JP2008514237A5 - - Google Patents

Download PDF

Info

Publication number
JP2008514237A5
JP2008514237A5 JP2007534832A JP2007534832A JP2008514237A5 JP 2008514237 A5 JP2008514237 A5 JP 2008514237A5 JP 2007534832 A JP2007534832 A JP 2007534832A JP 2007534832 A JP2007534832 A JP 2007534832A JP 2008514237 A5 JP2008514237 A5 JP 2008514237A5
Authority
JP
Japan
Prior art keywords
tissue culture
flow rate
concentration
clarified tissue
specific flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007534832A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008514237A (ja
JP5579966B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2005/035364 external-priority patent/WO2006039588A2/en
Publication of JP2008514237A publication Critical patent/JP2008514237A/ja
Publication of JP2008514237A5 publication Critical patent/JP2008514237A5/ja
Application granted granted Critical
Publication of JP5579966B2 publication Critical patent/JP5579966B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2007534832A 2004-09-30 2005-09-30 生体分子の一貫連続製造のための装置及び方法 Expired - Lifetime JP5579966B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61499504P 2004-09-30 2004-09-30
US60/614,995 2004-09-30
PCT/US2005/035364 WO2006039588A2 (en) 2004-09-30 2005-09-30 Devices and methods for integrated continuous manufacturing of biological molecules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012129422A Division JP5762360B2 (ja) 2004-09-30 2012-06-07 生体分子の一貫連続製造のための装置及び方法

Publications (3)

Publication Number Publication Date
JP2008514237A JP2008514237A (ja) 2008-05-08
JP2008514237A5 true JP2008514237A5 (https=) 2014-07-03
JP5579966B2 JP5579966B2 (ja) 2014-08-27

Family

ID=36143124

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007534832A Expired - Lifetime JP5579966B2 (ja) 2004-09-30 2005-09-30 生体分子の一貫連続製造のための装置及び方法
JP2012129422A Expired - Lifetime JP5762360B2 (ja) 2004-09-30 2012-06-07 生体分子の一貫連続製造のための装置及び方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012129422A Expired - Lifetime JP5762360B2 (ja) 2004-09-30 2012-06-07 生体分子の一貫連続製造のための装置及び方法

Country Status (24)

Country Link
US (3) US9045725B2 (https=)
EP (2) EP2550971B1 (https=)
JP (2) JP5579966B2 (https=)
KR (2) KR101238798B1 (https=)
CN (2) CN102794109B (https=)
AU (1) AU2005292358B2 (https=)
BR (1) BRPI0515849B1 (https=)
CA (1) CA2579845C (https=)
CY (1) CY1117699T1 (https=)
DK (2) DK2550971T3 (https=)
ES (2) ES2570006T3 (https=)
HR (1) HRP20070097B1 (https=)
HU (2) HUE032538T2 (https=)
IL (5) IL181775A (https=)
LT (1) LT2550971T (https=)
NO (2) NO341439B1 (https=)
NZ (2) NZ588616A (https=)
PL (1) PL1807101T3 (https=)
PT (1) PT2550971T (https=)
RU (1) RU2390526C2 (https=)
SI (1) SI2550971T1 (https=)
UA (3) UA112529C2 (https=)
WO (1) WO2006039588A2 (https=)
ZA (1) ZA200702578B (https=)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1807101T3 (pl) 2004-09-30 2016-11-30 Urządzenia i sposoby do zintegrowanego wytwarzania cząsteczek biologicznych w sposób ciągły
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
AU2007294731B2 (en) 2006-09-13 2014-04-17 Abbvie Inc. Cell culture improvements
FR2920429B1 (fr) * 2007-08-30 2012-10-05 Lfb Biotechnologies Procede de purification du facteur viii et du facteur von willebrand
NZ592095A (en) 2008-10-20 2013-01-25 Abbott Lab Isolation and purification of il-12 and tnf-alpha antibodies using protein a affinity chromatography
BRPI0920572A8 (pt) 2008-10-20 2015-10-27 Abbott Lab Inativação viral durante a purificação dos anticorpos
US9527010B2 (en) 2009-09-25 2016-12-27 Ge Healthcare Bio-Sciences Corp. Separation system and method
JP5860887B2 (ja) 2010-10-15 2016-02-16 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 大容量使い捨て限外濾過システム及び方法
CN102154408B (zh) * 2011-01-13 2013-06-05 天津市工业微生物研究所 小核菌硬葡聚糖在线发酵提取方法及系统
US9982227B2 (en) 2011-03-08 2018-05-29 University Of Maryland, Baltimore County System and method for production of on-demand proteins in a portable unit for point of care delivery
US10774304B2 (en) * 2011-03-08 2020-09-15 University Of Maryland, Baltimore County System and method for production of on-demand proteins in a portable unit for point of care delivery
US12227734B2 (en) 2011-03-08 2025-02-18 University Of Maryland, Baltimore County Microscale bioprocessing system and method for protein manufacturing from human blood
US9388373B2 (en) * 2011-03-08 2016-07-12 University Of Maryland Baltimore County Microscale bioprocessing system and method for protein manufacturing
US9062106B2 (en) 2011-04-27 2015-06-23 Abbvie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
CA2852052C (en) * 2011-10-11 2017-01-17 Sentry Depressurization Systems, Inc. Depressurization system for an electrical transformer
CA2861270C (en) 2012-01-18 2021-08-03 Bayer Healthcare Llc Perfusion bioreactor systems comprising a cell aggregate trap and methods of operating the same
US9997264B2 (en) * 2012-02-14 2018-06-12 Control Components, Inc. Enhanced nuclear sump strainer system
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
HK1211981A1 (en) 2012-09-02 2016-06-03 Abbvie Inc. Methods to control protein heterogeneity
SG10201806083RA (en) 2013-02-22 2018-08-30 Genzyme Corp Microcarrier perfusion culturing methods and uses thereof
HUE042094T2 (hu) 2013-02-22 2019-06-28 Genzyme Corp Mikrokarrier-perfúziós tenyésztési eljárások és alkalmazásuk
AU2014226126B2 (en) 2013-03-08 2019-02-14 Genzyme Corporation Continuous purification of therapeutic proteins
HK1207960A1 (en) 2013-03-12 2016-02-19 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
US20170058308A1 (en) * 2014-05-02 2017-03-02 Novo Nordisk A/S Integrated continuous biomanufacturing process
EP4218991A1 (en) 2014-05-13 2023-08-02 Amgen Inc. Process control systems and methods for use with filters and filtration processes
AU2015267312B2 (en) * 2014-05-27 2018-06-28 Artificial Cell Technologies, Inc. Automated layer by layer construction of multilayer coated cores by TFF
TWI743024B (zh) 2014-06-06 2021-10-21 美商健臻公司 灌注培養方法及其用途
TWI707949B (zh) 2014-06-09 2020-10-21 美商健臻公司 種子罐培養法(seed train processes)及其用途
WO2015195453A2 (en) 2014-06-16 2015-12-23 Emd Millipore Corporation Methods for increasing the capacity of flow-through processes
US10207225B2 (en) 2014-06-16 2019-02-19 Emd Millipore Corporation Single-pass filtration systems and processes
ES2742704T3 (es) 2014-06-25 2020-02-17 Emd Millipore Corp Elementos, módulos y sistemas de filtro compactos, enrollados en espiral
SG11201508664VA (en) 2014-08-29 2016-03-30 Emd Millipore Corp Single Pass Tangential Flow Filtration Systems and Tangential Flow Filtration Systems withRecirculation of Retentate
CN108325391B (zh) 2014-08-29 2021-05-18 Emd 密理博公司 过滤液体进料的方法
USD761381S1 (en) 2014-12-18 2016-07-12 Emd Millipore Corporation Retentate plate
USD762811S1 (en) 2014-12-18 2016-08-02 Emd Millipore Corporation Diverter plate
EP3093335A1 (de) 2015-05-13 2016-11-16 Bayer Technology Services GmbH Prozessleitsystem zur regelung und steuerung einer modular aufgebauten anlage zur produktion von biopharmazeutischen und biologischen makromolekularen produkten
ITUA20161506A1 (it) * 2016-03-09 2017-09-09 Della Toffola Spa Metodo ed impianto perfezionato di filtrazione tangenziale
US20200289987A1 (en) 2016-03-14 2020-09-17 Pendotech Processing System for Multiple Tangential Flow Filtration Stations in Bioprocessing Applications
CA3023486C (en) 2016-06-09 2022-03-29 Emd Millipore Corporation Radial-path filter elements, systems and methods of using same
CN109475868B (zh) * 2016-07-21 2021-08-17 新加坡科技研究局 用于高体积分数颗粒微滤的外壁聚焦的设备及其制造方法
KR20190079662A (ko) * 2016-11-11 2019-07-05 바이엘 악티엔게젤샤프트 연속적 유동 내의 오염물을 모니터링하기 위한 유체 스트림의 샘플링 방법
EP3141594A3 (en) * 2016-11-11 2017-06-14 Bayer Pharma Aktiengesellschaft Method for sampling fluid streams for monitoring contaminants in a continuous flow
EP3535047A1 (en) * 2016-12-09 2019-09-11 Lonza Ltd Method for the reduction of viral titer in pharmaceuticals
EP3354330A1 (en) 2017-01-25 2018-08-01 Sartorius Stedim Biotech GmbH Automated modular filtration system
CA2994643A1 (en) * 2017-02-14 2018-08-14 Bart Lipkens Bioreactor using acoustic standing waves
CN110268043A (zh) 2017-03-03 2019-09-20 富士胶片株式会社 细胞培养装置及细胞培养方法
JP2018153168A (ja) * 2017-03-21 2018-10-04 国立大学法人九州大学 微生物収集装置
DE102017110482A1 (de) * 2017-05-15 2018-11-15 Sartorius Stedim Biotech Gmbh Filtrationsmodul bzw. Reinigungsmodul für modulares Filtrationssystem
DE102017111133A1 (de) * 2017-05-22 2018-11-22 Sartorius Stedim Biotech Gmbh Vorkonfigurierte Einweg-Filtrationsvorrichtung
TWI675696B (zh) * 2017-06-01 2019-11-01 美商Emd密理博公司 用於灌注應用之切向流過濾裝置
US11364469B2 (en) 2017-06-20 2022-06-21 Asahi Kasei Kabushiki Kaisha Hollow fiber membrane module and filtering method
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
US12071607B2 (en) * 2018-06-01 2024-08-27 Lonza Ltd. Midscale model for organic growth and phasing
GB201810772D0 (en) * 2018-06-29 2018-08-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
AU2019332764B2 (en) 2018-08-31 2025-05-29 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
GB201816871D0 (en) * 2018-10-17 2018-11-28 Ge Healthcare Bio Sciences Ab A bioprocessing fluid sensor arrangement
DE102019100209A1 (de) 2019-01-07 2020-07-09 Sartorius Stedim Biotech Gmbh Vorrichtung und Verfahren zum Ausgleich von kurzfristigen Druck- oder Volumenschwankungen eines Mediums in einem kontinuierlich geführten biopharmazeutischen Prozess
JP2022520793A (ja) * 2019-02-15 2022-04-01 ジャスト-エヴォテック バイオロジックス、インコーポレイテッド 自動バイオ製造システム、施設、及びプロセス
CN111018968B (zh) * 2019-12-16 2021-07-27 兴盟生物医药(苏州)有限公司 一种通过超滤浓缩制备高浓度抗体制剂的方法
US12050448B2 (en) 2021-01-29 2024-07-30 Tata Consultancy Services Limited Method and system to control a continuous bioprocessing
GB202109015D0 (en) * 2021-06-23 2021-08-04 Puridify Ltd A method for purifying a feed in a chromatography system
JPWO2023191008A1 (https=) * 2022-03-30 2023-10-05
EP4501335A4 (en) * 2022-03-30 2025-07-23 Fujifilm Corp METHOD FOR PRODUCING ACTIVE INGREDIENT OF BIOLOGICAL DRUG, SYSTEM FOR PRODUCING ACTIVE INGREDIENT OF BIOLOGICAL DRUG, AND ACTIVE INGREDIENT OF BIOLOGICAL DRUG
EP4594462A1 (en) * 2022-09-28 2025-08-06 Genzyme Corporation Systems and devices for producing biological products and methods of using the same

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157113A (en) * 1987-08-10 1992-10-20 Miles Inc. Removal of nucleic acids from monoclonal antibody preparations
US5256294A (en) * 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
US5463029A (en) * 1992-11-23 1995-10-31 Immunex Corporation Purification of fusion proteins comprising GM-CSF and IL-3
ATE328068T1 (de) * 1994-05-16 2006-06-15 Merck & Co Inc Papillomavirus vakzine
US5616595A (en) * 1995-06-07 1997-04-01 Abbott Laboratories Process for recovering water insoluble compounds from a fermentation broth
JP3566461B2 (ja) 1996-06-28 2004-09-15 ユニ・チャーム株式会社 使い捨ての体液吸収性物品
US7122344B2 (en) * 1997-05-28 2006-10-17 Claragen, Inc. Methods for the production of purified recombinant human uteroglobin for the treatment of inflammatory and fibrotic conditions
DE19837391A1 (de) * 1997-08-22 1999-02-25 Hoffmann La Roche Immunologische Materialien und Verfahren zum Nachweis von Dihydropyrimidindehydrogenase
US6022477A (en) * 1997-11-14 2000-02-08 New Jersey Institute Of Technology Method and apparatus for isolation purification of biomolecules
US7820796B2 (en) 1998-03-12 2010-10-26 Genetics Institute, Llc. Methods for producing Factor VIII proteins
US6444223B1 (en) * 1999-05-28 2002-09-03 Alkermes Controlled Therapeutics, Inc. Method of producing submicron particles of a labile agent and use thereof
US6544424B1 (en) * 1999-12-03 2003-04-08 Refined Technology Company Fluid filtration system
US6350382B1 (en) * 2000-06-23 2002-02-26 Scilog, Inc. Enhancing filtration yields in tangential flow filtration
WO2003004690A2 (en) * 2001-07-06 2003-01-16 454$m(3) CORPORATION Method for isolation of independent, parallel chemical micro-reactions using a porous filter
DK1451290T3 (da) * 2001-08-31 2011-04-26 Bayer Schering Pharma Ag Indretning og fremgangsmåde til udførelse af fermentering af høj celledensitet
US6875459B2 (en) * 2001-09-10 2005-04-05 Henry B. Kopf Method and apparatus for separation of milk, colostrum, and whey
US7078507B2 (en) * 2001-11-09 2006-07-18 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Synthetic genes for malarial proteins and methods of use
US20060172376A1 (en) * 2003-02-11 2006-08-03 Hassan Chadjaa Method and device for the continuous production of biomolecules
AU2003261387A1 (en) * 2003-02-24 2004-09-17 Gtc Biotherapeutics, Inc. Methods of tangential flow filtration and an apparatus therefore
US20050197496A1 (en) * 2004-03-04 2005-09-08 Gtc Biotherapeutics, Inc. Methods of protein fractionation using high performance tangential flow filtration
PL1807101T3 (pl) 2004-09-30 2016-11-30 Urządzenia i sposoby do zintegrowanego wytwarzania cząsteczek biologicznych w sposób ciągły

Similar Documents

Publication Publication Date Title
JP2008514237A5 (https=)
JP2006515227A5 (https=)
WO2006039588A3 (en) Devices and methods for integrated continuous manufacturing of biological molecules
FI4104859T3 (fi) Menetelmä vasta-aineiden ja niiden terapeuttisten tuotteiden väkevöimiseksi
AU2009285736B2 (en) Method of concentrating shear-sensitive biopolymers using hollow fibre membranes
AU766583B2 (en) Filter membranes for physiologically active substances
RU2015103990A (ru) Способы культивирования клеток, размножения и очистки вирусов
EP1457460A3 (en) Water purification system and method, and module for the system
CN203866137U (zh) 楼宇管道直饮水净化系统
FR2867394B1 (fr) Procede de nettoyage de membranes de filtration, et installation pour la mise en oeuvre de ce procede
JP2013538588A5 (https=)
JP2010150248A5 (https=)
Carrère et al. Modelling the microfiltration of lactic acid fermentation broths and comparison of operating modes
CN202415421U (zh) 简易蛋白质动态透析系统
JP2012144578A5 (https=)
JP6052866B2 (ja) 水処理方法
JP2000033241A (ja) 膜分離装置の運転方法
DK2048963T3 (da) Fremgangsmåde til fremstilling af ost i en beholder
CN204824431U (zh) 一种膜过滤净化装置
CN207512108U (zh) 一种l-脯氨酸发酵液的全膜提取设备
CN202785831U (zh) 一种多功能饮用水净化器
CN207347312U (zh) 净水机复合滤芯
CN221701227U (zh) 一种超滤反渗透装置
CN211189773U (zh) 一种低压多膜分离盐分浓缩系统
ATE291932T1 (de) Verfahren zur reduzierung der gesamtkeimzahl in wässrigen dispersionen nicht-homogener zwei- oder mehrphasengemische