JP2008542280A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008542280A5 JP2008542280A5 JP2008513596A JP2008513596A JP2008542280A5 JP 2008542280 A5 JP2008542280 A5 JP 2008542280A5 JP 2008513596 A JP2008513596 A JP 2008513596A JP 2008513596 A JP2008513596 A JP 2008513596A JP 2008542280 A5 JP2008542280 A5 JP 2008542280A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- omega
- subject
- choline
- contact
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002503 metabolic effect Effects 0.000 claims 55
- 239000002243 precursor Substances 0.000 claims 55
- 239000003814 drug Substances 0.000 claims 39
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims 34
- 235000020665 omega-6 fatty acid Nutrition 0.000 claims 23
- 229940033080 omega-6 fatty acid Drugs 0.000 claims 23
- 229940079593 drug Drugs 0.000 claims 19
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 19
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 19
- 150000003904 phospholipids Chemical class 0.000 claims 18
- DJJCXFVJDGTHFX-UHFFFAOYSA-N Uridinemonophosphate Natural products OC1C(O)C(COP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-UHFFFAOYSA-N 0.000 claims 17
- 125000002252 acyl group Chemical group 0.000 claims 17
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 claims 17
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims 17
- 229940045145 uridine Drugs 0.000 claims 17
- DJJCXFVJDGTHFX-XVFCMESISA-N uridine 5'-monophosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-XVFCMESISA-N 0.000 claims 17
- 210000004958 brain cell Anatomy 0.000 claims 14
- 239000004381 Choline salt Substances 0.000 claims 13
- 229960001231 choline Drugs 0.000 claims 13
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 13
- 235000019417 choline salt Nutrition 0.000 claims 13
- 150000003248 quinolines Chemical class 0.000 claims 13
- RZZPDXZPRHQOCG-OJAKKHQRSA-M CDP-choline(1-) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-M 0.000 claims 12
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 12
- 239000003795 chemical substances by application Substances 0.000 claims 11
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 10
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 10
- 230000015572 biosynthetic process Effects 0.000 claims 10
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 10
- 238000004519 manufacturing process Methods 0.000 claims 10
- 238000003786 synthesis reaction Methods 0.000 claims 10
- 230000001965 increasing effect Effects 0.000 claims 9
- 239000006014 omega-3 oil Substances 0.000 claims 9
- 235000021342 arachidonic acid Nutrition 0.000 claims 6
- 229940114079 arachidonic acid Drugs 0.000 claims 6
- 210000002569 neuron Anatomy 0.000 claims 6
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 claims 5
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 5
- 235000021294 Docosapentaenoic acid Nutrition 0.000 claims 5
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 5
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 5
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 5
- 229940090949 docosahexaenoic acid Drugs 0.000 claims 5
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 5
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 5
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 5
- 229960004488 linolenic acid Drugs 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- RZZPDXZPRHQOCG-UHFFFAOYSA-N [[5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] 2-(trimethylazaniumyl)ethyl phosphate Chemical compound OC1C(O)C(COP([O-])(=O)OP(O)(=O)OCC[N+](C)(C)C)OC1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-UHFFFAOYSA-N 0.000 claims 4
- 210000004556 brain Anatomy 0.000 claims 4
- 235000013350 formula milk Nutrition 0.000 claims 4
- 210000000225 synapse Anatomy 0.000 claims 4
- 210000002182 synaptic membrane Anatomy 0.000 claims 4
- 230000006651 lactation Effects 0.000 claims 3
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 2
- 235000013336 milk Nutrition 0.000 claims 2
- 239000008267 milk Substances 0.000 claims 2
- 210000004080 milk Anatomy 0.000 claims 2
- 230000001537 neural effect Effects 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 2
- 150000003905 phosphatidylinositols Chemical class 0.000 claims 2
- 230000035935 pregnancy Effects 0.000 claims 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 235000020778 linoleic acid Nutrition 0.000 claims 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68335205P | 2005-05-23 | 2005-05-23 | |
| US60/683,352 | 2005-05-23 | ||
| US71607705P | 2005-09-13 | 2005-09-13 | |
| US60/716,077 | 2005-09-13 | ||
| US75505806P | 2006-01-03 | 2006-01-03 | |
| US60/755,058 | 2006-01-03 | ||
| US76175306P | 2006-01-25 | 2006-01-25 | |
| US60/761,753 | 2006-01-25 | ||
| PCT/US2006/019778 WO2006127627A2 (en) | 2005-05-23 | 2006-05-23 | Compostions containing pufa and/or uridine and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008542280A JP2008542280A (ja) | 2008-11-27 |
| JP2008542280A5 true JP2008542280A5 (enExample) | 2009-07-09 |
| JP5566604B2 JP5566604B2 (ja) | 2014-08-06 |
Family
ID=37452701
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008513592A Active JP5566603B2 (ja) | 2005-05-23 | 2006-05-23 | Ｐｕｆａを含有する組成物及びそれを使用した方法 |
| JP2008513596A Expired - Fee Related JP5566604B2 (ja) | 2005-05-23 | 2006-05-23 | Ｐｕｆａ及び／又はウリジンを含有する組成物及びそれを使用した方法 |
| JP2014088988A Active JP5823564B2 (ja) | 2005-05-23 | 2014-04-23 | Ｐｕｆａを含有する組成物及びそれを使用した方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008513592A Active JP5566603B2 (ja) | 2005-05-23 | 2006-05-23 | Ｐｕｆａを含有する組成物及びそれを使用した方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014088988A Active JP5823564B2 (ja) | 2005-05-23 | 2014-04-23 | Ｐｕｆａを含有する組成物及びそれを使用した方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10086009B2 (enExample) |
| EP (3) | EP3090740A1 (enExample) |
| JP (3) | JP5566603B2 (enExample) |
| CN (1) | CN105663151A (enExample) |
| AU (2) | AU2006251569B2 (enExample) |
| BR (2) | BRPI0613303A8 (enExample) |
| CA (2) | CA2645645C (enExample) |
| DK (1) | DK1888081T3 (enExample) |
| ES (2) | ES2615521T3 (enExample) |
| HU (1) | HUE031206T2 (enExample) |
| NZ (3) | NZ600740A (enExample) |
| PL (1) | PL1888081T3 (enExample) |
| PT (1) | PT1888081T (enExample) |
| RU (1) | RU2603470C2 (enExample) |
| WO (2) | WO2006127620A2 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070004670A1 (en) * | 1998-07-31 | 2007-01-04 | Richard Wurtman | Compositions containing citicoline, and methods of use thereof |
| US8143234B2 (en) | 1998-07-31 | 2012-03-27 | Massachusetts Institute Of Technology | Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function |
| US8518882B2 (en) * | 1998-07-31 | 2013-08-27 | Massachusetts Institute Of Technology | Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same |
| US8314064B2 (en) | 1998-07-31 | 2012-11-20 | Massachusetts Institute Of Technology | Uridine administration stimulates membrane production |
| EP1572115B1 (en) * | 2002-11-27 | 2015-01-21 | Ampio Pharmaceuticals, Inc. | Treatment of diseases and conditions mediated by increased phosphorylation |
| PT1888081T (pt) * | 2005-05-23 | 2017-03-01 | Massachusetts Inst Technology | Composições contendo pufa e seus métodos de utilização |
| MX336435B (es) * | 2005-07-08 | 2016-01-19 | Dsm Ip Assets Bv | Acidos grasos poliinsaturados para el tratamiento de demencia y condiciones relacionadas con pre-demencia. |
| EP1951308B1 (de) * | 2005-11-25 | 2013-02-20 | Gisela Susilo | Kombinationspräparate enthaltend physiologische zellmembran-bestandteile, einschliesslich phosphatidylserin, cholin und ein pyrimidinnukleos/tid |
| CN101636167B (zh) * | 2006-12-28 | 2012-10-03 | 株式会社明治 | 含有乳来源的磷脂的婴幼儿脑发育促进剂以及含有该促进剂的食品组合物 |
| NZ582329A (en) * | 2007-06-26 | 2012-09-28 | Nutricia Nv | Improving memory in subjects with mini-mental state examination of 24-26 |
| WO2009002146A1 (en) | 2007-06-26 | 2008-12-31 | N.V. Nutricia | Supporting activities of daily living |
| WO2009002145A1 (en) | 2007-06-26 | 2008-12-31 | N.V. Nutricia | Lipid composition for improving function of brain functioning |
| WO2009002148A1 (en) * | 2007-06-27 | 2008-12-31 | N.V. Nutricia | Food composition for prodromal dementia patients |
| US8343753B2 (en) | 2007-11-01 | 2013-01-01 | Wake Forest University School Of Medicine | Compositions, methods, and kits for polyunsaturated fatty acids from microalgae |
| WO2009057994A1 (en) | 2007-11-02 | 2009-05-07 | N.V. Nutricia | Unit dosage for brain health |
| WO2009059306A1 (en) * | 2007-11-02 | 2009-05-07 | Massachusetts Institute Of Technology | Uridine dietary supplementation compliance methods and use thereof |
| PL2609812T3 (pl) | 2007-12-20 | 2019-02-28 | N.V. Nutricia | Ciekły produkt zawierający nukleotydy/nukleozydy |
| WO2010088700A1 (en) * | 2009-02-02 | 2010-08-05 | Martek Biosciences Corporation | Methods for improving cognitive function and decreasing heart rate |
| WO2011133580A1 (en) * | 2010-04-19 | 2011-10-27 | Back Bay Scientific Llc | Use of drugs that activate p2y receptors to enhance synaptogenesis |
| WO2012125020A1 (en) | 2011-03-14 | 2012-09-20 | N.V. Nutricia | Method for treating neurotrauma |
| JP2015501426A (ja) * | 2011-10-21 | 2015-01-15 | オムセラ・ファーマシューティカルズ・インコーポレイテッド | 注意欠陥多動障害を処置するまたは予防する方法および組成物 |
| WO2013066152A1 (en) * | 2011-10-31 | 2013-05-10 | N.V. Nutricia | Method for improving executive function |
| BR112014020177A8 (pt) * | 2012-03-02 | 2021-10-19 | Nutricia Nv | Uso de uma composição para a fabricação de um produto para diminuir, prevenir ou reverter a conectividade cerebral funcional prejudicada e/ou organização da rede cerebral prejudicada |
| WO2013129914A1 (en) * | 2012-03-02 | 2013-09-06 | N.V. Nutricia | Method for improving functional synaptic connectivity |
| WO2014171813A1 (en) * | 2013-04-17 | 2014-10-23 | N.V. Nutricia | Nutritional composition for improving brain function in phenylketonuria |
| CN103877144B (zh) * | 2013-05-02 | 2017-02-22 | 杭州耐奇睿生物医药科技有限公司 | 花生衣活性组分的应用及包含该花生衣活性组分的组合物 |
| WO2015138879A1 (en) * | 2014-03-13 | 2015-09-17 | Massachusetts Institute Of Technology | Compositions containing pufa, uridine and choline and methods of use thereof |
| WO2016083362A1 (en) * | 2014-11-25 | 2016-06-02 | Fonden For Helene Elsass Centeret | Composition for improving cognitive functions |
| WO2017069613A1 (en) | 2015-10-23 | 2017-04-27 | N.V. Nutricia | Method for improving recognition and/or working memory in hyperphenylalanimenia and phenylketonuria patients |
| WO2017155387A1 (en) | 2016-03-08 | 2017-09-14 | N.V. Nutricia | Method for supporting memory function and/or cognitive function |
| WO2017167415A1 (en) * | 2016-03-30 | 2017-10-05 | Nestec S.A. | Compositions comprising fatty acids and their use |
| JP2019518798A (ja) * | 2016-06-27 | 2019-07-04 | オハイオ・ステイト・イノベーション・ファウンデーション | リポヌクレオチドに基づくａｒｄｓの治療 |
| EP3518919A1 (en) * | 2016-09-29 | 2019-08-07 | Société des Produits Nestlé S.A. | Omega 3 fatty acids and choline as neuroprotectant in patients with no dementia |
| US20210077446A1 (en) * | 2016-12-13 | 2021-03-18 | Dsm Ip Assets B.V. | Pufa salt formulations (ii) |
| WO2021231566A1 (en) * | 2020-05-12 | 2021-11-18 | Massachusetts Institute Of Technology | The use of choline supplementation as therapy for apoe4-related disorders |
| EP4190319A4 (en) | 2020-07-29 | 2024-05-01 | Novamedica Limited Liability Company | PHARMACEUTICAL COMPOSITION CONTAINING MEMANTINE AND CITICOLINE |
| WO2022258873A1 (es) * | 2021-06-09 | 2022-12-15 | Hospital Sant Joan De Deu | Combinación nutracéutica y su uso para el tratamiento de trastornos neurológicos |
| CN113577092B (zh) * | 2021-07-30 | 2022-07-01 | 陈玉松 | 一种延缓衰老的含核苷酸的组合物及其制备方法和应用 |
| CN115774059A (zh) * | 2021-09-07 | 2023-03-10 | 中国科学院深圳先进技术研究院 | 一种阿尔兹海默症生物标志物及其筛选方法和应用 |
| TR2021016704A2 (tr) * | 2021-10-26 | 2021-11-22 | Bursa Uludag Ueniversitesi | Üri̇di̇ni̇n ön uyaran aracili i̇nhi̇bi̇syon bozukluğu i̇le seyreden hastaliklarin tedavi̇si̇nde kullanimi |
| WO2023150389A1 (en) * | 2022-02-07 | 2023-08-10 | Cornell University | Compositions and methods for increasing dha availability |
| CN115334384B (zh) | 2022-08-05 | 2025-03-14 | 立臻科技(昆山)有限公司 | 一种移动终端会议音箱 |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4221784A (en) * | 1979-04-05 | 1980-09-09 | Massachusetts Institute Of Technology | Process and composition for treating disorders by administering lecithin |
| GB8601915D0 (en) * | 1986-01-27 | 1986-03-05 | Efamol Ltd | Pharmaceutical compositions |
| US5198468A (en) * | 1987-06-24 | 1993-03-30 | Efamol Holdings Plc | Essential fatty acid composition |
| US5470838A (en) | 1987-10-28 | 1995-11-28 | Pro-Neuron, Inc. | Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine |
| JP2524217B2 (ja) * | 1988-04-18 | 1996-08-14 | マルハ株式会社 | 脳機能改善組成物、学習能力増強剤、記憶力増強剤、痴呆予防剤または痴呆治療剤 |
| CA2596241C (en) * | 1993-06-09 | 2011-04-19 | Martek Biosciences Corporation | Methods and pharmaceutical compositions useful for treating neurological disorders |
| US20050027004A1 (en) | 1993-06-09 | 2005-02-03 | Martek Biosciences Corporation | Methods of treating senile dementia and Alzheimer's diseases using docosahexaenoic acid and arachidonic acid compositions |
| US5492899A (en) * | 1994-01-10 | 1996-02-20 | Abbott Laboratories | Infant nutritional formula with ribo-nucleotides |
| JPH07143862A (ja) | 1994-05-06 | 1995-06-06 | Maruha Corp | 脳機能改善効果を有する機能性食品。 |
| EP0831805A1 (en) * | 1995-06-07 | 1998-04-01 | Martek Biosciences Corporation | Methods for controlling highly unsaturated fatty acid content in various tissues |
| JPH0975000A (ja) * | 1995-07-07 | 1997-03-25 | Nisshin Oil Mills Ltd:The | 母子栄養用油脂含有飲食物 |
| US6200624B1 (en) | 1996-01-26 | 2001-03-13 | Abbott Laboratories | Enteral formula or nutritional supplement containing arachidonic and docosahexaenoic acids |
| DE19608137A1 (de) * | 1996-03-02 | 1997-09-04 | Meyer Lucas Gmbh & Co | Lipid-Zubereitungen für diätetische Zwecke |
| JP3627043B2 (ja) | 1996-04-24 | 2005-03-09 | 明治乳業株式会社 | ｎ−６系列／ｎ−３系列脂肪酸バランス 改善ヌクレオチド含有乳児用食品 |
| DK0935667T3 (da) * | 1996-07-23 | 2007-04-10 | Nagase Chemtex Corp | Fremgangsmåde til fremstilling af docosahexaensyre og docosapentaensyre |
| PL343902A1 (en) | 1997-02-21 | 2001-09-10 | Abbott Lab | Methods of and compositions for reducing enteritis and colitis morbidity rate |
| US6080787A (en) | 1997-02-21 | 2000-06-27 | Abbott Laboratories | Methods for reducing the incidence of necrotizing enterocolitis |
| JPH10327804A (ja) | 1997-06-04 | 1998-12-15 | Meiji Milk Prod Co Ltd | 核酸関連物質、ｄｈａ、アラキドン酸及び コレステロール含有栄養組成物 |
| JP3731983B2 (ja) * | 1997-08-27 | 2006-01-05 | 明治製菓株式会社 | 痴呆犬の夜鳴き改善薬 |
| JP3408958B2 (ja) * | 1997-10-24 | 2003-05-19 | 旭化成株式会社 | 魚介類由来の有用物質を含む組成物およびその有用物質の製造方法 |
| US5977174A (en) * | 1997-11-26 | 1999-11-02 | Neuromedica, Inc. | Cholinergic compositions and uses thereof |
| US7413759B2 (en) | 1998-05-21 | 2008-08-19 | Beech-Nut Nutrition Corporation | Method of enhancing cognitive ability in infant fed DHA containing baby-food compositions |
| US8518882B2 (en) * | 1998-07-31 | 2013-08-27 | Massachusetts Institute Of Technology | Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same |
| DK2145627T3 (da) | 1998-07-31 | 2014-07-21 | Massachusetts Inst Technology | Anvendelse af uridin i kombination med cholin til behandling af en humør-lidelse eller en følelsesmæssig lidelse. |
| US20070004670A1 (en) * | 1998-07-31 | 2007-01-04 | Richard Wurtman | Compositions containing citicoline, and methods of use thereof |
| US20050203053A1 (en) † | 1999-07-30 | 2005-09-15 | Wurtman Richard J. | Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function |
| US6472378B2 (en) * | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
| AU6384099A (en) | 1998-08-31 | 2000-03-21 | Proteotech, Inc. | Blended compositions for treatment of alzheimer's disease and other amyloidoses |
| US6596302B2 (en) | 2000-04-13 | 2003-07-22 | Abbott Laboratories | Infant formulas containing long-chain polyunsaturated fatty acids and uses thereof |
| US7226916B1 (en) * | 2000-05-08 | 2007-06-05 | N.V. Nutricia | Preparation for the prevention and/or treatment of vascular disorders |
| CA2344564C (en) | 2000-09-14 | 2008-07-22 | General Electric Canada Inc. | Graded electric field insulation system for dynamoelectric machine |
| US6964969B2 (en) * | 2001-04-19 | 2005-11-15 | Mccleary Edward Larry | Composition and method for treating impaired or deteriorating neurological function |
| GB0111282D0 (en) | 2001-05-09 | 2001-06-27 | Laxdale Ltd | Potentiation of therapeutic effects of fatty acids |
| JP2003048831A (ja) * | 2001-08-02 | 2003-02-21 | Suntory Ltd | 脳機能の低下に起因する症状あるいは疾患の予防又は改善作用を有する組成物 |
| US6541043B2 (en) | 2001-08-28 | 2003-04-01 | Dexgen Pharmaceuticals, Inc. | Method and synergistic composition for treating attention deficit/hyperactivity disorder |
| EP1302196A1 (de) | 2001-10-16 | 2003-04-16 | Habinger, René, Ing. Mag. | Intelligenzfördernde Zahncreme |
| NL1019368C2 (nl) * | 2001-11-14 | 2003-05-20 | Nutricia Nv | Preparaat voor het verbeteren van receptorwerking. |
| US6677470B2 (en) | 2001-11-20 | 2004-01-13 | Natural Asa | Functional acylglycerides |
| US20030114415A1 (en) * | 2001-12-14 | 2003-06-19 | Wurtman Richard J. | Compositions and methods for treating and preventing memory impairment using citicoline |
| US20040048926A1 (en) | 2002-03-15 | 2004-03-11 | Hoffman Dennis Robert | Use of docosahexaenoic acid and arachidonic acid to enhance the visual development of term infants breast-fed up to the age of six months |
| WO2004028529A1 (en) * | 2002-09-24 | 2004-04-08 | Suntory Limited | Composition with effects of decline prevention, improvement or enhancement of normal responses of cognitive abilities of a healthy person |
| JP2004231585A (ja) | 2002-12-05 | 2004-08-19 | Fancl Corp | 生体内ホモシステインレベル低減用および上昇抑制用組成物 |
| CA2508995A1 (en) * | 2002-12-20 | 2004-07-15 | The Mclean Hospital Corporation | Use of cytidine-, creatine-, and adenosine-containing compounds and adenosine-elevating compounds for normalizing sleep/wake cycle, treating a sleep disorder or improving cognitive function |
| CN1203867C (zh) | 2003-03-11 | 2005-06-01 | 刘威 | 精制海狗油在制备防治老年痴呆药中的应用 |
| US7867541B2 (en) | 2003-04-14 | 2011-01-11 | Mead Johnson Nutrition Company | Compositions and methods of formulation for enteral formulas containing sialic acid |
| US7951410B2 (en) * | 2003-04-14 | 2011-05-31 | Mead Johnson Nutrition Company | Enteral compositions containing caseinoglycomacropeptide having an enhanced concentration of sialic acid |
| EP1670324A1 (en) | 2003-09-26 | 2006-06-21 | Nestec S.A. | Nutritional composition with unsaturated fatty acids and trace elements |
| US8921422B2 (en) | 2003-10-01 | 2014-12-30 | The Iams Company | Methods and kits for enhancing ability to learn in a puppy or kitten |
| AU2004317087A1 (en) | 2003-10-08 | 2005-09-22 | The Mclean Hospital Corporation | Methods of treating psychiatric, substance abuse, and other disorders using combinations containing omega-3 fatty acids |
| EP1634599A1 (en) | 2004-08-20 | 2006-03-15 | N.V. Nutricia | Iimmune stimulatory infant nutrition |
| EP1656839A1 (en) | 2004-11-11 | 2006-05-17 | N.V. Nutricia | Nutrition containing lipid blend |
| US20060247153A1 (en) | 2005-04-29 | 2006-11-02 | Mcmahon Robert J | Method of improving learning and memory in mammals |
| PT1888081T (pt) * | 2005-05-23 | 2017-03-01 | Massachusetts Inst Technology | Composições contendo pufa e seus métodos de utilização |
| US7829126B2 (en) | 2005-10-26 | 2010-11-09 | Abbott Laboratories | Infant formulas containing docosahexaenoic acid and lutein |
-
2006
- 2006-05-23 PT PT67708628T patent/PT1888081T/pt unknown
- 2006-05-23 PL PL06770862T patent/PL1888081T3/pl unknown
- 2006-05-23 NZ NZ600740A patent/NZ600740A/en unknown
- 2006-05-23 AU AU2006251569A patent/AU2006251569B2/en active Active
- 2006-05-23 DK DK06770862.8T patent/DK1888081T3/en active
- 2006-05-23 NZ NZ563660A patent/NZ563660A/xx unknown
- 2006-05-23 HU HUE06770862A patent/HUE031206T2/en unknown
- 2006-05-23 CA CA2645645A patent/CA2645645C/en active Active
- 2006-05-23 EP EP16171448.0A patent/EP3090740A1/en not_active Withdrawn
- 2006-05-23 JP JP2008513592A patent/JP5566603B2/ja active Active
- 2006-05-23 EP EP06770871.9A patent/EP1909801B2/en active Active
- 2006-05-23 WO PCT/US2006/019766 patent/WO2006127620A2/en not_active Ceased
- 2006-05-23 CA CA2645647A patent/CA2645647C/en active Active
- 2006-05-23 EP EP06770862.8A patent/EP1888081B1/en active Active
- 2006-05-23 AU AU2006251562A patent/AU2006251562B2/en active Active
- 2006-05-23 BR BRPI0613303A patent/BRPI0613303A8/pt not_active Application Discontinuation
- 2006-05-23 US US11/920,915 patent/US10086009B2/en active Active
- 2006-05-23 ES ES06770862.8T patent/ES2615521T3/es active Active
- 2006-05-23 BR BRPI0613274-0A patent/BRPI0613274A2/pt not_active Application Discontinuation
- 2006-05-23 CN CN201610212919.6A patent/CN105663151A/zh active Pending
- 2006-05-23 US US11/920,914 patent/US10525071B2/en active Active
- 2006-05-23 JP JP2008513596A patent/JP5566604B2/ja not_active Expired - Fee Related
- 2006-05-23 NZ NZ563659A patent/NZ563659A/en active IP Right Revival
- 2006-05-23 WO PCT/US2006/019778 patent/WO2006127627A2/en not_active Ceased
- 2006-05-23 ES ES06770871T patent/ES2624702T5/es active Active
-
2011
- 2011-05-20 RU RU2011120440/15A patent/RU2603470C2/ru active
-
2014
- 2014-04-23 JP JP2014088988A patent/JP5823564B2/ja active Active
-
2018
- 2018-10-01 US US16/148,546 patent/US10736912B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008542280A5 (enExample) | ||
| JP2008545693A5 (enExample) | ||
| ES2642635T3 (es) | Alimento para lactantes para mejorar la composición de ácidos grasos de las membranas cerebrales | |
| Küllenberg et al. | Health effects of dietary phospholipids | |
| ES2939943T3 (es) | Efectos de impronta metabólica de componentes lipídicos específicamente diseñados | |
| JP5566604B2 (ja) | Ｐｕｆａ及び／又はウリジンを含有する組成物及びそれを使用した方法 | |
| US8470345B2 (en) | Lipids containing omega-3 and omega-6 fatty acids | |
| EP3362061B1 (en) | Infant formula with milk fat for promoting healthy growth | |
| EP3574771B1 (en) | Infant formula with special lipid architecture for promoting healthy growth | |
| BRPI0910184B1 (pt) | Preparação compreendendo uma mistura derivada de não mamíferos de conjugados de glicerofosfolipídio de soro, uso de uma preparação, e composição nutricional, farmacêutica ou nutracêutica ou alimento funcional | |
| US20090182050A1 (en) | Salts of Fatty Acids and Methods of Making and Using thereof | |
| AU2010283998A1 (en) | Vesicular formulations | |
| JP2014074076A (ja) | ミニメンタルステート検査２４〜２６点の被験者における記憶力改善 | |
| RU2018125738A (ru) | Питательная композиция и детская смесь для стимулирования первичной миелинизации | |
| EP3179868B1 (en) | Lipid composition for improving behaviour | |
| CN110177467A (zh) | 用于改善细胞膜的营养组合物 | |
| JP2009500503A5 (enExample) | ||
| JP5759663B2 (ja) | 皮膚バリア機能改善剤等 | |
| Romero et al. | Effect of postlactation iron deficiency on the composition of fatty acids of whole brain myelin | |
| WO2022258873A1 (es) | Combinación nutracéutica y su uso para el tratamiento de trastornos neurológicos | |
| US20160235778A1 (en) | Compositions containing pufa, uridine and choline and methods of use thereof | |
| RU2007147952A (ru) | Композиции, содержащие полиненасыщенные жирные кислоты (пнжк), и способы их применения | |
| BR102017017843A2 (pt) | Cápsula ingerível e uso de cápsula ingerível | |
| AU2015202217A1 (en) | Vesicular formulations |