JP2008524998A5 - - Google Patents
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- JP2008524998A5 JP2008524998A5 JP2007547391A JP2007547391A JP2008524998A5 JP 2008524998 A5 JP2008524998 A5 JP 2008524998A5 JP 2007547391 A JP2007547391 A JP 2007547391A JP 2007547391 A JP2007547391 A JP 2007547391A JP 2008524998 A5 JP2008524998 A5 JP 2008524998A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- psa
- prostate cancer
- amount
- ratio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 206010060862 Prostate cancer Diseases 0.000 claims description 50
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 44
- 108091033411 PCA3 Proteins 0.000 claims description 43
- 150000007523 nucleic acids Chemical class 0.000 claims description 38
- 239000012472 biological sample Substances 0.000 claims description 27
- 108020004999 messenger RNA Proteins 0.000 claims description 14
- 108020004707 nucleic acids Proteins 0.000 claims description 12
- 102000039446 nucleic acids Human genes 0.000 claims description 12
- 108091034117 Oligonucleotide Proteins 0.000 claims description 9
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 9
- 230000003321 amplification Effects 0.000 claims description 8
- 238000003556 assay Methods 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 238000003752 polymerase chain reaction Methods 0.000 claims description 3
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 45
- 102000007066 Prostate-Specific Antigen Human genes 0.000 claims 45
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 23
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 238000004393 prognosis Methods 0.000 claims 6
- 230000002596 correlated effect Effects 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 3
- 210000002307 prostate Anatomy 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 238000011156 evaluation Methods 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 230000004614 tumor growth Effects 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 238000001574 biopsy Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000006073 displacement reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000007834 ligase chain reaction Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000002250 progressing effect Effects 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 description 4
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000003757 reverse transcription PCR Methods 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 239000003155 DNA primer Substances 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2,491,067 | 2004-12-24 | ||
| CA002491067A CA2491067A1 (en) | 2004-12-24 | 2004-12-24 | Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer |
| US71955705P | 2005-09-23 | 2005-09-23 | |
| US60/719,557 | 2005-09-23 | ||
| PCT/EP2005/014021 WO2006066965A2 (en) | 2004-12-24 | 2005-12-23 | Mrna ratios in urinary sediments and/or urine as a prognostic and/or theranostic marker for prostate cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008524998A JP2008524998A (ja) | 2008-07-17 |
| JP2008524998A5 true JP2008524998A5 (enExample) | 2009-02-12 |
| JP4944041B2 JP4944041B2 (ja) | 2012-05-30 |
Family
ID=36636708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007547391A Expired - Lifetime JP4944041B2 (ja) | 2004-12-24 | 2005-12-23 | 前立腺癌の予後判定用マーカー及び／又はテラノスティックマーカーとなる、尿沈渣及び／又は尿のｍＲＮＡ比 |
Country Status (12)
| Country | Link |
|---|---|
| US (8) | US7960109B2 (enExample) |
| EP (3) | EP2226394B1 (enExample) |
| JP (1) | JP4944041B2 (enExample) |
| AT (1) | ATE457362T1 (enExample) |
| AU (1) | AU2005318369B2 (enExample) |
| CA (2) | CA2491067A1 (enExample) |
| DE (1) | DE602005019294D1 (enExample) |
| DK (1) | DK1761651T3 (enExample) |
| ES (2) | ES2340513T3 (enExample) |
| IL (1) | IL183476A0 (enExample) |
| WO (1) | WO2006066965A2 (enExample) |
| ZA (1) | ZA200703746B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| ES2324503T3 (es) | 1997-04-10 | 2009-08-07 | Stichting Katholieke Universiteit University Medical Centre Nijmegen | Pca3, genes pca3 y metodos de uso. |
| JP2003510075A (ja) * | 1999-09-29 | 2003-03-18 | ディグノキュアー・インコーポレーテッド | 良性および悪性の前立腺組織におけるｐｃａ３メッセンジャーｒｎａ種 |
| JP4824540B2 (ja) | 2003-02-07 | 2011-11-30 | ダイアノキュアー インク． | サンプル中の前立腺癌を検出する方法 |
| US11105808B2 (en) | 2004-11-12 | 2021-08-31 | Health Discovery Corporation | Methods for screening, predicting and monitoring prostate cancer |
| CA2491067A1 (en) | 2004-12-24 | 2006-06-24 | Stichting Katholieke Universiteit | Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer |
| WO2007109321A2 (en) | 2006-03-20 | 2007-09-27 | The Regents Of The University Of California | Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting |
| JP4943074B2 (ja) * | 2006-07-03 | 2012-05-30 | シスメックス株式会社 | がん転移の判定方法及び装置 |
| CA2698343C (en) | 2007-09-04 | 2018-06-12 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection |
| US20090226912A1 (en) * | 2007-12-21 | 2009-09-10 | Wake Forest University Health Sciences | Methods and compositions for correlating genetic markers with prostate cancer risk |
| US7888035B2 (en) | 2008-10-30 | 2011-02-15 | Caris Mpi, Inc. | Methods for assessing RNA patterns |
| GB2465088C (en) * | 2008-10-30 | 2016-01-27 | Caris Mpi Inc | miRNA expression in the characterisation and classification of cancer |
| EP3181705A1 (en) * | 2008-11-12 | 2017-06-21 | Caris Life Sciences Switzerland Holdings GmbH | Methods and systems of using exosomes for determining phenotypes |
| EP2398504B1 (en) | 2009-02-17 | 2018-11-28 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| JP2010233542A (ja) * | 2009-03-31 | 2010-10-21 | Kanazawa Univ | Ｒａｇｅ遺伝子の２種類のスプライシングバリアントを区別して増幅可能なプライマーセット及びプローブ |
| EP2320234A1 (en) | 2009-11-06 | 2011-05-11 | IMG Institut für medizinische Genomforschung Planungsgesellschaft M.B.H. | Marker combination for prostate cancer diagnosis |
| EP2320235A1 (en) | 2009-11-06 | 2011-05-11 | IMG Institut für medizinische Genomforschung Planungsgesellschaft M.B.H. | Marker for prostate cancer diagnosis |
| US8772459B2 (en) | 2009-12-02 | 2014-07-08 | Imaginab, Inc. | J591 minibodies and Cys-diabodies for targeting human prostate specific membrane antigen (PSMA) and methods for their use |
| CN103237901B (zh) | 2010-03-01 | 2016-08-03 | 卡里斯生命科学瑞士控股有限责任公司 | 用于治疗诊断的生物标志物 |
| CA2795776A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
| TWI655356B (zh) * | 2010-04-16 | 2019-04-01 | 美商亨特道格拉斯公司 | 製造捲簾之方法 |
| US9732389B2 (en) | 2010-09-03 | 2017-08-15 | Wake Forest University Health Sciences | Methods and compositions for correlating genetic markers with prostate cancer risk |
| ES2541054T3 (es) * | 2010-10-20 | 2015-07-15 | Université De Bordeaux | Firmas del resultado clínico en tumores estromales gastrointestinales y método de tratamiento de tumores estromales gastrointestinales |
| US9534256B2 (en) | 2011-01-06 | 2017-01-03 | Wake Forest University Health Sciences | Methods and compositions for correlating genetic markers with risk of aggressive prostate cancer |
| EP2748335B1 (en) * | 2011-08-22 | 2018-10-03 | Exosome Diagnostics, Inc. | Urine biomarkers |
| EP2574929A1 (en) | 2011-09-28 | 2013-04-03 | IMG Institut für medizinische Genomforschung Planungsgesellschaft M.B.H. | Marker in diagnosing prostate cancer (PC) |
| US10301681B2 (en) * | 2013-08-06 | 2019-05-28 | Exosome Diagnostics, Inc. | Methods of treating a subject with a high gleason score prostate cancer |
| CA2935720A1 (en) | 2014-01-16 | 2015-07-23 | Illumina, Inc. | Gene expression panel for prognosis of prostate cancer recurrence |
| US9994912B2 (en) | 2014-07-03 | 2018-06-12 | Abbott Molecular Inc. | Materials and methods for assessing progression of prostate cancer |
| JP6877340B2 (ja) | 2014-11-06 | 2021-05-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | 血栓溶解剤の存在下における粘弾性解析を用いた新規病態の確認 |
| US11187710B2 (en) | 2015-06-08 | 2021-11-30 | The Regents Of The University Of Colorado, A Body Corporate | Time independent viscoelastic analysis parameter for prediction of patient outcome |
| ES3020458T3 (en) | 2015-08-07 | 2025-05-22 | Imaginab Inc | Antigen binding constructs to target molecules |
| WO2017091640A1 (en) | 2015-11-24 | 2017-06-01 | The Johns Hopkins University | Raman spectroscopy reporters and methods for molecular imaging of tissue in vivo |
| EP3455366A4 (en) | 2016-05-11 | 2020-02-26 | Michael P. Chapman | ANALYSIS OF VISCOELASTICITY IN PATIENTS WITH A DISEASE ASSOCIATED WITH THE CARDIOVASCULAR SYSTEM |
| CA3023839A1 (en) * | 2016-05-13 | 2017-11-16 | F. Hoffmann-La Roche Ag | Detection of met exon 14 deletions and associated therapies |
| US11266745B2 (en) | 2017-02-08 | 2022-03-08 | Imaginab, Inc. | Extension sequences for diabodies |
| CN111655833A (zh) * | 2017-11-13 | 2020-09-11 | 株式会社理光 | 检测判断装置 |
| WO2019169336A1 (en) * | 2018-03-02 | 2019-09-06 | The Johns Hopkins University | Methods for prostate cancer detection |
| CN110423797A (zh) * | 2019-07-11 | 2019-11-08 | 杨海涛 | 一种前列腺癌pca3基因双重实时pcr的引物、方法及试剂盒 |
| CN114743593B (zh) * | 2022-06-13 | 2023-02-24 | 北京橡鑫生物科技有限公司 | 一种基于尿液进行前列腺癌早期筛查模型的构建方法、筛查模型及试剂盒 |
Family Cites Families (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2422956A1 (fr) | 1978-04-13 | 1979-11-09 | Pasteur Institut | Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4690890A (en) | 1984-04-04 | 1987-09-01 | Cetus Corporation | Process for simultaneously detecting multiple antigens using dual sandwich immunometric assay |
| US4786600A (en) | 1984-05-25 | 1988-11-22 | The Trustees Of Columbia University In The City Of New York | Autocatalytic replication of recombinant RNA |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| WO1987002671A1 (en) | 1985-11-01 | 1987-05-07 | International Genetic Engineering, Inc. | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US4851331A (en) | 1986-05-16 | 1989-07-25 | Allied Corporation | Method and kit for polynucleotide assay including primer-dependant DNA polymerase |
| FR2602592B1 (fr) | 1986-08-06 | 1989-06-30 | Alain Baret | Utilisation du systeme enzymatique xanthine-oxydase en immuno-analyse, procedes de dosage correspondants et coffrets de reactifs necessaires pour la mise en oeuvre de ces procedes. |
| US5541308A (en) | 1986-11-24 | 1996-07-30 | Gen-Probe Incorporated | Nucleic acid probes for detection and/or quantitation of non-viral organisms |
| US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| US5149625A (en) | 1987-08-11 | 1992-09-22 | President And Fellows Of Harvard College | Multiplex analysis of DNA |
| US5639604A (en) | 1987-09-21 | 1997-06-17 | Gen-Probe Incorporated | Homogeneous protection assay |
| US5283174A (en) | 1987-09-21 | 1994-02-01 | Gen-Probe, Incorporated | Homogenous protection assay |
| US5585481A (en) | 1987-09-21 | 1996-12-17 | Gen-Probe Incorporated | Linking reagents for nucleotide probes |
| CA1323293C (en) | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| US5002867A (en) | 1988-04-25 | 1991-03-26 | Macevicz Stephen C | Nucleic acid sequence determination by multiple mixed oligonucleotide probes |
| NL8801147A (nl) | 1988-05-02 | 1989-12-01 | Tno | Werkwijze voor het detecteren van genetische variatie, en daarvoor geschikte kit. |
| DK167254B1 (da) | 1988-07-21 | 1993-09-27 | Hartmann As Brdr | Fremgangsmaade til fremstilling af formede genstande af et fluidiseret cellulosefibermateriale |
| US5183949A (en) | 1988-09-22 | 1993-02-02 | The United States Of America As Represented By The Department Of Health And Human Services | Rabbit model for diagnosing and testing vaccines or therapeutic agents against aids |
| US5118801A (en) | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| US5219989A (en) | 1988-12-13 | 1993-06-15 | Mcgill University | Bifunctional protein for the isolation of capped mRNA |
| US5082670A (en) | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
| US5175383A (en) | 1989-02-17 | 1992-12-29 | President And Fellows Of Harvard College | Animal model for benign prostatic disease |
| US5112736A (en) | 1989-06-14 | 1992-05-12 | University Of Utah | Dna sequencing using fluorescence background electroblotting membrane |
| US5656207A (en) | 1989-06-24 | 1997-08-12 | Gen Probe Incorporated | Detecting or quantifying multiple analytes using labelling techniques |
| US5174986A (en) | 1989-07-05 | 1992-12-29 | Genpharm International, Inc. | Method for determining oncogenic potential of a chemical compound |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| IE911869A1 (en) | 1990-06-01 | 1991-12-04 | Regeneron Pharma | A family of map2 protein kinases |
| AU662906B2 (en) | 1991-06-26 | 1995-09-21 | F. Hoffmann-La Roche Ag | Methods for detection of carcinoma metastases by nucleic acid amplification |
| CA2082411A1 (en) | 1991-06-28 | 1992-12-29 | Robert D. Rosenberg | Localized oligonucleotide therapy |
| WO1993003743A1 (en) | 1991-08-16 | 1993-03-04 | The General Hospital Corporation | Method of gene delivery to post-mitotic cells |
| WO1993008845A1 (en) | 1991-11-08 | 1993-05-13 | Massachusetts Institute Of Technology | Localized oligonucleotide therapy |
| EP0618972A1 (en) | 1991-12-16 | 1994-10-12 | E.I. Du Pont De Nemours And Company | CONSTITUTIVE EXPRESSION OF P450SOY AND FERREDOXIN-SOY IN $i(STREPTOMYCES), AND BIOTRANSFORMATION OF CHEMICALS BY RECOMBINANT ORGANISMS |
| DK1695979T3 (da) | 1991-12-24 | 2011-10-10 | Isis Pharmaceuticals Inc | Gappede modificerede oligonukleotider |
| CA2135073C (en) | 1992-05-06 | 2002-11-19 | Daniel L. Kacian | Nucleic acid sequence amplification method, composition and kit |
| US5674682A (en) | 1992-10-29 | 1997-10-07 | Thomas Jefferson University | Nucleic acid primers for detecting micrometastasis of prostate cancer |
| EP1757694A3 (en) | 1992-11-05 | 2008-02-27 | Sloan Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
| US5503980A (en) | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
| US5773705A (en) | 1992-12-31 | 1998-06-30 | Wisconsin Alumni Research Foundation | Ubiquitin fusion protein system for protein production in plants |
| CA2153158A1 (en) | 1993-01-07 | 1994-07-21 | Andrew Zalewski | Antisense inhibition of c-myc to modulate the proliferation of smooth muscle cells |
| US5422252A (en) | 1993-06-04 | 1995-06-06 | Becton, Dickinson And Company | Simultaneous amplification of multiple targets |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US5861242A (en) | 1993-06-25 | 1999-01-19 | Affymetrix, Inc. | Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same |
| US6323184B1 (en) | 1993-10-15 | 2001-11-27 | Thomas Jefferson University | Arteriovenous and venous graft treatments: methods and compositions |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| JPH09510351A (ja) | 1994-03-16 | 1997-10-21 | ジェン−プローブ・インコーポレイテッド | 等温鎖置換核酸増幅法 |
| EP0760006A1 (en) | 1994-04-15 | 1997-03-05 | The Trustees Of Columbia University In The City Of New York | Method for molecular staging of prostate cancer |
| US6169169B1 (en) | 1994-05-19 | 2001-01-02 | Dako A/S | PNA probes for detection of Neisseria gonorrhoeae and Chlamydia trachomatis |
| AU3889595A (en) | 1994-10-05 | 1996-05-02 | Amgen, Inc. | Method for inhibiting smooth muscle cell proliferation and oligonucleotides for use therein |
| DE69535240T2 (de) | 1994-10-28 | 2007-06-06 | Gen-Probe Inc., San Diego | Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen |
| US5919652A (en) | 1994-11-09 | 1999-07-06 | The Regents Of The University Of California | Nucleic acid molecules comprising the prostate specific antigen (PSA) promoter and uses thereof |
| DE19513152A1 (de) | 1995-04-07 | 1996-10-10 | Bundesrep Deutschland | Verwendung eines "Immundefizienzvirus-supprimierenden Lymphokins (ISL)" zur Hemmung der Virusvermehrung, insbesondere von Retroviren |
| US5731148A (en) | 1995-06-07 | 1998-03-24 | Gen-Probe Incorporated | Adduct protection assay |
| EP0912767B1 (en) | 1996-07-16 | 2006-09-13 | Gen-Probe Incorporated | Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific tm |
| US6479263B1 (en) | 1996-11-14 | 2002-11-12 | Baylor College Of Medicine | Method for detection of micrometastatic prostate cancer |
| US6261562B1 (en) | 1997-02-25 | 2001-07-17 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| US6395278B1 (en) | 1997-02-25 | 2002-05-28 | Corixa Corporation | Prostate specific fusion protein compositions |
| US6800746B2 (en) | 1997-02-25 | 2004-10-05 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6465611B1 (en) | 1997-02-25 | 2002-10-15 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| EP1005546A2 (en) | 1997-02-25 | 2000-06-07 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| ES2324503T3 (es) | 1997-04-10 | 2009-08-07 | Stichting Katholieke Universiteit University Medical Centre Nijmegen | Pca3, genes pca3 y metodos de uso. |
| US6534273B2 (en) | 1997-05-02 | 2003-03-18 | Gen-Probe Incorporated | Two-step hybridization and capture of a polynucleotide |
| DK0975807T3 (da) | 1997-05-02 | 2007-01-29 | Gen Probe Inc | To-trins hybridisering og indfangning af et polynukleotid |
| AU732455C (en) * | 1997-05-08 | 2002-09-05 | Merck Sharp & Dohme Limited | Substituted 1,2,4-triazolo{3,4-a}phthalazine derivatives as gaba alpha 5 ligands |
| DE69841989D1 (de) | 1997-05-30 | 2010-12-16 | Trovagene Inc | Verfahren zur Bestimmung von Nukleinsäuresequenzen in Urin |
| US20020035244A1 (en) | 1997-09-09 | 2002-03-21 | Maurice Cohen | Reagents and methods useful for detecting diseases of the prostate |
| US6124120A (en) | 1997-10-08 | 2000-09-26 | Yale University | Multiple displacement amplification |
| US6200765B1 (en) * | 1998-05-04 | 2001-03-13 | Pacific Northwest Cancer Foundation | Non-invasive methods to detect prostate cancer |
| TR200100916T2 (enExample) | 1998-07-14 | 2002-06-21 | Corixa@@Corporation | |
| US6037130A (en) | 1998-07-28 | 2000-03-14 | The Public Health Institute Of The City Of New York, Inc. | Wavelength-shifting probes and primers and their use in assays and kits |
| EP1151142A2 (en) | 1999-01-28 | 2001-11-07 | Gen-Probe Incorporated | Nucleic acid sequences for detecting genetic markers for cancer in a biological sample |
| FI990382A0 (fi) | 1999-02-23 | 1999-02-23 | Arctic Partners Oy Ab | Uusi diagnostinen menetelmä |
| US6528260B1 (en) | 1999-03-25 | 2003-03-04 | Genset, S.A. | Biallelic markers related to genes involved in drug metabolism |
| DE60044350D1 (de) | 1999-03-26 | 2010-06-17 | Jackson H M Found Military Med | Prostata-spezifisches gen pcgem1 und methoden zu dessen verwendung zur erkennung, behandlung und prävention von prostatakrebs |
| JP2003510075A (ja) | 1999-09-29 | 2003-03-18 | ディグノキュアー・インコーポレーテッド | 良性および悪性の前立腺組織におけるｐｃａ３メッセンジャーｒｎａ種 |
| AU7859900A (en) | 1999-10-04 | 2001-05-10 | Corixa Corporation | Compositions and methods for wt1 specific immunotherapy |
| AU7994200A (en) | 1999-10-04 | 2001-05-10 | Corixa Corporation | Compositions and methods for therapy and diagnosis of prostate cancer |
| JP2004537252A (ja) | 1999-11-12 | 2004-12-16 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
| AU784444B2 (en) | 1999-12-17 | 2006-04-06 | Bio Merieux | Process for labeling a nucleic acid |
| HUP0203968A3 (en) | 2000-01-14 | 2004-09-28 | Corixa Corp Seattle | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US20020168638A1 (en) | 2000-01-24 | 2002-11-14 | Robert Schlegel | Compositions, kits, and methods for identification, assessment, prevention, and therapy of human prostate cancer |
| WO2001060860A2 (en) | 2000-02-17 | 2001-08-23 | Millennium Predictive Medicine, Inc. | Genes differentially expressed in human prostate cancer and their use |
| EP1311673A2 (en) | 2000-03-27 | 2003-05-21 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| FR2810114B1 (fr) | 2000-06-13 | 2002-08-23 | Bio Merieux | Methode, procede, test immunologique et kit de diagnostic d'un adenocarcinome de la prostate ou d'une hypertrophie benigne de la prostate |
| AU2001292842A1 (en) | 2000-09-19 | 2002-04-02 | Diadexus, Inc. | Compositions and methods relating to prostate specific genes and proteins |
| EP1474528A4 (en) | 2000-10-13 | 2006-06-14 | Protein Design Labs Inc | METHODS FOR DIAGNOSING PROSTATE CANCER, COMPOSITIONS AND METHODS FOR SCREENING PROSTATE CANCER MODULATORS |
| US6897024B2 (en) | 2001-05-31 | 2005-05-24 | Stichting Katholieke Universiteit More Particularly The University Medical Centre Nijmegen | Nucleic acid molecules comprising the promoter for PCA3, and uses thereof |
| JP4824540B2 (ja) * | 2003-02-07 | 2011-11-30 | ダイアノキュアー インク． | サンプル中の前立腺癌を検出する方法 |
| CA2432365A1 (en) | 2003-06-30 | 2004-12-30 | Jack A. Schalken | Specific method of prostate cancer detection based on pca3, and kits therefore |
| CA2491067A1 (en) * | 2004-12-24 | 2006-06-24 | Stichting Katholieke Universiteit | Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer |
-
2004
- 2004-12-24 CA CA002491067A patent/CA2491067A1/en not_active Abandoned
-
2005
- 2005-12-23 ES ES05843726T patent/ES2340513T3/es not_active Expired - Lifetime
- 2005-12-23 DK DK05843726.0T patent/DK1761651T3/da active
- 2005-12-23 US US11/794,048 patent/US7960109B2/en active Active
- 2005-12-23 JP JP2007547391A patent/JP4944041B2/ja not_active Expired - Lifetime
- 2005-12-23 EP EP10152258.9A patent/EP2226394B1/en not_active Expired - Lifetime
- 2005-12-23 AT AT05843726T patent/ATE457362T1/de active
- 2005-12-23 DE DE602005019294T patent/DE602005019294D1/de not_active Expired - Lifetime
- 2005-12-23 AU AU2005318369A patent/AU2005318369B2/en active Active
- 2005-12-23 CA CA2594125A patent/CA2594125C/en not_active Expired - Lifetime
- 2005-12-23 EP EP10181472A patent/EP2325334A1/en not_active Withdrawn
- 2005-12-23 ES ES10152258.9T patent/ES2546193T3/es not_active Expired - Lifetime
- 2005-12-23 WO PCT/EP2005/014021 patent/WO2006066965A2/en not_active Ceased
- 2005-12-23 EP EP05843726A patent/EP1761651B1/en not_active Expired - Lifetime
-
2007
- 2007-05-09 ZA ZA200703746A patent/ZA200703746B/xx unknown
- 2007-05-28 IL IL183476A patent/IL183476A0/en unknown
-
2011
- 2011-05-05 US US13/101,440 patent/US8257924B2/en not_active Expired - Lifetime
-
2012
- 2012-08-09 US US13/571,124 patent/US20120309007A1/en not_active Abandoned
-
2013
- 2013-06-10 US US13/914,303 patent/US9096907B2/en not_active Expired - Lifetime
-
2015
- 2015-06-22 US US14/745,955 patent/US20150307948A1/en not_active Abandoned
-
2016
- 2016-04-13 US US15/097,758 patent/US9951390B2/en not_active Expired - Lifetime
-
2018
- 2018-03-16 US US15/924,040 patent/US10752957B2/en not_active Expired - Lifetime
-
2020
- 2020-08-24 US US17/001,352 patent/US20200392588A1/en not_active Abandoned
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