FR3015287B1 - Combinaison de bezafibrate et de resveratrol pour le traitement et la prevention des maladies impliquant un dysfonctionnement energetique des mitochondries. - Google Patents
Combinaison de bezafibrate et de resveratrol pour le traitement et la prevention des maladies impliquant un dysfonctionnement energetique des mitochondries.Info
- Publication number
- FR3015287B1 FR3015287B1 FR1363027A FR1363027A FR3015287B1 FR 3015287 B1 FR3015287 B1 FR 3015287B1 FR 1363027 A FR1363027 A FR 1363027A FR 1363027 A FR1363027 A FR 1363027A FR 3015287 B1 FR3015287 B1 FR 3015287B1
- Authority
- FR
- France
- Prior art keywords
- bezafibrate
- resveratrol
- treatment
- combination
- diseases involving
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 title abstract 3
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 title abstract 3
- IIBYAHWJQTYFKB-UHFFFAOYSA-N bezafibrate Chemical compound C1=CC(OC(C)(C)C(O)=O)=CC=C1CCNC(=O)C1=CC=C(Cl)C=C1 IIBYAHWJQTYFKB-UHFFFAOYSA-N 0.000 title abstract 3
- 229960000516 bezafibrate Drugs 0.000 title abstract 3
- 229940016667 resveratrol Drugs 0.000 title abstract 3
- 235000021283 resveratrol Nutrition 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 230000004064 dysfunction Effects 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title 1
- 210000003470 mitochondria Anatomy 0.000 abstract 2
- 230000006735 deficit Effects 0.000 abstract 1
- 150000004668 long chain fatty acids Chemical class 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000035806 respiratory chain Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
Abstract
La présente invention concerne l'utilisation combinée du bézafibrate et du resvératrol pour le traitement des maladies impliquant un dysfonctionnement énergétique des mitochondries, ainsi qu'un kit pharmaceutique comprenant à la fois du bézafibrate et du resvératrol. La combinaison est plus particulièrement utilisée dans le traitement des déficits modérés de la β-oxydation des acides gras à chaîne longue ou de la chaîne respiratoire des mitochondries.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1363027A FR3015287B1 (fr) | 2013-12-19 | 2013-12-19 | Combinaison de bezafibrate et de resveratrol pour le traitement et la prevention des maladies impliquant un dysfonctionnement energetique des mitochondries. |
PCT/EP2014/078910 WO2015092043A1 (fr) | 2013-12-19 | 2014-12-19 | Combinaison de bézafibrate et de resvératrol ou de dérivés de resvératrol pour le traitement et la prévention des maladies impliquant un dysfonctionnement énergétique des mitochondries |
US15/105,116 US10376484B2 (en) | 2013-12-19 | 2014-12-19 | Combination of bezafibrate and of resveratrol or resveratrol derivatives for the treatment and prevention of diseases involving a mitochondrial energy dysfunction |
EP14815388.5A EP3082780A1 (fr) | 2013-12-19 | 2014-12-19 | Combinaison de bézafibrate et de resvératrol ou de dérivés de resvératrol pour le traitement et la prévention des maladies impliquant un dysfonctionnement énergétique des mitochondries |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1363027A FR3015287B1 (fr) | 2013-12-19 | 2013-12-19 | Combinaison de bezafibrate et de resveratrol pour le traitement et la prevention des maladies impliquant un dysfonctionnement energetique des mitochondries. |
Publications (2)
Publication Number | Publication Date |
---|---|
FR3015287A1 FR3015287A1 (fr) | 2015-06-26 |
FR3015287B1 true FR3015287B1 (fr) | 2016-12-23 |
Family
ID=50489245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR1363027A Expired - Fee Related FR3015287B1 (fr) | 2013-12-19 | 2013-12-19 | Combinaison de bezafibrate et de resveratrol pour le traitement et la prevention des maladies impliquant un dysfonctionnement energetique des mitochondries. |
Country Status (4)
Country | Link |
---|---|
US (1) | US10376484B2 (fr) |
EP (1) | EP3082780A1 (fr) |
FR (1) | FR3015287B1 (fr) |
WO (1) | WO2015092043A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4085906A1 (fr) * | 2021-05-06 | 2022-11-09 | Universite De Bordeaux | Composition comprenant un modulateur de ppar et un dérivé d'urolithine et ses utilisations |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003255893A1 (en) * | 2002-09-03 | 2004-03-29 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | USE OF A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPAR $f(a)) AGONIST FOR THE TREATMENT OF CARNITINE PALMITOYL TRANSFERASE-2 DEFICIENCIES |
US20060276393A1 (en) | 2005-01-13 | 2006-12-07 | Sirtris Pharmaceuticals, Inc. | Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders |
US20120016037A1 (en) * | 2006-07-24 | 2012-01-19 | Frank Toppo | Method for prevention and treatment of Alzheimers |
WO2008157537A2 (fr) * | 2007-06-19 | 2008-12-24 | Ironwood Pharmaceuticals, Inc | Compositions et procédés d'utilisation pour traiter ou prévenir des troubles liés aux lipides |
US8815936B2 (en) | 2008-03-03 | 2014-08-26 | Nad Life Pty Ltd | Pharmaceutical formulations of resveratrol and methods of use thereof for treating cell disorders |
KR20120112973A (ko) * | 2011-04-04 | 2012-10-12 | 전남대학교산학협력단 | 비만 또는 제 2형 당뇨의 예방 또는 치료용 조성물 |
WO2013071077A1 (fr) * | 2011-11-09 | 2013-05-16 | Cornell University | Utilisation d'agonistes pan-ppar pour la prévention et le traitement de la maladie de huntington et de tauopathies |
-
2013
- 2013-12-19 FR FR1363027A patent/FR3015287B1/fr not_active Expired - Fee Related
-
2014
- 2014-12-19 US US15/105,116 patent/US10376484B2/en active Active
- 2014-12-19 EP EP14815388.5A patent/EP3082780A1/fr not_active Withdrawn
- 2014-12-19 WO PCT/EP2014/078910 patent/WO2015092043A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
FR3015287A1 (fr) | 2015-06-26 |
WO2015092043A1 (fr) | 2015-06-25 |
EP3082780A1 (fr) | 2016-10-26 |
US20160317483A1 (en) | 2016-11-03 |
US10376484B2 (en) | 2019-08-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PLFP | Fee payment |
Year of fee payment: 3 |
|
PLFP | Fee payment |
Year of fee payment: 4 |
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PLFP | Fee payment |
Year of fee payment: 5 |
|
PLFP | Fee payment |
Year of fee payment: 6 |
|
ST | Notification of lapse |
Effective date: 20200910 |