JP2008526927A5 - - Google Patents
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- Publication number
- JP2008526927A5 JP2008526927A5 JP2007550797A JP2007550797A JP2008526927A5 JP 2008526927 A5 JP2008526927 A5 JP 2008526927A5 JP 2007550797 A JP2007550797 A JP 2007550797A JP 2007550797 A JP2007550797 A JP 2007550797A JP 2008526927 A5 JP2008526927 A5 JP 2008526927A5
- Authority
- JP
- Japan
- Prior art keywords
- oxycodone
- pain
- formulation
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 43
- 238000009472 formulation Methods 0.000 claims 40
- 239000000203 mixture Substances 0.000 claims 40
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims 36
- 229960002085 oxycodone Drugs 0.000 claims 36
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 28
- 239000003814 drug Substances 0.000 claims 16
- 229960005181 morphine Drugs 0.000 claims 14
- 208000009935 visceral pain Diseases 0.000 claims 14
- 208000002193 Pain Diseases 0.000 claims 8
- 238000002360 preparation method Methods 0.000 claims 7
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims 6
- 206010000087 Abdominal pain upper Diseases 0.000 claims 4
- 208000005171 Dysmenorrhea Diseases 0.000 claims 4
- 208000000112 Myalgia Diseases 0.000 claims 4
- 238000013270 controlled release Methods 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 208000004998 Abdominal Pain Diseases 0.000 claims 3
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 claims 3
- 229960004126 codeine Drugs 0.000 claims 3
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 claims 3
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims 3
- 229960000240 hydrocodone Drugs 0.000 claims 3
- 229960005118 oxymorphone Drugs 0.000 claims 3
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 claims 3
- 239000004925 Acrylic resin Substances 0.000 claims 2
- 229920000178 Acrylic resin Polymers 0.000 claims 2
- 206010003011 Appendicitis Diseases 0.000 claims 2
- 208000019399 Colonic disease Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 208000015877 Duodenal disease Diseases 0.000 claims 2
- 206010013935 Dysmenorrhoea Diseases 0.000 claims 2
- 208000037767 Gallbladder pain Diseases 0.000 claims 2
- 206010019705 Hepatic pain Diseases 0.000 claims 2
- 208000004550 Postoperative Pain Diseases 0.000 claims 2
- 206010038490 Renal pain Diseases 0.000 claims 2
- 238000012084 abdominal surgery Methods 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 238000004090 dissolution Methods 0.000 claims 2
- 230000002183 duodenal effect Effects 0.000 claims 2
- 208000018595 duodenum disease Diseases 0.000 claims 2
- 201000006549 dyspepsia Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000001130 gallstones Diseases 0.000 claims 2
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims 2
- 229960001410 hydromorphone Drugs 0.000 claims 2
- 208000008384 ileus Diseases 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 239000008024 pharmaceutical diluent Substances 0.000 claims 2
- 210000002784 stomach Anatomy 0.000 claims 2
- 208000018556 stomach disease Diseases 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 208000002881 Colic Diseases 0.000 claims 1
- 208000007914 Labor Pain Diseases 0.000 claims 1
- 208000035945 Labour pain Diseases 0.000 claims 1
- 206010035623 Pleuritic pain Diseases 0.000 claims 1
- 210000004224 pleura Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64549005P | 2005-01-18 | 2005-01-18 | |
| US60/645,490 | 2005-01-18 | ||
| PCT/EP2006/050252 WO2006077212A1 (en) | 2005-01-18 | 2006-01-17 | Use of oxycodone for treating visceral pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008526927A JP2008526927A (ja) | 2008-07-24 |
| JP2008526927A5 true JP2008526927A5 (https=) | 2009-02-05 |
| JP5049139B2 JP5049139B2 (ja) | 2012-10-17 |
Family
ID=35871217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007550797A Expired - Fee Related JP5049139B2 (ja) | 2005-01-18 | 2006-01-17 | 内臓痛を治療するためのオキシコドンの使用 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US20080200493A1 (https=) |
| EP (1) | EP1838318B1 (https=) |
| JP (1) | JP5049139B2 (https=) |
| KR (10) | KR20230170811A (https=) |
| CN (1) | CN101106996B (https=) |
| AP (1) | AP2249A (https=) |
| AR (1) | AR052880A1 (https=) |
| AT (2) | ATE446092T1 (https=) |
| AU (1) | AU2006207498B2 (https=) |
| BR (1) | BRPI0606247A2 (https=) |
| CA (1) | CA2595043C (https=) |
| CY (1) | CY1109660T1 (https=) |
| DE (2) | DE602006009899D1 (https=) |
| DK (2) | DK1838318T3 (https=) |
| EA (1) | EA013544B1 (https=) |
| ES (1) | ES2333901T3 (https=) |
| HR (1) | HRP20090679T1 (https=) |
| IL (1) | IL184530A (https=) |
| ME (1) | ME01066B (https=) |
| MX (1) | MX2007007207A (https=) |
| MY (1) | MY144471A (https=) |
| NO (1) | NO338968B1 (https=) |
| NZ (1) | NZ555852A (https=) |
| PL (1) | PL1838318T3 (https=) |
| PT (1) | PT1838318E (https=) |
| RS (1) | RS51069B (https=) |
| SI (1) | SI1838318T1 (https=) |
| TW (1) | TWI432196B (https=) |
| UA (1) | UA85471C2 (https=) |
| WO (1) | WO2006077212A1 (https=) |
| ZA (1) | ZA200705231B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3069731A1 (en) | 2005-11-14 | 2016-09-21 | Labrys Biologics Inc. | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| EP2155167A2 (en) | 2007-06-04 | 2010-02-24 | Egalet A/S | Controlled release pharmaceutical compositions for prolonged effect |
| RU2522493C2 (ru) | 2008-03-04 | 2014-07-20 | Пфайзер Лимитед | Способы лечения хронической боли |
| NZ594207A (en) | 2009-02-06 | 2013-03-28 | Egalet Ltd | Immediate release composition resistant to abuse by intake of alcohol |
| NZ597283A (en) | 2009-06-24 | 2013-07-26 | Egalet Ltd | Controlled release formulations |
| CN102740884A (zh) | 2009-08-28 | 2012-10-17 | 瑞纳神经科学公司 | 通过施用针对降钙素基因相关肽的拮抗性抗体来治疗内脏痛的方法 |
| PE20141787A1 (es) | 2011-05-20 | 2014-12-07 | Alderbio Holdings Llc | Composiciones anti-cgrp y uso de las mismas |
| TWI705825B (zh) | 2011-05-20 | 2020-10-01 | 美商艾爾德生物控股有限責任公司 | 抗降血鈣素基因相關胜肽（ａｎｔｉ－ｃｇｒｐ）或抗降血鈣素基因相關胜肽受器（ａｎｔｉ－ｃｇｒｐ－ｒ）抗體或抗體片段治療或預防慢性及急性型腹瀉之用途 |
| CN107827982B (zh) | 2011-05-20 | 2021-07-06 | H.伦德贝克公司 | 抗cgrp抗体和抗体片段用于在有需要的受试者中预防或抑制畏光或厌光的用途 |
| US20170114122A1 (en) | 2015-10-23 | 2017-04-27 | Alderbio Holdings Llc | Regulation of glucose metabolism using anti-cgrp antibodies |
| US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| AU2015230933B2 (en) | 2014-03-21 | 2020-08-13 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| CN109952314A (zh) | 2016-09-23 | 2019-06-28 | 泰瓦制药国际有限公司 | 治疗难治性偏头痛 |
| CA3115122A1 (en) | 2018-11-19 | 2020-05-28 | Jazz Pharmaceuticals Ireland Limited | Alcohol-resistant drug formulations |
| WO2020146527A1 (en) | 2019-01-08 | 2020-07-16 | Alder Biopharmaceuticals, Inc. | Acute treatment and rapid treatment of headache using anti-cgrp antibodies |
| CA3077973A1 (en) | 2020-04-06 | 2021-10-06 | H. Lundbeck A/S | Treatment of most bothersome symptom (mbs) associated with migraine using anti-cgrp antibodies |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5656295A (en) * | 1991-11-27 | 1997-08-12 | Euro-Celtique, S.A. | Controlled release oxycodone compositions |
| US5478577A (en) * | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
| US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| US5958459A (en) * | 1991-12-24 | 1999-09-28 | Purdue Pharma L.P. | Opioid formulations having extended controlled released |
| IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
| US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
| UA48219C2 (uk) * | 1996-03-25 | 2002-08-15 | Елі Ліллі Енд Компані | Композиція для вгамування болю (варіанти) та спосіб вгамування болю |
| UA81224C2 (uk) * | 2001-05-02 | 2007-12-25 | Euro Celtic S A | Дозована форма оксикодону та її застосування |
| US6992193B2 (en) * | 2003-06-10 | 2006-01-31 | Adolor Corporation | Sulfonylamino phenylacetamide derivatives and methods of their use |
-
2006
- 2006-01-05 TW TW095100458A patent/TWI432196B/zh not_active IP Right Cessation
- 2006-01-09 MY MYPI20060082A patent/MY144471A/en unknown
- 2006-01-17 EA EA200701541A patent/EA013544B1/ru not_active IP Right Cessation
- 2006-01-17 KR KR1020237042001A patent/KR20230170811A/ko not_active Ceased
- 2006-01-17 ES ES06700652T patent/ES2333901T3/es not_active Expired - Lifetime
- 2006-01-17 KR KR1020217034339A patent/KR20210131450A/ko not_active Ceased
- 2006-01-17 DE DE602006009899T patent/DE602006009899D1/de not_active Expired - Lifetime
- 2006-01-17 KR KR1020177004572A patent/KR20170021905A/ko not_active Ceased
- 2006-01-17 CA CA2595043A patent/CA2595043C/en not_active Expired - Lifetime
- 2006-01-17 EP EP06700652A patent/EP1838318B1/en not_active Expired - Lifetime
- 2006-01-17 KR KR1020147018838A patent/KR20140091782A/ko not_active Ceased
- 2006-01-17 JP JP2007550797A patent/JP5049139B2/ja not_active Expired - Fee Related
- 2006-01-17 KR KR1020077018905A patent/KR20070100368A/ko not_active Ceased
- 2006-01-17 US US11/814,020 patent/US20080200493A1/en not_active Abandoned
- 2006-01-17 BR BRPI0606247-4A patent/BRPI0606247A2/pt not_active Application Discontinuation
- 2006-01-17 KR KR1020197035201A patent/KR20190135557A/ko not_active Ceased
- 2006-01-17 KR KR1020127011713A patent/KR20120089710A/ko not_active Ceased
- 2006-01-17 PT PT06700652T patent/PT1838318E/pt unknown
- 2006-01-17 PL PL06700652T patent/PL1838318T3/pl unknown
- 2006-01-17 DK DK06700652T patent/DK1838318T3/da active
- 2006-01-17 KR KR1020227041445A patent/KR20220165797A/ko not_active Ceased
- 2006-01-17 KR KR1020087029312A patent/KR20080106991A/ko not_active Ceased
- 2006-01-17 AP AP2007004057A patent/AP2249A/xx active
- 2006-01-17 HR HR20090679T patent/HRP20090679T1/hr unknown
- 2006-01-17 SI SI200630538T patent/SI1838318T1/sl unknown
- 2006-01-17 DE DE202006019887U patent/DE202006019887U1/de not_active Expired - Lifetime
- 2006-01-17 WO PCT/EP2006/050252 patent/WO2006077212A1/en not_active Ceased
- 2006-01-17 ME MEP-2009-352A patent/ME01066B/me unknown
- 2006-01-17 UA UAA200708142A patent/UA85471C2/ru unknown
- 2006-01-17 AT AT06700652T patent/ATE446092T1/de active
- 2006-01-17 AU AU2006207498A patent/AU2006207498B2/en not_active Expired
- 2006-01-17 KR KR1020207031796A patent/KR20200128451A/ko not_active Ceased
- 2006-01-17 RS RSP-2009/0553A patent/RS51069B/sr unknown
- 2006-01-17 MX MX2007007207A patent/MX2007007207A/es active IP Right Grant
- 2006-01-17 NZ NZ555852A patent/NZ555852A/en unknown
- 2006-01-17 CN CN2006800024739A patent/CN101106996B/zh not_active Expired - Lifetime
- 2006-01-18 AR ARP060100177A patent/AR052880A1/es unknown
-
2007
- 2007-03-09 AT AT0014807U patent/AT9895U1/de not_active IP Right Cessation
- 2007-07-02 ZA ZA200705231A patent/ZA200705231B/xx unknown
- 2007-07-10 IL IL184530A patent/IL184530A/en active IP Right Grant
- 2007-07-24 DK DK200700207U patent/DK200700207U3/da not_active IP Right Cessation
- 2007-08-14 NO NO20074174A patent/NO338968B1/no not_active IP Right Cessation
-
2009
- 2009-12-16 CY CY20091101308T patent/CY1109660T1/el unknown
-
2014
- 2014-10-15 US US14/515,216 patent/US9271974B2/en not_active Expired - Lifetime
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