JP2008520658A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008520658A5 JP2008520658A5 JP2007542955A JP2007542955A JP2008520658A5 JP 2008520658 A5 JP2008520658 A5 JP 2008520658A5 JP 2007542955 A JP2007542955 A JP 2007542955A JP 2007542955 A JP2007542955 A JP 2007542955A JP 2008520658 A5 JP2008520658 A5 JP 2008520658A5
- Authority
- JP
- Japan
- Prior art keywords
- contrast agent
- amino acid
- formula
- agent according
- units
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 2
- 150000003973 alkyl amines Chemical class 0.000 claims description 2
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 125000002837 carbocyclic group Chemical group 0.000 claims description 2
- 125000003709 fluoroalkyl group Chemical group 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 239000002872 contrast media Substances 0.000 claims 11
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 239000012217 radiopharmaceutical Substances 0.000 claims 4
- 229940121896 radiopharmaceutical Drugs 0.000 claims 4
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 4
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical group OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- 239000004472 Lysine Substances 0.000 claims 3
- 239000002738 chelating agent Substances 0.000 claims 3
- 235000018417 cysteine Nutrition 0.000 claims 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 2
- 235000003704 aspartic acid Nutrition 0.000 claims 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 2
- 239000013522 chelant Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- IYKLZBIWFXPUCS-VIFPVBQESA-N (2s)-2-(naphthalen-1-ylamino)propanoic acid Chemical group C1=CC=C2C(N[C@@H](C)C(O)=O)=CC=CC2=C1 IYKLZBIWFXPUCS-VIFPVBQESA-N 0.000 claims 1
- BLCJBICVQSYOIF-UHFFFAOYSA-N 2,2-diaminobutanoic acid Chemical compound CCC(N)(N)C(O)=O BLCJBICVQSYOIF-UHFFFAOYSA-N 0.000 claims 1
- GNTIRRQEPHPUCI-UHFFFAOYSA-N 2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethylamino]-2-oxoethoxy]acetic acid Chemical compound NCCOCCOCCOCCNC(=O)COCC(O)=O GNTIRRQEPHPUCI-UHFFFAOYSA-N 0.000 claims 1
- PECYZEOJVXMISF-UHFFFAOYSA-N 3-aminoalanine Chemical compound [NH3+]CC(N)C([O-])=O PECYZEOJVXMISF-UHFFFAOYSA-N 0.000 claims 1
- 125000004080 3-carboxypropanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C(O[H])=O 0.000 claims 1
- UQTZMGFTRHFAAM-ZETCQYMHSA-N 3-iodo-L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(I)=C1 UQTZMGFTRHFAAM-ZETCQYMHSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- NTWVQPHTOUKMDI-YFKPBYRVSA-N N-Methyl-arginine Chemical compound CN[C@H](C(O)=O)CCCN=C(N)N NTWVQPHTOUKMDI-YFKPBYRVSA-N 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- 125000003368 amide group Chemical group 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 229940009098 aspartate Drugs 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001142 dicarboxylic acid group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229930195712 glutamate Natural products 0.000 claims 1
- 229940049906 glutamate Drugs 0.000 claims 1
- 125000000350 glycoloyl group Chemical group O=C([*])C([H])([H])O[H] 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 238000011503 in vivo imaging Methods 0.000 claims 1
- 229960003646 lysine Drugs 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 125000000542 sulfonic acid group Chemical group 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20045081 | 2004-11-22 | ||
| NO20045081 | 2004-11-22 | ||
| PCT/NO2005/000435 WO2006054904A2 (en) | 2004-11-22 | 2005-11-21 | Contrast agents to target extracellular matrix |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012144870A Division JP2012207027A (ja) | 2004-11-22 | 2012-06-28 | 造影剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008520658A JP2008520658A (ja) | 2008-06-19 |
| JP2008520658A5 true JP2008520658A5 (cg-RX-API-DMAC7.html) | 2012-02-23 |
| JP5116480B2 JP5116480B2 (ja) | 2013-01-09 |
Family
ID=36182407
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007542955A Expired - Fee Related JP5116480B2 (ja) | 2004-11-22 | 2005-11-21 | 造影剤 |
| JP2012144870A Pending JP2012207027A (ja) | 2004-11-22 | 2012-06-28 | 造影剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012144870A Pending JP2012207027A (ja) | 2004-11-22 | 2012-06-28 | 造影剤 |
Country Status (17)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0610395D0 (en) * | 2006-05-25 | 2006-07-05 | Ge Healthcare Ltd | Novel imaging agents |
| EP2056886A2 (en) * | 2006-08-28 | 2009-05-13 | GE Healthcare Limited | 68ga-labeled peptide-based radiopharmaceuticals |
| JP2008266194A (ja) * | 2007-04-19 | 2008-11-06 | Hiroshi Tanaka | 分子プローブの原料として有用な新規有機化合物 |
| GB0722650D0 (en) * | 2007-11-19 | 2007-12-27 | Ge Healthcare Ltd | Novel imaging method |
| WO2009074628A1 (en) * | 2007-12-13 | 2009-06-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Polypeptides, cyclic polypeptides and pharmaceutical comprising thereof for non invasive specific imaging of fibrosis |
| AU2009205950C1 (en) * | 2008-01-18 | 2015-08-06 | Visen Medical, Inc. | Fluorescent imaging agents |
| EP2300032A4 (en) | 2008-05-13 | 2012-12-05 | Univ Kansas | MARKER PRESENTING IN THE FORM OF A MAP PEPTIDE (METAL ABSTRACTION PEPTIDE) AND ASSOCIATED METHODS |
| GB0814722D0 (en) * | 2008-08-12 | 2008-09-17 | Ge Healthcare Ltd | Treatment monitoring |
| GB0910013D0 (en) * | 2009-06-10 | 2009-07-22 | Ge Healthcare Ltd | PET imaging of fibogenesis |
| KR100991716B1 (ko) * | 2009-10-22 | 2010-11-04 | 경북대학교 산학협력단 | 광학영상 조영제, 그 용도 및 장치 |
| CN102504603B (zh) * | 2011-10-20 | 2014-01-29 | 中国海洋大学 | 一种多聚物与生物染色剂的偶合物及其制备方法和用途 |
| WO2013181461A2 (en) | 2012-06-01 | 2013-12-05 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
| US20170050989A1 (en) * | 2013-12-03 | 2017-02-23 | The General Hospital Corporation | Molecular Imaging Probes |
| CN117623996B (zh) * | 2022-08-10 | 2025-07-22 | 中国药科大学 | 一种二价keap1-nrf2抑制剂、制备方法及其医药用途 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4647447A (en) | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| US4615876A (en) * | 1983-04-25 | 1986-10-07 | Curators Of The University Of Missouri | Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides |
| US4687659A (en) | 1984-11-13 | 1987-08-18 | Salutar, Inc. | Diamide-DTPA-paramagnetic contrast agents for MR imaging |
| US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| US6048982A (en) | 1986-04-18 | 2000-04-11 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
| DE68927479T2 (de) | 1988-05-02 | 1997-04-03 | Phanos Tech Inc | Verbindungen, zusammensetzungen und verfahren zum binden von bio-affektions-substanzen an oberflächenmembranen von bioteilchen |
| GB8903022D0 (en) | 1989-02-10 | 1989-03-30 | Celltech Ltd | Chemical compounds |
| WO1993011120A1 (en) | 1991-11-27 | 1993-06-10 | Zynaxis Technologies, Incorporated | Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles |
| ATE314097T1 (de) | 1996-10-28 | 2006-01-15 | Amersham Health As | Kontrastmittel |
| CA2269985A1 (en) | 1996-10-28 | 1998-05-07 | Aslak Godal | Improvements in or relating to diagnostic/therapeutic agents |
| CN1246059A (zh) * | 1997-01-29 | 2000-03-01 | 奈科姆成像有限公司 | 聚合物 |
| EP1037947B1 (en) | 1997-07-28 | 2003-09-10 | Amersham plc | Cyanine dyes |
| US5942637A (en) * | 1998-03-30 | 1999-08-24 | North Dakota State University Research Foundation | Compounds containing tetradecachlorocyclohexasilane dianion |
| US6852318B1 (en) * | 1998-05-08 | 2005-02-08 | The Regents Of The University Of California | Methods for detecting and inhibiting angiogenesis |
| EP2044955A3 (en) * | 1998-05-08 | 2009-04-29 | The Regents of the University of California | Methods for detecting and inhibiting angiogenesis |
| JP2000095758A (ja) * | 1998-09-18 | 2000-04-04 | Schering Ag | 近赤外蛍光造影剤および蛍光造影方法 |
| US6230777B1 (en) | 1999-02-04 | 2001-05-15 | Midmac Systems, Inc. | Filter forming and joining apparatus |
| WO2001077145A2 (en) * | 2000-04-12 | 2001-10-18 | Amersham Health As | Integrin binding peptide derivatives |
| NO20004795D0 (no) * | 2000-09-26 | 2000-09-26 | Nycomed Imaging As | Peptidbaserte forbindelser |
| JP2005506952A (ja) * | 2000-11-27 | 2005-03-10 | ブリストル−マイヤーズ・スクイブ・メディカル・イメージング・インコーポレイテッド | 心臓潅流およびビトロネクチンレセプター標的造影剤の同時造影 |
| GB0116815D0 (en) * | 2001-07-10 | 2001-08-29 | Nycomed Amersham Plc | Improved chelator conjugates |
| CN1622830A (zh) * | 2001-07-10 | 2005-06-01 | 安盛药业有限公司 | 肽基化合物 |
| GB0206750D0 (en) | 2002-03-22 | 2002-05-01 | Amersham Plc | Radiofluorination methods |
| WO2003105886A2 (en) | 2002-06-17 | 2003-12-24 | Cartela Ab | Methods and uses of the integrin alpha 10 chain, for preventing progression of atherosclerosis plaque formation |
| US7063158B2 (en) | 2003-06-16 | 2006-06-20 | Deepwater Technologies, Inc. | Bottom tensioned offshore oil well production riser |
| NO20033115D0 (no) * | 2003-07-08 | 2003-07-08 | Amersham Health As | Peptid-baserte forbindelser |
| GB0317815D0 (en) | 2003-07-30 | 2003-09-03 | Amersham Health As | Imaging agents |
| WO2005019247A2 (en) * | 2003-08-15 | 2005-03-03 | Board Of Regents, The University Of Texas System | Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy |
| US7431914B2 (en) * | 2003-11-24 | 2008-10-07 | Ge Healthcare As | Contrast agent |
| DE602005017475D1 (de) * | 2004-03-04 | 2009-12-17 | Ge Healthcare As | Konjugate von angiotensin-peptid analoga und chelatbildner für diagnose und therapie |
| RU2393167C2 (ru) * | 2004-06-16 | 2010-06-27 | Джи-И Хелткер АС | Пептидные соединения |
| CN102532264A (zh) | 2004-06-16 | 2012-07-04 | 通用电气医疗集团股份有限公司 | 基于肽的化合物 |
-
2005
- 2005-11-21 KR KR1020077011496A patent/KR20070091609A/ko not_active Withdrawn
- 2005-11-21 AU AU2005307195A patent/AU2005307195A1/en not_active Abandoned
- 2005-11-21 BR BRPI0518328-6A patent/BRPI0518328A2/pt not_active Application Discontinuation
- 2005-11-21 CA CA002586621A patent/CA2586621A1/en not_active Abandoned
- 2005-11-21 RU RU2007118385/04A patent/RU2007118385A/ru not_active Application Discontinuation
- 2005-11-21 AT AT05817391T patent/ATE494913T1/de not_active IP Right Cessation
- 2005-11-21 JP JP2007542955A patent/JP5116480B2/ja not_active Expired - Fee Related
- 2005-11-21 CN CN2005800470720A patent/CN101107016B/zh not_active Expired - Fee Related
- 2005-11-21 EP EP10169506A patent/EP2243496A3/en not_active Withdrawn
- 2005-11-21 US US11/719,662 patent/US8182790B2/en not_active Expired - Fee Related
- 2005-11-21 WO PCT/NO2005/000435 patent/WO2006054904A2/en not_active Ceased
- 2005-11-21 ES ES05817391T patent/ES2358745T3/es not_active Expired - Lifetime
- 2005-11-21 MX MX2007006050A patent/MX2007006050A/es not_active Application Discontinuation
- 2005-11-21 EP EP05817391A patent/EP1814598B1/en not_active Expired - Lifetime
- 2005-11-21 DE DE602005025911T patent/DE602005025911D1/de not_active Expired - Lifetime
-
2007
- 2007-05-01 IL IL182898A patent/IL182898A0/en unknown
- 2007-06-07 ZA ZA200705043A patent/ZA200705043B/xx unknown
- 2007-06-14 NO NO20073039A patent/NO20073039L/no not_active Application Discontinuation
-
2012
- 2012-06-28 JP JP2012144870A patent/JP2012207027A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008520658A5 (cg-RX-API-DMAC7.html) | ||
| JP2003531835A5 (cg-RX-API-DMAC7.html) | ||
| AU710923B2 (en) | Radiolabeled peptides for diagnosis and therapy | |
| JP7162592B2 (ja) | 線維芽細胞活性化タンパク質（ｆａｐ）標的イメージングおよび治療 | |
| RU2003137593A (ru) | Соединения на основе пептидов для направленной доставки к рецепторам интегринов | |
| CA2717427C (en) | Bombesin analog peptide antagonist conjugates | |
| JP2007530441A5 (cg-RX-API-DMAC7.html) | ||
| RU2017118326A (ru) | Бициклические пептидные лиганды, специфичные для мт1-ммр | |
| JP2013155195A5 (cg-RX-API-DMAC7.html) | ||
| RU2007112115A (ru) | Изобретение, относящееся к glp-1 и эксендинам | |
| JP2005518361A5 (cg-RX-API-DMAC7.html) | ||
| JP2012529433A5 (cg-RX-API-DMAC7.html) | ||
| HRP20161614T1 (hr) | Terapijska sredstva za smanjenje razina paratiroidnog hormona | |
| JP6164556B2 (ja) | 非特異的腎集積が低減された放射性標識ポリペプチド作製用薬剤 | |
| RU2007118385A (ru) | Контрастные агенты для направлений доставки во внеклеточный матрикс | |
| CN1161698A (zh) | 环六肽抑生长素类似物 | |
| JP2008504237A5 (cg-RX-API-DMAC7.html) | ||
| JPH09509419A (ja) | ペプチド−キレート化剤複合体 | |
| RU2006144279A (ru) | Пептидные соединения | |
| JP2954355B2 (ja) | 血栓イメージング用の放射性同位体標識化合物 | |
| KR860004081A (ko) | 폴리펩티드의 제조방법 | |
| JP2020522557A (ja) | 診断及び治療のための、改善された薬物動態及びコレシストキニン−２受容体（ｃｃｋ２ｒ）への標的化 | |
| CN1087955C (zh) | 锝－99m标记的成像剂 | |
| CN112672747B (zh) | 用于激活骨祖细胞中细胞信号传导的肽 | |
| JP2006523608A5 (cg-RX-API-DMAC7.html) |