JP2008526996A5 - - Google Patents
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- Publication number
- JP2008526996A5 JP2008526996A5 JP2007551428A JP2007551428A JP2008526996A5 JP 2008526996 A5 JP2008526996 A5 JP 2008526996A5 JP 2007551428 A JP2007551428 A JP 2007551428A JP 2007551428 A JP2007551428 A JP 2007551428A JP 2008526996 A5 JP2008526996 A5 JP 2008526996A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- group
- alkyl
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 38
- 125000000623 heterocyclic group Chemical group 0.000 claims description 36
- 229910052739 hydrogen Inorganic materials 0.000 claims description 29
- 239000001257 hydrogen Substances 0.000 claims description 29
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims description 26
- 125000003118 aryl group Chemical group 0.000 claims description 25
- 125000003342 alkenyl group Chemical group 0.000 claims description 20
- 125000000304 alkynyl group Chemical group 0.000 claims description 20
- 229910052736 halogen Inorganic materials 0.000 claims description 9
- 150000002367 halogens Chemical class 0.000 claims description 9
- 125000004429 atom Chemical group 0.000 claims description 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 5
- 125000003107 substituted aryl group Chemical group 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims 23
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 claims 10
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 230000001404 mediated effect Effects 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 8
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 102100022718 Atypical chemokine receptor 2 Human genes 0.000 claims 3
- 101000678892 Homo sapiens Atypical chemokine receptor 2 Proteins 0.000 claims 3
- 101000716070 Homo sapiens C-C chemokine receptor type 9 Proteins 0.000 claims 3
- 125000006585 (C6-C10) arylene group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
- 206010063725 Idiopathic pneumonia syndrome Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 230000001760 anti-analgesic effect Effects 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 208000007915 ichthyosis prematurity syndrome Diseases 0.000 claims 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 4
- 241000257303 Hymenoptera Species 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64410305P | 2005-01-14 | 2005-01-14 | |
| US60/644,103 | 2005-01-14 | ||
| US74282105P | 2005-12-06 | 2005-12-06 | |
| US60/742,821 | 2005-12-06 | ||
| US75098505P | 2005-12-16 | 2005-12-16 | |
| US60/750,985 | 2005-12-16 | ||
| PCT/US2006/001341 WO2006076644A2 (en) | 2005-01-14 | 2006-01-13 | Heteroaryl sulfonamides and ccr2 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008526996A JP2008526996A (ja) | 2008-07-24 |
| JP2008526996A5 true JP2008526996A5 (enExample) | 2012-05-17 |
| JP5253815B2 JP5253815B2 (ja) | 2013-07-31 |
Family
ID=36678244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007551428A Active JP5253815B2 (ja) | 2005-01-14 | 2006-01-13 | ヘテロアリールスルホンアミドおよびｃｃｒ２ |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060173019A1 (enExample) |
| EP (3) | EP2474532A1 (enExample) |
| JP (1) | JP5253815B2 (enExample) |
| AT (1) | ATE503741T1 (enExample) |
| AU (1) | AU2006204750C1 (enExample) |
| CA (1) | CA2594726C (enExample) |
| DE (1) | DE602006020979D1 (enExample) |
| DK (2) | DK1838674T3 (enExample) |
| ES (1) | ES2440965T3 (enExample) |
| IL (1) | IL184539A (enExample) |
| MX (1) | MX2007008474A (enExample) |
| PL (2) | PL1838674T3 (enExample) |
| WO (1) | WO2006076644A2 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2402310A1 (en) | 2002-05-24 | 2012-01-04 | Millennium Pharmaceuticals, Inc. | CCR9 inhibitors and methods of use thereof |
| CA2500492C (en) | 2002-11-18 | 2010-03-16 | Solomon Ungashe | Aryl sulfonamides |
| EP1748989A2 (en) * | 2004-05-12 | 2007-02-07 | ChemoCentryx Inc | Aryl sulfonamides |
| US7622583B2 (en) * | 2005-01-14 | 2009-11-24 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
| EP1871374B1 (en) * | 2005-04-21 | 2011-09-14 | Merck Serono SA | 2,3 substituted pyrazine sulfonamides as inhibitors of crth2 |
| GB0524786D0 (en) * | 2005-12-05 | 2006-01-11 | Glaxo Group Ltd | Compounds |
| GB0526445D0 (en) * | 2005-12-23 | 2006-02-08 | Novartis Ag | Organic compounds |
| US7718683B2 (en) | 2006-07-14 | 2010-05-18 | Chemocentryx, Inc. | Triazolyl phenyl benzenesulfonamides |
| US8519135B2 (en) * | 2006-07-14 | 2013-08-27 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2/CCR9 |
| WO2008008374A2 (en) * | 2006-07-14 | 2008-01-17 | Chemocentryx, Inc. | Ccr2 inhibitors and methods of use thereof |
| US7683176B2 (en) * | 2006-07-14 | 2010-03-23 | Chemocentryx, Inc. | Triazolyl pyridyl benzenesulfonamides |
| US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
| CA2677096A1 (en) * | 2007-01-31 | 2008-08-07 | Vertex Pharmaceuticals Incorporated | Kinase inhibitors |
| US7776877B2 (en) * | 2007-06-22 | 2010-08-17 | Chemocentryx, Inc. | N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides |
| JP5306344B2 (ja) | 2007-07-12 | 2013-10-02 | ケモセントリックス， インコーポレイテッド | 炎症の治療のためのｃｃｒ２モジュレーターとしての縮合ヘテロアリールピリジルおよびフェニルベンゼンスルホンアミド |
| WO2009126675A1 (en) * | 2008-04-09 | 2009-10-15 | Boehringer Ingelheim International Gmbh | 2-sulfonylamino-4-heteroaryl butyramide antagonists of ccr10 |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| HRP20150355T1 (hr) | 2009-01-12 | 2015-06-19 | Pfizer Limited | Sulfonamidni derivati |
| EP2590972B1 (en) | 2010-07-09 | 2015-01-21 | Pfizer Limited | N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels |
| KR101890443B1 (ko) * | 2010-08-03 | 2018-09-28 | 닛뽕 케미파 가부시키가이샤 | Ｐ2ｘ4 수용체 길항제 |
| RU2654213C9 (ru) | 2010-12-16 | 2018-06-25 | Аллерган, Инк. | Новые 1,2-бис-сульфонамидные производные как модуляторы хемокинового рецептора |
| CA2822039C (en) * | 2010-12-16 | 2019-05-28 | Allergan, Inc. | Sulfur derivatives as chemokine receptor modulators |
| US20140329809A1 (en) | 2011-10-28 | 2014-11-06 | Galderma Research & Development | New leukocyte infiltrate markers for rosacea and uses thereof |
| WO2013169889A1 (en) * | 2012-05-08 | 2013-11-14 | Anvyl Llc | Alpha 7 nicotinic acetylcholine receptor allosteric modulators, their derivatives and uses thereof |
| ES2735360T3 (es) | 2013-12-02 | 2019-12-18 | Chemocentryx Inc | Compuestos CCR6 |
| RS62639B1 (sr) | 2015-07-06 | 2021-12-31 | Alkermes Inc | Hetero-halo inhibitori histonskih deacetilaza |
| EP3319968A1 (en) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| RU2740902C2 (ru) | 2016-06-03 | 2021-01-21 | Хемоцентрикс, Инк. | Способ лечения фиброза печени |
| US10251888B2 (en) | 2016-06-13 | 2019-04-09 | Chemocentryx, Inc. | Method of treating pancreatic cancer |
| US10195188B2 (en) | 2016-06-13 | 2019-02-05 | Chemocentryx, Inc. | Method of treating pancreatic cancer |
| US10973809B2 (en) | 2016-11-23 | 2021-04-13 | Chemocentryx, Inc. | Method of treating focal segmental glomerulosclerosis |
| PT3562821T (pt) | 2016-12-28 | 2021-03-03 | Minoryx Therapeutics S L | Compostos de isoquinolina, métodos para a sua preparação e utilizações terapêuticas dos mesmos em condições associadas à alteração da atividade da beta-galactosidade |
| CN106854177B (zh) * | 2017-01-04 | 2019-10-11 | 苏州健雄职业技术学院 | 一种6-氯-4-羟基吡啶-3-甲醛的制备方法 |
| JP6756925B2 (ja) | 2017-01-11 | 2020-09-16 | ロダン・セラピューティクス，インコーポレーテッド | ヒストンデアセチラーゼの二環式阻害剤 |
| ES2914355T3 (es) | 2017-08-07 | 2022-06-09 | Alkermes Inc | Inhibidores bicíclicos de la histona desacetilasa |
| MX386699B (es) | 2017-10-11 | 2025-03-19 | Chemocentryx Inc | Tratamiento de glomerulosclerosis segmentaria focal con antagonistas ccr2 |
| EP3996711A4 (en) | 2019-07-10 | 2023-08-16 | ChemoCentryx, Inc. | Indanes as pd-l1 inhibitors |
| US11866429B2 (en) | 2019-10-16 | 2024-01-09 | Chemocentryx, Inc. | Heteroaryl-biphenyl amines for the treatment of PD-L1 diseases |
| KR20220084119A (ko) | 2019-10-16 | 2022-06-21 | 케모센트릭스, 인크. | Pd-l1 질환의 치료를 위한 헤테로아릴-바이페닐 아미드 |
| TW202237119A (zh) | 2020-12-10 | 2022-10-01 | 美商住友製藥腫瘤公司 | Ａｌｋ﹘５抑制劑和彼之用途 |
| CN113248427B (zh) * | 2021-06-01 | 2023-05-02 | 苏州大学 | 磺酰胺基烟酸衍生物、酰胺基烟酸衍生物及其制备方法和应用 |
| WO2023031308A1 (en) * | 2021-08-31 | 2023-03-09 | Artica Therapeutics B.V. | Ccr2 inhibitors |
| NL2037411B1 (en) * | 2024-04-08 | 2025-10-31 | Univ Leiden | Protac compounds |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3901855A (en) * | 1974-08-07 | 1975-08-26 | Us Air Force | Preparation of polybenzimidazoles |
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US4403607A (en) * | 1980-05-09 | 1983-09-13 | The Regents Of The University Of California | Compatible internal bone fixation plate |
| JPS61113060A (ja) * | 1984-11-08 | 1986-05-30 | Fuji Photo Film Co Ltd | ハロゲン化銀カラ−写真感光材料 |
| DE69129611T2 (de) * | 1990-08-20 | 1998-12-17 | Eisai Co., Ltd., Tokio/Tokyo | Sulfonamid-Derivate |
| JPH06135934A (ja) * | 1991-12-27 | 1994-05-17 | Ishihara Sangyo Kaisha Ltd | ピリジン誘導体又はその塩を含有するホスホリパーゼ▲ａ２▼阻害剤、抗炎症剤又は抗膵炎剤 |
| US5514555A (en) | 1993-03-12 | 1996-05-07 | Center For Blood Research, Inc. | Assays and therapeutic methods based on lymphocyte chemoattractants |
| US5571775A (en) * | 1994-07-11 | 1996-11-05 | Dowelanco | N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides |
| EP0896533B1 (en) * | 1996-02-22 | 2003-09-10 | Tularik, Inc. | Pentafluorobenzenesulfonamides and analogs |
| US5780488A (en) * | 1996-04-03 | 1998-07-14 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AR015104A1 (es) * | 1996-11-13 | 2001-04-18 | Dowelanco | Compuestos de n-arilsulfilimina sustituidos, utiles como catalizadores en la preparacion de compuestos de n-arilarilsulfonamida; proceso para preparar dichos compuestos y su uso para catalizar dicha preparacion. |
| GB9803228D0 (en) * | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
| EP0937711A1 (de) * | 1998-02-18 | 1999-08-25 | Roche Diagnostics GmbH | Neue Thiobenzamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel |
| JP4327915B2 (ja) * | 1998-03-30 | 2009-09-09 | 株式会社デ・ウエスタン・セラピテクス研究所 | スルフォンアミド誘導体 |
| US6380206B1 (en) * | 1998-11-23 | 2002-04-30 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with 4,5-diaminopyrimidine derivatives |
| JP2000159665A (ja) * | 1998-11-27 | 2000-06-13 | Nippon Kayaku Co Ltd | リウマチの予防または治療剤 |
| US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| EP1196408B1 (en) * | 1999-06-28 | 2004-09-15 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
| JP2001089412A (ja) * | 1999-09-22 | 2001-04-03 | Otsuka Pharmaceut Co Ltd | ベンゼン誘導体またはその医薬的に許容される塩 |
| AU2001243158A1 (en) * | 2000-02-18 | 2001-08-27 | Merck And Co., Inc. | Inhibitors of prenyl-protein transferase |
| JP2001335714A (ja) * | 2000-03-22 | 2001-12-04 | Fuji Photo Film Co Ltd | アゾ色素、その製造方法、インクジェット用インク、インクジェット記録方法 |
| US6525051B2 (en) * | 2000-03-27 | 2003-02-25 | Schering Aktiengesellschaft | N-heterocyclic derivatives as NOS inhibitors |
| JP2002036052A (ja) * | 2000-07-25 | 2002-02-05 | Sankyo Mfg Co Ltd | 自動工具交換装置 |
| JP4233092B2 (ja) | 2001-06-07 | 2009-03-04 | ケモセントリックス， インコーポレイテッド | 細胞移動アッセイ |
| US7468253B2 (en) | 2001-06-07 | 2008-12-23 | Chemocentryx, Inc. | Method for multiple chemokine receptor screening for antagonists using RAM assay |
| EP1453516A2 (de) * | 2001-10-17 | 2004-09-08 | Boehringer Ingelheim Pharma GmbH & Co.KG | 5-substituierte 4-amino-2-phenylamino-pyrimdinderivate und ihre verwendung als beta-amyloid modulatoren |
| WO2003051870A1 (en) * | 2001-12-18 | 2003-06-26 | Astrazeneca Ab | Novel compounds |
| AU2003220401A1 (en) * | 2002-03-18 | 2003-10-08 | Bristol-Myers Squibb Company | Uracil derivatives as inhibitors of tnf-alpha converting enzyme (tace) and matrix metalloproteinases |
| EP2402310A1 (en) * | 2002-05-24 | 2012-01-04 | Millennium Pharmaceuticals, Inc. | CCR9 inhibitors and methods of use thereof |
| CA2500492C (en) * | 2002-11-18 | 2010-03-16 | Solomon Ungashe | Aryl sulfonamides |
| US20070021466A1 (en) * | 2002-11-18 | 2007-01-25 | Solomon Ungashe | CCR2 inhibitors and methods of use thereof |
| CA2510471A1 (en) * | 2002-12-19 | 2004-07-08 | Neurogen Corporation | Substituted biphenyl-4-carboxylic acid arylamide analogues as capsaicin receptor modulators |
| AU2003290346A1 (en) * | 2002-12-24 | 2004-07-22 | Biofocus Plc | Compound libraries of 2,3-substituted pyrazine derivatives capable of binding to g-protein coupled receptors |
| JP2007500240A (ja) * | 2003-05-29 | 2007-01-11 | アボット・ラボラトリーズ | Ａｂｔ−７５１による持続投与レジメン |
| US7393873B2 (en) * | 2003-07-02 | 2008-07-01 | Merck & Co., Inc. | Arylsulfonamide derivatives |
| US7622583B2 (en) * | 2005-01-14 | 2009-11-24 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
| US9715915B2 (en) | 2014-10-30 | 2017-07-25 | Samsung Electronics Co., Ltd. | Magneto-resistive devices including a free layer having different magnetic properties during operations |
-
2006
- 2006-01-13 AT AT06718419T patent/ATE503741T1/de active
- 2006-01-13 US US11/332,786 patent/US20060173019A1/en not_active Abandoned
- 2006-01-13 AU AU2006204750A patent/AU2006204750C1/en active Active
- 2006-01-13 EP EP12162572A patent/EP2474532A1/en not_active Withdrawn
- 2006-01-13 DK DK06718419.2T patent/DK1838674T3/da active
- 2006-01-13 CA CA2594726A patent/CA2594726C/en active Active
- 2006-01-13 WO PCT/US2006/001341 patent/WO2006076644A2/en not_active Ceased
- 2006-01-13 EP EP06718419A patent/EP1838674B9/en active Active
- 2006-01-13 DK DK11002389.2T patent/DK2354126T3/da active
- 2006-01-13 DE DE602006020979T patent/DE602006020979D1/de active Active
- 2006-01-13 MX MX2007008474A patent/MX2007008474A/es active IP Right Grant
- 2006-01-13 JP JP2007551428A patent/JP5253815B2/ja active Active
- 2006-01-13 EP EP11002389.2A patent/EP2354126B1/en active Active
- 2006-01-13 PL PL06718419T patent/PL1838674T3/pl unknown
- 2006-01-13 ES ES11002389.2T patent/ES2440965T3/es active Active
- 2006-01-13 PL PL11002389T patent/PL2354126T3/pl unknown
-
2007
- 2007-07-11 IL IL184539A patent/IL184539A/en active IP Right Grant
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