JP2013500001A5 - - Google Patents
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- Publication number
- JP2013500001A5 JP2013500001A5 JP2012520964A JP2012520964A JP2013500001A5 JP 2013500001 A5 JP2013500001 A5 JP 2013500001A5 JP 2012520964 A JP2012520964 A JP 2012520964A JP 2012520964 A JP2012520964 A JP 2012520964A JP 2013500001 A5 JP2013500001 A5 JP 2013500001A5
- Authority
- JP
- Japan
- Prior art keywords
- gmip
- ikbke
- endometrial cancer
- level
- p4hb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000523 sample Substances 0.000 claims 23
- 206010014733 Endometrial cancer Diseases 0.000 claims 22
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 22
- 102100034265 GEM-interacting protein Human genes 0.000 claims 20
- 101710102635 GEM-interacting protein Proteins 0.000 claims 20
- 101100508538 Homo sapiens IKBKE gene Proteins 0.000 claims 20
- 102100021857 Inhibitor of nuclear factor kappa-B kinase subunit epsilon Human genes 0.000 claims 20
- 101001072202 Homo sapiens Protein disulfide-isomerase Proteins 0.000 claims 19
- 102100036352 Protein disulfide-isomerase Human genes 0.000 claims 19
- 239000000090 biomarker Substances 0.000 claims 19
- 229920002791 poly-4-hydroxybutyrate Polymers 0.000 claims 19
- 238000002405 diagnostic procedure Methods 0.000 claims 15
- 238000000338 in vitro Methods 0.000 claims 15
- 102100028067 EGF-containing fibulin-like extracellular matrix protein 2 Human genes 0.000 claims 13
- 101001060248 Homo sapiens EGF-containing fibulin-like extracellular matrix protein 2 Proteins 0.000 claims 13
- 102100024784 Suppressor of cytokine signaling 2 Human genes 0.000 claims 11
- 102100036725 Epithelial discoidin domain-containing receptor 1 Human genes 0.000 claims 10
- 101710131668 Epithelial discoidin domain-containing receptor 1 Proteins 0.000 claims 10
- 101000687808 Homo sapiens Suppressor of cytokine signaling 2 Proteins 0.000 claims 10
- 102100037789 FAST kinase domain-containing protein 1, mitochondrial Human genes 0.000 claims 9
- 101000878541 Homo sapiens FAST kinase domain-containing protein 1, mitochondrial Proteins 0.000 claims 9
- 108020004999 messenger RNA Proteins 0.000 claims 9
- 102100035218 Epidermal growth factor receptor kinase substrate 8-like protein 2 Human genes 0.000 claims 8
- 101000876686 Homo sapiens Epidermal growth factor receptor kinase substrate 8-like protein 2 Proteins 0.000 claims 8
- 239000012530 fluid Substances 0.000 claims 8
- 101001122747 Homo sapiens Protein phosphatase 1 regulatory subunit 16A Proteins 0.000 claims 7
- 102100028722 Protein phosphatase 1 regulatory subunit 16A Human genes 0.000 claims 7
- 230000000295 complement effect Effects 0.000 claims 7
- 239000002299 complementary DNA Substances 0.000 claims 7
- 101000616738 Homo sapiens NAD-dependent protein deacetylase sirtuin-6 Proteins 0.000 claims 6
- 102100021840 NAD-dependent protein deacetylase sirtuin-6 Human genes 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 101001098179 Homo sapiens P2X purinoceptor 4 Proteins 0.000 claims 4
- 101000731078 Homo sapiens Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Proteins 0.000 claims 4
- 102100037601 P2X purinoceptor 4 Human genes 0.000 claims 4
- 102100032391 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Human genes 0.000 claims 4
- 102100039217 3-ketoacyl-CoA thiolase, peroxisomal Human genes 0.000 claims 3
- 102100034531 AP-1 complex subunit mu-2 Human genes 0.000 claims 3
- 102100033473 Cingulin Human genes 0.000 claims 3
- 102100040322 E3 ubiquitin-protein ligase RNF183 Human genes 0.000 claims 3
- 101000670146 Homo sapiens 3-ketoacyl-CoA thiolase, peroxisomal Proteins 0.000 claims 3
- 101000924636 Homo sapiens AP-1 complex subunit mu-2 Proteins 0.000 claims 3
- 101000944124 Homo sapiens Cingulin Proteins 0.000 claims 3
- 101001104297 Homo sapiens E3 ubiquitin-protein ligase RNF183 Proteins 0.000 claims 3
- 101001064427 Homo sapiens Liprin-beta-2 Proteins 0.000 claims 3
- 101000712974 Homo sapiens Ras association domain-containing protein 7 Proteins 0.000 claims 3
- 101000785517 Homo sapiens Tight junction protein ZO-3 Proteins 0.000 claims 3
- 102100031981 Liprin-beta-2 Human genes 0.000 claims 3
- -1 PKHG2 Proteins 0.000 claims 3
- 102100033241 Ras association domain-containing protein 7 Human genes 0.000 claims 3
- 102100026640 Tight junction protein ZO-3 Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102100035784 Decorin Human genes 0.000 claims 1
- 101001000206 Homo sapiens Decorin Proteins 0.000 claims 1
- 101710137422 Suppressor of cytokine signaling 2 Proteins 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000002357 endometrial effect Effects 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 238000003753 real-time PCR Methods 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09166398 | 2009-07-24 | ||
| EP09166398.9 | 2009-07-24 | ||
| PCT/EP2010/004550 WO2011009637A2 (en) | 2009-07-24 | 2010-07-23 | Markers for endometrial cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013500001A JP2013500001A (ja) | 2013-01-07 |
| JP2013500001A5 true JP2013500001A5 (enExample) | 2013-09-05 |
| JP5934093B2 JP5934093B2 (ja) | 2016-06-15 |
Family
ID=42751506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012520964A Expired - Fee Related JP5934093B2 (ja) | 2009-07-24 | 2010-07-23 | 子宮内膜がんのマーカー |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9046522B2 (enExample) |
| EP (2) | EP2848700B1 (enExample) |
| JP (1) | JP5934093B2 (enExample) |
| KR (1) | KR101828290B1 (enExample) |
| CN (2) | CN105132529A (enExample) |
| AU (1) | AU2010275699B2 (enExample) |
| BR (1) | BR112012001469B1 (enExample) |
| CA (1) | CA2767914C (enExample) |
| DK (1) | DK2456889T3 (enExample) |
| ES (2) | ES2654340T3 (enExample) |
| HR (1) | HRP20141062T1 (enExample) |
| IN (1) | IN2012DN00707A (enExample) |
| MX (1) | MX2012000921A (enExample) |
| PL (1) | PL2456889T3 (enExample) |
| PT (1) | PT2456889E (enExample) |
| RU (1) | RU2596394C2 (enExample) |
| WO (1) | WO2011009637A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2012DN00707A (enExample) * | 2009-07-24 | 2015-06-19 | Geadic Biotec Aie | |
| WO2013044187A2 (en) * | 2011-09-22 | 2013-03-28 | Memorial Sloan-Kettering Cancer Center | Detecting ovarian cancer |
| EP2787350A1 (en) * | 2013-04-05 | 2014-10-08 | Atlas Antibodies AB | ASRGL1 in endometrial cancer |
| KR102113310B1 (ko) * | 2013-09-03 | 2020-05-20 | 아주대학교 산학협력단 | 암 세포 분리용 조성물, 키트 및 이를 이용한 분리 방법 |
| CA2956723C (en) | 2014-08-12 | 2023-04-11 | Nextgen Jane, Inc. | System and method for monitoring health based on collected bodily fluid |
| ES2897782T3 (es) * | 2014-09-17 | 2022-03-02 | Merck Patent Gmbh | Método de tratamiento de las enfermedades de la metástasis ósea, medicamentos para el tratamiento y método para predecir el resultado clínico del tratamiento de las enfermedades causadas por metástasis ósea |
| CN107102141A (zh) * | 2016-02-23 | 2017-08-29 | 中国科学院生物物理研究所 | 分子标记物cd71及在子宫内膜癌诊断、分期及预后中的应用 |
| EP3442706B1 (en) | 2016-04-13 | 2025-07-23 | NextGen Jane, Inc. | Sample collection and preservation methods |
| JP7240712B2 (ja) * | 2016-05-04 | 2023-03-16 | フンダシオ オスピタル ウニベルシタリ バル デブロン－インスティテュート デ レセルカ | 子宮内膜がんのマーカーとしてのｐｅｒｍ |
| GB201702392D0 (en) * | 2017-02-14 | 2017-03-29 | Univ Edinburgh | Methods for cancer diagnosis using a gene expression signature |
| CN108732351A (zh) * | 2017-04-20 | 2018-11-02 | 中国科学院上海生命科学研究院 | Eps8l2作为指示肝内结节及早期预警肝癌的生物标志物 |
| CN108732349A (zh) * | 2017-04-20 | 2018-11-02 | 中国科学院上海生命科学研究院 | Lta4h作为指示肝内结节及早期预警肝癌的生物标志物 |
| CN108732350A (zh) * | 2017-04-20 | 2018-11-02 | 中国科学院上海生命科学研究院 | Pla2g6作为指示肝内结节及早期预警肝癌的生物标志物 |
| CN109085359A (zh) * | 2017-06-13 | 2018-12-25 | 中国医学科学院肿瘤医院 | 血清蛋白标志物组合在结直肠癌筛查和诊治中的应用 |
| PT3655778T (pt) * | 2017-07-21 | 2023-08-18 | Fundacio Hospital Univ Vall Dhebron Institut De Recerca | Agrin como marcador de cancro do endométrio |
| JP2021526812A (ja) * | 2018-06-13 | 2021-10-11 | ２３イキガイ ピーティーイー リミテッド | 多能性幹細胞バイオマーカーを分析するための方法およびその実施 |
| CN109097462B (zh) * | 2018-09-10 | 2022-01-11 | 青岛市海慈医疗集团 | Ap1m2基因作为诊断青光眼的分子标志物的应用 |
| WO2020130190A1 (ko) * | 2018-12-20 | 2020-06-25 | 경상대학교병원 | 신장암의 발병 위험성 예측 또는 진단을 위한 정보제공방법 |
| EP3914163A4 (en) * | 2019-01-23 | 2022-04-13 | Gina-Life Diagnostics Ltd. | CANCER DIAGNOSTIC AND MONITORING APPARATUS, SYSTEMS AND METHODS |
| CN109797217A (zh) * | 2019-03-27 | 2019-05-24 | 河北医科大学第二医院 | 帕金森生物标志物及其在制备检测产品中的应用 |
| CN109811058B (zh) * | 2019-03-31 | 2021-11-12 | 青岛泱深生物医药有限公司 | 与宫颈疾病发生发展相关的生物标志物及其应用 |
| US20240218454A1 (en) * | 2021-04-22 | 2024-07-04 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Diagnostic to support clinical trial matching and exploratory biomarker analyses in cancer patients |
| CN114317750B (zh) * | 2021-12-29 | 2024-05-14 | 上海市第十人民医院 | 一种卵巢癌生物标志物及其在制备用于卵巢癌腹水转移疾病的药物或试剂盒中的应用 |
| KR102584898B1 (ko) * | 2022-10-24 | 2023-10-04 | 연세대학교 산학협력단 | 자궁내막암 진단 방법 및 이를 이용한 키트 |
| WO2024192014A1 (en) * | 2023-03-12 | 2024-09-19 | Novelna Inc. | Endometrial cancer detection proteins and methods of use thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| AUPO573697A0 (en) * | 1997-03-20 | 1997-04-10 | Prince Henry's Institute Of Medical Research | Diagnosis of endometrial cancer |
| US7014996B1 (en) * | 1998-10-02 | 2006-03-21 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating gynecologic cancers |
| AUPQ219799A0 (en) | 1999-08-13 | 1999-09-02 | R. Lurie Pty Ltd | Apparatus for obtaining potological samples |
| US6884578B2 (en) | 2000-03-31 | 2005-04-26 | Affymetrix, Inc. | Genes differentially expressed in secretory versus proliferative endometrium |
| RU2232397C2 (ru) * | 2002-04-03 | 2004-07-10 | НИИ онкологии им. проф. Н.Н. Петрова | Способ ранней диагностики патологических состояний эндометрия |
| US20040063120A1 (en) * | 2002-07-10 | 2004-04-01 | The Regents Of The University Of Michigan | Expression profile of lung cancer |
| WO2004105573A2 (en) * | 2003-05-21 | 2004-12-09 | The Wistar Institute Of Anatomy And Biology | Method of diagnosis of cancer based on gene expression profiles in cells |
| WO2005034978A2 (en) | 2003-10-02 | 2005-04-21 | Xantos Biomedicine Ag | MEDICAL USE OF IKKϵ OR OF INHIBITORS THEREOF |
| JP5629894B2 (ja) | 2004-12-07 | 2014-11-26 | 国立大学法人大阪大学 | 甲状腺乳頭癌を診断するための新規のマーカー |
| EP2295601A1 (en) | 2005-02-10 | 2011-03-16 | Oncotherapy Science, Inc. | Method of diagnosing bladder cancer |
| EP2266561A3 (en) * | 2005-09-07 | 2011-05-18 | Merck Serono S.A. | IKK Inhibitors for the Treatment of Endometriosis |
| US20070134687A1 (en) * | 2005-09-12 | 2007-06-14 | Aurelium Biopharma Inc. | Focused microarray and methods of diagnosing cancer |
| CN101384903A (zh) * | 2006-02-09 | 2009-03-11 | 南佛罗里达大学 | 利用bcl-2水平的增高检测癌肿 |
| US20070287158A1 (en) * | 2006-06-09 | 2007-12-13 | George Gorodeski | Cell collection and disease screening |
| EP1978106A1 (en) | 2007-04-07 | 2008-10-08 | Universitätsklinikum Hamburg-Eppendorf | Detection of ESR1 amplification in endometrium cancer and ovary cancer |
| WO2008137591A2 (en) | 2007-05-02 | 2008-11-13 | Biocept, Inc. | Non-invasive detection of endometrial cancer |
| JP5419195B2 (ja) | 2007-08-03 | 2014-02-19 | 国立大学法人愛媛大学 | 頭頸部癌の腫瘍マーカー |
| US20110136123A1 (en) * | 2007-08-15 | 2011-06-09 | Universite De Sherbrooke | Alternative splicing gene variants in cancer |
| US8053198B2 (en) * | 2007-09-14 | 2011-11-08 | Meso Scale Technologies, Llc | Diagnostic methods |
| US20110028344A1 (en) | 2008-04-11 | 2011-02-03 | Expression Pathology, Inc. | Biomarkers for endometrial disease |
| IN2012DN00707A (enExample) * | 2009-07-24 | 2015-06-19 | Geadic Biotec Aie |
-
2010
- 2010-07-23 IN IN707DEN2012 patent/IN2012DN00707A/en unknown
- 2010-07-23 WO PCT/EP2010/004550 patent/WO2011009637A2/en not_active Ceased
- 2010-07-23 EP EP14183077.8A patent/EP2848700B1/en not_active Not-in-force
- 2010-07-23 EP EP10736990.2A patent/EP2456889B1/en active Active
- 2010-07-23 ES ES14183077.8T patent/ES2654340T3/es active Active
- 2010-07-23 MX MX2012000921A patent/MX2012000921A/es active IP Right Grant
- 2010-07-23 RU RU2012106432/10A patent/RU2596394C2/ru active
- 2010-07-23 KR KR1020127004840A patent/KR101828290B1/ko not_active Expired - Fee Related
- 2010-07-23 HR HRP20141062AT patent/HRP20141062T1/hr unknown
- 2010-07-23 PL PL10736990T patent/PL2456889T3/pl unknown
- 2010-07-23 CN CN201510425228.XA patent/CN105132529A/zh active Pending
- 2010-07-23 ES ES10736990.2T patent/ES2523683T3/es active Active
- 2010-07-23 DK DK10736990.2T patent/DK2456889T3/en active
- 2010-07-23 AU AU2010275699A patent/AU2010275699B2/en not_active Ceased
- 2010-07-23 US US13/386,536 patent/US9046522B2/en active Active
- 2010-07-23 CA CA2767914A patent/CA2767914C/en active Active
- 2010-07-23 PT PT107369902T patent/PT2456889E/pt unknown
- 2010-07-23 BR BR112012001469-2A patent/BR112012001469B1/pt not_active IP Right Cessation
- 2010-07-23 JP JP2012520964A patent/JP5934093B2/ja not_active Expired - Fee Related
- 2010-07-23 CN CN201080042678.6A patent/CN102549169B/zh not_active Expired - Fee Related
-
2015
- 2015-06-01 US US14/727,549 patent/US20150337392A1/en not_active Abandoned
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