ES2654340T3 - Marcadores para cáncer endometrial - Google Patents
Marcadores para cáncer endometrial Download PDFInfo
- Publication number
- ES2654340T3 ES2654340T3 ES14183077.8T ES14183077T ES2654340T3 ES 2654340 T3 ES2654340 T3 ES 2654340T3 ES 14183077 T ES14183077 T ES 14183077T ES 2654340 T3 ES2654340 T3 ES 2654340T3
- Authority
- ES
- Spain
- Prior art keywords
- endometrial cancer
- markers
- level
- ikbke
- diagnosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010014733 Endometrial cancer Diseases 0.000 title abstract 3
- 206010014759 Endometrial neoplasm Diseases 0.000 title abstract 3
- 101100508538 Homo sapiens IKBKE gene Proteins 0.000 abstract 2
- 102100021857 Inhibitor of nuclear factor kappa-B kinase subunit epsilon Human genes 0.000 abstract 2
- 239000000090 biomarker Substances 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57442—Specifically defined cancers of the uterus and endometrial
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
Abstract
Un procedimiento de diagnóstico in vitro para el diagnóstico de cáncer endometrial que comprende detectar el nivel del biomarcador IKBKE en una muestra de una paciente en el que un incremento en el nivel de IKBKE en comparación con un valor control indica la existencia de cáncer endometrial
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09166398 | 2009-07-24 | ||
EP09166398 | 2009-07-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2654340T3 true ES2654340T3 (es) | 2018-02-13 |
Family
ID=42751506
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES10736990.2T Active ES2523683T3 (es) | 2009-07-24 | 2010-07-23 | Marcadores para cáncer endometrial |
ES14183077.8T Active ES2654340T3 (es) | 2009-07-24 | 2010-07-23 | Marcadores para cáncer endometrial |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES10736990.2T Active ES2523683T3 (es) | 2009-07-24 | 2010-07-23 | Marcadores para cáncer endometrial |
Country Status (17)
Country | Link |
---|---|
US (2) | US9046522B2 (es) |
EP (2) | EP2848700B1 (es) |
JP (1) | JP5934093B2 (es) |
KR (1) | KR101828290B1 (es) |
CN (2) | CN105132529A (es) |
AU (1) | AU2010275699B2 (es) |
BR (1) | BR112012001469B1 (es) |
CA (1) | CA2767914C (es) |
DK (1) | DK2456889T3 (es) |
ES (2) | ES2523683T3 (es) |
HR (1) | HRP20141062T1 (es) |
IN (1) | IN2012DN00707A (es) |
MX (1) | MX2012000921A (es) |
PL (1) | PL2456889T3 (es) |
PT (1) | PT2456889E (es) |
RU (1) | RU2596394C2 (es) |
WO (1) | WO2011009637A2 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2010275699B2 (en) * | 2009-07-24 | 2016-06-16 | Geadic Biotec, Aie. | Markers for endometrial cancer |
EP3249399A1 (en) * | 2011-09-22 | 2017-11-29 | Memorial Sloan-Kettering Cancer Center | Detecting ovarian cancer |
EP2787350A1 (en) * | 2013-04-05 | 2014-10-08 | Atlas Antibodies AB | ASRGL1 in endometrial cancer |
KR102113310B1 (ko) * | 2013-09-03 | 2020-05-20 | 아주대학교 산학협력단 | 암 세포 분리용 조성물, 키트 및 이를 이용한 분리 방법 |
BR112017002888A2 (pt) | 2014-08-12 | 2017-12-05 | Nextgen Jane Inc | sistema e método para monitoramento de saúde em fluido corpóreo coletado |
US10435472B2 (en) * | 2014-09-17 | 2019-10-08 | Merck Patent Gmbh | Method of treating bone metastasis diseases, medicaments therefore, and a method of predicting the clinical outcome of treating bone metastasis diseases |
CN107102141A (zh) * | 2016-02-23 | 2017-08-29 | 中国科学院生物物理研究所 | 分子标记物cd71及在子宫内膜癌诊断、分期及预后中的应用 |
EP3442706A4 (en) | 2016-04-13 | 2020-02-19 | NextGen Jane, Inc. | SAMPLE COLLECTION AND PRESERVATION DEVICES, SYSTEMS AND METHODS |
US20190137499A1 (en) * | 2016-05-04 | 2019-05-09 | Fundació Hospital Universitari Vall D'h'ebron-Institut De Recerca | Markers of Endometrial Cancer |
GB201702392D0 (en) * | 2017-02-14 | 2017-03-29 | Univ Edinburgh | Methods for cancer diagnosis using a gene expression signature |
CN108732349A (zh) * | 2017-04-20 | 2018-11-02 | 中国科学院上海生命科学研究院 | Lta4h作为指示肝内结节及早期预警肝癌的生物标志物 |
CN108732351A (zh) * | 2017-04-20 | 2018-11-02 | 中国科学院上海生命科学研究院 | Eps8l2作为指示肝内结节及早期预警肝癌的生物标志物 |
CN108732350A (zh) * | 2017-04-20 | 2018-11-02 | 中国科学院上海生命科学研究院 | Pla2g6作为指示肝内结节及早期预警肝癌的生物标志物 |
CN109085359A (zh) * | 2017-06-13 | 2018-12-25 | 中国医学科学院肿瘤医院 | 血清蛋白标志物组合在结直肠癌筛查和诊治中的应用 |
CA3070041A1 (en) * | 2017-07-21 | 2019-01-24 | Fundacio Hospital Universitari Vall D'hebron-Institut De Recerca | Ctnb1 as a marker for endometrial cancer |
CN109097462B (zh) * | 2018-09-10 | 2022-01-11 | 青岛市海慈医疗集团 | Ap1m2基因作为诊断青光眼的分子标志物的应用 |
WO2020130190A1 (ko) * | 2018-12-20 | 2020-06-25 | 경상대학교병원 | 신장암의 발병 위험성 예측 또는 진단을 위한 정보제공방법 |
CN109797217A (zh) * | 2019-03-27 | 2019-05-24 | 河北医科大学第二医院 | 帕金森生物标志物及其在制备检测产品中的应用 |
CN109811058B (zh) * | 2019-03-31 | 2021-11-12 | 青岛泱深生物医药有限公司 | 与宫颈疾病发生发展相关的生物标志物及其应用 |
WO2022226381A1 (en) * | 2021-04-22 | 2022-10-27 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Diagnostic to support clinical trial matching and exploratory biomarker analyses in cancer patients |
CN114317750A (zh) * | 2021-12-29 | 2022-04-12 | 上海市第十人民医院 | 一种卵巢癌生物标志物及其在制备用于卵巢癌腹水转移疾病的药物或试剂盒中的应用 |
KR102584898B1 (ko) * | 2022-10-24 | 2023-10-04 | 연세대학교 산학협력단 | 자궁내막암 진단 방법 및 이를 이용한 키트 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
AUPO573697A0 (en) * | 1997-03-20 | 1997-04-10 | Prince Henry's Institute Of Medical Research | Diagnosis of endometrial cancer |
US7014996B1 (en) * | 1998-10-02 | 2006-03-21 | Diadexus, Inc. | Method of diagnosing, monitoring, staging, imaging and treating gynecologic cancers |
AUPQ219799A0 (en) | 1999-08-13 | 1999-09-02 | R. Lurie Pty Ltd | Apparatus for obtaining potological samples |
US6884578B2 (en) * | 2000-03-31 | 2005-04-26 | Affymetrix, Inc. | Genes differentially expressed in secretory versus proliferative endometrium |
RU2232397C2 (ru) * | 2002-04-03 | 2004-07-10 | НИИ онкологии им. проф. Н.Н. Петрова | Способ ранней диагностики патологических состояний эндометрия |
WO2004005891A2 (en) * | 2002-07-10 | 2004-01-15 | The Regents Of The University Of Michigan | Expression profile of lung cancer |
US7640114B2 (en) * | 2003-05-21 | 2009-12-29 | The Wistar Institute Of Anatomy & Biology | Method of diagnosis of cancer based on gene expression profiles in cells |
WO2005035746A2 (en) * | 2003-10-02 | 2005-04-21 | Xantos Biomedicine Ag | Medical use of tbk-1 or of inhibitors thereof |
JP5629894B2 (ja) | 2004-12-07 | 2014-11-26 | 国立大学法人大阪大学 | 甲状腺乳頭癌を診断するための新規のマーカー |
WO2006085684A2 (en) | 2005-02-10 | 2006-08-17 | Oncotherapy Science, Inc. | Method of diagnosing bladder cancer |
CA2621057A1 (en) | 2005-09-07 | 2007-03-15 | Laboratoires Serono S.A. | Ikk inhibitors for the treatment of endometriosis |
US20070134687A1 (en) * | 2005-09-12 | 2007-06-14 | Aurelium Biopharma Inc. | Focused microarray and methods of diagnosing cancer |
KR20080114689A (ko) * | 2006-02-09 | 2008-12-31 | 유니버시티 오브 사우스 플로리다 | 증가된 bcl-2에 의한 암의 발견 |
US20070287158A1 (en) * | 2006-06-09 | 2007-12-13 | George Gorodeski | Cell collection and disease screening |
EP1978106A1 (en) * | 2007-04-07 | 2008-10-08 | Universitätsklinikum Hamburg-Eppendorf | Detection of ESR1 amplification in endometrium cancer and ovary cancer |
WO2008137591A2 (en) * | 2007-05-02 | 2008-11-13 | Biocept, Inc. | Non-invasive detection of endometrial cancer |
JP5419195B2 (ja) | 2007-08-03 | 2014-02-19 | 国立大学法人愛媛大学 | 頭頸部癌の腫瘍マーカー |
WO2009021338A1 (en) * | 2007-08-15 | 2009-02-19 | UNIVERSITé DE SHERBROOKE | Alternative splicing gene variants in cancer detection |
US8053198B2 (en) * | 2007-09-14 | 2011-11-08 | Meso Scale Technologies, Llc | Diagnostic methods |
WO2009126969A2 (en) * | 2008-04-11 | 2009-10-15 | Expression Pathology Inc. | Biomarkers for endometrial disease |
AU2010275699B2 (en) * | 2009-07-24 | 2016-06-16 | Geadic Biotec, Aie. | Markers for endometrial cancer |
-
2010
- 2010-07-23 AU AU2010275699A patent/AU2010275699B2/en active Active
- 2010-07-23 IN IN707DEN2012 patent/IN2012DN00707A/en unknown
- 2010-07-23 PL PL10736990T patent/PL2456889T3/pl unknown
- 2010-07-23 EP EP14183077.8A patent/EP2848700B1/en active Active
- 2010-07-23 BR BR112012001469-2A patent/BR112012001469B1/pt active IP Right Grant
- 2010-07-23 KR KR1020127004840A patent/KR101828290B1/ko active IP Right Grant
- 2010-07-23 WO PCT/EP2010/004550 patent/WO2011009637A2/en active Application Filing
- 2010-07-23 EP EP10736990.2A patent/EP2456889B1/en active Active
- 2010-07-23 MX MX2012000921A patent/MX2012000921A/es active IP Right Grant
- 2010-07-23 ES ES10736990.2T patent/ES2523683T3/es active Active
- 2010-07-23 PT PT107369902T patent/PT2456889E/pt unknown
- 2010-07-23 CN CN201510425228.XA patent/CN105132529A/zh active Pending
- 2010-07-23 DK DK10736990.2T patent/DK2456889T3/en active
- 2010-07-23 RU RU2012106432/10A patent/RU2596394C2/ru active
- 2010-07-23 JP JP2012520964A patent/JP5934093B2/ja active Active
- 2010-07-23 CA CA2767914A patent/CA2767914C/en active Active
- 2010-07-23 ES ES14183077.8T patent/ES2654340T3/es active Active
- 2010-07-23 CN CN201080042678.6A patent/CN102549169B/zh active Active
- 2010-07-23 US US13/386,536 patent/US9046522B2/en active Active
-
2014
- 2014-11-03 HR HRP20141062AT patent/HRP20141062T1/hr unknown
-
2015
- 2015-06-01 US US14/727,549 patent/US20150337392A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2456889B1 (en) | 2014-09-03 |
WO2011009637A3 (en) | 2011-04-14 |
JP2013500001A (ja) | 2013-01-07 |
CA2767914A1 (en) | 2011-01-27 |
US9046522B2 (en) | 2015-06-02 |
CN105132529A (zh) | 2015-12-09 |
MX2012000921A (es) | 2012-06-12 |
KR20120047334A (ko) | 2012-05-11 |
HRP20141062T1 (hr) | 2015-01-02 |
PL2456889T3 (pl) | 2015-02-27 |
BR112012001469A2 (pt) | 2020-08-11 |
KR101828290B1 (ko) | 2018-02-12 |
EP2848700A1 (en) | 2015-03-18 |
US20150337392A1 (en) | 2015-11-26 |
BR112012001469B1 (pt) | 2021-08-10 |
WO2011009637A2 (en) | 2011-01-27 |
CA2767914C (en) | 2020-02-25 |
IN2012DN00707A (es) | 2015-06-19 |
JP5934093B2 (ja) | 2016-06-15 |
ES2523683T3 (es) | 2014-11-28 |
PT2456889E (pt) | 2014-11-21 |
CN102549169B (zh) | 2016-02-24 |
EP2848700B1 (en) | 2017-10-04 |
DK2456889T3 (en) | 2014-12-01 |
RU2596394C2 (ru) | 2016-09-10 |
US20120122726A1 (en) | 2012-05-17 |
EP2456889A2 (en) | 2012-05-30 |
CN102549169A (zh) | 2012-07-04 |
AU2010275699B2 (en) | 2016-06-16 |
AU2010275699A1 (en) | 2012-02-02 |
RU2012106432A (ru) | 2013-08-27 |
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