JP2008527002A - 神経変性障害および血液凝固障害を予防および処置するための新規組成物 - Google Patents

神経変性障害および血液凝固障害を予防および処置するための新規組成物 Download PDF

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JP2008527002A
JP2008527002A JP2007551449A JP2007551449A JP2008527002A JP 2008527002 A JP2008527002 A JP 2008527002A JP 2007551449 A JP2007551449 A JP 2007551449A JP 2007551449 A JP2007551449 A JP 2007551449A JP 2008527002 A JP2008527002 A JP 2008527002A
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compound
formula
sirtuin activating
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further embodiment
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JP2008527002A5 (enExample
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マイケル ミルバーン，
ジル ミルン，
クリストファー エイチ． ウェストファール，
カール ディー． ノーミングトン，
ジェニファー フジイ，
ミシェル ディップ，
ピーター エリオット，
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サートリス ファーマシューティカルズ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/065—Diphenyl-substituted acyclic alcohols
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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    • A61P9/06—Antiarrhythmics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
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  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
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  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007551449A 2005-01-13 2006-01-13 神経変性障害および血液凝固障害を予防および処置するための新規組成物 Withdrawn JP2008527002A (ja)

Applications Claiming Priority (6)

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US64392105P 2005-01-13 2005-01-13
US66717905P 2005-03-30 2005-03-30
US69278505P 2005-06-22 2005-06-22
US73652805P 2005-11-14 2005-11-14
US75360605P 2005-12-23 2005-12-23
PCT/US2006/001428 WO2006076681A2 (en) 2005-01-13 2006-01-13 Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders

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JP2008527002A5 JP2008527002A5 (enExample) 2009-02-19

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JP2012274969A Withdrawn JP2013082723A (ja) 2005-01-13 2012-12-17 神経変性障害および血液凝固障害を予防および処置するための新規組成物

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US (1) US20060276393A1 (enExample)
EP (1) EP1850840A2 (enExample)
JP (2) JP2008527002A (enExample)
AU (1) AU2006204699B2 (enExample)
CA (1) CA2595159A1 (enExample)
WO (1) WO2006076681A2 (enExample)

Cited By (22)

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JP2008542296A (ja) * 2005-05-25 2008-11-27 サートリス ファーマシューティカルズ， インコーポレイテッド サーチュイン活性化剤による眼障害の処置
JP2012500283A (ja) * 2008-08-19 2012-01-05 ノップ ニューロサイエンシーズ、インク． （ｒ）−プラミペキソールを使用した組成物並びにその方法
JP2013241380A (ja) * 2012-05-22 2013-12-05 Apion Japan Kk サーチュイン１（ｓｉｒｔ１）遺伝子活性化剤
JP2014510064A (ja) * 2011-02-25 2014-04-24 ザ ジョンズ ホプキンス ユニバーシティ Ｎｒｆ２活性剤としてのカルコン誘導体
JP2014516359A (ja) * 2011-04-15 2014-07-10 ネステク ソシエテ アノニム サーチュイン遺伝子発現の調節方法
KR101466700B1 (ko) * 2011-02-28 2014-11-28 동아대학교 산학협력단 Ｓｉｒ－ＦＯＸＯ 신호전달체계 활성인자를 포함하는 퇴행성 신경질환 치료용 조성물
JP2016507538A (ja) * 2013-02-07 2016-03-10 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 置換キノキサリン誘導体およびｍＧｌｕＲ４の正のアロステリックモジュレーターとしてのそれらの使用
JP2016041680A (ja) * 2014-04-25 2016-03-31 森永製菓株式会社 サーチュイン発現増強剤
JP2016094406A (ja) * 2014-11-06 2016-05-26 森永製菓株式会社 アストロサイト分化誘導剤及びｇｆａｐ発現誘導剤
JP2016518448A (ja) * 2013-05-13 2016-06-23 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ サーチュイン調節剤としての置換架橋尿素類似体
US9512096B2 (en) 2011-12-22 2016-12-06 Knopp Biosciences, LLP Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
JP2017206526A (ja) * 2011-06-29 2017-11-24 ザ ジェネラル ホスピタル コーポレイション 雌性生殖細胞における生体エネルギー状態を増強するための組成物及び方法
JP2018517728A (ja) * 2015-06-15 2018-07-05 ラッシュ・ユニバーシティ・メディカル・センター 脳由来のＰＰＡＲαリガンド
US10028940B2 (en) 2013-08-13 2018-07-24 Knopp Biosciences Llc Compositions and methods for treating plasma cell disorders and B-cell prolymphocytic disorders
KR101922903B1 (ko) 2016-03-11 2018-11-28 전북대학교산학협력단 항신경변성 천연물 소재의 스크리닝 방법
US10195183B2 (en) 2013-08-13 2019-02-05 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
US10383857B2 (en) 2013-07-12 2019-08-20 Knopp Biosciences Llc Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils
WO2020145331A1 (ja) * 2019-01-09 2020-07-16 公立大学法人大阪 神経変性疾患の予防又は治療薬
WO2020153434A1 (ja) * 2019-01-25 2020-07-30 第一三共株式会社 ピラゾール化合物
JP2022523919A (ja) * 2019-02-05 2022-04-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 神経変性疾患を治療するための物質および方法
JP2022150176A (ja) * 2021-03-26 2022-10-07 国立大学法人九州大学 サーチュイン活性化剤、食品、および化粧品

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WO2005069998A2 (en) * 2004-01-20 2005-08-04 Brigham Young University Technology Transfer Office Novel sirtuin activating compounds and methods for making the same
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WO2020153434A1 (ja) * 2019-01-25 2020-07-30 第一三共株式会社 ピラゾール化合物
JP2022523919A (ja) * 2019-02-05 2022-04-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 神経変性疾患を治療するための物質および方法
JP2022150176A (ja) * 2021-03-26 2022-10-07 国立大学法人九州大学 サーチュイン活性化剤、食品、および化粧品

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WO2006076681A2 (en) 2006-07-20
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