ES2654340T3 - Marcadores para cáncer endometrial - Google Patents

Marcadores para cáncer endometrial Download PDF

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Publication number
ES2654340T3
ES2654340T3 ES14183077.8T ES14183077T ES2654340T3 ES 2654340 T3 ES2654340 T3 ES 2654340T3 ES 14183077 T ES14183077 T ES 14183077T ES 2654340 T3 ES2654340 T3 ES 2654340T3
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Spain
Prior art keywords
endometrial cancer
markers
level
ikbke
diagnosis
Prior art date
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Active
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ES14183077.8T
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English (en)
Inventor
Miguel Abal Posada
Andreas Doll
Antonio Gil Moreno
Tamara Maes
Cristina Perez
Jaume REVENTÓS PUIGJANER
Elisabet Rosell
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Geadic Biotec AIE
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Geadic Biotec AIE
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5755—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the uterine cervix, uterine corpus or endometrium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Un procedimiento de diagnóstico in vitro para el diagnóstico de cáncer endometrial que comprende detectar el nivel del biomarcador IKBKE en una muestra de una paciente en el que un incremento en el nivel de IKBKE en comparación con un valor control indica la existencia de cáncer endometrial
ES14183077.8T 2009-07-24 2010-07-23 Marcadores para cáncer endometrial Active ES2654340T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09166398 2009-07-24
EP09166398 2009-07-24

Publications (1)

Publication Number Publication Date
ES2654340T3 true ES2654340T3 (es) 2018-02-13

Family

ID=42751506

Family Applications (2)

Application Number Title Priority Date Filing Date
ES10736990.2T Active ES2523683T3 (es) 2009-07-24 2010-07-23 Marcadores para cáncer endometrial
ES14183077.8T Active ES2654340T3 (es) 2009-07-24 2010-07-23 Marcadores para cáncer endometrial

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES10736990.2T Active ES2523683T3 (es) 2009-07-24 2010-07-23 Marcadores para cáncer endometrial

Country Status (17)

Country Link
US (2) US9046522B2 (es)
EP (2) EP2848700B1 (es)
JP (1) JP5934093B2 (es)
KR (1) KR101828290B1 (es)
CN (2) CN105132529A (es)
AU (1) AU2010275699B2 (es)
BR (1) BR112012001469B1 (es)
CA (1) CA2767914C (es)
DK (1) DK2456889T3 (es)
ES (2) ES2523683T3 (es)
HR (1) HRP20141062T1 (es)
IN (1) IN2012DN00707A (es)
MX (1) MX2012000921A (es)
PL (1) PL2456889T3 (es)
PT (1) PT2456889E (es)
RU (1) RU2596394C2 (es)
WO (1) WO2011009637A2 (es)

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IN2012DN00707A (es) * 2009-07-24 2015-06-19 Geadic Biotec Aie
EP2758777B1 (en) * 2011-09-22 2018-02-07 Memorial Sloan-Kettering Cancer Center Detecting ovarian cancer
EP2787350A1 (en) * 2013-04-05 2014-10-08 Atlas Antibodies AB ASRGL1 in endometrial cancer
KR102113310B1 (ko) * 2013-09-03 2020-05-20 아주대학교 산학협력단 암 세포 분리용 조성물, 키트 및 이를 이용한 분리 방법
EP3180611B1 (en) 2014-08-12 2025-04-09 NextGen Jane, Inc. System and method for monitoring health based on collected bodily fluid
CN106714835A (zh) * 2014-09-17 2017-05-24 默克专利股份公司 治疗骨转移疾病的方法、其药物以及预测治疗骨转移疾病的临床结果的方法
CN107102141A (zh) * 2016-02-23 2017-08-29 中国科学院生物物理研究所 分子标记物cd71及在子宫内膜癌诊断、分期及预后中的应用
WO2017180909A1 (en) 2016-04-13 2017-10-19 Nextgen Jane, Inc. Sample collection and preservation devices, systems and methods
EP4610655A3 (en) * 2016-05-04 2025-12-10 Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca Markers of endometrial cancer
GB201702392D0 (en) * 2017-02-14 2017-03-29 Univ Edinburgh Methods for cancer diagnosis using a gene expression signature
CN108732349A (zh) * 2017-04-20 2018-11-02 中国科学院上海生命科学研究院 Lta4h作为指示肝内结节及早期预警肝癌的生物标志物
CN108732350A (zh) * 2017-04-20 2018-11-02 中国科学院上海生命科学研究院 Pla2g6作为指示肝内结节及早期预警肝癌的生物标志物
CN108732351A (zh) * 2017-04-20 2018-11-02 中国科学院上海生命科学研究院 Eps8l2作为指示肝内结节及早期预警肝癌的生物标志物
CN109085359A (zh) * 2017-06-13 2018-12-25 中国医学科学院肿瘤医院 血清蛋白标志物组合在结直肠癌筛查和诊治中的应用
CN117288953A (zh) * 2017-07-21 2023-12-26 瓦尔德西布伦大学医院基金会研究所 一种子宫内膜癌的预后方法
WO2019239431A1 (en) * 2018-06-13 2019-12-19 Tzar Management Technology Private Limited Method for analysing pluripotent stem cell biomarkers, and implementations thereof
CN109097462B (zh) * 2018-09-10 2022-01-11 青岛市海慈医疗集团 Ap1m2基因作为诊断青光眼的分子标志物的应用
WO2020130190A1 (ko) * 2018-12-20 2020-06-25 경상대학교병원 신장암의 발병 위험성 예측 또는 진단을 위한 정보제공방법
CN113329697A (zh) * 2019-01-23 2021-08-31 吉娜-生命诊断有限公司 癌症诊断和监测设备、其系统和方法
CN109797217A (zh) * 2019-03-27 2019-05-24 河北医科大学第二医院 帕金森生物标志物及其在制备检测产品中的应用
CN109811058B (zh) * 2019-03-31 2021-11-12 青岛泱深生物医药有限公司 与宫颈疾病发生发展相关的生物标志物及其应用
WO2022226381A1 (en) * 2021-04-22 2022-10-27 H. Lee Moffitt Cancer Center And Research Institute, Inc. Diagnostic to support clinical trial matching and exploratory biomarker analyses in cancer patients
CN114317750B (zh) * 2021-12-29 2024-05-14 上海市第十人民医院 一种卵巢癌生物标志物及其在制备用于卵巢癌腹水转移疾病的药物或试剂盒中的应用
KR102584898B1 (ko) * 2022-10-24 2023-10-04 연세대학교 산학협력단 자궁내막암 진단 방법 및 이를 이용한 키트
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Also Published As

Publication number Publication date
JP5934093B2 (ja) 2016-06-15
KR20120047334A (ko) 2012-05-11
US9046522B2 (en) 2015-06-02
DK2456889T3 (en) 2014-12-01
CN105132529A (zh) 2015-12-09
EP2848700B1 (en) 2017-10-04
MX2012000921A (es) 2012-06-12
JP2013500001A (ja) 2013-01-07
US20120122726A1 (en) 2012-05-17
EP2848700A1 (en) 2015-03-18
CN102549169B (zh) 2016-02-24
PT2456889E (pt) 2014-11-21
AU2010275699B2 (en) 2016-06-16
CA2767914C (en) 2020-02-25
BR112012001469B1 (pt) 2021-08-10
ES2523683T3 (es) 2014-11-28
EP2456889B1 (en) 2014-09-03
AU2010275699A1 (en) 2012-02-02
BR112012001469A2 (pt) 2020-08-11
WO2011009637A2 (en) 2011-01-27
WO2011009637A3 (en) 2011-04-14
CA2767914A1 (en) 2011-01-27
HRP20141062T1 (hr) 2015-01-02
IN2012DN00707A (es) 2015-06-19
RU2012106432A (ru) 2013-08-27
KR101828290B1 (ko) 2018-02-12
PL2456889T3 (pl) 2015-02-27
RU2596394C2 (ru) 2016-09-10
US20150337392A1 (en) 2015-11-26
CN102549169A (zh) 2012-07-04
EP2456889A2 (en) 2012-05-30

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