BRPI0613274A2 - composições que contêm pufa e métodos de uso das mesmas - Google Patents
composições que contêm pufa e métodos de uso das mesmasInfo
- Publication number
- BRPI0613274A2 BRPI0613274A2 BRPI0613274-0A BRPI0613274A BRPI0613274A2 BR PI0613274 A2 BRPI0613274 A2 BR PI0613274A2 BR PI0613274 A BRPI0613274 A BR PI0613274A BR PI0613274 A2 BRPI0613274 A2 BR PI0613274A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- disorder
- pufa
- omega
- individual
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 abstract 2
- 208000014644 Brain disease Diseases 0.000 abstract 1
- 208000026139 Memory disease Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000004958 brain cell Anatomy 0.000 abstract 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000006984 memory degeneration Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 210000003061 neural cell Anatomy 0.000 abstract 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 abstract 1
- 229940012843 omega-3 fatty acid Drugs 0.000 abstract 1
- 235000020665 omega-6 fatty acid Nutrition 0.000 abstract 1
- 229940033080 omega-6 fatty acid Drugs 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 210000000225 synapse Anatomy 0.000 abstract 1
- 230000000946 synaptic effect Effects 0.000 abstract 1
- 210000002182 synaptic membrane Anatomy 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 abstract 1
- 229940045145 uridine Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Fertilizers (AREA)
- Medicinal Preparation (AREA)
- Carbon And Carbon Compounds (AREA)
- Separation, Recovery Or Treatment Of Waste Materials Containing Plastics (AREA)
Abstract
COMPOSIçõES QUE CONTêM PUFA E MéTODOS DE USO DAS MESMAS. A presente invenção apresenta métodos para aumentar ou intensificar a síntese e os níveis de fosfolipídios, sinapses, proteínas sinápticas, e membranas sinápticas por uma célula neural ou uma célula do cérebro; métodos de tratamento de um individuo com um distúrbio da memória, degeneração da memória, distúrbio neurológico, ou doença ou distúrbio do cerebro que compreende a administração ao indivíduo de uma composição que compreende um ácido graxo ómega-3, um ácido graxo ómega-6, uridina, um precursor metabólico dos mesmos, ou uma combinação destes.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68335205P | 2005-05-23 | 2005-05-23 | |
US71607705P | 2005-09-13 | 2005-09-13 | |
US75505806P | 2006-01-03 | 2006-01-03 | |
US76175306P | 2006-01-25 | 2006-01-25 | |
PCT/US2006/019766 WO2006127620A2 (en) | 2005-05-23 | 2006-05-23 | Compositions containing pufa and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0613274A2 true BRPI0613274A2 (pt) | 2009-08-04 |
Family
ID=37452701
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0613274-0A BRPI0613274A2 (pt) | 2005-05-23 | 2006-05-23 | composições que contêm pufa e métodos de uso das mesmas |
BRPI0613303A BRPI0613303A8 (pt) | 2005-05-23 | 2006-05-23 | composições que contêm pufa e/ou uridina e métodos de uso das mesmas |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0613303A BRPI0613303A8 (pt) | 2005-05-23 | 2006-05-23 | composições que contêm pufa e/ou uridina e métodos de uso das mesmas |
Country Status (15)
Country | Link |
---|---|
US (3) | US10525071B2 (pt) |
EP (3) | EP3090740A1 (pt) |
JP (3) | JP5566604B2 (pt) |
CN (1) | CN105663151A (pt) |
AU (2) | AU2006251569B2 (pt) |
BR (2) | BRPI0613274A2 (pt) |
CA (2) | CA2645645C (pt) |
DK (1) | DK1888081T3 (pt) |
ES (2) | ES2615521T3 (pt) |
HU (1) | HUE031206T2 (pt) |
NZ (3) | NZ600740A (pt) |
PL (1) | PL1888081T3 (pt) |
PT (1) | PT1888081T (pt) |
RU (1) | RU2603470C2 (pt) |
WO (2) | WO2006127627A2 (pt) |
Families Citing this family (37)
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US8518882B2 (en) * | 1998-07-31 | 2013-08-27 | Massachusetts Institute Of Technology | Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same |
US8143234B2 (en) | 1998-07-31 | 2012-03-27 | Massachusetts Institute Of Technology | Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function |
US8314064B2 (en) | 1998-07-31 | 2012-11-20 | Massachusetts Institute Of Technology | Uridine administration stimulates membrane production |
US20070004670A1 (en) * | 1998-07-31 | 2007-01-04 | Richard Wurtman | Compositions containing citicoline, and methods of use thereof |
KR101188292B1 (ko) * | 2002-11-27 | 2012-10-09 | 디엠아이 바이오사이언시스, 인크 | 인산화 증가로 인한 질병 및 증상의 치료방법 |
PL1888081T3 (pl) | 2005-05-23 | 2017-07-31 | Massachusetts Institute Of Technology | Kompozycje zawierające PUFA i sposoby ich zastosowania |
KR20130101596A (ko) * | 2005-07-08 | 2013-09-13 | 마텍 바이오싸이언스스 코포레이션 | 치매 및 치매-전단계와 관련된 용태의 치료를 위한 다중불포화 지방산 |
EP1951308B1 (de) * | 2005-11-25 | 2013-02-20 | Gisela Susilo | Kombinationspräparate enthaltend physiologische zellmembran-bestandteile, einschliesslich phosphatidylserin, cholin und ein pyrimidinnukleos/tid |
JP5959137B2 (ja) * | 2006-12-28 | 2016-08-02 | 株式会社明治 | 乳由来リン脂質を含有する乳幼児脳発達促進剤及びそれを含有する食品組成物 |
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WO2009057994A1 (en) | 2007-11-02 | 2009-05-07 | N.V. Nutricia | Unit dosage for brain health |
CN101896119A (zh) * | 2007-11-02 | 2010-11-24 | 麻省理工学院 | 尿苷饮食添加顺应性方法及其用途 |
PL2222311T3 (pl) | 2007-12-20 | 2013-08-30 | Nutricia Nv | Ciekły produkt zawierający nukleotydy/nukleozydy |
WO2010088700A1 (en) * | 2009-02-02 | 2010-08-05 | Martek Biosciences Corporation | Methods for improving cognitive function and decreasing heart rate |
US8691775B2 (en) | 2010-04-19 | 2014-04-08 | Back Bay Scientific, Llc | Use of drugs that activate P2Y receptors to enhance synaptogenesis |
WO2012125020A1 (en) | 2011-03-14 | 2012-09-20 | N.V. Nutricia | Method for treating neurotrauma |
WO2013059669A1 (en) * | 2011-10-21 | 2013-04-25 | Omthera Pharmaceuticals, Inc. | Methods and compositions for treating or preventing attention deficit hyperactivity disorder |
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WO2013129914A1 (en) * | 2012-03-02 | 2013-09-06 | N.V. Nutricia | Method for improving functional synaptic connectivity |
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WO2014171813A1 (en) * | 2013-04-17 | 2014-10-23 | N.V. Nutricia | Nutritional composition for improving brain function in phenylketonuria |
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US20160235778A1 (en) * | 2014-03-13 | 2016-08-18 | Massachusetts Institute Of Technology | Compositions containing pufa, uridine and choline and methods of use thereof |
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BR112019004055A2 (pt) | 2016-09-29 | 2019-05-21 | Nestec S.A. | ácidos graxos ômega 3, nenhum composto liberador e vitamina b12 como neuroprotetor em pacientes sem demência |
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BR0317586A (pt) | 2002-12-20 | 2005-11-22 | Mclean Hospital Corp | Compostos para normalização do ciclo sono/vigìlia |
CN1203867C (zh) | 2003-03-11 | 2005-06-01 | 刘威 | 精制海狗油在制备防治老年痴呆药中的应用 |
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