JP2008514237A5 - - Google Patents
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- JP2008514237A5 JP2008514237A5 JP2007534832A JP2007534832A JP2008514237A5 JP 2008514237 A5 JP2008514237 A5 JP 2008514237A5 JP 2007534832 A JP2007534832 A JP 2007534832A JP 2007534832 A JP2007534832 A JP 2007534832A JP 2008514237 A5 JP2008514237 A5 JP 2008514237A5
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- JP
- Japan
- Prior art keywords
- tissue culture
- flow rate
- concentration
- clarified tissue
- specific flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61499504P | 2004-09-30 | 2004-09-30 | |
| US60/614,995 | 2004-09-30 | ||
| PCT/US2005/035364 WO2006039588A2 (en) | 2004-09-30 | 2005-09-30 | Devices and methods for integrated continuous manufacturing of biological molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012129422A Division JP5762360B2 (ja) | 2004-09-30 | 2012-06-07 | 生体分子の一貫連続製造のための装置及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008514237A JP2008514237A (ja) | 2008-05-08 |
| JP2008514237A5 true JP2008514237A5 (cg-RX-API-DMAC10.html) | 2014-07-03 |
| JP5579966B2 JP5579966B2 (ja) | 2014-08-27 |
Family
ID=36143124
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534832A Expired - Lifetime JP5579966B2 (ja) | 2004-09-30 | 2005-09-30 | 生体分子の一貫連続製造のための装置及び方法 |
| JP2012129422A Expired - Lifetime JP5762360B2 (ja) | 2004-09-30 | 2012-06-07 | 生体分子の一貫連続製造のための装置及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012129422A Expired - Lifetime JP5762360B2 (ja) | 2004-09-30 | 2012-06-07 | 生体分子の一貫連続製造のための装置及び方法 |
Country Status (24)
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102794109B (zh) | 2004-09-30 | 2015-10-07 | 拜耳医药保健有限公司 | 用于集成连续生产生物分子的装置和方法 |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| TW201516149A (zh) | 2006-09-13 | 2015-05-01 | Abbvie Inc | 細胞培養改良 |
| FR2920429B1 (fr) * | 2007-08-30 | 2012-10-05 | Lfb Biotechnologies | Procede de purification du facteur viii et du facteur von willebrand |
| CN104974251A (zh) | 2008-10-20 | 2015-10-14 | Abbvie公司 | 在抗体纯化过程中的病毒灭活 |
| CA2932207A1 (en) * | 2008-10-20 | 2010-12-09 | Abbvie Inc. | Isolation and purification of antibodies using protein a affinity chromatography |
| US9527010B2 (en) | 2009-09-25 | 2016-12-27 | Ge Healthcare Bio-Sciences Corp. | Separation system and method |
| WO2012051517A2 (en) | 2010-10-15 | 2012-04-19 | Xcellerex, Inc. | Large volume disposable ultrafiltration systems and methods |
| CN102154408B (zh) * | 2011-01-13 | 2013-06-05 | 天津市工业微生物研究所 | 小核菌硬葡聚糖在线发酵提取方法及系统 |
| US10774304B2 (en) * | 2011-03-08 | 2020-09-15 | University Of Maryland, Baltimore County | System and method for production of on-demand proteins in a portable unit for point of care delivery |
| US9982227B2 (en) | 2011-03-08 | 2018-05-29 | University Of Maryland, Baltimore County | System and method for production of on-demand proteins in a portable unit for point of care delivery |
| US9388373B2 (en) * | 2011-03-08 | 2016-07-12 | University Of Maryland Baltimore County | Microscale bioprocessing system and method for protein manufacturing |
| US12227734B2 (en) | 2011-03-08 | 2025-02-18 | University Of Maryland, Baltimore County | Microscale bioprocessing system and method for protein manufacturing from human blood |
| WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| CN104025408A (zh) * | 2011-10-11 | 2014-09-03 | 森春减压系统有限公司 | 用于电力变压器的减压系统 |
| WO2013109520A1 (en) | 2012-01-18 | 2013-07-25 | Bayer Healthcare Llc | Perfusion bioreactor systems and methods of operating the same |
| US9997264B2 (en) * | 2012-02-14 | 2018-06-12 | Control Components, Inc. | Enhanced nuclear sump strainer system |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| EP2682168A1 (en) | 2012-07-02 | 2014-01-08 | Millipore Corporation | Purification of biological molecules |
| HK1211981A1 (en) | 2012-09-02 | 2016-06-03 | Abbvie Inc. | Methods to control protein heterogeneity |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| CN105143443A (zh) | 2013-02-22 | 2015-12-09 | 建新公司 | 微载体灌注培养方法及其用途 |
| CN105209603A (zh) | 2013-02-22 | 2015-12-30 | 建新公司 | 微载体灌注培养方法及其用途 |
| AU2014226126B2 (en) | 2013-03-08 | 2019-02-14 | Genzyme Corporation | Continuous purification of therapeutic proteins |
| SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| TWI709570B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析法及製法 |
| JP2017515501A (ja) * | 2014-05-02 | 2017-06-15 | ノヴォ ノルディスク アー/エス | 統合型連続バイオマニュファクチャリング方法 |
| KR102707370B1 (ko) | 2014-05-13 | 2024-09-13 | 암겐 인코포레이티드 | 필터 및 여과 공정과 함께 사용하기 위한 공정 제어 시스템 및 방법 |
| JP6671300B2 (ja) * | 2014-05-27 | 2020-03-25 | アーティフィシャル セル テクノロジーズ インコーポレイテッド | Tffによる多層コーティング化コアの自動交互積層構築 |
| TWI743024B (zh) | 2014-06-06 | 2021-10-21 | 美商健臻公司 | 灌注培養方法及其用途 |
| TWI776235B (zh) | 2014-06-09 | 2022-09-01 | 美商健臻公司 | 種子罐培養法(seed train processes)及其用途 |
| US10207225B2 (en) | 2014-06-16 | 2019-02-19 | Emd Millipore Corporation | Single-pass filtration systems and processes |
| WO2015195453A2 (en) | 2014-06-16 | 2015-12-23 | Emd Millipore Corporation | Methods for increasing the capacity of flow-through processes |
| KR101938948B1 (ko) | 2014-06-25 | 2019-01-15 | 이엠디 밀리포어 코포레이션 | 밀집한 나권형 필터 엘리먼트, 모듈 및 시스템 |
| EP4147769B1 (en) | 2014-08-29 | 2025-05-21 | EMD Millipore Corporation | Processes for filtering liquids using single pass tangential flow filtration systems and tangential flow filtration systems with recirculation of retentate |
| SG10201901555UA (en) | 2014-08-29 | 2019-03-28 | Emd Millipore Corp | Single Pass Tangential Flow Filtration Systems and Tangential Flow Filtration Systems withRecirculation of Retentate |
| USD762811S1 (en) | 2014-12-18 | 2016-08-02 | Emd Millipore Corporation | Diverter plate |
| USD761381S1 (en) | 2014-12-18 | 2016-07-12 | Emd Millipore Corporation | Retentate plate |
| EP3093335A1 (de) | 2015-05-13 | 2016-11-16 | Bayer Technology Services GmbH | Prozessleitsystem zur regelung und steuerung einer modular aufgebauten anlage zur produktion von biopharmazeutischen und biologischen makromolekularen produkten |
| ITUA20161506A1 (it) * | 2016-03-09 | 2017-09-09 | Della Toffola Spa | Metodo ed impianto perfezionato di filtrazione tangenziale |
| WO2017160739A1 (en) | 2016-03-14 | 2017-09-21 | Pendo TECH | Processing system for multiple tangential flow filtration stations in bioprocessing applications |
| CA3077712C (en) | 2016-06-09 | 2022-03-22 | Emd Millipore Corporation | Radial-path filter elements, systems and methods of using same |
| CN113663749B (zh) * | 2016-07-21 | 2023-06-20 | 新加坡科技研究局 | 用于高体积分数颗粒微滤的外壁聚焦的设备及其制造方法 |
| EP3141594A3 (en) * | 2016-11-11 | 2017-06-14 | Bayer Pharma Aktiengesellschaft | Method for sampling fluid streams for monitoring contaminants in a continuous flow |
| US20190359930A1 (en) * | 2016-11-11 | 2019-11-28 | Bayer Aktiengesellschaft | Method for sampling fluid streams for monitoring contaminants in a continuous flow |
| US11034721B2 (en) | 2016-12-09 | 2021-06-15 | Lonza Ltd | Method for the reduction of viral titer in pharmaceuticals |
| EP3354330A1 (en) * | 2017-01-25 | 2018-08-01 | Sartorius Stedim Biotech GmbH | Automated modular filtration system |
| CA2994643A1 (en) * | 2017-02-14 | 2018-08-14 | Bart Lipkens | Bioreactor using acoustic standing waves |
| CN110268043A (zh) | 2017-03-03 | 2019-09-20 | 富士胶片株式会社 | 细胞培养装置及细胞培养方法 |
| JP2018153168A (ja) * | 2017-03-21 | 2018-10-04 | 国立大学法人九州大学 | 微生物収集装置 |
| DE102017110482A1 (de) * | 2017-05-15 | 2018-11-15 | Sartorius Stedim Biotech Gmbh | Filtrationsmodul bzw. Reinigungsmodul für modulares Filtrationssystem |
| DE102017111133A1 (de) * | 2017-05-22 | 2018-11-22 | Sartorius Stedim Biotech Gmbh | Vorkonfigurierte Einweg-Filtrationsvorrichtung |
| TWI675696B (zh) * | 2017-06-01 | 2019-11-01 | 美商Emd密理博公司 | 用於灌注應用之切向流過濾裝置 |
| US11364469B2 (en) | 2017-06-20 | 2022-06-21 | Asahi Kasei Kabushiki Kaisha | Hollow fiber membrane module and filtering method |
| TWI846694B (zh) * | 2018-05-04 | 2024-07-01 | 美商健臻公司 | 具有過濾系統的灌注式生物反應器 |
| US12071607B2 (en) * | 2018-06-01 | 2024-08-27 | Lonza Ltd. | Midscale model for organic growth and phasing |
| GB201810772D0 (en) | 2018-06-29 | 2018-08-15 | Ge Healthcare Bio Sciences Ab | Method in bioprocess purification system |
| JP7699537B2 (ja) | 2018-08-31 | 2025-06-27 | ジェンザイム・コーポレーション | 無菌クロマトグラフィー樹脂および製造方法におけるその使用 |
| GB201816871D0 (en) | 2018-10-17 | 2018-11-28 | Ge Healthcare Bio Sciences Ab | A bioprocessing fluid sensor arrangement |
| DE102019100209B4 (de) | 2019-01-07 | 2026-08-13 | Sartorius Stedim Biotech Gmbh | Verfahren zum Ausgleich von kurzfristigen Druck- oder Volumenschwankungen eines Mediums in einem kontinuierlich geführten biopharmazeutischen Prozess |
| JP2022520793A (ja) * | 2019-02-15 | 2022-04-01 | ジャスト-エヴォテック バイオロジックス、インコーポレイテッド | 自動バイオ製造システム、施設、及びプロセス |
| CN111018968B (zh) * | 2019-12-16 | 2021-07-27 | 兴盟生物医药(苏州)有限公司 | 一种通过超滤浓缩制备高浓度抗体制剂的方法 |
| EP4036672B1 (en) | 2021-01-29 | 2024-03-06 | Tata Consultancy Services Limited | Method to control a continuous bioprocessing |
| GB202109015D0 (en) * | 2021-06-23 | 2021-08-04 | Puridify Ltd | A method for purifying a feed in a chromatography system |
| AR128770A1 (es) | 2022-03-14 | 2024-06-12 | Amgen Inc | Procedimiento automatizado de llenado de fármacos |
| EP4501334A4 (en) * | 2022-03-30 | 2025-07-16 | Fujifilm Corp | METHOD FOR THE MANUFACTURE OF A BIOPHARMACEUTICAL DRUG SUBSTANCE, SYSTEM FOR THE MANUFACTURE OF A BIOPHARMACEUTICAL DRUG SUBSTANCE, AND BIOPHARMACEUTICAL DRUG SUBSTANCE |
| EP4501335A4 (en) * | 2022-03-30 | 2025-07-23 | Fujifilm Corp | METHOD FOR PRODUCING ACTIVE INGREDIENT OF BIOLOGICAL DRUG, SYSTEM FOR PRODUCING ACTIVE INGREDIENT OF BIOLOGICAL DRUG, AND ACTIVE INGREDIENT OF BIOLOGICAL DRUG |
| CN119968454A (zh) * | 2022-09-28 | 2025-05-09 | 建新公司 | 用于生产生物产品的系统和装置及其使用方法 |
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|---|---|---|---|---|
| US5157113A (en) * | 1987-08-10 | 1992-10-20 | Miles Inc. | Removal of nucleic acids from monoclonal antibody preparations |
| US5256294A (en) | 1990-09-17 | 1993-10-26 | Genentech, Inc. | Tangential flow filtration process and apparatus |
| US5463029A (en) | 1992-11-23 | 1995-10-31 | Immunex Corporation | Purification of fusion proteins comprising GM-CSF and IL-3 |
| ES2264126T3 (es) * | 1994-05-16 | 2006-12-16 | MERCK & CO., INC. | Vacunas contra el papilomavirus. |
| US5616595A (en) * | 1995-06-07 | 1997-04-01 | Abbott Laboratories | Process for recovering water insoluble compounds from a fermentation broth |
| JP3566461B2 (ja) | 1996-06-28 | 2004-09-15 | ユニ・チャーム株式会社 | 使い捨ての体液吸収性物品 |
| US7122344B2 (en) | 1997-05-28 | 2006-10-17 | Claragen, Inc. | Methods for the production of purified recombinant human uteroglobin for the treatment of inflammatory and fibrotic conditions |
| DE19837391A1 (de) * | 1997-08-22 | 1999-02-25 | Hoffmann La Roche | Immunologische Materialien und Verfahren zum Nachweis von Dihydropyrimidindehydrogenase |
| US6022477A (en) * | 1997-11-14 | 2000-02-08 | New Jersey Institute Of Technology | Method and apparatus for isolation purification of biomolecules |
| US7820796B2 (en) | 1998-03-12 | 2010-10-26 | Genetics Institute, Llc. | Methods for producing Factor VIII proteins |
| US6444223B1 (en) * | 1999-05-28 | 2002-09-03 | Alkermes Controlled Therapeutics, Inc. | Method of producing submicron particles of a labile agent and use thereof |
| US6544424B1 (en) * | 1999-12-03 | 2003-04-08 | Refined Technology Company | Fluid filtration system |
| US6350382B1 (en) * | 2000-06-23 | 2002-02-26 | Scilog, Inc. | Enhancing filtration yields in tangential flow filtration |
| WO2003004690A2 (en) * | 2001-07-06 | 2003-01-16 | 454$m(3) CORPORATION | Method for isolation of independent, parallel chemical micro-reactions using a porous filter |
| EP1451290B1 (en) * | 2001-08-31 | 2011-01-05 | Bayer Schering Pharma Aktiengesellschaft | A unit and a process for carrying out high cell density fermentation |
| US6875459B2 (en) * | 2001-09-10 | 2005-04-05 | Henry B. Kopf | Method and apparatus for separation of milk, colostrum, and whey |
| WO2003062374A2 (en) * | 2001-11-09 | 2003-07-31 | Entremed, Inc. | Synthetic genes for malarial proteins and methods of use |
| CA2457262A1 (fr) * | 2003-02-11 | 2004-08-11 | Centre National En Electrochimie Et En Technologies Environnementales In C. | Procede et dispositif pour la production de biomolecules en continu |
| RU2005129745A (ru) * | 2003-02-24 | 2006-03-20 | Джитиси Байотерапьютикс, Инк. (Us) | Способы и устройство проточной фильтрации вдоль потока |
| US20050197496A1 (en) | 2004-03-04 | 2005-09-08 | Gtc Biotherapeutics, Inc. | Methods of protein fractionation using high performance tangential flow filtration |
| CN102794109B (zh) | 2004-09-30 | 2015-10-07 | 拜耳医药保健有限公司 | 用于集成连续生产生物分子的装置和方法 |
-
2005
- 2005-09-30 CN CN201210289781.1A patent/CN102794109B/zh not_active Expired - Lifetime
- 2005-09-30 BR BRPI0515849-4A patent/BRPI0515849B1/pt not_active IP Right Cessation
- 2005-09-30 NZ NZ588616A patent/NZ588616A/en not_active IP Right Cessation
- 2005-09-30 ES ES12179336.8T patent/ES2634323T3/es not_active Expired - Lifetime
- 2005-09-30 HR HRP20070097AA patent/HRP20070097B1/hr not_active IP Right Cessation
- 2005-09-30 DK DK12179336.8T patent/DK2550971T3/en active
- 2005-09-30 CN CN2005800331770A patent/CN101076347B/zh not_active Expired - Lifetime
- 2005-09-30 RU RU2007115901/13A patent/RU2390526C2/ru active
- 2005-09-30 US US11/576,097 patent/US9045725B2/en active Active
- 2005-09-30 NZ NZ554307A patent/NZ554307A/en not_active IP Right Cessation
- 2005-09-30 KR KR1020127030406A patent/KR101335936B1/ko not_active Expired - Lifetime
- 2005-09-30 AU AU2005292358A patent/AU2005292358B2/en not_active Ceased
- 2005-09-30 PT PT121793368T patent/PT2550971T/pt unknown
- 2005-09-30 JP JP2007534832A patent/JP5579966B2/ja not_active Expired - Lifetime
- 2005-09-30 UA UAA201304498A patent/UA112529C2/uk unknown
- 2005-09-30 PL PL05800224.7T patent/PL1807101T3/pl unknown
- 2005-09-30 EP EP05800224.7A patent/EP1807101B1/en not_active Expired - Lifetime
- 2005-09-30 HU HUE12179336A patent/HUE032538T2/en unknown
- 2005-09-30 CA CA2579845A patent/CA2579845C/en not_active Expired - Lifetime
- 2005-09-30 EP EP12179336.8A patent/EP2550971B1/en not_active Expired - Lifetime
- 2005-09-30 WO PCT/US2005/035364 patent/WO2006039588A2/en not_active Ceased
- 2005-09-30 UA UAA200704547A patent/UA99249C2/ru unknown
- 2005-09-30 HU HUE05800224A patent/HUE027136T2/en unknown
- 2005-09-30 ES ES05800224.7T patent/ES2570006T3/es not_active Expired - Lifetime
- 2005-09-30 KR KR1020077008684A patent/KR101238798B1/ko not_active Expired - Lifetime
- 2005-09-30 SI SI200532141T patent/SI2550971T1/sl unknown
- 2005-09-30 UA UAA201202077A patent/UA107937C2/ru unknown
- 2005-09-30 LT LTEP12179336.8T patent/LT2550971T/lt unknown
- 2005-09-30 DK DK05800224.7T patent/DK1807101T3/en active
-
2007
- 2007-03-07 IL IL181775A patent/IL181775A/en active IP Right Grant
- 2007-03-28 ZA ZA2007/02578A patent/ZA200702578B/en unknown
- 2007-04-26 NO NO20072174A patent/NO341439B1/no unknown
-
2010
- 2010-04-21 IL IL205228A patent/IL205228A/en active IP Right Grant
-
2011
- 2011-12-22 IL IL217157A patent/IL217157A/en active IP Right Grant
- 2011-12-22 IL IL217159A patent/IL217159A/en active IP Right Grant
- 2011-12-22 IL IL217158A patent/IL217158A/en active IP Right Grant
-
2012
- 2012-06-07 JP JP2012129422A patent/JP5762360B2/ja not_active Expired - Lifetime
-
2013
- 2013-03-12 US US13/795,346 patent/US20130345402A1/en not_active Abandoned
- 2013-03-12 US US13/795,298 patent/US9133433B2/en not_active Expired - Lifetime
-
2016
- 2016-05-11 CY CY20161100396T patent/CY1117699T1/el unknown
-
2017
- 2017-07-10 NO NO20171138A patent/NO341885B1/no unknown
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