JP2008528447A5 - - Google Patents
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- Publication number
- JP2008528447A5 JP2008528447A5 JP2007549577A JP2007549577A JP2008528447A5 JP 2008528447 A5 JP2008528447 A5 JP 2008528447A5 JP 2007549577 A JP2007549577 A JP 2007549577A JP 2007549577 A JP2007549577 A JP 2007549577A JP 2008528447 A5 JP2008528447 A5 JP 2008528447A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- alkyl
- independently selected
- substituted
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000004432 carbon atom Chemical group C* 0.000 claims 184
- 125000000217 alkyl group Chemical group 0.000 claims 143
- 125000005842 heteroatom Chemical group 0.000 claims 132
- 125000001072 heteroaryl group Chemical group 0.000 claims 94
- 239000000203 mixture Substances 0.000 claims 91
- 125000000623 heterocyclic group Chemical group 0.000 claims 88
- 125000000753 cycloalkyl group Chemical group 0.000 claims 73
- 125000001188 haloalkyl group Chemical group 0.000 claims 68
- 125000003118 aryl group Chemical group 0.000 claims 55
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 41
- 229910052739 hydrogen Inorganic materials 0.000 claims 41
- 239000001257 hydrogen Substances 0.000 claims 41
- 150000001875 compounds Chemical class 0.000 claims 33
- 150000003839 salts Chemical class 0.000 claims 30
- 125000001424 substituent group Chemical group 0.000 claims 27
- 125000004093 cyano group Chemical group *C#N 0.000 claims 22
- -1 4,5-dihydro - oxazolyl Chemical group 0.000 claims 21
- 125000000842 isoxazolyl group Chemical group 0.000 claims 21
- 125000002971 oxazolyl group Chemical group 0.000 claims 21
- 125000004076 pyridyl group Chemical group 0.000 claims 21
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 21
- 125000003831 tetrazolyl group Chemical group 0.000 claims 21
- 125000003710 aryl alkyl group Chemical group 0.000 claims 20
- 125000003545 alkoxy group Chemical group 0.000 claims 18
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 14
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000002619 bicyclic group Chemical group 0.000 claims 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 8
- 125000002950 monocyclic group Chemical group 0.000 claims 8
- 125000001781 1,3,4-oxadiazolyl group Chemical group 0.000 claims 7
- 125000004438 haloalkoxy group Chemical group 0.000 claims 7
- 125000000335 thiazolyl group Chemical group 0.000 claims 7
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 6
- 125000004122 cyclic group Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 150000004820 halides Chemical class 0.000 claims 3
- 125000000547 substituted alkyl group Chemical group 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000003094 microcapsule Substances 0.000 claims 1
- 239000002324 mouth wash Substances 0.000 claims 1
- 229940051866 mouthwash Drugs 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 235000010603 pastilles Nutrition 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 claims 1
- 0 CC(C=C(CN(*)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N(*)*)=N)=C Chemical compound CC(C=C(CN(*)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N(*)*)=N)=C 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64079804P | 2004-12-31 | 2004-12-31 | |
| US60/640,798 | 2004-12-31 | ||
| PCT/US2005/047203 WO2006073973A2 (en) | 2004-12-31 | 2005-12-28 | Novel benzylamine derivatives as cetp inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008528447A JP2008528447A (ja) | 2008-07-31 |
| JP2008528447A5 true JP2008528447A5 (OSRAM) | 2012-02-23 |
| JP5096927B2 JP5096927B2 (ja) | 2012-12-12 |
Family
ID=36648035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007549577A Expired - Fee Related JP5096927B2 (ja) | 2004-12-31 | 2005-12-28 | Cetpインヒビターとしての新規ベンジルアミン誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9040558B2 (OSRAM) |
| EP (1) | EP1848430B1 (OSRAM) |
| JP (1) | JP5096927B2 (OSRAM) |
| KR (1) | KR101238525B1 (OSRAM) |
| CN (2) | CN103102303B (OSRAM) |
| CA (1) | CA2605214C (OSRAM) |
| DK (1) | DK1848430T3 (OSRAM) |
| ES (2) | ES2644450T3 (OSRAM) |
| MX (1) | MX2007007919A (OSRAM) |
| WO (1) | WO2006073973A2 (OSRAM) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103102303B (zh) | 2004-12-31 | 2015-10-28 | 雷迪博士实验室有限公司 | 作为cetp抑制剂的苄胺衍生物 |
| US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
| EP1981342B1 (en) * | 2005-12-28 | 2016-11-30 | Dr. Reddy's Laboratories Ltd. | Selective benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors |
| KR20080086917A (ko) * | 2005-12-29 | 2008-09-26 | 노파르티스 아게 | 콜레스테릴 에스테르 전달 단백질 (cetp) 억제제로서의피리디닐 아민 유도체 |
| UY30117A1 (es) | 2006-01-31 | 2007-06-29 | Tanabe Seiyaku Co | Compuesto amina trisustituido |
| PE20071025A1 (es) * | 2006-01-31 | 2007-10-17 | Mitsubishi Tanabe Pharma Corp | Compuesto amina trisustituido |
| US8383660B2 (en) * | 2006-03-10 | 2013-02-26 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| MX2008014284A (es) * | 2006-05-10 | 2008-11-18 | Novartis Ag | Derivados biciclicos como inhibidores de cetp. |
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| US20090181929A1 (en) * | 2006-05-11 | 2009-07-16 | Kazuhide Konishi | Organic compounds |
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| US7750019B2 (en) | 2006-08-11 | 2010-07-06 | Kowa Company, Ltd. | Pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same |
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| JP4846769B2 (ja) * | 2007-07-30 | 2011-12-28 | 田辺三菱製薬株式会社 | 医薬組成物 |
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| US8470841B2 (en) | 2008-07-09 | 2013-06-25 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
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| EP2396315B1 (en) | 2009-02-13 | 2016-08-31 | UCB Biopharma SPRL | Quinoline derivatives as pi3k kinase inhibitors |
| ES2443016T3 (es) | 2009-08-26 | 2014-02-17 | Sanofi | Nuevos hidratos cristalinos de fluoroglicósidos heteroaromáticos, productos farmacéuticos que comprenden estos compuestos, y su empleo |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2744803A2 (en) * | 2011-08-18 | 2014-06-25 | Dr. Reddy's Laboratories Ltd. | Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (cetp) inhibitors |
| AU2012313971B2 (en) * | 2011-09-27 | 2016-09-29 | Dr. Reddy's Laboratories, Ltd. | 5 - benzylaminomethyl - 6 - aminopyrazolo [3, 4 -b] pyridine derivatives as cholesteryl ester -transfer protein (CETP) inhibitors useful for the treatment of atherosclerosis |
| EP2789347A4 (en) | 2011-11-29 | 2015-12-16 | Kowa Co | MEANS TO INHIBIT THE EXPRESSION OF NPC1L1 AND / OR LIPG-MRNA AND MEDICAMENTS FOR THE PREVENTION AND / OR TREATMENT OF ADIPOSITAS |
| JPWO2014017569A1 (ja) * | 2012-07-26 | 2016-07-11 | 興和株式会社 | 血中ldlを低下させるための医薬 |
| CA2891502A1 (en) * | 2012-11-19 | 2014-05-22 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions of cetp inhibitors |
| WO2014128564A2 (en) | 2013-02-21 | 2014-08-28 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions of cetp inhibitors |
| JP2015054838A (ja) * | 2013-09-12 | 2015-03-23 | 興和株式会社 | 血中ldlコレステロールを低下させる医薬 |
| US10214502B2 (en) * | 2016-10-04 | 2019-02-26 | Mayo Foundation For Medical Education And Research | Method of inhibiting apolipoprotein-E expression while increasing expression of at least one of LDL-receptor protein or AbcA1 protein comprising administering a small compound |
| CN108329330B (zh) * | 2017-01-20 | 2021-05-04 | 复旦大学 | 2-苄氧苯基噁唑并吡啶类化合物及其药物用途 |
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2005
- 2005-12-28 CN CN201210404509.3A patent/CN103102303B/zh not_active Expired - Fee Related
- 2005-12-28 MX MX2007007919A patent/MX2007007919A/es active IP Right Grant
- 2005-12-28 EP EP05855717.4A patent/EP1848430B1/en not_active Expired - Lifetime
- 2005-12-28 WO PCT/US2005/047203 patent/WO2006073973A2/en not_active Ceased
- 2005-12-28 ES ES05855717.4T patent/ES2644450T3/es not_active Expired - Lifetime
- 2005-12-28 US US11/320,120 patent/US9040558B2/en not_active Expired - Fee Related
- 2005-12-28 CN CN200580048913XA patent/CN101443006B/zh not_active Expired - Fee Related
- 2005-12-28 KR KR1020077017632A patent/KR101238525B1/ko not_active Expired - Fee Related
- 2005-12-28 JP JP2007549577A patent/JP5096927B2/ja not_active Expired - Fee Related
- 2005-12-28 DK DK05855717.4T patent/DK1848430T3/da active
- 2005-12-28 CA CA2605214A patent/CA2605214C/en not_active Expired - Fee Related
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2006
- 2006-06-29 ES ES06774300.5T patent/ES2615340T3/es active Active
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- 2015-04-15 US US14/687,467 patent/US9782407B2/en not_active Expired - Fee Related
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