JP2008545693A - Pufaを含有する組成物及びそれを使用した方法 - Google Patents
Pufaを含有する組成物及びそれを使用した方法 Download PDFInfo
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- JP2008545693A JP2008545693A JP2008513592A JP2008513592A JP2008545693A JP 2008545693 A JP2008545693 A JP 2008545693A JP 2008513592 A JP2008513592 A JP 2008513592A JP 2008513592 A JP2008513592 A JP 2008513592A JP 2008545693 A JP2008545693 A JP 2008545693A
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Abstract
【解決手段】本発明に係る方法は、記憶障害、精神障害、又は脳の疾患若しくは障害を有する対象者に、オメガ3脂肪酸、オメガ6脂肪酸、ウリジン、それらの代謝前駆体、又はそれらの組み合わせを含有する組成物を投与するステップを含み、それによって、神経細胞又は脳細胞のリン脂質、シナプス、シナプス・タンパク質及びシナプス膜の合成及びレベルを増加又は増進させる。
【選択図】図1
Description
を投与するステップを含み、それによって、対象者の脳内におけるシナプスの数を増加させるようにした方法を提供する。他の実施形態では、前記対象者は記憶障害を有する。他の実施形態では、前記記憶障害は、加齢に関連する。各可能な形態は、本発明の異なる実施形態に相当する。
1晩インキュベートし、TBST緩衝液で5回洗浄した後に、ブロットをペルオキシダーゼに結合した適切な2次抗体と1時間インキュベートした。次に、ブロットをTBST緩衝液で5回洗浄し、ECLシステム(Amersham Biosciences、iscataway、NJ、米国)及びKodak X-ARフィルムを使用してタンパク質抗体の複合体を検出及び可視化した。透過アダプタを有するSupervista S-12スキャナー(UMAX Technologies、Freemont、CA、米国)を使用して膜をデジタル化した。Public Domain NIH Imageプログラムを使用することで、密度測定で免疫反応バンドを比較した。吸光度曲線の下の領域は、同じブロットにおいて対照群で生じた領域のパーセンテージとして標準化した。タンパク質レベルは、対照群のタンパク質量のパーセンテージとして表した。
ラットの海馬細胞をNeurobasal+B27培地で成熟するまでに(3週間)培養した。実験の日に、細胞を、DHAを含む又は含まないDMEM+コリンで培養した。14Cコリンを加え、細胞をさらに2時間培養し、新たに形成された14C標識のPCを実施例1に記載したように抽出し、測定した。
Claims (48)
- 加齢関連記憶障害の対象者における神経細胞又は脳細胞のシナプス膜の量を増加させる方法であって、
前記神経細胞又は脳細胞に、オメガ3脂肪酸又はその代謝前駆体を接触させるステップを含み、
それによって、加齢関連記憶障害の対象者における神経細胞又は脳細胞のシナプス膜の量を増加させるようにした方法。 - 請求項1に記載の方法であって、
前記リン脂質は、ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルイノシトール、ホスファチジルセリン又はスフィンゴミエリンであることを特徴とする方法。 - 請求項1に記載の方法であって、
前記オメガ3脂肪酸は、ドコサヘキサエン酸、エイコサペンタエン酸、ドコサペンタエン酸、αリノレン酸又はそれらの代謝前駆体であることを特徴とする方法。 - 請求項1に記載の方法であって、
前記オメガ3脂肪酸又はその代謝前駆体で、前記神経細胞又は脳細胞のリン脂質の合成を増加させることによって、前記リン脂質のレベルを増加させるようにしたことを特徴とする方法。 - 請求項1に記載の方法であって、
前記神経細胞又は脳細胞に、ウリジン、そのアシル誘導体、ウリジン・リン酸又はCDPコリンを接触させるステップをさらに含むことを特徴とする方法。 - 請求項1に記載の方法であって、
前記神経細胞又は脳細胞に、コリン、その代謝前駆体又はコリン塩を接触させるステップをさらに含むことを特徴とする方法。 - 加齢関連記憶障害の対象者における神経細胞又は脳細胞のシナプス膜の量を増加させる方法であって、
前記神経細胞又は脳細胞に、オメガ6脂肪酸又はその代謝前駆体を接触させるステップを含み、
それによって、加齢関連記憶障害の対象者における神経細胞又は脳細胞のシナプス膜の量を増加させるようにした方法。 - 請求項7に記載の方法であって、
前記リン脂質は、ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルイノシトール、ホスファチジルセリン又はスフィンゴミエリンであることを特徴とする方法。 - 請求項7に記載の方法であって、
前記オメガ6脂肪酸は、アラキドン酸、リノール酸又はそれらの代謝前駆体であることを特徴とする方法。 - 請求項7に記載の方法であって、
前記オメガ6脂肪酸又はその代謝前駆体で、前記神経細胞又は脳細胞のリン脂質の合成を増加させることによって、前記リン脂質のレベルを増加させるようにしたことを特徴とする方法。 - 請求項7に記載の方法であって、
前記神経細胞又は脳細胞に、ウリジン、そのアシル誘導体、ウリジン・リン酸又はCDPコリンを接触させるステップをさらに含むことを特徴とする方法。 - 請求項7に記載の方法であって、
前記神経細胞又は脳細胞に、コリン、その代謝前駆体又はコリン塩を接触させるステップをさらに含むことを特徴とする方法。 - アルツハイマー病、記憶障害又は記憶喪失の対象者を治療する方法であって、
前記対象者に、オメガ3脂肪酸又はその代謝前駆体を含有する医薬組成物を接触させるステップを含み、
前記オメガ3脂肪酸又はその代謝前駆体で、神経細胞のリン脂質の合成を増加させることによって、アルツハイマー病、記憶障害又は記憶喪失の対象者を治療するようにした方法。 - 請求項13に記載の方法であって、
前記アルツハイマー病は、初期又は軽症段階であることを特徴とする方法。 - 請求項13に記載の方法であって、
前記アルツハイマー病は、中症又は重症段階であることを特徴とする方法。 - 請求項13に記載の方法であって、
前記リン脂質は、ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルイノシトール、ホスファチジルセリン又はスフィンゴミエリンであることを特徴とする方法。 - 請求項13に記載の方法であって、
前記オメガ3脂肪酸は、ドコサヘキサエン酸、エイコサペンタエン酸、ドコサペンタエン酸、αリノレン酸又はそれらの代謝前駆体であることを特徴とする方法。 - 請求項13に記載の方法であって、
前記対象者に、ウリジン、そのアシル誘導体、ウリジン・リン酸又はCDPコリンを含有する医薬組成物を接触させるステップをさらに含むことを特徴とする方法。 - 請求項13に記載の方法であって、
前記対象者に、コリン、その代謝前駆体又はコリン塩を含有する医薬組成物を接触させるステップをさらに含むことを特徴とする方法。 - 請求項13に記載の方法であって、
前記記憶障害は、加齢に関連する、或いは、脳血管疾患、うつ病又は不眠症によって二次的に生じたものであることを特徴とする方法。 - アルツハイマー病、記憶障害又は記憶喪失の対象者を治療する方法であって、
前記対象者に、オメガ6脂肪酸又はその代謝前駆体を含有する医薬組成物を接触させるステップを含み、
前記オメガ6脂肪酸又はその代謝前駆体で、神経細胞のリン脂質の合成を増加させることによって、アルツハイマー病、記憶障害又は記憶障害の対象者を治療するようにした方法。 - 請求項21に記載の方法であって、
前記アルツハイマー病は、初期又は軽症段階にあることを特徴とする方法。 - 請求項21に記載の方法であって、
前記アルツハイマー病は、中症又は重症段階にあることを特徴とする方法。 - 請求項21に記載の方法であって、
前記リン脂質は、ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルイノシトール、ホスファチジルセリン又はスフィンゴミエリンであることを特徴とする方法。 - 請求項21に記載の方法であって、
前記オメガ6脂肪酸は、アラキドン酸、リノール酸又はそれらの代謝前駆体であることを特徴とする方法。 - 請求項21に記載の方法であって、
前記対象者に、ウリジン、そのアシル誘導体、ウリジン・リン酸又はCDPコリンを含有する医薬組成物を接触させるステップをさらに含むことを特徴とする方法。 - 請求項21に記載の方法であって、
前記対象者に、コリン、その代謝前駆体又はコリン塩を含有する医薬組成物を接触させるステップをさらに含むことを特徴とする方法。 - 請求項21に記載の方法であって、
前記記憶障害は、加齢に関連する、或いは、脳血管疾患、うつ病又は不眠症によって二次的に生じたものであることを特徴とする方法。 - ピック病、レビー小体病、ハンチントン病及び軽度認知障害(MCI:mild cognitive impairment)から成る群より選択される病気を有する対象者を治療する方法であって、
前記対象者に、オメガ3脂肪酸又はその代謝前駆体を含有する医薬組成物を接触させるステップを含み、
前記オメガ3脂肪酸又はその代謝前駆体で、神経細胞のリン脂質の合成を増加させることによって、前記病気を有する対象者を治療するようにした方法。 - 請求項29に記載の方法であって、
前記リン脂質は、ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルイノシトール、ホスファチジルセリン又はスフィンゴミエリンであることを特徴とする方法。 - 請求項29に記載の方法であって、
前記オメガ3脂肪酸は、ドコサヘキサエン酸、エイコサペンタエン酸、ドコサペンタエン酸、αリノレン酸又はそれらの代謝前駆体であることを特徴とする方法。 - 請求項29に記載の方法であって、
前記対象者に、ウリジン、そのアシル誘導体、ウリジン・リン酸又はCDPコリンを含有する医薬組成物を接触させるステップをさらに含むことを特徴とする方法。 - 請求項29に記載の方法であって、
前記対象者に、コリン、その代謝前駆体又はコリン塩を含有する医薬組成物を接触させるステップをさらに含むことを特徴とする方法。 - ピック病、レビー小体病、ハンチントン病及び軽度認知障害(MCI:mild cognitive impairment)から成る群より選択される病気を有する対象者を治療する方法であって、
前記対象者に、オメガ6脂肪酸又はその代謝前駆体を含有する医薬組成物を接触させるステップを含み、
前記オメガ6脂肪酸又はその代謝前駆体で、神経細胞のリン脂質の合成を増加させることによって、前記病気を有する対象者を治療するようにした方法。 - 請求項34に記載の方法であって、
前記リン脂質は、ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルイノシトール、ホスファチジルセリン又はスフィンゴミエリンであることを特徴とする方法。 - 請求項34に記載の方法であって、
前記オメガ6脂肪酸は、アラキドン酸、リノール酸又はそれらの代謝前駆体であることを特徴とする方法。 - 請求項34に記載の方法であって、
前記対象者に、ウリジン、そのアシル誘導体、ウリジン・リン酸又はCDPコリンを含有する医薬組成物を接触させるステップをさらに含むことを特徴とする方法。 - 請求項34に記載の方法であって、
前記対象者に、コリン、その代謝前駆体又はコリン塩を含有する医薬組成物を接触させるステップをさらに含むことを特徴とする方法。 - 加齢関連記憶障害の対象者における脳内のシナプスのサイズ及び数を増加させる方法であって、
前記対象者に、オメガ3脂肪酸又はその代謝前駆体を含有する医薬組成物を接触させるステップを含み、
それによって、加齢関連記憶障害の対象者における脳内のシナプスのサイズ及び数を増加させるようにした方法。 - 請求項39に記載の方法であって、
前記オメガ3脂肪酸は、ドコサヘキサエン酸、エイコサペンタエン酸、ドコサペンタエン酸、αリノレン酸又はそれらの代謝前駆体であることを特徴とする方法。 - 請求項39に記載の方法であって、
前記オメガ3脂肪酸又はその代謝前駆体によって、前記対象者における脳細胞のリン脂質の合成を増加させるようにしたことを特徴とする方法。 - 請求項39に記載の方法であって、
前記対象者に、ウリジン、そのアシル誘導体、ウリジン・リン酸又はCDPコリンを含有する医薬組成物を接触させるステップをさらに含むことを特徴とする方法。 - 請求項39に記載の方法であって、
前記対象者に、コリン、その代謝前駆体又はコリン塩を含有する医薬組成物を接触させるステップをさらに含むことを特徴とする方法。 - 加齢関連記憶障害の対象者における脳内のシナプスのサイズ及び数を増加させる方法であって、
前記対象者に、オメガ6脂肪酸又はその代謝前駆体を含有する医薬組成物を接触させるステップを含み、
それによって、加齢関連記憶障害の対象者における脳内のシナプスのサイズ及び数を増加させるようにした方法。 - 請求項44に記載の方法であって、
前記オメガ6脂肪酸は、アラキドン酸、リノール酸又はそれらの代謝前駆体であることを特徴とする方法。 - 請求項44に記載の方法であって、
前記オメガ6脂肪酸又はその代謝前駆体によって、前記対象者における脳細胞のリン脂質の合成を増加させるようにしたことを特徴とする方法。 - 請求項44に記載の方法であって、
前記対象者に、ウリジン、そのアシル誘導体、ウリジン・リン酸又はCDPコリンを含有する医薬組成物を接触させるステップをさらに含むことを特徴とする方法。 - 請求項44に記載の方法であって、
前記対象者に、コリン、その代謝前駆体又はコリン塩を含有する医薬組成物を接触させるステップをさらに含むことを特徴とする方法。
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JP2008542280A (ja) * | 2005-05-23 | 2008-11-27 | マサチューセッツ・インスティチュート・オブ・テクノロジー | Pufa及び/又はウリジンを含有する組成物及びそれを使用した方法 |
JP2015143248A (ja) * | 2009-02-02 | 2015-08-06 | ディーエスエム アイピー アセッツ ビー.ブイ. | 認知機能改善および心拍数低下のための方法 |
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