JP2010501162A5 - - Google Patents

Info

Publication number

JP2010501162A5

JP2010501162A5 JP2009524367A JP2009524367A JP2010501162A5 JP 2010501162 A5 JP2010501162 A5 JP 2010501162A5 JP 2009524367 A JP2009524367 A JP 2009524367A JP 2009524367 A JP2009524367 A JP 2009524367A JP 2010501162 A5 JP2010501162 A5 JP 2010501162A5

Authority

JP

Japan

Prior art keywords

imp

gene

lung cancer

detecting

expression level

Prior art date

2007-08-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 claims description 66
• 101710150697 Inositol monophosphatase 1 Proteins 0.000 claims description 46
• 101710126181 Insulin-like growth factor 2 mRNA-binding protein 1 Proteins 0.000 claims description 46
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 34
• 201000005202 lung cancer Diseases 0.000 claims description 34
• 208000020816 lung neoplasm Diseases 0.000 claims description 34
• 239000002773 nucleotide Substances 0.000 claims description 26
• 125000003729 nucleotide group Chemical group 0.000 claims description 26
• 102100029083 Minor histocompatibility antigen H13 Human genes 0.000 claims description 23
• 108091081021 Sense strand Proteins 0.000 claims description 21
• 230000000692 anti-sense effect Effects 0.000 claims description 19
• 108091028664 Ribonucleotide Proteins 0.000 claims description 16
• 239000002336 ribonucleotide Substances 0.000 claims description 16
• 125000002652 ribonucleotide group Chemical group 0.000 claims description 16
• 239000003814 drug Substances 0.000 claims description 13
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 13
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 13
• 239000012472 biological sample Substances 0.000 claims description 12
• 229940124597 therapeutic agent Drugs 0.000 claims description 12
• 210000004027 cell Anatomy 0.000 claims description 11
• 108090000623 proteins and genes Proteins 0.000 claims description 11
• 230000000295 complement effect Effects 0.000 claims description 8
• 108091033319 polynucleotide Proteins 0.000 claims description 8
• 239000002157 polynucleotide Substances 0.000 claims description 8
• 102000040430 polynucleotide Human genes 0.000 claims description 8
• 108020004459 Small interfering RNA Proteins 0.000 claims description 7
• 108020004999 messenger RNA Proteins 0.000 claims description 7
• 108091034117 Oligonucleotide Proteins 0.000 claims description 6
• 230000004071 biological effect Effects 0.000 claims description 6
• 238000004393 prognosis Methods 0.000 claims description 6
• 206010028980 Neoplasm Diseases 0.000 claims description 5
• 201000011510 cancer Diseases 0.000 claims description 5
• 210000002919 epithelial cell Anatomy 0.000 claims description 4
• 238000009396 hybridization Methods 0.000 claims description 4
• 108020004707 nucleic acids Proteins 0.000 claims description 4
• 102000039446 nucleic acids Human genes 0.000 claims description 4
• 150000007523 nucleic acids Chemical class 0.000 claims description 4
• 102000004169 proteins and genes Human genes 0.000 claims description 4
• 238000001514 detection method Methods 0.000 claims description 3
• 108020004414 DNA Proteins 0.000 claims description 2
• 238000010837 poor prognosis Methods 0.000 claims description 2
• 239000000523 sample Substances 0.000 claims description 2
• 239000003153 chemical reaction reagent Substances 0.000 claims 2
• 230000007423 decrease Effects 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 description 20
• 108090000765 processed proteins & peptides Proteins 0.000 description 9
• 239000012634 fragment Substances 0.000 description 8
• 229920001184 polypeptide Polymers 0.000 description 8
• 102000004196 processed proteins & peptides Human genes 0.000 description 8
• 108700008625 Reporter Genes Proteins 0.000 description 3
• 230000000694 effects Effects 0.000 description 2
• 230000001105 regulatory effect Effects 0.000 description 2
• 230000002103 transcriptional effect Effects 0.000 description 2
• 101710150707 Inositol monophosphatase 2 Proteins 0.000 description 1
• 101710126176 Insulin-like growth factor 2 mRNA-binding protein 2 Proteins 0.000 description 1
• 206010036790 Productive cough Diseases 0.000 description 1
• 102100030403 Signal peptide peptidase-like 2A Human genes 0.000 description 1
• 108050005900 Signal peptide peptidase-like 2a Proteins 0.000 description 1
• 102100023501 Signal peptide peptidase-like 3 Human genes 0.000 description 1
• 101710111748 Signal peptide peptidase-like 3 Proteins 0.000 description 1
• 239000004480 active ingredient Substances 0.000 description 1
• 239000000427 antigen Substances 0.000 description 1
• 108091007433 antigens Proteins 0.000 description 1
• 102000036639 antigens Human genes 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 150000001875 compounds Chemical class 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 208000024794 sputum Diseases 0.000 description 1
• 210000003802 sputum Anatomy 0.000 description 1
• 208000024891 symptom Diseases 0.000 description 1