JP2014074076A - ミニメンタルステート検査24〜26点の被験者における記憶力改善 - Google Patents
ミニメンタルステート検査24〜26点の被験者における記憶力改善 Download PDFInfo
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- JP2014074076A JP2014074076A JP2014016605A JP2014016605A JP2014074076A JP 2014074076 A JP2014074076 A JP 2014074076A JP 2014016605 A JP2014016605 A JP 2014016605A JP 2014016605 A JP2014016605 A JP 2014016605A JP 2014074076 A JP2014074076 A JP 2014074076A
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- uridine
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Abstract
【解決手段】 本発明は、(a)ウリジン又はウリジンリン酸、並びに(b)ドコサヘキサエン酸及び/又はエイコサペンタエン酸を含み、ミニメンタルステート検査が24〜26点である被験者において、記憶力の改善及び/又は記憶機能障害の治療若しくは予防を目的とする組成物であって、被験者に経腸的に投与する上記組成物の使用に関する。
【選択図】 なし
Description
a.ウリジン又はウリジンリン酸、並びに
b.ドコサヘキサエン酸及び/又はエイコサペンタエン酸
を含み、ミニメンタルステート検査が24〜26点の被験者において、記憶力の改善及び/又は記憶機能障害の治療若しくは予防を目的とする組成物であって、被験者に経腸的に投与する上記組成物の使用に関する。
本発明は、ミニメンタルステート検査が24、25又は26点、すなわち24〜26点の被験者に関する。ミニメンタルステート検査(MMSE)は、認知力を評価する目的に使用される、簡潔な30点満点の質問形式のテストである。約10分の時間で、記憶力及び見当識を含む様々な機能をサンプリングする。MMSEテストには、数多くの領域、すなわちテストの日時と場所、列挙した言葉の反復、言語の使用及び理解力、並びに基本的な運動技能についての単純な質問及び問題が含まれている。(30点満点中)27点以上であれば、事実上、正常であり、20〜26点は軽度の認知症を、10〜19点は中度認知症を、そして10点未満は重度認知症を意味する。MMSEは標準テストである。版権のため、本発明者らが質問表の写しを本明細書に取り込むことは許可されないが、インターネットで容易にアクセス可能であり、版権所有者であるPsychological Assessment Resources(PAR)社を通じて入手可能である。このテストは、最初にFolsteinら(Psych Res12:189、1975)によって紹介され、小さな変更が加えられながら、認知力を評価する目的に広く用いられている。
本発明は、(i)記憶力の改善並びに/又は(ii)記憶機能障害の治療及び/若しくは予防のための本組成物の使用に関する。また、本発明は、(i)記憶力の改善並びに/又は(ii)記憶機能障害の治療及び/若しくは予防のための方法であって、その方法を必要とする被験者において、本組成物を前記被験者に投与することを含む方法を提供する。特に、本発明は、記憶機能障害の治療に関する。本組成物を被験者に投与したとき、記憶機能が実際に改善されることが明らかになった。ヒトの被験者の記憶機能は、(修正を加えた)ADAS−cog、ウェクスラー式記憶検査法(Wechsler Memory Scale)、改定版WMSを使用して、適切に判定することができる。
好ましくは、本組成物はウリジン及び/又はウリジンリン酸を含む。好ましくは、本組成物は、ウリジン一リン酸(UMP)、ウリジン二リン酸(UDP)及びウリジン三リン酸(UTP)から選択される1つ又は複数のウリジンリン酸を含む。
本組成物は、少なくともドコサヘキサエン酸(22:6、ω−3、DHA)及び/又はエイコサペンタエン酸(20:5、ω−3、EPA)を含むことが好ましく、DHAとEPAとを含むことが好ましい。DHA及び/又はEPAは、トリグリセリド、ジグリセリド、モノグリセリド、遊離脂肪酸又はそれらの塩又はエスエル、リン脂質、リゾリン脂質、グリセロールエーテル、リポタンパク質、セラミド、糖脂質又はそれらの組合せとして供給されることが好ましい。本組成物は少なくともトリグリセリドの形のDHAを含むことが好ましい。
本組成物は、好ましくは飽和脂肪酸及び/又は一価不飽和脂肪酸を含む。飽和脂肪酸の量は、脂肪酸の総量に基づいて6〜60重量%であることが好ましく、12〜40重量%であることが好ましく、脂肪酸の総量に基づいて20〜40重量%であることがより好ましい。特に、C14:0(ミリスチン酸)+C16:0(パルミチン酸)の量は脂肪酸の総量に基づいて5〜50重量%であることが好ましく、8〜36重量%であることが好ましく、15〜30重量%であることがより好ましい。オレイン酸及びパルミトレイン酸等の一価不飽和脂肪酸の総量は、5から40重量%であることが好ましく、15から30重量%であることがより好ましい。これらの好ましい量を有する組成物は非常に効果的であることが明らかになった。
好ましくは、本組成物は、リン脂質を含むことが好ましく、脂質の総重量に基づいて0.1〜50重量%のリン脂質を含むことが好ましく、より好ましくは脂質の総重量に基づいて0.5〜20重量%、さらに好ましくは1から10重量%の間、最も好ましくは1から5重量%の間のリン脂質を含む。脂質の総量は、乾燥物質に対して10から30重量%の間及び/又は液体組成物の場合、100ml当たり脂質が2から10gの間であることが好ましい。本組成物は、100ml当たり0.01から1グラムのレシチンを含むことが好ましく、100ml当たり0.05から0.5グラムのレシチンを含むことがより好ましい。これらの好ましい量を有する組成物は非常に効果的であることが明らかになった。
好ましくは、本組成物はコリン及び/又はホスファチジルコリンを含む。本方法は1日当たり50mgを超える量、好ましくは1日当たり80〜2000mg、より好ましくは1日当たり120〜1000mg、最も好ましくは1日当たり150〜600mgのコリンの投与を含むことが好ましい。本組成物は液剤100ml当たり50mgから3グラムのコリンを含むことが好ましく、100ml当たり200mg〜1000mgのコリンを含むことがより好ましい。
本組成物は、有利には、ビタミンを含むこともでき、好ましくはビタミンC、ビタミンE及びビタミンBを、より好ましくはビタミンC、ビタミンE、ビタミンB6、ビタミンB12及び葉酸を含むことができる。有利には、ビタミンB12及び葉酸は含まれる。本組成物は、液体生成物100ml当たり葉酸を好ましくは50〜1000μg、より好ましくは150〜750μg、最も好ましくは200〜500μg含む。本方法は、好ましくは1日当たり50〜1000μg、より好ましくは1日当たり150〜750μg、最も好ましくは1日当たり200〜500μgの葉酸を投与することを含む。本組成物は、液体生成物100ml当たりビタミンB12を好ましくは0.5〜15μg、より好ましくは1〜10μg、最も好ましくは1.5〜5μg含む。本方法は、好ましくは1日当たり0.5〜15μg、より好ましくは1日当たり1〜10μg、最も好ましくは1.5〜5μgのビタミンB12を投与することを含む。
本組成物は、すぐに使える液状、固体状又は半液状の生成物であることが好ましい。本組成物は、経腸投与することが好ましく、経口投与することがより好ましい。本組成物はストローを使って投与することが最も好ましい。すぐに使える液状であるときは、1日の液体量は、1日当たり又は1単位当たり75から200mlの間であることが好ましく、1日当たり90から150mlの間であることが最も好ましい。
125ml当たりに、以下を含む包装された組成物:
エネルギー125kcal、タンパク質3.9g、炭水化物16.5g、脂肪4.9g。
臨床研究
記憶機能に障害のある被験者における栄養の役割を示す証拠が増加している。本研究は、薬物未使用で、非常に軽度のアルツハイマー病(AD)を患っている被験者における医療食品による介入の効果を評価する目的で実施された。MMSE24〜26点の、薬物未使用で、非常に軽度のAD被験者は、12週間の二重盲検試験に無作為に割り当てられ、(a)例1による処方(有効な生成物)又は(b)例1によるが、EPA、DHA、リン脂質、コリン、UMP、ビタミンE、ビタミンC、セレン、ビタミンB12、ビタミンB6及び葉酸を抜いた、等カロリーの対照飲料(対照生成物)を含む、125ml(125kcal)の、乳主体の飲料を1日1回摂取した。
ベースラインでは、有効生成物で処置されたグループと対照生成物で処置されたグループの間に、有意な差はなかった。しかし、ベースラインから治療の12週間後までの間の遅延言語記憶課題(改定版ウェクスラー式記憶検査法(WMS−r)に由来)における変化では、2つのグループの間に有意な差が生じた。対照生成物を摂取したグループ(n=60)は、0を含む95%の信頼区間(−0.938から0.610)での低下平均値は−0.164であったのに対し、有効な生成物を摂取したグループ(n=60)は、WMS−rに由来した遅延言語記憶検査で、0より上の95%の信頼区間(0.214から1.752)で、平均0.983ポイントの改善が見られた。
Claims (15)
- ミニメンタルステート検査が24又は25点の被験者において、記憶力の改善、及び/又は記憶機能障害の治療若しくは予防防をするための製品の製造における、
a.ウリジン又はウリジンリン酸、並びに
b.ドコサヘキサエン酸及び/又はエイコサペンタエン酸
を含む組成物の使用であって、被験者に経腸的に投与される該組成物の、上記使用。
- (i)被験者の遅延再生機能の改善、並びに/又は(ii)被験者の遅延再生機能障害の治療及び/若しくは予防をするための製品の製造における、
a.ウリジン又はウリジンリン酸、並びに
b.ドコサヘキサエン酸及び/又はエイコサペンタエン酸
を含む組成物の使用であって、被験者に経腸的に投与される該組成物の、上記使用。 - 前記被験者のミニメンタルステート検査が24〜26点である、請求項2に記載の使用。
- 該組成物がリン脂質、コリン、ビタミンE、ビタミンC、セレン、ビタミンB12、ビタミンB6及び葉酸の一つ以上を含む、請求項1から3のいずれか一項に記載の使用。
- 該組成物がリン脂質、コリン、ビタミンE、ビタミンC、セレン、ビタミンB12、ビタミンB6及び葉酸を含む、請求項4に記載の使用。
- 該組成物がビタミンB12及び葉酸を含み、好ましくは100ml当たり0.5〜15μgのビタミンB12及び50〜1000μgの葉酸を含む、請求項4又は5に記載の使用。
- 該組成物が少なくとも3週間の期間にわたり、被験者に少なくとも1日に1回、経腸的に投与される、請求項1から6までのいずれか一項に記載の使用。
- 該組成物が1日の投与単位当たりのウリジンをウリジン一リン酸として計算して0.1〜2g、並びに1日の投与単位当たりのDHA及びEPAを合計で400〜5000mg含む、請求項1から7までのいずれか一項に記載の使用。
- 該組成物が100ml当たり可消化炭水化物を1から50グラムの間、100ml当たりタンパク質を0.5〜10g、並びに0.2及び3kcal/ml含む、請求項1から8までのいずれか一項に記載の使用。
- 該組成物が100ml当たりタンパク質を0.5〜10g含む、請求項1から9までのいずれか一項に記載の使用。
- 該タンパク質が少なくとも80重量%の乳由来のタンパク質、好ましくは乳清及び/又はカゼインである、請求項10に記載の使用。
- 該組成物が液体生成物であり、20℃で100s−1の剪断速度で測定した場合、1から100mPa.sの間の粘度を有する、請求項1から11までのいずれか一項に記載の使用。
- DHAのアラキドン酸に対する重量比が少なくとも5、好ましくは少なくとも10、より好ましくは少なくも15、及び/又は脂肪酸の総量に基づくアラキドン酸が2.5重量%未満である、請求項1から12までのいずれか一項に記載の使用。
- ω−6/ω−3脂肪酸の比率は、0.5未満、好ましくは0.2未満である、請求項1から13までのいずれか一項に記載の使用。
- 薬物未使用の該被験者である、請求項1から14までのいずれか一項に記載の使用。
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EP2689782A1 (en) | 2014-01-29 |
CN101765427A (zh) | 2010-06-30 |
US20200197345A1 (en) | 2020-06-25 |
US20220280466A1 (en) | 2022-09-08 |
BRPI0813770A2 (pt) | 2014-12-30 |
DK2170316T3 (en) | 2014-02-24 |
JP5841723B2 (ja) | 2016-01-13 |
PL2170316T3 (pl) | 2014-06-30 |
NZ582329A (en) | 2012-09-28 |
EP2170316B1 (en) | 2013-12-18 |
EP2170316A1 (en) | 2010-04-07 |
US11395810B2 (en) | 2022-07-26 |
JP2010531351A (ja) | 2010-09-24 |
RU2014122168A (ru) | 2015-12-10 |
RU2529815C2 (ru) | 2014-09-27 |
EP2689782B1 (en) | 2020-05-13 |
WO2009002166A1 (en) | 2008-12-31 |
AU2008269728A1 (en) | 2008-12-31 |
RU2010102237A (ru) | 2011-08-10 |
CN104825480A (zh) | 2015-08-12 |
BRPI0813770B1 (pt) | 2018-05-08 |
CA2692309A1 (en) | 2008-12-31 |
PT2170316E (pt) | 2014-01-30 |
ES2445401T3 (es) | 2014-03-03 |
NZ599748A (en) | 2013-11-29 |
RU2677345C2 (ru) | 2019-01-16 |
US20100331258A1 (en) | 2010-12-30 |
BRPI0813770A8 (pt) | 2017-06-06 |
JP5934265B2 (ja) | 2016-06-15 |
MX2010000224A (es) | 2010-05-03 |
ES2808406T3 (es) | 2021-02-26 |
CA2692309C (en) | 2016-08-16 |
AU2008269728B2 (en) | 2013-10-31 |
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