JP2008521827A - S1p受容体アゴニストの投与レジメン - Google Patents

S1p受容体アゴニストの投与レジメン Download PDF

Info

Publication number
JP2008521827A
JP2008521827A JP2007543584A JP2007543584A JP2008521827A JP 2008521827 A JP2008521827 A JP 2008521827A JP 2007543584 A JP2007543584 A JP 2007543584A JP 2007543584 A JP2007543584 A JP 2007543584A JP 2008521827 A JP2008521827 A JP 2008521827A
Authority
JP
Japan
Prior art keywords
agonist
receptor
alkyl
daily dose
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2007543584A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008521827A5 (enExample
Inventor
ジョン・エム・コバリック
ジルケ・アッペル−ディンゲマンゼ
Original Assignee
ノバルティス アクチエンゲゼルシャフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36046868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2008521827(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ノバルティス アクチエンゲゼルシャフト filed Critical ノバルティス アクチエンゲゼルシャフト
Publication of JP2008521827A publication Critical patent/JP2008521827A/ja
Publication of JP2008521827A5 publication Critical patent/JP2008521827A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Storage Device Security (AREA)
JP2007543584A 2004-11-29 2005-11-28 S1p受容体アゴニストの投与レジメン Withdrawn JP2008521827A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63148304P 2004-11-29 2004-11-29
PCT/US2005/043044 WO2006058316A1 (en) 2004-11-29 2005-11-28 Dosage regimen of an s1p receptor agonist

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2012040574A Division JP2012107059A (ja) 2004-11-29 2012-02-27 S1p受容体アゴニストの投与レジメン
JP2013043351A Division JP2013129664A (ja) 2004-11-29 2013-03-05 S1p受容体アゴニストの投与レジメン

Publications (2)

Publication Number Publication Date
JP2008521827A true JP2008521827A (ja) 2008-06-26
JP2008521827A5 JP2008521827A5 (enExample) 2009-02-05

Family

ID=36046868

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2007543584A Withdrawn JP2008521827A (ja) 2004-11-29 2005-11-28 S1p受容体アゴニストの投与レジメン
JP2012040574A Withdrawn JP2012107059A (ja) 2004-11-29 2012-02-27 S1p受容体アゴニストの投与レジメン
JP2013043351A Withdrawn JP2013129664A (ja) 2004-11-29 2013-03-05 S1p受容体アゴニストの投与レジメン
JP2014266267A Pending JP2015061883A (ja) 2004-11-29 2014-12-26 S1p受容体アゴニストの投与レジメン

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2012040574A Withdrawn JP2012107059A (ja) 2004-11-29 2012-02-27 S1p受容体アゴニストの投与レジメン
JP2013043351A Withdrawn JP2013129664A (ja) 2004-11-29 2013-03-05 S1p受容体アゴニストの投与レジメン
JP2014266267A Pending JP2015061883A (ja) 2004-11-29 2014-12-26 S1p受容体アゴニストの投与レジメン

Country Status (21)

Country Link
US (3) US20090275553A1 (enExample)
EP (3) EP1819326B1 (enExample)
JP (4) JP2008521827A (enExample)
KR (4) KR20130041385A (enExample)
CN (2) CN101068536B (enExample)
AU (1) AU2005309378B2 (enExample)
BR (1) BRPI0518674A2 (enExample)
CA (1) CA2589265A1 (enExample)
ES (1) ES2495690T3 (enExample)
IL (2) IL183134A0 (enExample)
MA (1) MA29034B1 (enExample)
MX (1) MX2007006373A (enExample)
NO (2) NO20072401L (enExample)
NZ (2) NZ554720A (enExample)
PL (1) PL1819326T3 (enExample)
PT (1) PT1819326E (enExample)
RU (2) RU2478384C2 (enExample)
SG (2) SG158096A1 (enExample)
TN (1) TNSN07209A1 (enExample)
WO (1) WO2006058316A1 (enExample)
ZA (1) ZA200703328B (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012500247A (ja) * 2008-08-18 2012-01-05 ノバルティス アーゲー 末梢神経障害の治療のための化合物
JP2012512885A (ja) * 2008-12-18 2012-06-07 ノバルティス アーゲー 新規な塩
JP2012107059A (ja) * 2004-11-29 2012-06-07 Novartis Ag S1p受容体アゴニストの投与レジメン
JP2012512881A (ja) * 2008-12-18 2012-06-07 ノバルティス アーゲー 1−[4−[1−(4−シクロヘキシル−3−トリフルオロメチル−ベンジルオキシイミノ)−エチル]−2−エチル−ベンジル]−アゼチジン−3−カルボン酸ヘミフマル酸塩
JP2012513401A (ja) * 2008-12-22 2012-06-14 ノバルティス アーゲー S1p受容体アゴニストの投与レジメン
JP2016155840A (ja) * 2009-09-29 2016-09-01 ノバルティス アーゲー S1p受容体モジュレーターの投与計画

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2007109207A (ru) 2004-08-13 2008-09-20 Прикис Фамэсьютикэлс, Инк. (US) Соединения-модуляторы активности рецептора сфингозин-1-фосфата (варианты), фармацевтическая композиция, содержащая указанные соединения, и способ лечения нарушения, ассоциированного со сфингозин-1-фосфатом
PL1926483T3 (pl) * 2005-09-09 2011-05-31 Novartis Ag Leczenie chorób autoimmunologicznych
GB0612721D0 (en) * 2006-06-27 2006-08-09 Novartis Ag Organic compounds
AU2008248648B2 (en) * 2007-05-04 2012-02-23 Novartis Ag Use of S1P receptor modulator
DK2278960T4 (da) 2008-03-17 2020-01-27 Actelion Pharmaceuticals Ltd Dosisregimen til en selektiv sip1 receptoragonist
NZ589412A (en) * 2008-05-20 2012-11-30 Kyorin Seiyaku Kk Use of a sphingosine-1-phosphate (S1P) agonist for maintance of induced remission of autoimmune or inflammatory diseases after inital treatment
AU2009273259B2 (en) * 2008-07-23 2013-05-02 Novartis Ag Sphingosine 1 phosphate receptor modulators and their use to treat muscle inflammation
MX2011006610A (es) 2008-12-18 2011-06-30 Novartis Ag Nueva forma polimorfica de acido 1-(4-{l-[(e)-4-ciclohexil-3 -trifluorometil-benciloxi-imino]-etil)-2-etil-bencil)-azetidin-3 carboxilico.
CA2747992C (en) * 2008-12-22 2017-11-07 Novartis Ag Dosage regimen of an s1p receptor agonist
AU2015275246B2 (en) * 2008-12-22 2018-02-01 Novartis Ag Dosage regimen for a S1P receptor agonist
US20110124605A1 (en) * 2009-11-20 2011-05-26 Shreeram Aradhye Use of an S1P Receptor Agonist
US8791100B2 (en) 2010-02-02 2014-07-29 Novartis Ag Aryl benzylamine compounds
CA2794607A1 (en) * 2010-05-06 2011-11-10 Novartis Ag Dosage regimen of diaryl sulfide derivatives
PH12013501442B1 (en) 2011-01-07 2018-04-20 Novartis Ag Immunosuppressant formulations
BR112014009141A8 (pt) * 2011-10-21 2017-06-20 Novartis Ag regime de dosagem para um modulador ou agonista do receptor s1p
HRP20200883T1 (hr) 2012-08-17 2020-09-04 Actelion Pharmaceuticals Ltd. Postupak za pripremanje (2z,5z)-5-(3-kloro-4-((r)-2,3-dihidroksipropoksi)benziliden)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona i međuproizvodi koji se koriste u navedenom postupku
CN102887829B (zh) * 2012-09-05 2014-07-02 中国科学院上海药物研究所 芬戈莫德粘酸盐及其晶体的制备方法和用途
JP6401257B2 (ja) 2013-10-11 2018-10-10 テイコク ファーマ ユーエスエー インコーポレーテッド 局所用スフィンゴシン−1−リン酸受容体アゴニスト製剤及びその使用方法
WO2015053879A1 (en) 2013-10-11 2015-04-16 Teikoku Pharma Usa, Inc. Sphingosine-1-phosphate receptor agonist iontophoretic devices and methods of using the same
MA41139B1 (fr) 2014-12-11 2026-02-27 Laboratoires Juvise Pharmaceuticals Combinaison pharmaceutique comprenant du ponesimod et son utilisation dans le traitement de la sclérose en plaque
EA036075B1 (ru) 2014-12-11 2020-09-23 Актелион Фармасьютиклз Лтд Схема дозирования для селективного агониста рецептора s1p1
US20180042895A1 (en) 2015-02-26 2018-02-15 Novartis Ag Treatment of autoimmune disease in a patient receiving additionally a beta-blocker
US10250466B2 (en) * 2016-03-29 2019-04-02 Juniper Networks, Inc. Application signature generation and distribution
US11629124B2 (en) 2017-03-09 2023-04-18 Novartis Ag Solid forms comprising an oxime ether compound, compositions and methods of use thereof
WO2021084068A1 (en) 2019-10-31 2021-05-06 Idorsia Pharmaceuticals Ltd Combination of a cxcr7 antagonist with an s1p1 receptor modulator

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11116479A (ja) * 1997-10-10 1999-04-27 Sugen Inc 脳癌のための組み合わせ化学療法処置
WO2002078766A2 (en) * 2001-04-02 2002-10-10 Genentech, Inc. Combination therapy
WO2002080902A1 (en) * 2001-04-02 2002-10-17 Astrazeneca Ab Solid pharmaceutical composition comprising 4 -cyano-trifluoro-3-(4-fluorophenylsulphonyl)-2-hydroxy-2-methylpropiono- m toluidide and pvp
WO2004028521A2 (en) * 2002-09-24 2004-04-08 Novartis Ag Sphingosine-1-phosphate receptor agonists in the treatment of demyelinating disorders

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994008943A1 (fr) * 1992-10-21 1994-04-28 Yoshitomi Pharmaceutical Industries, Ltd. Compose 2-amino-1,3-propanediol et immunosuppresseur
ATE211726T1 (de) 1994-08-22 2002-01-15 Welfide Corp Benzolderivate und deren medizinische verwendung
HU224814B1 (en) * 1995-12-28 2006-02-28 Mitsubishi Pharma Corp Use of propane-1,3-diol derivative for the preparation of a medicament useful for the topical treating of inflammatory and immune diseases
US6476004B1 (en) * 1996-07-18 2002-11-05 Mitsubishi Pharma Corporation Pharmaceutical composition
KR20000075745A (ko) * 1997-02-27 2000-12-26 가마후라 아키오 의약 조성물
USRE39072E1 (en) 1997-04-04 2006-04-18 Mitsubishi Pharma Corporation 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same
JPH1180026A (ja) * 1997-09-02 1999-03-23 Yoshitomi Pharmaceut Ind Ltd 新規免疫抑制剤、その使用方法およびその同定方法
EP1300405B1 (en) 2000-07-13 2007-04-18 Sankyo Company, Limited Amino alcohol derivatives
EP1315735A4 (en) 2000-08-31 2005-04-06 Merck & Co Inc Phosphate derivatives as immunoregulatory compounds
MXPA03008755A (es) 2001-03-26 2004-02-18 Novartis Ag Derivados de 2-amino-propanol.
JP2002316985A (ja) 2001-04-20 2002-10-31 Sankyo Co Ltd ベンゾチオフェン誘導体
JP4476623B2 (ja) * 2001-06-08 2010-06-09 ノバルティス アーゲー インスリン産生細胞移植片拒絶の処置または予防
DE60235900D1 (de) 2001-09-27 2010-05-20 Kyorin Seiyaku Kk Osuppressivum
CA2461212C (en) 2001-09-27 2010-08-17 Kyorin Pharmaceutical Co., Ltd. Diaryl sulfide derivatives, salts thereof and immunosuppressive agents using the same
ATE441654T1 (de) 2002-01-18 2009-09-15 Merck & Co Inc Edg-rezeptoragonisten
US20050070506A1 (en) 2002-01-18 2005-03-31 Doherty George A. Selective s1p1/edg1 receptor agonists
AU2003202994B2 (en) 2002-01-18 2007-11-22 Merck Sharp & Dohme Corp. N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as Edg receptor agonists
MY150088A (en) * 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
WO2005000833A1 (en) 2003-05-19 2005-01-06 Irm, Llc Immunosuppressant compounds and compositions
UA74941C2 (en) 2004-04-26 2006-02-15 Fos Internat S A A metal-thermal process for producing magnesium and vacuum induction furnace for realizing the same
WO2005113330A1 (en) 2004-05-05 2005-12-01 Adler, Richard, S. Systems and methods for protecting ship from attack on the surface or under water
WO2006041015A1 (ja) * 2004-10-12 2006-04-20 Kyorin Pharmaceutical Co., Ltd. アミノアルコール誘導体とその付加塩及び免疫抑制剤
CA2589265A1 (en) * 2004-11-29 2006-06-01 Novartis Ag Dosage regimen of an s1p receptor agonist
GT200600350A (es) * 2005-08-09 2007-03-28 Formulaciones líquidas

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11116479A (ja) * 1997-10-10 1999-04-27 Sugen Inc 脳癌のための組み合わせ化学療法処置
WO2002078766A2 (en) * 2001-04-02 2002-10-10 Genentech, Inc. Combination therapy
WO2002080902A1 (en) * 2001-04-02 2002-10-17 Astrazeneca Ab Solid pharmaceutical composition comprising 4 -cyano-trifluoro-3-(4-fluorophenylsulphonyl)-2-hydroxy-2-methylpropiono- m toluidide and pvp
WO2004028521A2 (en) * 2002-09-24 2004-04-08 Novartis Ag Sphingosine-1-phosphate receptor agonists in the treatment of demyelinating disorders

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JPN6011050780; KAHAN,B.D.: Transplantation proceedings Vol.33, No.7-8, 2001, p.3081-3 *
JPN6011050782; SKERJANEC,A. et al: Am J Transplant Vol.2, Suppl.3, 2002 *
JPN6011050784; 加藤隆一: NEW薬理学 , 1997, p.19-20の『反復投与の場合』の項, 南江堂 *
JPN6011050786; FUJINO,M. et al: The Journal of pharmacology and experimental therapeutics Vol.305, No.1, 2003, p.70-7 *
JPN6011050788; WEBB,M. et al: Journal of neuroimmunology Vol.153, No.1-2, 200408, p.108-21 *
JPN6011050790; OGILVIE,R.I.: Journal of chronic diseases Vol.36, No.1, 1983, p.121-7 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012107059A (ja) * 2004-11-29 2012-06-07 Novartis Ag S1p受容体アゴニストの投与レジメン
JP2012500247A (ja) * 2008-08-18 2012-01-05 ノバルティス アーゲー 末梢神経障害の治療のための化合物
JP2012512885A (ja) * 2008-12-18 2012-06-07 ノバルティス アーゲー 新規な塩
JP2012512881A (ja) * 2008-12-18 2012-06-07 ノバルティス アーゲー 1−[4−[1−(4−シクロヘキシル−3−トリフルオロメチル−ベンジルオキシイミノ)−エチル]−2−エチル−ベンジル]−アゼチジン−3−カルボン酸ヘミフマル酸塩
JP2012513401A (ja) * 2008-12-22 2012-06-14 ノバルティス アーゲー S1p受容体アゴニストの投与レジメン
JP2014144970A (ja) * 2008-12-22 2014-08-14 Novartis Ag S1p受容体アゴニストの投与レジメン
JP2017141238A (ja) * 2008-12-22 2017-08-17 ノバルティス アーゲー S1p受容体アゴニストの投与レジメン
JP2019167360A (ja) * 2008-12-22 2019-10-03 ノバルティス アーゲー S1p受容体アゴニストの投与レジメン
JP7329965B2 (ja) 2008-12-22 2023-08-21 ノバルティス アーゲー S1p受容体アゴニストの投与レジメン
JP2016155840A (ja) * 2009-09-29 2016-09-01 ノバルティス アーゲー S1p受容体モジュレーターの投与計画
JP2018172401A (ja) * 2009-09-29 2018-11-08 ノバルティス アーゲー S1p受容体モジュレーターの投与計画
JP2020203892A (ja) * 2009-09-29 2020-12-24 ノバルティス アーゲー S1p受容体モジュレーターの投与計画

Also Published As

Publication number Publication date
CA2589265A1 (en) 2006-06-01
IL223502A0 (en) 2013-02-03
CN101068536A (zh) 2007-11-07
KR20070085465A (ko) 2007-08-27
IL183134A0 (en) 2008-04-13
TNSN07209A1 (en) 2008-11-21
EP1819326B1 (en) 2014-07-02
NZ554720A (en) 2011-04-29
NO20121305L (no) 2007-06-22
JP2013129664A (ja) 2013-07-04
SG187468A1 (en) 2013-02-28
NO20072401L (no) 2007-06-22
PL1819326T3 (pl) 2014-12-31
EP2384749A1 (en) 2011-11-09
PT1819326E (pt) 2014-09-25
CN101068536B (zh) 2012-12-05
RU2007124327A (ru) 2009-01-10
EP2359821A1 (en) 2011-08-24
RU2012141951A (ru) 2014-04-10
JP2015061883A (ja) 2015-04-02
US20090275553A1 (en) 2009-11-05
ES2495690T3 (es) 2014-09-17
ZA200703328B (en) 2008-08-27
KR20150028858A (ko) 2015-03-16
EP1819326A1 (en) 2007-08-22
KR20140095109A (ko) 2014-07-31
MA29034B1 (fr) 2007-11-01
US20150087720A1 (en) 2015-03-26
US20120071446A1 (en) 2012-03-22
MX2007006373A (es) 2007-06-20
KR20130041385A (ko) 2013-04-24
NZ590054A (en) 2012-07-27
JP2012107059A (ja) 2012-06-07
CN102600472A (zh) 2012-07-25
WO2006058316A1 (en) 2006-06-01
AU2005309378A1 (en) 2006-06-01
AU2005309378B2 (en) 2010-02-11
BRPI0518674A2 (pt) 2008-12-02
SG158096A1 (en) 2010-01-29
RU2478384C2 (ru) 2013-04-10
HK1109057A1 (en) 2008-05-30

Similar Documents

Publication Publication Date Title
JP2013129664A (ja) S1p受容体アゴニストの投与レジメン
KR101473494B1 (ko) 액상 제제
US8741963B2 (en) S1P receptor modulators for treating multiple sclerosis
KR101528125B1 (ko) S1p 수용체 조절제의 용도
HK1161247A (en) Dosage regimen of an s1p receptor agonist
HK1158943A (en) Dosage regimen of an s1p receptor agonist
HK1109057B (en) Dosage regimen of an s1p receptor agonist
KR20070102538A (ko) S1p 수용체 효능제/조절제와 면역억제성 약물의 조합에의한 항림프구 항체 유도

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081127

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20081127

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110927

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20111212

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20111219

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120227

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20121106

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130305

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20130509

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20130712

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140512

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140516

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20140718

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20140728

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20140723