JP2009500503A5 - - Google Patents

Info

Publication number

JP2009500503A5

JP2009500503A5 JP2008520696A JP2008520696A JP2009500503A5 JP 2009500503 A5 JP2009500503 A5 JP 2009500503A5 JP 2008520696 A JP2008520696 A JP 2008520696A JP 2008520696 A JP2008520696 A JP 2008520696A JP 2009500503 A5 JP2009500503 A5 JP 2009500503A5

Authority

JP

Japan

Prior art keywords

hyaluronic acid

phospholipid

phospholipids

acid

glyceride

Prior art date

2006-07-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000003904 phospholipids Chemical class 0.000 claims 9
• 238000000034 method Methods 0.000 claims 6
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 5
• 229920002674 hyaluronan Polymers 0.000 claims 5
• 229960003160 hyaluronic acid Drugs 0.000 claims 5
• -1 phosphatidylchlorin Chemical class 0.000 claims 5
• 239000000203 mixture Substances 0.000 claims 4
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
• PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims 2
• XYZZKVRWGOWVGO-UHFFFAOYSA-N Glycerol-phosphate Chemical compound OP(O)(O)=O.OCC(O)CO XYZZKVRWGOWVGO-UHFFFAOYSA-N 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 2
• 229930183167 cerebroside Natural products 0.000 claims 2
• 150000001784 cerebrosides Chemical class 0.000 claims 2
• 235000015872 dietary supplement Nutrition 0.000 claims 2
• 239000006185 dispersion Substances 0.000 claims 2
• 238000002156 mixing Methods 0.000 claims 2
• 238000002360 preparation method Methods 0.000 claims 2
• KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 1
• SLKDGVPOSSLUAI-PGUFJCEWSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine zwitterion Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCCCCCCCCCC SLKDGVPOSSLUAI-PGUFJCEWSA-N 0.000 claims 1
• TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
• HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 claims 1
• GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 1
• ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
• 229930186217 Glycolipid Natural products 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 235000004279 alanine Nutrition 0.000 claims 1
• 235000001014 amino acid Nutrition 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 239000007864 aqueous solution Substances 0.000 claims 1
• MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 1
• 229920002678 cellulose Polymers 0.000 claims 1
• 239000001913 cellulose Substances 0.000 claims 1
• 230000002490 cerebral effect Effects 0.000 claims 1
• 238000006243 chemical reaction Methods 0.000 claims 1
• 239000001177 diphosphate Substances 0.000 claims 1
• 235000011180 diphosphates Nutrition 0.000 claims 1
• 239000002612 dispersion medium Substances 0.000 claims 1
• 150000002270 gangliosides Chemical class 0.000 claims 1
• 229960002442 glucosamine Drugs 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• 150000004676 glycans Chemical class 0.000 claims 1
• 125000005456 glyceride group Chemical group 0.000 claims 1
• 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims 1
• 239000003163 gonadal steroid hormone Substances 0.000 claims 1
• 241000411851 herbal medicine Species 0.000 claims 1
• 230000036571 hydration Effects 0.000 claims 1
• 238000006703 hydration reaction Methods 0.000 claims 1
• 239000002502 liposome Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000010907 mechanical stirring Methods 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 239000008363 phosphate buffer Substances 0.000 claims 1
• 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 1
• 150000003907 phosphatidylinositol monophosphates Chemical class 0.000 claims 1
• 150000003905 phosphatidylinositols Chemical class 0.000 claims 1
• 239000002504 physiological saline solution Substances 0.000 claims 1
• 239000003375 plant hormone Substances 0.000 claims 1
• 229920001282 polysaccharide Polymers 0.000 claims 1
• 239000005017 polysaccharide Substances 0.000 claims 1
• 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims 1
• 239000000843 powder Substances 0.000 claims 1
• 239000006041 probiotic Substances 0.000 claims 1
• 235000018291 probiotics Nutrition 0.000 claims 1
• 235000018102 proteins Nutrition 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 230000035484 reaction time Effects 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000002904 solvent Substances 0.000 claims 1
• 238000000527 sonication Methods 0.000 claims 1
• 238000003756 stirring Methods 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 239000011573 trace mineral Substances 0.000 claims 1
• 235000013619 trace mineral Nutrition 0.000 claims 1
• 239000001226 triphosphate Substances 0.000 claims 1
• 235000011178 triphosphate Nutrition 0.000 claims 1
• UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims 1
• 239000011782 vitamin Substances 0.000 claims 1
• 235000013343 vitamin Nutrition 0.000 claims 1
• 229940088594 vitamin Drugs 0.000 claims 1
• 229930003231 vitamin Natural products 0.000 claims 1