CN101031548B - N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n'-(4-(2-甲基丙氧基)-苯基甲基)脲的盐及其制备 - Google Patents

N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n'-(4-(2-甲基丙氧基)-苯基甲基)脲的盐及其制备 Download PDF

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CN101031548B
CN101031548B CN2005800326490A CN200580032649A CN101031548B CN 101031548 B CN101031548 B CN 101031548B CN 2005800326490 A CN2005800326490 A CN 2005800326490A CN 200580032649 A CN200580032649 A CN 200580032649A CN 101031548 B CN101031548 B CN 101031548B
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formula
crystalline
salt
acid
disease
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CN101031548A (zh
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米克尔·蒂格森
纳塔利·施林格
博-拉格纳·托尔夫
弗里茨·布拉特尔
约尔格·贝格豪森
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Acadia Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Biomedical Technology (AREA)
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  • Pain & Pain Management (AREA)
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  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CN2005800326490A 2004-09-27 2005-09-26 N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n'-(4-(2-甲基丙氧基)-苯基甲基)脲的盐及其制备 Expired - Lifetime CN101031548B (zh)

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US61401404P 2004-09-27 2004-09-27
US60/614,014 2004-09-27
PCT/US2005/034376 WO2006036874A1 (en) 2004-09-27 2005-09-26 Salts of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and their preparation

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CN101031548A CN101031548A (zh) 2007-09-05
CN101031548B true CN101031548B (zh) 2011-04-06

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CN2005800326490A Expired - Lifetime CN101031548B (zh) 2004-09-27 2005-09-26 N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n'-(4-(2-甲基丙氧基)-苯基甲基)脲的盐及其制备
CN2005800326503A Expired - Lifetime CN101035759B (zh) 2004-09-27 2005-09-26 N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n’-(4-(2-甲基丙氧基)苯基甲基)脲及其酒石酸盐的合成和晶形
CN201110039289.4A Expired - Lifetime CN102153505B (zh) 2004-09-27 2005-09-26 N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n’-(4-(2-甲基丙氧基)苯基甲基)脲及其酒石酸盐的合成和晶形

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CN2005800326503A Expired - Lifetime CN101035759B (zh) 2004-09-27 2005-09-26 N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n’-(4-(2-甲基丙氧基)苯基甲基)脲及其酒石酸盐的合成和晶形
CN201110039289.4A Expired - Lifetime CN102153505B (zh) 2004-09-27 2005-09-26 N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n’-(4-(2-甲基丙氧基)苯基甲基)脲及其酒石酸盐的合成和晶形

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US (6) US7868176B2 (https=)
EP (3) EP2289879B1 (https=)
JP (2) JP4996467B2 (https=)
KR (2) KR101260036B1 (https=)
CN (3) CN101031548B (https=)
AU (2) AU2005289635A1 (https=)
BR (1) BRPI0516063A (https=)
CA (2) CA2580136C (https=)
DK (1) DK1794126T3 (https=)
ES (2) ES2412207T3 (https=)
MX (2) MX2007003433A (https=)
NZ (1) NZ553702A (https=)
PL (2) PL2289879T3 (https=)
RU (2) RU2417986C2 (https=)
SG (2) SG157378A1 (https=)
WO (2) WO2006037043A1 (https=)
ZA (3) ZA200702345B (https=)

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