JP2008514627A5 - - Google Patents
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- JP2008514627A5 JP2008514627A5 JP2007533699A JP2007533699A JP2008514627A5 JP 2008514627 A5 JP2008514627 A5 JP 2008514627A5 JP 2007533699 A JP2007533699 A JP 2007533699A JP 2007533699 A JP2007533699 A JP 2007533699A JP 2008514627 A5 JP2008514627 A5 JP 2008514627A5
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- Prior art keywords
- pharmaceutical composition
- disease
- motomeko
- salt according
- psychosis
- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61401404P | 2004-09-27 | 2004-09-27 | |
| US60/614,014 | 2004-09-27 | ||
| PCT/US2005/034376 WO2006036874A1 (en) | 2004-09-27 | 2005-09-26 | Salts of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and their preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008514627A JP2008514627A (ja) | 2008-05-08 |
| JP2008514627A5 true JP2008514627A5 (https=) | 2008-11-13 |
| JP5154227B2 JP5154227B2 (ja) | 2013-02-27 |
Family
ID=35539440
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007533762A Expired - Lifetime JP4996467B2 (ja) | 2004-09-27 | 2005-09-26 | Ｎ−（４−フルオロベンジル）−ｎ−（１−メチルピペリジン−４−イル）−ｎ’−（４−（２−メチルプロピルオキシ）フェニルメチル）カルバミド、並びにその酒石酸塩及び結晶形態の合成 |
| JP2007533699A Expired - Lifetime JP5154227B2 (ja) | 2004-09-27 | 2005-09-26 | Ｎ−（４−フルオロベンジル）−ｎ−（１−メチルピペリジン−４−イル）−ｎ’−（４−（２−メチルプロピルオキシ）フェニルメチル）カルバミドの塩及びその調製 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007533762A Expired - Lifetime JP4996467B2 (ja) | 2004-09-27 | 2005-09-26 | Ｎ−（４−フルオロベンジル）−ｎ−（１−メチルピペリジン−４−イル）−ｎ’−（４−（２−メチルプロピルオキシ）フェニルメチル）カルバミド、並びにその酒石酸塩及び結晶形態の合成 |
Country Status (17)
| Country | Link |
|---|---|
| US (6) | US7868176B2 (https=) |
| EP (3) | EP2289879B1 (https=) |
| JP (2) | JP4996467B2 (https=) |
| KR (2) | KR101260036B1 (https=) |
| CN (3) | CN101031548B (https=) |
| AU (2) | AU2005289635A1 (https=) |
| BR (1) | BRPI0516063A (https=) |
| CA (2) | CA2580136C (https=) |
| DK (1) | DK1794126T3 (https=) |
| ES (2) | ES2412207T3 (https=) |
| MX (2) | MX2007003433A (https=) |
| NZ (1) | NZ553702A (https=) |
| PL (2) | PL2289879T3 (https=) |
| RU (2) | RU2417986C2 (https=) |
| SG (2) | SG157378A1 (https=) |
| WO (2) | WO2006037043A1 (https=) |
| ZA (3) | ZA200702345B (https=) |
Families Citing this family (74)
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| RU2002126554A (ru) * | 2000-03-06 | 2004-03-20 | Акадиа Фармасьютикалз, Инк. (Us) | Азациклические соединения для применения при лечении опосредованных серотонином заболеваний |
| WO2003057698A2 (en) * | 2001-12-28 | 2003-07-17 | Acadia Pharmaceuticals, Inc. | Spiroazacyclic compounds as monoamine receptor modulators |
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| US7253186B2 (en) * | 2002-06-24 | 2007-08-07 | Carl-Magnus Andersson | N-substituted piperidine derivatives as serotonin receptor agents |
| US7538222B2 (en) | 2002-06-24 | 2009-05-26 | Acadia Pharmaceuticals, Inc. | N-substituted piperidine derivatives as serotonin receptor agents |
| MY139563A (en) * | 2002-09-04 | 2009-10-30 | Bristol Myers Squibb Co | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
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| US20050261278A1 (en) | 2004-05-21 | 2005-11-24 | Weiner David M | Selective serotonin receptor inverse agonists as therapeutics for disease |
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| JP4996467B2 (ja) * | 2004-09-27 | 2012-08-08 | アカディア ファーマシューティカルズ インコーポレイテッド | Ｎ−（４−フルオロベンジル）−ｎ−（１−メチルピペリジン−４−イル）−ｎ’−（４−（２−メチルプロピルオキシ）フェニルメチル）カルバミド、並びにその酒石酸塩及び結晶形態の合成 |
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| US20100029942A1 (en) * | 2008-06-30 | 2010-02-04 | Sergio Cesco-Cancian | Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives |
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| AR091507A1 (es) * | 2012-06-21 | 2015-02-11 | Intra Cellular Therapies Inc | SALES DE (6aR,9aS)-5,6a,7,8,9,9a-HEXAHIDRO-5-METIL-3-(FENILAMINO)-2-((4-(6-FLUOROPIRIDIN-2-IL)FENIL)METIL)-CICLOPENT[4,5]IMIDAZO[1,2-a]PIRAZOLO[4,3-e]PIRIMIDIN-4(2H)-ONA |
| US9446037B2 (en) | 2012-11-27 | 2016-09-20 | Acadia Pharmaceuticals Inc. | Methods for the treatment of parkinson's disease psychosis using pimavanserin |
| US9630971B2 (en) * | 2013-06-21 | 2017-04-25 | Intra-Cellular Therapies, Inc. | Free base crystals |
| JP2015117192A (ja) * | 2013-12-17 | 2015-06-25 | 東和薬品株式会社 | シロドシンγ型結晶及びその製造方法 |
| CN104961671B (zh) * | 2014-09-05 | 2018-01-02 | 苏州晶云药物科技有限公司 | N‑(4‑氟苄基)‑n‑(1‑甲基哌啶‑4‑基)‑n’‑(4‑(2‑甲基丙氧基)‑苯基甲基)脲半酒石酸盐的晶型及其制备方法 |
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| CN104961672B (zh) * | 2015-05-20 | 2017-10-20 | 沈阳药科大学 | 一种n‑(4‑氟苄基)‑n‑(1‑甲基哌啶‑4‑基)‑n’‑(4‑异丁氧基苄基)脲的酒石酸盐的合成方法 |
| CN104844502B (zh) * | 2015-06-05 | 2018-07-31 | 齐鲁师范学院 | 一种匹莫范色林的制备方法 |
| PL3325444T3 (pl) * | 2015-07-20 | 2021-12-06 | Acadia Pharmaceuticals Inc. | Sposoby wytwarzania N-(4-fluorobenzylo)-N-(1-metylopiperydyn-4-ylo)-N'-(4-(2-metylopropyloksy)fenylometylo)karbamidu oraz jego soli winianowej i postaci polimorficznej C |
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| CN105111135A (zh) * | 2015-09-09 | 2015-12-02 | 安徽省逸欣铭医药科技有限公司 | 取代的尿素衍生物制备方法 |
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| CN105153016B (zh) * | 2015-10-12 | 2017-10-03 | 北京诺康达医药科技有限公司 | 一种匹莫范色林的制备方法 |
| CN106588753B (zh) * | 2015-10-19 | 2021-07-09 | 重庆医药工业研究院有限责任公司 | 一种制备匹马色林的方法 |
| CN106699637A (zh) * | 2015-11-17 | 2017-05-24 | 重庆医药工业研究院有限责任公司 | 一种匹马色林单酒石酸盐晶型及其制备方法 |
| CN105924381B (zh) * | 2015-12-18 | 2019-04-16 | 重庆两江药物研发中心有限公司 | 一种哌马色林晶型c的制备方法 |
| CN105481757A (zh) * | 2015-12-25 | 2016-04-13 | 北京康立生医药技术开发有限公司 | 一种哌马色林的制备方法 |
| CN105523993A (zh) * | 2015-12-28 | 2016-04-27 | 重庆两江药物研发中心有限公司 | N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n’-(4-(2-甲基丙氧基)苯基甲基)脲酒石酸盐晶型c及制备应用 |
| CN107021917B (zh) * | 2016-02-02 | 2020-08-04 | 江苏恩华药业股份有限公司 | 哌马色林半酒石酸盐的新晶型及其制备方法 |
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| CN114867473A (zh) | 2019-11-08 | 2022-08-05 | 凯莫森特里克斯股份有限公司 | 补体成分c5a受体的盐形式 |
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| CN112920108A (zh) * | 2021-01-29 | 2021-06-08 | 北京诺康达医药科技股份有限公司 | 酒石酸匹莫范色林晶型a的制备方法 |
| CN114874103B (zh) * | 2022-05-11 | 2024-09-06 | 合肥立方制药股份有限公司 | 一种匹莫范色林中间体4-异丁氧基苄胺的连续合成方法 |
| JP7406285B1 (ja) | 2023-03-09 | 2023-12-27 | 国立大学法人島根大学 | ビリルビン誘発性神経機能障害、黄疸を伴う精神疾患、又はビリルビンｕｄｐ－グルクロン酸転移酵素遺伝子変異に起因する精神疾患を治療、予防又は管理するための医薬組成物 |
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- 2005-09-26 AU AU2005289635A patent/AU2005289635A1/en not_active Abandoned
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- 2005-09-26 CN CN2005800326490A patent/CN101031548B/zh not_active Expired - Lifetime
- 2005-09-26 EP EP10180395.5A patent/EP2289879B1/en not_active Expired - Lifetime
- 2005-09-26 WO PCT/US2005/034813 patent/WO2006037043A1/en not_active Ceased
- 2005-09-26 RU RU2007115886/04A patent/RU2417986C2/ru active
- 2005-09-26 JP JP2007533699A patent/JP5154227B2/ja not_active Expired - Lifetime
- 2005-09-26 RU RU2007115921/04A patent/RU2387643C2/ru active
- 2005-09-26 EP EP05801891A patent/EP1794125A1/en not_active Withdrawn
- 2005-09-26 SG SG200907436-0A patent/SG157378A1/en unknown
- 2005-09-26 WO PCT/US2005/034376 patent/WO2006036874A1/en not_active Ceased
- 2005-09-26 SG SG201002293-7A patent/SG161221A1/en unknown
- 2005-09-26 AU AU2005289444A patent/AU2005289444B2/en not_active Expired
- 2005-09-26 NZ NZ553702A patent/NZ553702A/en not_active IP Right Cessation
- 2005-09-26 KR KR1020077009394A patent/KR101260036B1/ko not_active Expired - Lifetime
- 2005-09-26 CN CN2005800326503A patent/CN101035759B/zh not_active Expired - Lifetime
- 2005-09-26 US US11/235,381 patent/US7868176B2/en active Active
- 2005-09-26 US US11/235,558 patent/US7732615B2/en active Active
- 2005-09-26 CA CA002580129A patent/CA2580129A1/en not_active Abandoned
- 2005-09-26 CN CN201110039289.4A patent/CN102153505B/zh not_active Expired - Lifetime
- 2005-09-26 MX MX2007003433A patent/MX2007003433A/es active IP Right Grant
- 2005-09-26 DK DK05805643.3T patent/DK1794126T3/da active
- 2005-09-26 KR KR1020077009395A patent/KR20070083800A/ko not_active Withdrawn
- 2005-09-26 BR BRPI0516063-4A patent/BRPI0516063A/pt not_active Application Discontinuation
- 2005-09-26 PL PL05805643T patent/PL1794126T3/pl unknown
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- 2005-09-26 ES ES10180395.5T patent/ES2530258T3/es active Active
- 2005-09-26 EP EP05805643A patent/EP1794126B1/en not_active Expired - Lifetime
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- 2006-05-03 US US11/418,341 patent/US20060205781A1/en not_active Abandoned
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