JP2008525530A5 - - Google Patents
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- JP2008525530A5 JP2008525530A5 JP2007549605A JP2007549605A JP2008525530A5 JP 2008525530 A5 JP2008525530 A5 JP 2008525530A5 JP 2007549605 A JP2007549605 A JP 2007549605A JP 2007549605 A JP2007549605 A JP 2007549605A JP 2008525530 A5 JP2008525530 A5 JP 2008525530A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- compound
- aryl
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 37
- 150000001875 compounds Chemical class 0.000 claims 25
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 14
- 125000003545 alkoxy group Chemical group 0.000 claims 12
- 208000035475 disorder Diseases 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 125000002877 alkyl aryl group Chemical group 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 230000002062 proliferating effect Effects 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 5
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 4
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 230000005764 inhibitory process Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 208000010305 Epidermal Cyst Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 208000017338 epidermoid cysts Diseases 0.000 claims 2
- 201000005787 hematologic cancer Diseases 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 230000003463 hyperproliferative effect Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000000813 microbial effect Effects 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 206010000830 Acute leukaemia Diseases 0.000 claims 1
- 208000003200 Adenoma Diseases 0.000 claims 1
- 206010001233 Adenoma benign Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010012426 Dermal cyst Diseases 0.000 claims 1
- 208000001154 Dermoid Cyst Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 102000016621 Focal Adhesion Protein-Tyrosine Kinases Human genes 0.000 claims 1
- 108010067715 Focal Adhesion Protein-Tyrosine Kinases Proteins 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 206010024612 Lipoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025219 Lymphangioma Diseases 0.000 claims 1
- 206010027145 Melanocytic naevus Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000004304 Myofibromatosis Diseases 0.000 claims 1
- 241000232901 Nephroma Species 0.000 claims 1
- 208000007256 Nevus Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000030852 Parasitic disease Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000034541 Rare lymphatic malformation Diseases 0.000 claims 1
- 206010043276 Teratoma Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 208000001969 capillary hemangioma Diseases 0.000 claims 1
- 201000002797 childhood leukemia Diseases 0.000 claims 1
- 208000024207 chronic leukemia Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 201000011066 hemangioma Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 201000011489 infantile myofibromatosis Diseases 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 230000001926 lymphatic effect Effects 0.000 claims 1
- 208000003747 lymphoid leukemia Diseases 0.000 claims 1
- 208000019420 lymphoid neoplasm Diseases 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 208000025351 nephroma Diseases 0.000 claims 1
- 230000011164 ossification Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000010626 plasma cell neoplasm Diseases 0.000 claims 1
- 201000008261 skin carcinoma Diseases 0.000 claims 1
- 102000009076 src-Family Kinases Human genes 0.000 claims 1
- 108010087686 src-Family Kinases Proteins 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63983404P | 2004-12-28 | 2004-12-28 | |
| US60/639,834 | 2004-12-28 | ||
| US70455105P | 2005-08-01 | 2005-08-01 | |
| US60/704,551 | 2005-08-01 | ||
| US72734105P | 2005-10-17 | 2005-10-17 | |
| US60/727,341 | 2005-10-17 | ||
| PCT/US2005/047333 WO2006071960A2 (en) | 2004-12-28 | 2005-12-28 | Compositions and methods of treating cell proliferation disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012009251A Division JP2012082222A (ja) | 2004-12-28 | 2012-01-19 | 細胞増殖性障害を処置する組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008525530A JP2008525530A (ja) | 2008-07-17 |
| JP2008525530A5 true JP2008525530A5 (OSRAM) | 2009-02-19 |
| JP5124285B2 JP5124285B2 (ja) | 2013-01-23 |
Family
ID=36615518
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007549605A Expired - Lifetime JP5124285B2 (ja) | 2004-12-28 | 2005-12-28 | 細胞増殖性障害を処置する組成物および方法 |
| JP2012009251A Withdrawn JP2012082222A (ja) | 2004-12-28 | 2012-01-19 | 細胞増殖性障害を処置する組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012009251A Withdrawn JP2012082222A (ja) | 2004-12-28 | 2012-01-19 | 細胞増殖性障害を処置する組成物および方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US7300931B2 (OSRAM) |
| EP (1) | EP1836169B9 (OSRAM) |
| JP (2) | JP5124285B2 (OSRAM) |
| KR (2) | KR101328273B1 (OSRAM) |
| CN (2) | CN101184734B (OSRAM) |
| AT (1) | ATE544748T1 (OSRAM) |
| AU (1) | AU2005321966B2 (OSRAM) |
| BE (1) | BE2021C001I2 (OSRAM) |
| BR (1) | BRPI0519424B8 (OSRAM) |
| CA (1) | CA2594345C (OSRAM) |
| CY (1) | CY2022001I2 (OSRAM) |
| DK (1) | DK1836169T5 (OSRAM) |
| ES (1) | ES2382068T3 (OSRAM) |
| FR (1) | FR21C1064I2 (OSRAM) |
| HU (1) | HUS2100051I1 (OSRAM) |
| LU (1) | LUC00235I2 (OSRAM) |
| NL (1) | NL301145I2 (OSRAM) |
| PL (1) | PL1836169T3 (OSRAM) |
| WO (1) | WO2006071960A2 (OSRAM) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0519424B8 (pt) | 2004-12-28 | 2021-05-25 | Athenex Inc | compostos, composição e uso dos ditos compostos para a preparação de um medicamento para prevenção ou tratamento de um distúrbio de proliferação celular ou infecção microbiana |
| US7968574B2 (en) * | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
| CA2595607C (en) | 2005-01-25 | 2014-07-15 | Epix Delaware, Inc. | Substituted arylamine compounds and their use as 5-ht6 modulators |
| DK2041071T3 (da) * | 2006-06-29 | 2014-09-01 | Kinex Pharmaceuticals Llc | Biarylsammensætninger og fremgangsmåder til modulering af en kinasekaskade |
| CA2656564C (en) * | 2006-06-29 | 2015-06-16 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
| US20210198202A1 (en) * | 2006-12-28 | 2021-07-01 | Athenex, Inc. | Compositions for modulating a kinase cascade and methods of use thereof |
| AU2014200559B2 (en) * | 2006-12-28 | 2016-05-26 | Atnx Spv, Llc | Composition and Methods for Modulating a Kinase Cascade |
| TWI457336B (zh) * | 2006-12-28 | 2014-10-21 | Kinex Pharmaceuticals Llc | 調節激酶級聯之組成物及方法 |
| US7939529B2 (en) * | 2007-05-17 | 2011-05-10 | Kinex Pharmaceuticals, Llc | Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof |
| US7935697B2 (en) | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
| US20100256147A1 (en) * | 2007-04-13 | 2010-10-07 | Hangauer Jr David G | Biaryl acetamide derivatives as modulators of the kinase cascade for the treatment of hearing loss, osteoporosis and cell proliferation disorders |
| AU2014202221B2 (en) * | 2007-05-17 | 2016-06-23 | Atnx Spv, Llc | Process for the Preparation of Compositions for Modulating a Kinase Cascade and Methods of Use Thereof |
| JP5679811B2 (ja) * | 2007-05-17 | 2015-03-04 | キネックス ファーマシューティカルズ， エルエルシー | キナーゼカスケードを調節するための組成物の調製のための方法ならびにその使用方法 |
| WO2009009041A2 (en) * | 2007-07-06 | 2009-01-15 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
| EP3777832A1 (en) * | 2007-10-20 | 2021-02-17 | Athenex, Inc. | Pharmaceutical compositions for modulating a kinase cascade and methods of use thereof |
| US8598165B2 (en) * | 2007-11-26 | 2013-12-03 | University Of Kansas | Morpholines as selective inhibitors of cytochrome P450 2A13 |
| JP5693239B2 (ja) | 2008-01-23 | 2015-04-01 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ４−ピリジノン化合物および癌についてのその使用 |
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| AU2011276193B2 (en) | 2010-07-05 | 2015-01-22 | Merck Patent Gmbh | Bipyridyl derivatives useful for the treatment of kinase - induced diseases |
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| UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
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| JP6437452B2 (ja) | 2013-01-14 | 2018-12-12 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物 |
| ME03780B (me) | 2013-01-15 | 2021-04-20 | Incyte Holdings Corp | Jedinjenja tiazolkarboksamida i piridinkarboksamida korisna kao inhibitori pim kinaze |
| PE20151939A1 (es) | 2013-03-14 | 2016-01-08 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante |
| EA201690458A1 (ru) | 2013-08-23 | 2016-07-29 | Инсайт Корпорейшн | Фуро- и тиенопиридинкарбоксамиды, используемые в качестве ингибиторов pim-киназы |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| CR20170093A (es) * | 2014-09-10 | 2017-07-17 | Glaxosmithkline Ip Dev Ltd | Nuevos compuestos como inhibidores de ret (reorganizado durante la transfección) |
| WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
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| CN106902357B (zh) * | 2015-12-21 | 2021-08-03 | 广州市香雪制药股份有限公司 | 药物组合物及其应用、药物包合物、静脉制剂及制备方法 |
| CN106902358B (zh) | 2015-12-21 | 2020-07-10 | 广州市香雪制药股份有限公司 | 口服制剂及其制备方法 |
| CN110023310B (zh) | 2016-08-12 | 2024-05-10 | 阿西纳斯公司 | 用于调节激酶级联的联芳组合物和方法 |
| CN106810490A (zh) * | 2017-02-06 | 2017-06-09 | 重庆泰润制药有限公司 | 一种二芳基化合物的晶型及其制备方法和应用 |
| BR112019018687A2 (pt) | 2017-03-10 | 2020-04-07 | Athenex, Inc. | métodos de tratamento e/ou prevenção da ceratose actínica |
| MX388196B (es) | 2017-04-26 | 2025-03-19 | Basilea Pharm Int Ag | Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. |
| US10669236B2 (en) | 2017-09-07 | 2020-06-02 | Athenex HK Innovative Limited | Solid forms of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide |
| WO2019113487A1 (en) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| CN113117376B (zh) * | 2019-12-30 | 2022-08-19 | 中国科学院高能物理研究所 | 一种邻菲罗啉衍生的萃取剂及其制法和应用 |
| CN113461665B (zh) * | 2020-03-31 | 2023-05-19 | 成都赜灵生物医药科技有限公司 | 二芳基衍生物及其制备方法和用途 |
| CN113354575B (zh) * | 2021-06-07 | 2022-09-27 | 河南应用技术职业学院 | 一种特班布林的合成方法 |
| EP4186890A1 (en) | 2021-11-29 | 2023-05-31 | Moehs Ibérica, S.L. | Preparation of n-benzyl-2-(5-bromo-pyridin-2-yl)-acetamide for the synthesis of tirbanibulin |
| EP4444429A1 (en) | 2021-12-09 | 2024-10-16 | Deciphera Pharmaceuticals, LLC | Raf kinase inhibitors and methods of use thereof |
| WO2023134753A1 (zh) * | 2022-01-14 | 2023-07-20 | 武汉人福创新药物研发中心有限公司 | 微管蛋白-src双靶点抑制剂 |
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| WO2023134751A1 (zh) * | 2022-01-14 | 2023-07-20 | 武汉人福创新药物研发中心有限公司 | 微管蛋白-Src双靶点抑制剂和用途 |
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-
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- 2005-12-28 CA CA2594345A patent/CA2594345C/en not_active Expired - Lifetime
- 2005-12-28 ES ES05855828T patent/ES2382068T3/es not_active Expired - Lifetime
- 2005-12-28 CN CN2005800487967A patent/CN101184734B/zh not_active Expired - Lifetime
- 2005-12-28 JP JP2007549605A patent/JP5124285B2/ja not_active Expired - Lifetime
- 2005-12-28 AT AT05855828T patent/ATE544748T1/de active
- 2005-12-28 DK DK05855828.9T patent/DK1836169T5/da active
- 2005-12-28 CN CN201310139459.5A patent/CN103274961B/zh not_active Expired - Lifetime
- 2005-12-28 WO PCT/US2005/047333 patent/WO2006071960A2/en not_active Ceased
- 2005-12-28 AU AU2005321966A patent/AU2005321966B2/en active Active
- 2005-12-28 US US11/321,419 patent/US7300931B2/en active Active
- 2005-12-28 EP EP05855828A patent/EP1836169B9/en not_active Expired - Lifetime
- 2005-12-28 KR KR1020077017102A patent/KR101328273B1/ko not_active Expired - Lifetime
- 2005-12-28 PL PL05855828T patent/PL1836169T3/pl unknown
- 2005-12-28 KR KR1020137015670A patent/KR101478933B1/ko not_active Expired - Lifetime
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- 2007-04-26 US US11/796,200 patent/US8003641B2/en active Active
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- 2010-11-19 US US12/950,764 patent/US8980890B2/en not_active Expired - Lifetime
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- 2012-01-19 JP JP2012009251A patent/JP2012082222A/ja not_active Withdrawn
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