ITMI20041245A1 - Composizioni farmaceutiche iniettabnili comprendenti diclofenac sodico e b-ciclodestrina - Google Patents
Composizioni farmaceutiche iniettabnili comprendenti diclofenac sodico e b-ciclodestrinaInfo
- Publication number
- ITMI20041245A1 ITMI20041245A1 IT001245A ITMI20041245A ITMI20041245A1 IT MI20041245 A1 ITMI20041245 A1 IT MI20041245A1 IT 001245 A IT001245 A IT 001245A IT MI20041245 A ITMI20041245 A IT MI20041245A IT MI20041245 A1 ITMI20041245 A1 IT MI20041245A1
- Authority
- IT
- Italy
- Prior art keywords
- pharmaceutical compositions
- cyclodestrine
- injectable pharmaceutical
- compositions including
- diclofenac sodium
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229960001193 diclofenac sodium Drugs 0.000 title 1
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 title 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- 239000001116 FEMA 4028 Substances 0.000 abstract 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 abstract 1
- 229960004853 betadex Drugs 0.000 abstract 1
- KPHWPUGNDIVLNH-UHFFFAOYSA-M diclofenac sodium Chemical compound [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KPHWPUGNDIVLNH-UHFFFAOYSA-M 0.000 abstract 1
- 238000007918 intramuscular administration Methods 0.000 abstract 1
- 229950008882 polysorbate Drugs 0.000 abstract 1
- 229920000136 polysorbate Polymers 0.000 abstract 1
- 238000007920 subcutaneous administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001245A ITMI20041245A1 (it) | 2004-06-22 | 2004-06-22 | Composizioni farmaceutiche iniettabnili comprendenti diclofenac sodico e b-ciclodestrina |
| JP2005174529A JP5113323B2 (ja) | 2004-06-22 | 2005-06-15 | ジクロフェナクナトリウムとβ−シクロデキストリンとを有する注入可能薬学組成物 |
| CNB2005100768303A CN100569230C (zh) | 2004-06-22 | 2005-06-17 | 含有双氯芬酸钠和β-环糊精的可注射药物组合物 |
| KR1020050053096A KR101202649B1 (ko) | 2004-06-22 | 2005-06-20 | 소듐 디클로페낙 및 β-시클로덱스트린을 포함하는 주사용약학 조성물 |
| ES05105474T ES2293482T3 (es) | 2004-06-22 | 2005-06-21 | Composiciones farmaceuticas para inyeccion que comprenden diclofenaco sodico, betaciclodextrina y un polisorbato. |
| CA2510813A CA2510813C (en) | 2004-06-22 | 2005-06-21 | Injectable pharmaceutical compositions comprising sodium diclofenac and .beta.-cyclodextrin |
| DE602005002495T DE602005002495T2 (de) | 2004-06-22 | 2005-06-21 | Injizierbare Formulierung mit Natriumdiclofenac, Beta-Cyclodextrin und einem Polysorbat |
| PL05105474T PL1609481T3 (pl) | 2004-06-22 | 2005-06-21 | Nadająca się do wstrzykiwania kompozycja farmaceutyczna zawierająca diklofenak sodowy, beta-cyklodekstrynę i polisorbat |
| DK05105474T DK1609481T3 (da) | 2004-06-22 | 2005-06-21 | Injicerbar farmaceutiske kompositioner omfattende natrium diclofenac, betacyklodextrin og en polysorbat |
| US11/158,517 US7423028B2 (en) | 2004-06-22 | 2005-06-21 | Injectable pharmaceutical compositions comprising sodium diclofenac and β-cyclodextrin |
| AT05105474T ATE373489T1 (de) | 2004-06-22 | 2005-06-21 | Injizierbare formulierung mit natriumdiclofenac, beta-cyclodextrin und einem polysorbat |
| PT05105474T PT1609481E (pt) | 2004-06-22 | 2005-06-21 | Composições farmacêuticas injectáveis compreendendo diclofenaco de sódio de beta-ciclodextrina e um polissorbato |
| EP05105474A EP1609481B1 (en) | 2004-06-22 | 2005-06-21 | Injectable pharmaceutical compositions comprising sodium diclofenac, beta-cyclodextrin and a polysorbate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001245A ITMI20041245A1 (it) | 2004-06-22 | 2004-06-22 | Composizioni farmaceutiche iniettabnili comprendenti diclofenac sodico e b-ciclodestrina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITMI20041245A1 true ITMI20041245A1 (it) | 2004-09-22 |
Family
ID=35033310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT001245A ITMI20041245A1 (it) | 2004-06-22 | 2004-06-22 | Composizioni farmaceutiche iniettabnili comprendenti diclofenac sodico e b-ciclodestrina |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7423028B2 (it) |
| EP (1) | EP1609481B1 (it) |
| JP (1) | JP5113323B2 (it) |
| KR (1) | KR101202649B1 (it) |
| CN (1) | CN100569230C (it) |
| AT (1) | ATE373489T1 (it) |
| CA (1) | CA2510813C (it) |
| DE (1) | DE602005002495T2 (it) |
| DK (1) | DK1609481T3 (it) |
| ES (1) | ES2293482T3 (it) |
| IT (1) | ITMI20041245A1 (it) |
| PL (1) | PL1609481T3 (it) |
| PT (1) | PT1609481E (it) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008528572A (ja) | 2005-02-01 | 2008-07-31 | トロイカ ファーマスーティカルズ リミテッド | ジクロフェナクおよびその薬学的に許容しうる塩の注射可能な調製品 |
| BRPI0709409A2 (pt) * | 2006-03-28 | 2011-07-12 | Javelin Pharmaceuticals Inc | composição farmacêutica e método para tratar um mamìfero necessitando de analgesia |
| CA2647533A1 (en) * | 2006-03-28 | 2007-10-04 | Javelin Pharmaceuticals, Inc. | Formulations of low dose non-steroidal anti-inflammatory drugs and beta-cyclodextrin |
| ITMI20121205A1 (it) | 2012-07-11 | 2014-01-12 | Glycores 2000 Srl | Composizione con attivita' antinfiammatoria ed analgesica da somministrare per uso esterno mediante vaporizzazione |
| US20140275261A1 (en) | 2013-03-15 | 2014-09-18 | Dr. Reddy's Laboratories, Inc. | Diclofenac parenteral compositions |
| CN103432132B (zh) * | 2013-08-31 | 2015-01-21 | 西南大学 | 甲磺酸普立地诺双氯芬酸钠注射液及其制备方法 |
| SG11201804961UA (en) * | 2015-12-30 | 2018-07-30 | Genentech Inc | Formulations with reduced degradation of polysorbate |
| CN107126418B (zh) * | 2016-02-25 | 2020-05-29 | 江苏思邈医药科技有限公司 | 供注射用双氯芬酸钠药物组合物及其制备方法 |
| EP3216443A1 (en) | 2016-03-10 | 2017-09-13 | Athenion AG | Beverage preparation capsule for delivery of a solubilisate |
| IT201600075246A1 (it) | 2016-07-19 | 2018-01-19 | Jointherapeutics S R L | Composizioni comprendenti una matrice polisaccaridica per il rilascio controllato di principi attivi. |
| US11110073B2 (en) | 2017-03-24 | 2021-09-07 | Cadila Healthcare Limited | Storage stable aqueous injectable solution comprising diclofenac |
| EP3388054A1 (en) | 2017-04-12 | 2018-10-17 | Athenion AG | Dispensing cap containing a solubilisate of a pharmaceutically active agent or dietary supplement |
| US20220280463A1 (en) | 2019-09-09 | 2022-09-08 | Ftf Pharma Private Limited | Pharmaceutical formulations comprising diclofenac |
| US11707443B2 (en) | 2019-09-26 | 2023-07-25 | Rk Pharma Inc. | Storage stable aqueous parenteral solutions comprising diclofenac |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA949182B (en) * | 1993-12-02 | 1995-07-26 | South African Druggists Ltd | Pharmaceutical composition |
| US5554650A (en) * | 1994-07-28 | 1996-09-10 | Southern Research Institute | Antiphlogistic, analgesic, antipyretic injection preparation |
| CZ301382B6 (cs) * | 1997-03-12 | 2010-02-10 | Abbott Laboratories Chad377/Ap6D-2 | Hydrofilní binární systémy pro podávání cyklosporinu |
| US6365180B1 (en) * | 1998-01-20 | 2002-04-02 | Glenn A. Meyer | Oral liquid compositions |
| US6495164B1 (en) * | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| US20020016359A1 (en) * | 2000-06-29 | 2002-02-07 | Hellberg Mark R. | Compositions and methods of treating neurodegenerative diseases |
| US7008934B2 (en) * | 2001-06-28 | 2006-03-07 | Baxter International Inc. | Composition and method for reducing adverse interactions between phenothiazine derivatives and plasma using cyclodextrins |
-
2004
- 2004-06-22 IT IT001245A patent/ITMI20041245A1/it unknown
-
2005
- 2005-06-15 JP JP2005174529A patent/JP5113323B2/ja not_active Expired - Lifetime
- 2005-06-17 CN CNB2005100768303A patent/CN100569230C/zh not_active Expired - Lifetime
- 2005-06-20 KR KR1020050053096A patent/KR101202649B1/ko not_active Expired - Lifetime
- 2005-06-21 CA CA2510813A patent/CA2510813C/en not_active Expired - Lifetime
- 2005-06-21 EP EP05105474A patent/EP1609481B1/en not_active Expired - Lifetime
- 2005-06-21 US US11/158,517 patent/US7423028B2/en active Active
- 2005-06-21 DE DE602005002495T patent/DE602005002495T2/de not_active Expired - Lifetime
- 2005-06-21 ES ES05105474T patent/ES2293482T3/es not_active Expired - Lifetime
- 2005-06-21 AT AT05105474T patent/ATE373489T1/de active
- 2005-06-21 PL PL05105474T patent/PL1609481T3/pl unknown
- 2005-06-21 PT PT05105474T patent/PT1609481E/pt unknown
- 2005-06-21 DK DK05105474T patent/DK1609481T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| US20050282776A1 (en) | 2005-12-22 |
| DE602005002495D1 (de) | 2007-10-31 |
| JP5113323B2 (ja) | 2013-01-09 |
| ES2293482T3 (es) | 2008-03-16 |
| DE602005002495T2 (de) | 2008-06-12 |
| PL1609481T3 (pl) | 2008-02-29 |
| PT1609481E (pt) | 2007-12-31 |
| CA2510813C (en) | 2013-02-12 |
| CA2510813A1 (en) | 2005-12-22 |
| CN100569230C (zh) | 2009-12-16 |
| EP1609481A1 (en) | 2005-12-28 |
| DK1609481T3 (da) | 2008-01-07 |
| KR101202649B1 (ko) | 2012-11-19 |
| CN1711996A (zh) | 2005-12-28 |
| EP1609481B1 (en) | 2007-09-19 |
| US7423028B2 (en) | 2008-09-09 |
| KR20060049413A (ko) | 2006-05-18 |
| JP2006008684A (ja) | 2006-01-12 |
| ATE373489T1 (de) | 2007-10-15 |
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