JP5529529B2 - 口腔輸送システムに用いるリン酸カルシウム錯体及び塩 - Google Patents
口腔輸送システムに用いるリン酸カルシウム錯体及び塩 Download PDFInfo
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- JP5529529B2 JP5529529B2 JP2009504324A JP2009504324A JP5529529B2 JP 5529529 B2 JP5529529 B2 JP 5529529B2 JP 2009504324 A JP2009504324 A JP 2009504324A JP 2009504324 A JP2009504324 A JP 2009504324A JP 5529529 B2 JP5529529 B2 JP 5529529B2
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- calcium
- phosphate
- sugar
- confectionery
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Description
(a)哺乳類の口腔に口腔輸送システムを投与するステップであって、当該輸送システムが、
(i)リンペプチド又はリンタンパク質で安定化されたリン酸カルシウム又はフッ化リン酸カルシウム錯体と、
(ii)カルシウム塩、リン酸塩及びそれらの組み合わせから選択される塩を含有するステップと、
(b)口腔内に輸送システムを保持するステップであって、当該輸送システムと実質的に同様であるが、前記リンペプチド若しくはリンタンパク質で安定化されたリン酸カルシウム又はフッ化リン酸カルシウム錯体、並びに前記塩を含まない輸送システムを、同じ時間消費させるよりも高いレベルで、哺乳類の歯におけるエナメル表面下の病変を再石灰化するのに十分な時間、当該輸送システムを保持するステップ。
(a)口腔輸送システムであって、
(i)リンペプチド又はリンタンパク質で安定化されたリン酸カルシウム又はフッ化リン酸カルシウム錯体と、
(ii)カルシウム塩、リン酸塩及びそれらの組み合わせから選択される塩を含んでなり、消費されることにより、当該輸送システムと実質的に同様であるが、前記リンペプチド若しくはリンタンパク質で安定化された、リン酸カルシウム又はフッ化リン酸カルシウム錯体、並びに塩を含まない輸送システムより高いレベルで、哺乳類の歯のエナメル表面下の再石灰化を提供する、当該口腔輸送システムと、
(b)当該口腔輸送システムを使用するための一組の取扱説明書と、
(c)当該口腔輸送システム及び当該一組の取扱説明書を収納するためのパッケージを含んでなる。
口腔輸送システムには通常、充分な時間の口腔内で保持されて、歯の表面と接触し、所望の活性を呈するあらゆる製品が包含される。本願明細書に記載されている口腔輸送システムは、歯エナメルの再石灰化を促進する。これらの輸送システムは、リンペプチド又はリンタンパク質で安定化された、リン酸カルシウム又はフッ化リン酸カルシウム錯体、並びにカルシウム塩及び/又はリン酸塩を含んでなる。幾つかの実施形態では、当該リンペプチドはカゼインリンペプチドであり、それはリン酸カルシウム又はフッ化リン酸カルシウムを安定化された可溶性の形態で維持できる。望ましくは、当該錯体はCPP−ACPである。
Bosαs2カゼインX−5P(f59−79)[1]、
Bosβ−カゼインX−4P(f1−25)[2]、
Bosαs2−カゼインX−4P(f46−70)[3]、及び
Bosαs2−カゼインX−4P(f1−21)[4]:
[1]Gin59−Met−Glu−Ala−Glu−Ser(P)−Ile−Ser(P)−Ser(P)−Ser(P)−Glu−Glu−Ile−Val−Pro−Asn−Ser(P)−Val−Glu−Gin−Lys79αs1(59−79);
[2]Arg1−Glu−Leu−Glu−Glu−Leu−Asn−Val−Pro−Gly−Glu−Ile−Val−Glu−Ser(P)−Leu−Ser(P)−Ser(P)−Ser(P)−Glu−Glu−Ser−Ile−Thr−Arg25β(1−25);
[3]Asn46−Ala−Asn−Glu−Glu−Glu−Tyr−Ser−Ile−Ser(P)−Ser(P)−Ser(P)−Glu−Glu−Ser(P)−Ala−Glu−Val−Ala−Thr−Glu−Glu−Val−Lys70αs2(46−70);
[4]Lys1−Asn−Thr−Met−Glu−His−Val−Ser(P)−Ser(P)−Ser(P)−Glu−Glu−Ser−Ile−Ile−Ser(P)−Gln−Glu−Thr−Tyr−Lys21αs2(1−21)。
本願明細書に記載されている幾つかの実施形態では、チューインガム組成物以外の菓子組成物(キャンディを含む)の提供に関する。上記菓子組成物は、齲歯防止剤である、リンペプチド又はリンタンパク質で安定化されたリン酸カルシウム又はフッ化リン酸カルシウム錯体(例えばCPP−ACP)、並びにカルシウム塩及び/又はリン酸塩を含んでなる。菓子組成物はまた、製菓用担体を含んでなる。幾つかの実施形態では、少なくとも1つの糖甘味料を含有する、シュガー入りの菓子組成物の提供に関する。上記シュガー入りの菓子組成物は、糖甘味料に加えて、シュガーレスの甘味料を含有してもよい。他の実施形態では、シュガーレスの甘味料のみを含有するシュガーレスの菓子組成物の提供に関する。本願明細書に記載されている菓子組成物は、本発明の組成物と実質的に同様であるが、CPP−ACP、並びにカルシウム塩及び/又はリン酸塩を含まない菓子組成物と比較し、高いレベルで歯エナメルの再石灰化を促進する。
本願明細書に記載されている実施形態では、ガムベース、リンペプチド又はリンタンパク質で安定化されたリン酸カルシウム又はフッ化リン酸カルシウム錯体(例えばCPP−ACP)(齲歯防止剤)並びに、カルシウム塩及び/又はリン酸塩を含有するチューインガム組成物の提供に関する。幾つかの実施形態では、少なくとも1つの糖甘味料を含有する、シュガー入りチューインガム組成物の提供に関する。当該シュガー入りチューインガム組成物は、糖甘味料に加えて、シュガーレスの甘味料を含有してもよい。他の実施形態では、シュガーレスの甘味料のみを含有する、シュガーレスのチューインガム組成物の提供に関する。当該チューインガム組成物は、実質的に同様であるが、CPP−ACP及びカルシウム塩及び/又はリン酸塩を含まないチューインガム組成物と比較し、高いレベルで歯エナメルの再石灰化を促進する。
幾つかの実施形態では、上記口腔輸送システムは、様々なソフト菓子フォーマットの形態であってもよい。ソフト菓子フォーマットとしては、限定されないが、ヌガー、キャラメル、タフィー、グミ及びゼリーなどが挙げられる。かかる輸送システム中には、上記のいずれかの添加物を任意に含有させてもよい。
口腔輸送システムはまた、様々なチョコレート菓子フォーマットの形であってもよい。チョコレート菓子製品としては、ミルクチョコレート、ブラックチョコレート及び/又はホワイトチョコレートなどが挙げられる。ミルクチョコレートは、他のミルクチョコレート成分(例えばココアリキッド、カカオバター及び/又はその他脂肪、甘味料、乳化剤、風味剤など)と共に乳固形分を含有してもよい。幾つかの実施形態では、乳固形分は、ミルクチョコレート組成物に対して5重量%の量から、ミルクチョコレート組成物に対して40重量%超の量で存在してもよい。あるいは、乳固形分は乾燥粉ミルク又は液体の牛乳であってもよい。
幾つかの実施形態では、リンペプチド又はリンタンパク質で安定化されたリン酸カルシウム又はフッ化リン酸カルシウム錯体、並びにカルシウム塩及び/又はリン酸塩の輸送用のゲル、歯磨剤又は歯みがきの形の、口腔輸送システムの提供に関する。かかる輸送システムは、上記の添加物のいずれかを任意に含有してもよい。
幾つかの実施形態では、上記口腔輸送システムは、マウスウォッシュ、リンス又はスプレーであってもよい。マウスウォッシュ、すすぎ及びスプレーの成分は典型的には、組成物の約45%〜95重量%の量の水、組成物の70重量%以下の1つ以上のエタノール、組成物の50重量%以下の湿潤剤、組成物の約0.01%〜7重量%の界面活性剤、組成物の約0.04%〜2重量%の香料、組成物の約0.1%〜3重量%の甘味料、及び組成物の約0.001%〜0.5重量%の着色剤である。マウスウォッシュ、リンス及びスプレーは典型的には、組成物の約0.05%から0.3重量%の、1つ以上の齲歯防止剤(例えばフッ化物イオン)、及び組成物の約0.1%〜3重量%の歯石防止剤を含有する。また、上記の添加物のいずれかを任意に含有させもよい。
幾つかの実施形態では、リンペプチド又はリンタンパク質で安定化されたリン酸カルシウム又はフッ化リン酸カルシウム錯体、並びにカルシウム塩及び/又はリン酸塩の輸送のための、飲料形態の口腔輸送システムの提供に関する。様々な飲料組成物が使用できる。適切な飲料の実施形態を以下に示す。上記の添加物のいずれかを、かかる飲料組成物に任意に含有させてもよい。
ジュースベースの組成物は通常、果物又は野菜から得られるジュース成分を含有する。当該ジュース成分は、いかなる形態(例えば液状、濃縮物、抽出物、粉末等)において用いてもよい。
ミルクベースの組成物は通常、牛乳タンパク質(例えばカゼイン、乳漿タンパク質など)、脂肪、ラクトース及び水など、乳成分を様々な量で含有する。典型的な乳成分としては、上記の乳成分のうちの少なくとも1つを含んでなる、ヨーグルト、クリーム、全乳、低脂肪若しくは高脂肪の牛乳、脱脂乳、乳固形分、濃縮ミルク又はそれらの組合せが挙げられる。
本願明細書に記載されている組成物は更に、アルコール組成物であってもよい。好適なアルコールの組成物の例としては、上記の少なくとも1つを含んでなるビール、スピリッツ、リキュール、ワイン又はそれらの組合せが挙げられる。幾つかの実施形態では、アルコールの濃度(当該飲料組成物に含まれるエタノールの量で測定)は、飲料組成物に対して約0.5体積%〜20体積%であってもよい。
炭酸ガスを含有する飲料組成物は、典型的には飲料組成物の体積に対して、約0.1〜約5.0倍容のガス又は混合ガス(通常二酸化炭素)を含有する。炭酸封入は、飲料組成物に圧力下でガスを強力に導入することにより実施できる。飲料組成物を冷却することにより、飲料組成物中に溶解される二酸化炭素の量を増加させることができる。炭酸封入を行うことにより、組成物の風味、甘さ、味覚及び口あたりを刺激的にすることができる。更に、炭酸封入により、組成物のpHが低下する。
本明細書で用いられる「冷凍飲料組成物」は、懸濁されている氷晶を有する、粘着性であるが飲料として飲むことができる飲料組成物のことを指す。当該冷凍飲料組成物の密度を変化させることによって、「ぬかるんだ」、あるいは「スプーンですくうことができる」コンシステンシーとすることができる。氷晶は、冷凍飲料組成物の合計量に対して、約20〜約90重量%、具体的には約30〜約70重量%、より具体的には約40〜約50重量%の量で、冷凍飲料組成物に存在させてもよい。
本明細書で用いられる「ゲル飲料組成物」は、増粘剤を含有する、粘着性であるが飲むことができる、飲料組成物であってもよい。ゲル飲料組成物の密度を適宜調整することにより、「半固体」状、あるいは「スプーンですくうことができる」コンシステンシーとすることができる。増粘剤(時々ハイドロコロイドと呼ばれる)としては、限定されないが、天然及び合成ゴム(例えばイナゴマメガム、グアーガム、ジェランガム、キサン、ガティガム、修飾ガティガム、トラガカントガム、カラギーナンなど)、天然及び修飾澱粉、例えばゼラチン化澱粉(穀物、小麦、タピオカ)、ゼラチン化高アミロース含有澱粉、ゼラチン化加水分解澱粉(マルトデキストリン、コーンシロップ固形物)、化学修飾澱粉、例えばゼラチン化置換澱粉(例えばオクテニル琥珀酸エステル)、セルロース誘導体(例えばカルボキシメチルセルロース、カルボキシルメチルセルロースナトリウムなど)、ポリデキストロース、ホエイ又はホエイタンパク質濃縮物、ペクチン、ゼラチン、又はそれらの増粘剤のうちの少なくとも1つを含んでなる組合せなどが挙げられる。
濃縮組成物は、乾燥形態(例えば粉又は錠剤)であってもよく、又は液状(例えばシロップ、懸濁液又はエマルジョン)であってもよい。濃縮組成物は通常、液体媒体中に一定量の香料を含有し、最終的な飲料よりも液体媒体の量が少ない。濃縮物に、他の成分(甘味料、着色剤及び他の添加物(例えば食品グレードの酸、防腐剤など))を任意に添加してもよい。濃縮組成物は、最終的な飲料組成物の体積と比較し小さい体積を有し、それにより重量、ボリューム、貯蔵及び輸送経費を抑えることができ、同時に濃縮物では、飲料組成物と比較し貯蔵寿命が長期化する。
本願明細書に記載されている幾つかの実施形態では、哺乳類の歯エナメルを再石灰化する方法、具体的にはエナメル表面下の病変を再石灰化する方法の提供に関する。かかる方法は、特にヒトの歯エナメルの再石灰化に有用である。かかる方法では、上記の口腔輸送システムのいずれかを、哺乳類の口腔内に投与するのが好ましい。当該製品は、本願明細書に記載のように、リンペプチド又はリンタンパク質で安定化されたリン酸カルシウム又はフッ化リン酸カルシウム錯体(例えばCPP−ACP)、並びにカルシウム塩及び/又はリン酸塩を含んでなる。また、上記の他の添加物のいずれかを任意に含有してもよい。
この実施例は、対照のシュガー入りの菓子製品及び対照のシュガーレスの菓子製品と比較した場合の、CPP−ACPを含有するシュガー入りの菓子製品の再石灰化効果を示す。
この実施例は、対照のシュガー入りの菓子製品及び対照のシュガーレスの菓子製品と比較した、CPP−ACP、乳酸カルシウム及びリン酸ナトリウムを含有するシュガー入りの菓子製品の再石灰化効果を示す。
Claims (12)
- シュガー入り菓子組成物であって、
(a)少なくとも1つの糖甘味料と、
(b)前記菓子組成物中に0.1重量%〜2.5重量%の量で存在する、リンペプチド又はリンタンパク質で安定化されたリン酸カルシウム錯体又はフッ化リン酸カルシウム錯体と、
(c)前記菓子組成物中に1.5重量%〜3重量%の量で存在するカルシウム塩及び前記菓子組成物中に1重量%〜4重量%の量で存在するリン酸塩とを含んでなるシュガー入り菓子組成物。 - 前記リンペプチドがカゼインリンペプチドを含んでなる、請求項1に記載のシュガー入り菓子組成物。
- シュガー入り菓子組成物であって、
固体部分及び前記固体部分の溶解部分を含んでなり、
前記固体部分及び前記溶解部分が、少なくとも1つの糖甘味料と、カゼインリンペプチド−リン酸カルシウムと、カルシウム塩と、リン酸塩とを含んでなり、
前記カゼインリンペプチド−リン酸カルシウムが、前記菓子組成物中に0.1重量%〜2.5重量%の量で存在し、
前記カルシウム塩は、前記菓子組成物中に1.5重量%〜3重量%の量で存在し、
前記リン酸塩は、前記菓子組成物中に1重量%〜4重量%の量で存在するシュガー入り菓子組成物。 - シュガー入り菓子組成物であって、
(a)少なくとも1つの糖甘味料を含んでなる製菓用担体と、
(b)前記菓子組成物中に0.1重量%〜2.5重量%の量で存在するカゼインリンペプチド−リン酸カルシウムと、
(c)前記菓子組成物中に1.5重量%〜3重量%の量で存在するカルシウム塩及び前記菓子組成物中に1重量%〜4重量%の量で存在するリン酸塩とを含んでなるシュガー入り菓子組成物。 - 前記カルシウム塩は、前記菓子組成物中に1.6重量%〜2.8重量%以下の量で含有する、請求項1から4のいずれか1項に記載のシュガー入り菓子組成物。
- 前記リン酸塩は、前記菓子組成物中に3重量%以下の量で含有する、請求項1から5のいずれか1項に記載のシュガー入り菓子組成物。
- 前記リン酸塩は、前記菓子組成物中に1.8重量%以下の量で含有する、請求項1から6のいずれか1項に記載のシュガー入り菓子組成物。
- 風味剤、食品グレードの酸、過酸化物、及びキレート剤からなる群から選択される少なくとも1つの成分を更に含んでなる、請求項1から7のいずれか1項に記載のシュガー入り菓子組成物。
- シュガー入りチューインガム組成物であって、
固体部分及び前記固体部分の溶解部分を含んでなり、
前記固体部分が、ガムベースと、少なくとも1つの糖甘味料と、カゼインリンペプチド−リン酸カルシウムと、カルシウム塩と、リン酸塩とを含んでなり、
前記溶解部分が、少なくとも1つの糖甘味料と、前記カゼインリンペプチド−リン酸カルシウムと、前記カルシウム塩と、前記リン酸塩とを含んでなり、
前記カゼインリンペプチド−リン酸カルシウムが、前記シュガー入りチューインガム組成物中に0.1重量%〜2.5重量%の量で存在し、
前記カルシウム塩は、前記シュガー入りチューインガム組成物中に1.5重量%〜3重量%の量で存在し、
前記リン酸塩は、前記シュガー入りチューインガム組成物中に1重量%〜4重量%の量で存在するシュガー入りチューインガム組成物。 - 前記組成物が消費されることにより、哺乳類の歯において少なくとも2.8%のレベルでエナメル表面下の再石灰化が提供される、請求項1から9のいずれか1項記載の組成物。
- シュガー入りチューインガム組成物であって、
(a)ガムベースと、
(b)少なくとも1つの糖甘味料と、
(c)前記シュガー入りチューインガム組成物中に0.1重量%〜2.5重量%の量で存在するカゼインリンペプチド−リン酸カルシウムと、
(d)前記シュガー入りチューインガム組成物中に1.5重量%〜3重量%の量で存在するカルシウム塩及び前記シュガー入りチューインガム組成物中に1重量%〜4重量%の量で存在するリン酸塩とを含んでなるシュガー入りチューインガム組成物。 - 前記カルシウム塩及び前記リン酸塩の合計は、前記組成物に対して5重量%以下である、請求項1から11のいずれか1項記載の組成物。
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AU2007235359B2 (en) | 2011-03-10 |
EP2001436B1 (en) | 2017-01-04 |
MX2008012524A (es) | 2008-10-10 |
WO2007117627A2 (en) | 2007-10-18 |
ES2619161T3 (es) | 2017-06-23 |
CA2648460A1 (en) | 2007-10-18 |
JP2009534313A (ja) | 2009-09-24 |
RU2008133366A (ru) | 2010-05-10 |
RU2421207C2 (ru) | 2011-06-20 |
BRPI0709892A2 (pt) | 2011-07-26 |
BRPI0709892B1 (pt) | 2020-12-22 |
CA2648460C (en) | 2014-09-23 |
AU2007235359A1 (en) | 2007-10-18 |
US8133476B2 (en) | 2012-03-13 |
EP2001436A4 (en) | 2013-11-27 |
JP2013006851A (ja) | 2013-01-10 |
EP2001436A2 (en) | 2008-12-17 |
US20070237725A1 (en) | 2007-10-11 |
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