретение касается N-ацильных производных аминокислот общей формулы (I), (I)где n равно 2 или 3; иRпредставляет собойили,R=H, -CH, -CH,или их фармацевтически приемлемых солей, новых способов их получения, их применения как противоаллергических, антианафилактических, противовоспалительных и гиполипидемических средств, а также фармацевтической композиции, которая содержит указанные соединения в эффективном количестве, и способа лечения аллергических и воспалительных заболеваний и нарушений липидного обмена: бронхиальной астмы, аллергического ринита, полинозов, сезонного и круглогодичного ринита, аллергического воспаления легких, атонического дерматита, псориаза, крапивницы, аллергических (в том числе анафилактических) реакций на укусы насекомых и лекарственные
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2005118635/04A RU2335495C2 (ru) | 2005-06-15 | 2005-06-15 | N-ацильные производные аминокислот, их фармацевтически приемлевые соли, фармацевтическая композиция и применение в качестве гиполипидемических средств |
Publications (1)
Publication Number | Publication Date |
---|---|
UA94586C2 true UA94586C2 (ru) | 2011-05-25 |
Family
ID=37502176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200800495A UA94586C2 (ru) | 2005-06-15 | 2006-06-15 | N-ацильные производные аминокислот, способ их получения, фармацевтическая композиция и их применение как противоаллергических, противовоспалительных и гиполипидемических средств |
Country Status (10)
Country | Link |
---|---|
US (2) | US8940780B2 (ru) |
EP (1) | EP1905763B1 (ru) |
JP (2) | JP2008543830A (ru) |
KR (1) | KR101402855B1 (ru) |
CN (1) | CN101243053B (ru) |
CA (1) | CA2612324C (ru) |
EA (1) | EA013057B1 (ru) |
RU (1) | RU2335495C2 (ru) |
UA (1) | UA94586C2 (ru) |
WO (1) | WO2006135280A1 (ru) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2373934C1 (ru) | 2008-03-19 | 2009-11-27 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Применение производных глутаровой кислоты или их фармацевтически приемлемых солей в качестве противоаритмических средств |
SG10201400650QA (en) * | 2008-10-29 | 2014-05-29 | Kaneka Corp | Method For Producing L-Amino Acid |
WO2010064958A2 (ru) * | 2008-12-01 | 2010-06-10 | Закрытое Акционерное Общество "Мастерклон" | Ингибиторы протеинкиназы с, обладающие противовоспалительным, противоаллергическим и противоастматическим действием |
UA115431C2 (ru) * | 2011-10-11 | 2017-11-10 | Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" | Применение глутарилгистамина для лечения заболеваний дыхательных путей |
CN102757388B (zh) * | 2012-07-04 | 2015-05-20 | 四川百利药业有限责任公司 | 一种高纯度英加韦林的制备方法 |
RU2518314C2 (ru) * | 2012-08-30 | 2014-06-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Способ и средство активации irf-3 для лечения и профилактики заболеваний, вызываемых (+) phk-содержащими вирусами |
JP6741572B2 (ja) | 2013-03-15 | 2020-08-19 | モジュラー ジェネティクス, インコーポレイテッド | アシルアミノ酸の生成 |
RU2665688C2 (ru) * | 2013-04-12 | 2018-09-04 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения |
CN103288741B (zh) * | 2013-05-24 | 2015-09-30 | 华南农业大学 | 一种组胺半抗原、人工抗原、抗体及其制备方法与应用 |
US11446127B2 (en) * | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
RU2628800C2 (ru) * | 2014-03-12 | 2017-08-22 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Амидные соединения, способы получения, применение в качестве средств для лечения и профилактики заболеваний, вызываемых рнк-содержащими вирусами |
CN104119277B (zh) * | 2014-07-16 | 2016-08-17 | 华南农业大学 | 一种直接针对组胺的半抗原、人工抗原、抗体及其制备方法与应用 |
CN104230833B (zh) * | 2014-10-07 | 2016-01-20 | 张远强 | 含腈基的四氮唑乙酸类化合物、其制备方法及用途 |
US11371066B2 (en) | 2015-07-13 | 2022-06-28 | Modular Genetics, Inc. | Generation of acyl alcohols |
RU2665638C1 (ru) * | 2017-05-24 | 2018-09-03 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Амидное соединение и его применение в качестве средства для лечения и профилактики заболеваний, вызываемых рнк-содержащими вирусами |
CN110031583B (zh) * | 2018-12-29 | 2022-01-18 | 浙江工业大学 | 分离测定n-琥珀酰色氨酸对映异构体的液相色谱方法 |
CN114340612A (zh) * | 2019-05-24 | 2022-04-12 | 斯特姆德公司 | 包含n-酰基氨基酸作为有效成分的用于预防或治疗哮喘、鼻炎或结膜炎的组合物 |
AU2020283844B2 (en) * | 2019-05-24 | 2023-12-21 | Stemdr Inc. | Composition for preventing or treating asthma, rhinitis or conjunctivitis, comprising N-acyl amino acid as active ingredient |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07500580A (ja) | 1991-09-09 | 1995-01-19 | ペプテック リミテッド | 糖尿病の合併症及び病因の処理方法 |
RU2141483C1 (ru) * | 1997-07-04 | 1999-11-20 | Небольсин Владимир Евгеньевич | Производные пептидов или их фармацевтически приемлемые соли, способ их получения, применение и фармацевтическая композиция |
RU2217196C2 (ru) * | 2002-02-28 | 2003-11-27 | Небольсин Владимир Евгеньевич | Способ индукции дифференцировки клеток |
-
2005
- 2005-06-15 RU RU2005118635/04A patent/RU2335495C2/ru active
-
2006
- 2006-06-15 UA UAA200800495A patent/UA94586C2/ru unknown
- 2006-06-15 EA EA200800054A patent/EA013057B1/ru not_active IP Right Cessation
- 2006-06-15 KR KR1020087001210A patent/KR101402855B1/ko active IP Right Grant
- 2006-06-15 WO PCT/RU2006/000311 patent/WO2006135280A1/ru active Search and Examination
- 2006-06-15 EP EP06757984.7A patent/EP1905763B1/en not_active Not-in-force
- 2006-06-15 CN CN2006800296822A patent/CN101243053B/zh not_active Expired - Fee Related
- 2006-06-15 CA CA2612324A patent/CA2612324C/en not_active Expired - Fee Related
- 2006-06-15 JP JP2008516776A patent/JP2008543830A/ja not_active Withdrawn
- 2006-06-15 US US11/917,598 patent/US8940780B2/en not_active Expired - Fee Related
-
2010
- 2010-04-21 US US12/764,515 patent/US8318950B2/en not_active Expired - Fee Related
-
2013
- 2013-04-10 JP JP2013082349A patent/JP5836995B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP5836995B2 (ja) | 2015-12-24 |
CN101243053A (zh) | 2008-08-13 |
JP2008543830A (ja) | 2008-12-04 |
EA013057B1 (ru) | 2010-02-26 |
EA200800054A1 (ru) | 2008-06-30 |
WO2006135280A1 (fr) | 2006-12-21 |
CA2612324C (en) | 2014-12-30 |
CN101243053B (zh) | 2012-08-08 |
EP1905763A4 (en) | 2008-08-27 |
EP1905763A1 (en) | 2008-04-02 |
JP2013151551A (ja) | 2013-08-08 |
KR20080039872A (ko) | 2008-05-07 |
US20100267962A1 (en) | 2010-10-21 |
KR101402855B1 (ko) | 2014-06-03 |
US8318950B2 (en) | 2012-11-27 |
RU2005118635A (ru) | 2006-11-20 |
RU2335495C2 (ru) | 2008-10-10 |
US20080319040A1 (en) | 2008-12-25 |
US8940780B2 (en) | 2015-01-27 |
CA2612324A1 (en) | 2006-12-21 |
EP1905763B1 (en) | 2019-05-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UA94586C2 (ru) | N-ацильные производные аминокислот, способ их получения, фармацевтическая композиция и их применение как противоаллергических, противовоспалительных и гиполипидемических средств | |
NZ591914A (en) | Naphthylacetic acids | |
BRPI0511344A (pt) | composto, composição farmacêutica, uso de um composto, método para o tratamento de um sujeito que sofre de uma condição patológica ou doença susceptìvel de melhora pela inibição de fosfodiesterase 4 e produto combinado | |
JP4084410B2 (ja) | ヒスタミンh3受容体リガンドとして有用なテトラヒドロナフチリヂン誘導体 | |
UY26570A1 (es) | Carboxamidas de pirimidina útiles como inhibidores de isozimas pde4 | |
WO2010018109A3 (en) | Substituted aminotetralines | |
WO2010018112A3 (en) | Monoaryl aminotetralines | |
WO2005021515A3 (en) | Inhibitors of phosphodiesterase type-iv | |
SG155909A1 (en) | Pyridazin-3(2h)-one derivatives and their use as pde4 inhibitors | |
AU2005238291A1 (en) | Substituted methyl aryl or heteroaryl amide compounds | |
JP2002521463A (ja) | ヒスタミンh3−受容体リガンドとしての非イミダゾールアルキルアミンと、その治療への応用。 | |
MY145648A (en) | Dihydrogen phosphate salt of a prostaglandin d2 receptor antagonist | |
UA95950C2 (en) | 2,6-substituted-4-monosubstituted amino-pyrimidineasprostaglandin d2 receptor antagonists | |
JPS59148759A (ja) | 新規なω−メルカプトプロパンアミドおよびその同族体の誘導体,該誘導体の製造方法,その,薬剤としての用途,該薬剤を含む組成物並びに取得される新規な中間体 | |
WO2006011024A3 (en) | New tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them | |
TW200635932A (en) | New pyridothienopyrimidine derivatives | |
YU68601A (sh) | Jedinjenja i njihova upotreba za pripremu leka za tretiranje astme, alergije i inflamatornih bolesti | |
NO20080457L (no) | Kjemiske forbindelser | |
JP2008529965A (ja) | ムスカリン性m3受容体のリガンドとしてのピペリジニウムおよびピロリジニウム誘導体 | |
Cheng et al. | Design, synthesis, and biological activities of novel Ligustrazine derivatives | |
Cheng et al. | Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents | |
Ban et al. | Novel antiallergic agents. Part I: Synthesis and pharmacology of pyrimidine amide derivatives | |
DE69615019T2 (de) | Benzopyrane und diese enthaltende pharmazeutische zusammenstellungen | |
EP2048134B1 (en) | Meptazinol biligand derivatives and/or their salts, preparation method and uses thereof | |
EP1666473A4 (en) | CARBOXYLIC ACID COMPOUNDS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME AS ACTIVE INGREDIENT |