JP2008528572A5 - - Google Patents
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- Publication number
- JP2008528572A5 JP2008528572A5 JP2007552812A JP2007552812A JP2008528572A5 JP 2008528572 A5 JP2008528572 A5 JP 2008528572A5 JP 2007552812 A JP2007552812 A JP 2007552812A JP 2007552812 A JP2007552812 A JP 2007552812A JP 2008528572 A5 JP2008528572 A5 JP 2008528572A5
- Authority
- JP
- Japan
- Prior art keywords
- water
- diclofenac
- soluble salt
- injectable preparation
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 claims 49
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims 42
- 238000002360 preparation method Methods 0.000 claims 40
- 229960001259 diclofenac Drugs 0.000 claims 39
- 239000002904 solvent Substances 0.000 claims 37
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 27
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 27
- 150000005846 sugar alcohols Polymers 0.000 claims 24
- 239000006184 cosolvent Substances 0.000 claims 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 17
- 235000019441 ethanol Nutrition 0.000 claims 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 11
- 239000001089 [(2R)-oxolan-2-yl]methanol Substances 0.000 claims 11
- 229960001193 diclofenac sodium Drugs 0.000 claims 10
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 claims 10
- 235000019445 benzyl alcohol Nutrition 0.000 claims 9
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 claims 9
- JDSQBDGCMUXRBM-UHFFFAOYSA-N 2-[2-(2-butoxypropoxy)propoxy]propan-1-ol Chemical compound CCCCOC(C)COC(C)COC(C)CO JDSQBDGCMUXRBM-UHFFFAOYSA-N 0.000 claims 8
- -1 tetrahydrofurfuryl Chemical group 0.000 claims 7
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims 6
- 239000008227 sterile water for injection Substances 0.000 claims 6
- PRASJQIZRUFRTI-UHFFFAOYSA-N 1-(oxolan-2-yl)butane-2,3-diol Chemical compound CC(O)C(O)CC1CCCO1 PRASJQIZRUFRTI-UHFFFAOYSA-N 0.000 claims 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 239000003513 alkali Substances 0.000 claims 4
- 239000003963 antioxidant agent Substances 0.000 claims 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 150000001298 alcohols Chemical class 0.000 claims 3
- 229910052783 alkali metal Inorganic materials 0.000 claims 3
- 239000000872 buffer Substances 0.000 claims 3
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical class CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 230000005587 bubbling Effects 0.000 claims 2
- 239000007853 buffer solution Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims 2
- 238000003756 stirring Methods 0.000 claims 2
- 229940058015 1,3-butylene glycol Drugs 0.000 claims 1
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-Phenylethanol Natural products OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 claims 1
- 238000013019 agitation Methods 0.000 claims 1
- 235000019437 butane-1,3-diol Nutrition 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 150000004679 hydroxides Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 229940068886 polyethylene glycol 300 Drugs 0.000 claims 1
- 229940057847 polyethylene glycol 600 Drugs 0.000 claims 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims 1
- 159000000000 sodium salts Chemical group 0.000 claims 1
- 235000010265 sodium sulphite Nutrition 0.000 claims 1
- 230000007928 solubilization Effects 0.000 claims 1
- 238000005063 solubilization Methods 0.000 claims 1
- 239000011877 solvent mixture Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN96MU2005 | 2005-02-01 | ||
| PCT/IN2006/000033 WO2006095363A2 (en) | 2005-02-01 | 2006-01-30 | Injectable preparations of diclofenic and its pharmaceutically acceptable salts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008528572A JP2008528572A (ja) | 2008-07-31 |
| JP2008528572A5 true JP2008528572A5 (enExample) | 2008-12-11 |
Family
ID=36953757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007552812A Pending JP2008528572A (ja) | 2005-02-01 | 2006-01-30 | ジクロフェナクおよびその薬学的に許容しうる塩の注射可能な調製品 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8809393B2 (enExample) |
| EP (1) | EP1848419B1 (enExample) |
| JP (1) | JP2008528572A (enExample) |
| KR (1) | KR101226121B1 (enExample) |
| CN (1) | CN101123957B (enExample) |
| AP (1) | AP2888A (enExample) |
| AU (2) | AU2006221633B2 (enExample) |
| BR (1) | BRPI0606119B8 (enExample) |
| CA (1) | CA2596031C (enExample) |
| DK (1) | DK1848419T3 (enExample) |
| EA (1) | EA013616B1 (enExample) |
| ES (1) | ES2392097T3 (enExample) |
| IL (1) | IL184697A (enExample) |
| MX (1) | MX2007009312A (enExample) |
| NZ (1) | NZ554779A (enExample) |
| PL (1) | PL1848419T3 (enExample) |
| PT (1) | PT1848419E (enExample) |
| UA (1) | UA93365C2 (enExample) |
| WO (1) | WO2006095363A2 (enExample) |
| ZA (1) | ZA200705729B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009155315A (ja) * | 2007-12-26 | 2009-07-16 | Fujiyakuhin Co Ltd | 注射剤 |
| WO2013005226A1 (en) * | 2011-07-04 | 2013-01-10 | Zota Health Care Ltd | A novel combined pharmaceutical composition containing diclofenac and methods of making and using the same |
| US20140187635A1 (en) | 2012-12-28 | 2014-07-03 | Themis Medicare Limited | Diclofenac compositions |
| US20140275261A1 (en) | 2013-03-15 | 2014-09-18 | Dr. Reddy's Laboratories, Inc. | Diclofenac parenteral compositions |
| CN103432132B (zh) * | 2013-08-31 | 2015-01-21 | 西南大学 | 甲磺酸普立地诺双氯芬酸钠注射液及其制备方法 |
| WO2016170401A1 (en) * | 2015-04-20 | 2016-10-27 | Umedica Laboratories Pvt. Ltd | Novel injectable composition of diclofenac sodium |
| US20220280463A1 (en) | 2019-09-09 | 2022-09-08 | Ftf Pharma Private Limited | Pharmaceutical formulations comprising diclofenac |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8200488L (sv) | 1982-01-29 | 1983-07-30 | Svenska Flaektfabriken Ab | Arreteringsanordning, serskilt for forankring av till- och franluftventiler i ventilationskanaler |
| DE3328401A1 (de) * | 1983-08-05 | 1985-02-21 | Merckle GmbH, 7902 Blaubeuren | Injizierbare loesung zur behandlung von entzuendungen |
| DE3446873A1 (de) | 1984-12-21 | 1986-07-10 | Merckle Gmbh | Fluessige diclofenac-zubereitungen |
| DE3613799C1 (de) * | 1986-04-24 | 1987-09-03 | Nattermann A & Cie | Verwendung von Glycofurol zum Verfluessigen von Arzneimittelzubereitungen fuer das Abfuellen in Weichgelatinekapseln |
| ATE164080T1 (de) * | 1990-05-10 | 1998-04-15 | Bechgaard Int Res | Pharmazeutische zubereitung enthaltend n- glykofurole und n-äthylenglykole |
| US5389681A (en) * | 1992-10-22 | 1995-02-14 | Ciba-Geigy Corporation | Parenteral solutions for diclofenac salts |
| ZA949182B (en) * | 1993-12-02 | 1995-07-26 | South African Druggists Ltd | Pharmaceutical composition |
| US5554650A (en) * | 1994-07-28 | 1996-09-10 | Southern Research Institute | Antiphlogistic, analgesic, antipyretic injection preparation |
| GB9502695D0 (en) | 1995-02-11 | 1995-03-29 | Glaxo Spa | Pharmaceutical composition |
| US5747058A (en) * | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
| WO1997049411A1 (en) * | 1996-06-25 | 1997-12-31 | Glaxo Group Limited | Combinations comprising vx478, zidovudine, ftc and/or 3tc for use in the treatment of hiv |
| US5853263A (en) * | 1996-08-15 | 1998-12-29 | Accrued, Inc. | System for installing raised road markers |
| US6846495B2 (en) * | 1999-01-11 | 2005-01-25 | The Procter & Gamble Company | Compositions having improved delivery of actives |
| DE10105576C1 (de) * | 2001-02-07 | 2002-08-08 | Underberg Kg | Flasche mit im Boden ausgebildeten Griffmulden |
| IN192711B (enExample) | 2002-01-22 | 2004-05-15 | Ketan Rajnibhai Patel | |
| CH694034A8 (de) * | 2002-12-12 | 2004-08-31 | Mepha Ag | Diclofenac-Kalium-Injektionsloesung. |
| EP1605916A4 (en) * | 2003-02-12 | 2012-02-22 | R & P Korea Co Ltd | SOLVENT SYSTEM OF A SMOOTH MEDICAMENT WITH IMPROVED ELUTION RATE |
| KR100612070B1 (ko) * | 2003-02-12 | 2006-08-11 | 알앤피코리아주식회사 | 용출률이 향상된 난용성 약제의 용매 시스템 및 이를 함유한 제약학적 제제 |
| CN1557290A (zh) | 2004-01-19 | 2004-12-29 | 江苏扬子江药业集团有限公司 | 复方双氯芬酸钾注射液制剂 |
| AU2004317520B2 (en) | 2004-03-10 | 2011-06-09 | Shimoda Biotech (Pty) Ltd | Stable injectable diclofenac compositions |
| CN1279897C (zh) | 2004-04-30 | 2006-10-18 | 济南百诺医药科技开发有限公司 | 含有双氯芬酸盐和利多卡因的冻干制剂及其制备方法 |
| ITMI20041245A1 (it) | 2004-06-22 | 2004-09-22 | Ibsa Inst Biochimique Sa | Composizioni farmaceutiche iniettabnili comprendenti diclofenac sodico e b-ciclodestrina |
-
2006
- 2006-01-30 WO PCT/IN2006/000033 patent/WO2006095363A2/en not_active Ceased
- 2006-01-30 EA EA200701645A patent/EA013616B1/ru not_active IP Right Cessation
- 2006-01-30 KR KR1020077019888A patent/KR101226121B1/ko not_active Expired - Fee Related
- 2006-01-30 JP JP2007552812A patent/JP2008528572A/ja active Pending
- 2006-01-30 PL PL06745197T patent/PL1848419T3/pl unknown
- 2006-01-30 ES ES06745197T patent/ES2392097T3/es not_active Expired - Lifetime
- 2006-01-30 AP AP2007004101A patent/AP2888A/xx active
- 2006-01-30 BR BRPI0606119A patent/BRPI0606119B8/pt not_active IP Right Cessation
- 2006-01-30 NZ NZ554779A patent/NZ554779A/en not_active IP Right Cessation
- 2006-01-30 UA UAA200708877A patent/UA93365C2/ru unknown
- 2006-01-30 US US11/883,331 patent/US8809393B2/en active Active
- 2006-01-30 MX MX2007009312A patent/MX2007009312A/es active IP Right Grant
- 2006-01-30 AU AU2006221633A patent/AU2006221633B2/en not_active Ceased
- 2006-01-30 PT PT06745197T patent/PT1848419E/pt unknown
- 2006-01-30 DK DK06745197.1T patent/DK1848419T3/da active
- 2006-01-30 CA CA2596031A patent/CA2596031C/en not_active Expired - Lifetime
- 2006-01-30 CN CN2006800034355A patent/CN101123957B/zh not_active Expired - Fee Related
- 2006-01-30 EP EP06745197A patent/EP1848419B1/en not_active Expired - Lifetime
-
2007
- 2007-07-12 ZA ZA200705729A patent/ZA200705729B/xx unknown
- 2007-07-18 IL IL184697A patent/IL184697A/en not_active IP Right Cessation
-
2009
- 2009-10-29 AU AU2009233594A patent/AU2009233594A1/en not_active Withdrawn
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