JP2008521754A5 - - Google Patents

Info

Publication number

JP2008521754A5

JP2008521754A5 JP2007541584A JP2007541584A JP2008521754A5 JP 2008521754 A5 JP2008521754 A5 JP 2008521754A5 JP 2007541584 A JP2007541584 A JP 2007541584A JP 2007541584 A JP2007541584 A JP 2007541584A JP 2008521754 A5 JP2008521754 A5 JP 2008521754A5

Authority

JP

Japan

Prior art keywords

phosphopeptide

complex

solution

ions

ser

Prior art date

2005-11-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 108010001441 Phosphopeptides Proteins 0.000 claims 22
• 238000000034 method Methods 0.000 claims 8
• 102000011632 Caseins Human genes 0.000 claims 7
• 108010076119 Caseins Proteins 0.000 claims 7
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 6
• 239000005018 casein Substances 0.000 claims 5
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 5
• 235000021240 caseins Nutrition 0.000 claims 5
• 239000000203 mixture Substances 0.000 claims 5
• BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 4
• BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 claims 4
• 229910001424 calcium ion Inorganic materials 0.000 claims 4
• 229910000389 calcium phosphate Inorganic materials 0.000 claims 4
• 239000001506 calcium phosphate Substances 0.000 claims 4
• 235000011010 calcium phosphates Nutrition 0.000 claims 4
• 229950006137 dexfosfoserine Drugs 0.000 claims 4
• 235000013922 glutamic acid Nutrition 0.000 claims 4
• 239000004220 glutamic acid Substances 0.000 claims 4
• -1 hydroxide ions Chemical class 0.000 claims 4
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 4
• BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 claims 4
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 4
• 230000002265 prevention Effects 0.000 claims 3
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
• 235000003704 aspartic acid Nutrition 0.000 claims 2
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 2
• 230000015572 biosynthetic process Effects 0.000 claims 2
• 230000007073 chemical hydrolysis Effects 0.000 claims 2
• 230000007071 enzymatic hydrolysis Effects 0.000 claims 2
• 238000006047 enzymatic hydrolysis reaction Methods 0.000 claims 2
• 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 2
• 238000006460 hydrolysis reaction Methods 0.000 claims 2
• FDIKHVQUPVCJFA-UHFFFAOYSA-N phosphohistidine Chemical compound OP(=O)(O)NC(C(=O)O)CC1=CN=CN1 FDIKHVQUPVCJFA-UHFFFAOYSA-N 0.000 claims 2
• USRGIUJOYOXOQJ-GBXIJSLDSA-N phosphothreonine Chemical compound OP(=O)(O)O[C@H](C)[C@H](N)C(O)=O USRGIUJOYOXOQJ-GBXIJSLDSA-N 0.000 claims 2
• DCWXELXMIBXGTH-UHFFFAOYSA-N phosphotyrosine Chemical compound OC(=O)C(N)CC1=CC=C(OP(O)(O)=O)C=C1 DCWXELXMIBXGTH-UHFFFAOYSA-N 0.000 claims 2
• 239000002244 precipitate Substances 0.000 claims 2
• 208000006558 Dental Calculus Diseases 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 206010044029 Tooth deposit Diseases 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 claims 1
• 229910001634 calcium fluoride Inorganic materials 0.000 claims 1
• GFIKIVSYJDVOOZ-UHFFFAOYSA-L calcium;fluoro-dioxido-oxo-$l^{5}-phosphane Chemical compound [Ca+2].[O-]P([O-])(F)=O GFIKIVSYJDVOOZ-UHFFFAOYSA-L 0.000 claims 1
• 239000002131 composite material Substances 0.000 claims 1
• 238000005260 corrosion Methods 0.000 claims 1
• 230000007797 corrosion Effects 0.000 claims 1
• 208000002925 dental caries Diseases 0.000 claims 1
• 210000003298 dental enamel Anatomy 0.000 claims 1
• 230000003628 erosive effect Effects 0.000 claims 1
• 230000009610 hypersensitivity Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1