JP2008528705A5

JP2008528705A5 -

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Publication number: JP2008528705A5
Authority: JP; Japan
Prior art keywords: compound; groups; aliphatic; disorder; ring
Prior art date: 2006-02-02
Legal status : Granted

Application number

JP2007554283A

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English (en)

Japanese (ja)

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JP2008528705A (ja

JP5227032B2 (ja

Filing date

2006-02-02

Publication date

2009-02-19

2006-02-02 Application filed filed Critical

2006-02-02 Priority claimed from PCT/US2006/004019 external-priority patent/WO2006096270A1/en

2008-07-31 Publication of JP2008528705A publication Critical patent/JP2008528705A/ja

2009-02-19 Publication of JP2008528705A5 publication Critical patent/JP2008528705A5/ja

2013-07-03 Application granted granted Critical

2013-07-03 Publication of JP5227032B2 publication Critical patent/JP5227032B2/ja

Status Expired - Fee Related legal-status Critical Current

2026-02-02 Anticipated expiration legal-status Critical

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150000001875 compounds Chemical class 0.000 claims description 138
125000001931 aliphatic group Chemical group 0.000 claims description 86
239000000203 mixture Substances 0.000 claims description 85
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 67
125000000217 alkyl group Chemical group 0.000 claims description 51
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 45
125000000623 heterocyclic group Chemical group 0.000 claims description 42
201000010099 disease Diseases 0.000 claims description 40
229910052757 nitrogen Inorganic materials 0.000 claims description 40
125000001424 substituent group Chemical group 0.000 claims description 39
125000003118 aryl group Chemical group 0.000 claims description 38
229920006395 saturated elastomer Polymers 0.000 claims description 35
125000005842 heteroatom Chemical group 0.000 claims description 33
229910052760 oxygen Inorganic materials 0.000 claims description 33
229910052717 sulfur Chemical group 0.000 claims description 30
125000002723 alicyclic group Chemical group 0.000 claims description 28
229910052799 carbon Inorganic materials 0.000 claims description 28
239000011435 rock Substances 0.000 claims description 28
208000035475 disorder Diseases 0.000 claims description 27
125000002950 monocyclic group Chemical group 0.000 claims description 27
101000934996 Homo sapiens Tyrosine-protein kinase JAK3 Proteins 0.000 claims description 26
102100025387 Tyrosine-protein kinase JAK3 Human genes 0.000 claims description 26
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229910052739 hydrogen Inorganic materials 0.000 claims description 25
101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 claims description 24
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 24
229910052736 halogen Inorganic materials 0.000 claims description 24
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239000011593 sulfur Chemical group 0.000 claims description 23
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QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 16
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JP2007554283A 2005-02-03 2006-02-02 プロテインキナーゼの阻害剤として有用なピロロピリミジン Expired - Fee Related JP5227032B2 (ja)