BRPI0613274A2 - composições que contêm pufa e métodos de uso das mesmas - Google Patents

composições que contêm pufa e métodos de uso das mesmas

Info

Publication number
BRPI0613274A2
BRPI0613274A2 BRPI0613274-0A BRPI0613274A BRPI0613274A2 BR PI0613274 A2 BRPI0613274 A2 BR PI0613274A2 BR PI0613274 A BRPI0613274 A BR PI0613274A BR PI0613274 A2 BRPI0613274 A2 BR PI0613274A2
Authority
BR
Brazil
Prior art keywords
methods
disorder
pufa
omega
individual
Prior art date
Application number
BRPI0613274-0A
Other languages
English (en)
Inventor
Richard J Wurtman
Ingrid Richardson
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37452701&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0613274(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of BRPI0613274A2 publication Critical patent/BRPI0613274A2/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52Adding ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/14Quaternary ammonium compounds, e.g. edrophonium, choline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Fertilizers (AREA)
  • Medicinal Preparation (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Separation, Recovery Or Treatment Of Waste Materials Containing Plastics (AREA)

Abstract

COMPOSIçõES QUE CONTêM PUFA E MéTODOS DE USO DAS MESMAS. A presente invenção apresenta métodos para aumentar ou intensificar a síntese e os níveis de fosfolipídios, sinapses, proteínas sinápticas, e membranas sinápticas por uma célula neural ou uma célula do cérebro; métodos de tratamento de um individuo com um distúrbio da memória, degeneração da memória, distúrbio neurológico, ou doença ou distúrbio do cerebro que compreende a administração ao indivíduo de uma composição que compreende um ácido graxo ómega-3, um ácido graxo ómega-6, uridina, um precursor metabólico dos mesmos, ou uma combinação destes.
BRPI0613274-0A 2005-05-23 2006-05-23 composições que contêm pufa e métodos de uso das mesmas BRPI0613274A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US68335205P 2005-05-23 2005-05-23
US71607705P 2005-09-13 2005-09-13
US75505806P 2006-01-03 2006-01-03
US76175306P 2006-01-25 2006-01-25
PCT/US2006/019766 WO2006127620A2 (en) 2005-05-23 2006-05-23 Compositions containing pufa and methods of use thereof

Publications (1)

Publication Number Publication Date
BRPI0613274A2 true BRPI0613274A2 (pt) 2009-08-04

Family

ID=37452701

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0613274-0A BRPI0613274A2 (pt) 2005-05-23 2006-05-23 composições que contêm pufa e métodos de uso das mesmas
BRPI0613303A BRPI0613303A8 (pt) 2005-05-23 2006-05-23 composições que contêm pufa e/ou uridina e métodos de uso das mesmas

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0613303A BRPI0613303A8 (pt) 2005-05-23 2006-05-23 composições que contêm pufa e/ou uridina e métodos de uso das mesmas

Country Status (15)

Country Link
US (3) US10525071B2 (pt)
EP (3) EP3090740A1 (pt)
JP (3) JP5566604B2 (pt)
CN (1) CN105663151A (pt)
AU (2) AU2006251569B2 (pt)
BR (2) BRPI0613274A2 (pt)
CA (2) CA2645645C (pt)
DK (1) DK1888081T3 (pt)
ES (2) ES2615521T3 (pt)
HU (1) HUE031206T2 (pt)
NZ (3) NZ600740A (pt)
PL (1) PL1888081T3 (pt)
PT (1) PT1888081T (pt)
RU (1) RU2603470C2 (pt)
WO (2) WO2006127627A2 (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8518882B2 (en) * 1998-07-31 2013-08-27 Massachusetts Institute Of Technology Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same
US8143234B2 (en) 1998-07-31 2012-03-27 Massachusetts Institute Of Technology Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function
US8314064B2 (en) 1998-07-31 2012-11-20 Massachusetts Institute Of Technology Uridine administration stimulates membrane production
US20070004670A1 (en) * 1998-07-31 2007-01-04 Richard Wurtman Compositions containing citicoline, and methods of use thereof
KR101188292B1 (ko) * 2002-11-27 2012-10-09 디엠아이 바이오사이언시스, 인크 인산화 증가로 인한 질병 및 증상의 치료방법
PL1888081T3 (pl) 2005-05-23 2017-07-31 Massachusetts Institute Of Technology Kompozycje zawierające PUFA i sposoby ich zastosowania
KR20130101596A (ko) * 2005-07-08 2013-09-13 마텍 바이오싸이언스스 코포레이션 치매 및 치매-전단계와 관련된 용태의 치료를 위한 다중불포화 지방산
EP1951308B1 (de) * 2005-11-25 2013-02-20 Gisela Susilo Kombinationspräparate enthaltend physiologische zellmembran-bestandteile, einschliesslich phosphatidylserin, cholin und ein pyrimidinnukleos/tid
JP5959137B2 (ja) * 2006-12-28 2016-08-02 株式会社明治 乳由来リン脂質を含有する乳幼児脳発達促進剤及びそれを含有する食品組成物
WO2009002148A1 (en) * 2007-06-27 2008-12-31 N.V. Nutricia Food composition for prodromal dementia patients
WO2009002145A1 (en) 2007-06-26 2008-12-31 N.V. Nutricia Lipid composition for improving function of brain functioning
WO2009002166A1 (en) * 2007-06-26 2008-12-31 N.V. Nutricia Improving memory in subjects with mini-mental state examination of 24-26
WO2009002146A1 (en) 2007-06-26 2008-12-31 N.V. Nutricia Supporting activities of daily living
US8343753B2 (en) 2007-11-01 2013-01-01 Wake Forest University School Of Medicine Compositions, methods, and kits for polyunsaturated fatty acids from microalgae
WO2009057994A1 (en) 2007-11-02 2009-05-07 N.V. Nutricia Unit dosage for brain health
CN101896119A (zh) * 2007-11-02 2010-11-24 麻省理工学院 尿苷饮食添加顺应性方法及其用途
PL2222311T3 (pl) 2007-12-20 2013-08-30 Nutricia Nv Ciekły produkt zawierający nukleotydy/nukleozydy
WO2010088700A1 (en) * 2009-02-02 2010-08-05 Martek Biosciences Corporation Methods for improving cognitive function and decreasing heart rate
US8691775B2 (en) 2010-04-19 2014-04-08 Back Bay Scientific, Llc Use of drugs that activate P2Y receptors to enhance synaptogenesis
WO2012125020A1 (en) 2011-03-14 2012-09-20 N.V. Nutricia Method for treating neurotrauma
WO2013059669A1 (en) * 2011-10-21 2013-04-25 Omthera Pharmaceuticals, Inc. Methods and compositions for treating or preventing attention deficit hyperactivity disorder
WO2013066152A1 (en) * 2011-10-31 2013-05-10 N.V. Nutricia Method for improving executive function
WO2013129914A1 (en) * 2012-03-02 2013-09-06 N.V. Nutricia Method for improving functional synaptic connectivity
BR112014020177A8 (pt) * 2012-03-02 2021-10-19 Nutricia Nv Uso de uma composição para a fabricação de um produto para diminuir, prevenir ou reverter a conectividade cerebral funcional prejudicada e/ou organização da rede cerebral prejudicada
WO2014171813A1 (en) * 2013-04-17 2014-10-23 N.V. Nutricia Nutritional composition for improving brain function in phenylketonuria
CN103877144B (zh) * 2013-05-02 2017-02-22 杭州耐奇睿生物医药科技有限公司 花生衣活性组分的应用及包含该花生衣活性组分的组合物
US20160235778A1 (en) * 2014-03-13 2016-08-18 Massachusetts Institute Of Technology Compositions containing pufa, uridine and choline and methods of use thereof
WO2016083362A1 (en) * 2014-11-25 2016-06-02 Fonden For Helene Elsass Centeret Composition for improving cognitive functions
WO2017069613A1 (en) 2015-10-23 2017-04-27 N.V. Nutricia Method for improving recognition and/or working memory in hyperphenylalanimenia and phenylketonuria patients
WO2017155387A1 (en) 2016-03-08 2017-09-14 N.V. Nutricia Method for supporting memory function and/or cognitive function
CA3003651A1 (en) * 2016-03-30 2017-10-05 Nestec S.A. Compositions comprising fatty acids and their use
EP4292651A3 (en) * 2016-06-27 2024-03-13 Ohio State Innovation Foundation Liponucleotide-based therapy for ards
BR112019004055A2 (pt) 2016-09-29 2019-05-21 Nestec S.A. ácidos graxos ômega 3, nenhum composto liberador e vitamina b12 como neuroprotetor em pacientes sem demência
JP2020500855A (ja) * 2016-12-13 2020-01-16 ディーエスエム アイピー アセッツ ビー.ブイ.Dsm Ip Assets B.V. Pufa塩製剤(ii)
EP4190319A4 (en) 2020-07-29 2024-05-01 Novamedica Llc PHARMACEUTICAL COMPOSITION CONTAINING MEMANTINE AND CITICOLINE
TR2021016704A2 (tr) * 2021-10-26 2021-11-22 Bursa Uludag Ueniversitesi Üri̇di̇ni̇n ön uyaran aracili i̇nhi̇bi̇syon bozukluğu i̇le seyreden hastaliklarin tedavi̇si̇nde kullanimi
WO2023150389A1 (en) * 2022-02-07 2023-08-10 Cornell University Compositions and methods for increasing dha availability

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4221784A (en) * 1979-04-05 1980-09-09 Massachusetts Institute Of Technology Process and composition for treating disorders by administering lecithin
GB8601915D0 (en) * 1986-01-27 1986-03-05 Efamol Ltd Pharmaceutical compositions
US5198468A (en) * 1987-06-24 1993-03-30 Efamol Holdings Plc Essential fatty acid composition
US5470838A (en) 1987-10-28 1995-11-28 Pro-Neuron, Inc. Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine
JP2524217B2 (ja) * 1988-04-18 1996-08-14 マルハ株式会社 脳機能改善組成物、学習能力増強剤、記憶力増強剤、痴呆予防剤または痴呆治療剤
JPH08511533A (ja) * 1993-06-09 1996-12-03 マーテック・バイオサイエンスィズ・コーポレーション 神経学的障害の治療に有用な方法および医薬用組成物
US20050027004A1 (en) 1993-06-09 2005-02-03 Martek Biosciences Corporation Methods of treating senile dementia and Alzheimer's diseases using docosahexaenoic acid and arachidonic acid compositions
US5492899A (en) 1994-01-10 1996-02-20 Abbott Laboratories Infant nutritional formula with ribo-nucleotides
JPH07143862A (ja) * 1994-05-06 1995-06-06 Maruha Corp 脳機能改善効果を有する機能性食品。
WO1996040106A2 (en) 1995-06-07 1996-12-19 Martek Biosciences Corporation Methods for controlling highly unsaturated fatty acid content in various tissues
JPH0975000A (ja) 1995-07-07 1997-03-25 Nisshin Oil Mills Ltd:The 母子栄養用油脂含有飲食物
US6200624B1 (en) 1996-01-26 2001-03-13 Abbott Laboratories Enteral formula or nutritional supplement containing arachidonic and docosahexaenoic acids
DE19608137A1 (de) 1996-03-02 1997-09-04 Meyer Lucas Gmbh & Co Lipid-Zubereitungen für diätetische Zwecke
JP3627043B2 (ja) 1996-04-24 2005-03-09 明治乳業株式会社 n−6系列/n−3系列脂肪酸バランス 改善ヌクレオチド含有乳児用食品
DK1785492T3 (da) 1996-07-23 2010-07-26 Nagase Chemtex Corp Fremgangsmåde til fremstilling af docosahexaensyre og docosapentaensyre
PL343902A1 (en) 1997-02-21 2001-09-10 Abbott Lab Methods of and compositions for reducing enteritis and colitis morbidity rate
US6080787A (en) * 1997-02-21 2000-06-27 Abbott Laboratories Methods for reducing the incidence of necrotizing enterocolitis
JPH10327804A (ja) 1997-06-04 1998-12-15 Meiji Milk Prod Co Ltd 核酸関連物質、dha、アラキドン酸及び コレステロール含有栄養組成物
JP3731983B2 (ja) * 1997-08-27 2006-01-05 明治製菓株式会社 痴呆犬の夜鳴き改善薬
JP3408958B2 (ja) * 1997-10-24 2003-05-19 旭化成株式会社 魚介類由来の有用物質を含む組成物およびその有用物質の製造方法
US5977174A (en) 1997-11-26 1999-11-02 Neuromedica, Inc. Cholinergic compositions and uses thereof
US7413759B2 (en) 1998-05-21 2008-08-19 Beech-Nut Nutrition Corporation Method of enhancing cognitive ability in infant fed DHA containing baby-food compositions
US20050203053A1 (en) 1999-07-30 2005-09-15 Wurtman Richard J. Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function
US20070004670A1 (en) * 1998-07-31 2007-01-04 Richard Wurtman Compositions containing citicoline, and methods of use thereof
US8518882B2 (en) * 1998-07-31 2013-08-27 Massachusetts Institute Of Technology Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same
WO2000006174A1 (en) * 1998-07-31 2000-02-10 Massachusetts Institute Of Technology Methods for increasing cytidine levels in vivo and treating cytidine-dependent human diseases
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
WO2000012102A1 (en) 1998-08-31 2000-03-09 Proteotech, Inc. Blended compositions for treatment of alzheimer's disease and other amyloidoses
US6495599B2 (en) 2000-04-13 2002-12-17 Abbott Laboratories Infant formulas containing long-chain polyunsaturated fatty acids and uses therof
US7226916B1 (en) * 2000-05-08 2007-06-05 N.V. Nutricia Preparation for the prevention and/or treatment of vascular disorders
CA2344564C (en) 2000-09-14 2008-07-22 General Electric Canada Inc. Graded electric field insulation system for dynamoelectric machine
US6964969B2 (en) 2001-04-19 2005-11-15 Mccleary Edward Larry Composition and method for treating impaired or deteriorating neurological function
GB0111282D0 (en) 2001-05-09 2001-06-27 Laxdale Ltd Potentiation of therapeutic effects of fatty acids
JP2003048831A (ja) * 2001-08-02 2003-02-21 Suntory Ltd 脳機能の低下に起因する症状あるいは疾患の予防又は改善作用を有する組成物
US6541043B2 (en) * 2001-08-28 2003-04-01 Dexgen Pharmaceuticals, Inc. Method and synergistic composition for treating attention deficit/hyperactivity disorder
EP1302196A1 (de) 2001-10-16 2003-04-16 Habinger, René, Ing. Mag. Intelligenzfördernde Zahncreme
NL1019368C2 (nl) * 2001-11-14 2003-05-20 Nutricia Nv Preparaat voor het verbeteren van receptorwerking.
US6677470B2 (en) 2001-11-20 2004-01-13 Natural Asa Functional acylglycerides
US20030114415A1 (en) * 2001-12-14 2003-06-19 Wurtman Richard J. Compositions and methods for treating and preventing memory impairment using citicoline
US20040048926A1 (en) 2002-03-15 2004-03-11 Hoffman Dennis Robert Use of docosahexaenoic acid and arachidonic acid to enhance the visual development of term infants breast-fed up to the age of six months
EP1542670B2 (en) * 2002-09-24 2023-07-05 Suntory Holdings Limited Composition containing arachidonic acid alone or in combination with docosahexaenoic acid for enhancing cognitive abilities in adults
JP2004231585A (ja) 2002-12-05 2004-08-19 Fancl Corp 生体内ホモシステインレベル低減用および上昇抑制用組成物
BR0317586A (pt) 2002-12-20 2005-11-22 Mclean Hospital Corp Compostos para normalização do ciclo sono/vigìlia
CN1203867C (zh) 2003-03-11 2005-06-01 刘威 精制海狗油在制备防治老年痴呆药中的应用
US7867541B2 (en) 2003-04-14 2011-01-11 Mead Johnson Nutrition Company Compositions and methods of formulation for enteral formulas containing sialic acid
US7951410B2 (en) * 2003-04-14 2011-05-31 Mead Johnson Nutrition Company Enteral compositions containing caseinoglycomacropeptide having an enhanced concentration of sialic acid
WO2005029978A1 (en) 2003-09-26 2005-04-07 Nestec S.A. Nutritional composition with unsaturated fatty acids and trace elements
US8921422B2 (en) 2003-10-01 2014-12-30 The Iams Company Methods and kits for enhancing ability to learn in a puppy or kitten
CA2542023A1 (en) 2003-10-08 2005-09-22 The Mclean Hospital Corporation Methods of treating psychiatric, substance abuse, and other disorders using combinations containing omega-3 fatty acids
EP1634599A1 (en) * 2004-08-20 2006-03-15 N.V. Nutricia Iimmune stimulatory infant nutrition
EP1656839A1 (en) 2004-11-11 2006-05-17 N.V. Nutricia Nutrition containing lipid blend
US20060247153A1 (en) 2005-04-29 2006-11-02 Mcmahon Robert J Method of improving learning and memory in mammals
PL1888081T3 (pl) 2005-05-23 2017-07-31 Massachusetts Institute Of Technology Kompozycje zawierające PUFA i sposoby ich zastosowania
US7829126B2 (en) 2005-10-26 2010-11-09 Abbott Laboratories Infant formulas containing docosahexaenoic acid and lutein

Also Published As

Publication number Publication date
JP2008542280A (ja) 2008-11-27
NZ563659A (en) 2011-05-27
EP1888081A2 (en) 2008-02-20
RU2011120440A (ru) 2012-11-27
EP1909801B2 (en) 2020-03-18
EP1888081A4 (en) 2012-12-05
EP1888081B1 (en) 2016-12-28
NZ600740A (en) 2014-02-28
WO2006127620A3 (en) 2009-05-07
US20190167705A1 (en) 2019-06-06
EP3090740A1 (en) 2016-11-09
CA2645645C (en) 2015-07-14
CA2645645A1 (en) 2006-11-30
EP1909801B1 (en) 2016-12-28
US10736912B2 (en) 2020-08-11
NZ563660A (en) 2012-11-30
WO2006127627A2 (en) 2006-11-30
ES2624702T5 (es) 2020-12-11
RU2603470C2 (ru) 2016-11-27
JP5823564B2 (ja) 2015-11-25
PT1888081T (pt) 2017-03-01
CN105663151A (zh) 2016-06-15
HUE031206T2 (en) 2017-06-28
WO2006127627A3 (en) 2009-04-16
ES2624702T3 (es) 2017-07-17
JP2014133767A (ja) 2014-07-24
PL1888081T3 (pl) 2017-07-31
US20100022567A1 (en) 2010-01-28
JP5566604B2 (ja) 2014-08-06
BRPI0613303A2 (pt) 2009-08-04
AU2006251569B2 (en) 2012-06-21
JP5566603B2 (ja) 2014-08-06
DK1888081T3 (en) 2017-02-27
US10086009B2 (en) 2018-10-02
AU2006251562B2 (en) 2012-03-22
EP1909801A4 (en) 2012-12-05
US20100099645A1 (en) 2010-04-22
CA2645647A1 (en) 2006-11-30
BRPI0613303A8 (pt) 2018-01-30
AU2006251562A1 (en) 2006-11-30
WO2006127620A2 (en) 2006-11-30
US10525071B2 (en) 2020-01-07
CA2645647C (en) 2016-07-12
JP2008545693A (ja) 2008-12-18
AU2006251569A1 (en) 2006-11-30
ES2615521T3 (es) 2017-06-07
EP1909801A2 (en) 2008-04-16

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