NO341439B1 - Innretninger og fremgangsmåter for integrert, kontinuerlig fremstilling av biologiske molekyler - Google Patents

Innretninger og fremgangsmåter for integrert, kontinuerlig fremstilling av biologiske molekyler Download PDF

Info

Publication number
NO341439B1
NO341439B1 NO20072174A NO20072174A NO341439B1 NO 341439 B1 NO341439 B1 NO 341439B1 NO 20072174 A NO20072174 A NO 20072174A NO 20072174 A NO20072174 A NO 20072174A NO 341439 B1 NO341439 B1 NO 341439B1
Authority
NO
Norway
Prior art keywords
continuous
tissue culture
flow rate
culture fluid
protein
Prior art date
Application number
NO20072174A
Other languages
English (en)
Norwegian (no)
Swedish (sv)
Other versions
NO20072174L (no
Inventor
Jens Vogel
Roberto Giovannini
Konstantin B Konstantinov
Huong Nguyen
Paul Wu
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36143124&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO341439(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of NO20072174L publication Critical patent/NO20072174L/no
Publication of NO341439B1 publication Critical patent/NO341439B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/24—Apparatus for enzymology or microbiology tube or bottle type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/14—Pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/16—Flow or flux control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/10—Specific supply elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/10—Specific supply elements
    • B01D2313/105—Supply manifolds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/18—Specific valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2317/00—Membrane module arrangements within a plant or an apparatus
    • B01D2317/04—Elements in parallel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Filtration Of Liquid (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO20072174A 2004-09-30 2007-04-26 Innretninger og fremgangsmåter for integrert, kontinuerlig fremstilling av biologiske molekyler NO341439B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61499504P 2004-09-30 2004-09-30
PCT/US2005/035364 WO2006039588A2 (en) 2004-09-30 2005-09-30 Devices and methods for integrated continuous manufacturing of biological molecules

Publications (2)

Publication Number Publication Date
NO20072174L NO20072174L (no) 2007-06-27
NO341439B1 true NO341439B1 (no) 2017-11-13

Family

ID=36143124

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20072174A NO341439B1 (no) 2004-09-30 2007-04-26 Innretninger og fremgangsmåter for integrert, kontinuerlig fremstilling av biologiske molekyler
NO20171138A NO341885B1 (no) 2004-09-30 2017-07-10 Innretninger og fremgangsmåter for integrert, kontinuerlig fremstilling av biologiske molekyler

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20171138A NO341885B1 (no) 2004-09-30 2017-07-10 Innretninger og fremgangsmåter for integrert, kontinuerlig fremstilling av biologiske molekyler

Country Status (24)

Country Link
US (3) US9045725B2 (cg-RX-API-DMAC10.html)
EP (2) EP1807101B1 (cg-RX-API-DMAC10.html)
JP (2) JP5579966B2 (cg-RX-API-DMAC10.html)
KR (2) KR101335936B1 (cg-RX-API-DMAC10.html)
CN (2) CN102794109B (cg-RX-API-DMAC10.html)
AU (1) AU2005292358B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0515849B1 (cg-RX-API-DMAC10.html)
CA (1) CA2579845C (cg-RX-API-DMAC10.html)
CY (1) CY1117699T1 (cg-RX-API-DMAC10.html)
DK (2) DK2550971T3 (cg-RX-API-DMAC10.html)
ES (2) ES2634323T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20070097B1 (cg-RX-API-DMAC10.html)
HU (2) HUE032538T2 (cg-RX-API-DMAC10.html)
IL (5) IL181775A (cg-RX-API-DMAC10.html)
LT (1) LT2550971T (cg-RX-API-DMAC10.html)
NO (2) NO341439B1 (cg-RX-API-DMAC10.html)
NZ (2) NZ588616A (cg-RX-API-DMAC10.html)
PL (1) PL1807101T3 (cg-RX-API-DMAC10.html)
PT (1) PT2550971T (cg-RX-API-DMAC10.html)
RU (1) RU2390526C2 (cg-RX-API-DMAC10.html)
SI (1) SI2550971T1 (cg-RX-API-DMAC10.html)
UA (3) UA112529C2 (cg-RX-API-DMAC10.html)
WO (1) WO2006039588A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200702578B (cg-RX-API-DMAC10.html)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102794109B (zh) 2004-09-30 2015-10-07 拜耳医药保健有限公司 用于集成连续生产生物分子的装置和方法
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
TW201516149A (zh) 2006-09-13 2015-05-01 Abbvie Inc 細胞培養改良
FR2920429B1 (fr) * 2007-08-30 2012-10-05 Lfb Biotechnologies Procede de purification du facteur viii et du facteur von willebrand
CN104974251A (zh) 2008-10-20 2015-10-14 Abbvie公司 在抗体纯化过程中的病毒灭活
CA2932207A1 (en) * 2008-10-20 2010-12-09 Abbvie Inc. Isolation and purification of antibodies using protein a affinity chromatography
US9527010B2 (en) 2009-09-25 2016-12-27 Ge Healthcare Bio-Sciences Corp. Separation system and method
WO2012051517A2 (en) 2010-10-15 2012-04-19 Xcellerex, Inc. Large volume disposable ultrafiltration systems and methods
CN102154408B (zh) * 2011-01-13 2013-06-05 天津市工业微生物研究所 小核菌硬葡聚糖在线发酵提取方法及系统
US10774304B2 (en) * 2011-03-08 2020-09-15 University Of Maryland, Baltimore County System and method for production of on-demand proteins in a portable unit for point of care delivery
US9982227B2 (en) 2011-03-08 2018-05-29 University Of Maryland, Baltimore County System and method for production of on-demand proteins in a portable unit for point of care delivery
US9388373B2 (en) * 2011-03-08 2016-07-12 University Of Maryland Baltimore County Microscale bioprocessing system and method for protein manufacturing
US12227734B2 (en) 2011-03-08 2025-02-18 University Of Maryland, Baltimore County Microscale bioprocessing system and method for protein manufacturing from human blood
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
CN104025408A (zh) * 2011-10-11 2014-09-03 森春减压系统有限公司 用于电力变压器的减压系统
WO2013109520A1 (en) 2012-01-18 2013-07-25 Bayer Healthcare Llc Perfusion bioreactor systems and methods of operating the same
US9997264B2 (en) * 2012-02-14 2018-06-12 Control Components, Inc. Enhanced nuclear sump strainer system
US9150645B2 (en) 2012-04-20 2015-10-06 Abbvie, Inc. Cell culture methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
HK1211981A1 (en) 2012-09-02 2016-06-03 Abbvie Inc. Methods to control protein heterogeneity
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
CN105143443A (zh) 2013-02-22 2015-12-09 建新公司 微载体灌注培养方法及其用途
CN105209603A (zh) 2013-02-22 2015-12-30 建新公司 微载体灌注培养方法及其用途
AU2014226126B2 (en) 2013-03-08 2019-02-14 Genzyme Corporation Continuous purification of therapeutic proteins
SG11201507230PA (en) 2013-03-12 2015-10-29 Abbvie Inc Human antibodies that bind human tnf-alpha and methods of preparing the same
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
JP2017515501A (ja) * 2014-05-02 2017-06-15 ノヴォ ノルディスク アー／エス 統合型連続バイオマニュファクチャリング方法
KR102707370B1 (ko) 2014-05-13 2024-09-13 암겐 인코포레이티드 필터 및 여과 공정과 함께 사용하기 위한 공정 제어 시스템 및 방법
JP6671300B2 (ja) * 2014-05-27 2020-03-25 アーティフィシャル セル テクノロジーズ インコーポレイテッド Ｔｆｆによる多層コーティング化コアの自動交互積層構築
TWI743024B (zh) 2014-06-06 2021-10-21 美商健臻公司 灌注培養方法及其用途
TWI776235B (zh) 2014-06-09 2022-09-01 美商健臻公司 種子罐培養法(seed train processes)及其用途
US10207225B2 (en) 2014-06-16 2019-02-19 Emd Millipore Corporation Single-pass filtration systems and processes
WO2015195453A2 (en) 2014-06-16 2015-12-23 Emd Millipore Corporation Methods for increasing the capacity of flow-through processes
KR101938948B1 (ko) 2014-06-25 2019-01-15 이엠디 밀리포어 코포레이션 밀집한 나권형 필터 엘리먼트, 모듈 및 시스템
EP4147769B1 (en) 2014-08-29 2025-05-21 EMD Millipore Corporation Processes for filtering liquids using single pass tangential flow filtration systems and tangential flow filtration systems with recirculation of retentate
SG10201901555UA (en) 2014-08-29 2019-03-28 Emd Millipore Corp Single Pass Tangential Flow Filtration Systems and Tangential Flow Filtration Systems withRecirculation of Retentate
USD762811S1 (en) 2014-12-18 2016-08-02 Emd Millipore Corporation Diverter plate
USD761381S1 (en) 2014-12-18 2016-07-12 Emd Millipore Corporation Retentate plate
EP3093335A1 (de) 2015-05-13 2016-11-16 Bayer Technology Services GmbH Prozessleitsystem zur regelung und steuerung einer modular aufgebauten anlage zur produktion von biopharmazeutischen und biologischen makromolekularen produkten
ITUA20161506A1 (it) * 2016-03-09 2017-09-09 Della Toffola Spa Metodo ed impianto perfezionato di filtrazione tangenziale
WO2017160739A1 (en) 2016-03-14 2017-09-21 Pendo TECH Processing system for multiple tangential flow filtration stations in bioprocessing applications
CA3077712C (en) 2016-06-09 2022-03-22 Emd Millipore Corporation Radial-path filter elements, systems and methods of using same
CN113663749B (zh) * 2016-07-21 2023-06-20 新加坡科技研究局 用于高体积分数颗粒微滤的外壁聚焦的设备及其制造方法
EP3141594A3 (en) * 2016-11-11 2017-06-14 Bayer Pharma Aktiengesellschaft Method for sampling fluid streams for monitoring contaminants in a continuous flow
US20190359930A1 (en) * 2016-11-11 2019-11-28 Bayer Aktiengesellschaft Method for sampling fluid streams for monitoring contaminants in a continuous flow
US11034721B2 (en) 2016-12-09 2021-06-15 Lonza Ltd Method for the reduction of viral titer in pharmaceuticals
EP3354330A1 (en) * 2017-01-25 2018-08-01 Sartorius Stedim Biotech GmbH Automated modular filtration system
CA2994643A1 (en) * 2017-02-14 2018-08-14 Bart Lipkens Bioreactor using acoustic standing waves
CN110268043A (zh) 2017-03-03 2019-09-20 富士胶片株式会社 细胞培养装置及细胞培养方法
JP2018153168A (ja) * 2017-03-21 2018-10-04 国立大学法人九州大学 微生物収集装置
DE102017110482A1 (de) * 2017-05-15 2018-11-15 Sartorius Stedim Biotech Gmbh Filtrationsmodul bzw. Reinigungsmodul für modulares Filtrationssystem
DE102017111133A1 (de) * 2017-05-22 2018-11-22 Sartorius Stedim Biotech Gmbh Vorkonfigurierte Einweg-Filtrationsvorrichtung
TWI675696B (zh) * 2017-06-01 2019-11-01 美商Ｅｍｄ密理博公司 用於灌注應用之切向流過濾裝置
US11364469B2 (en) 2017-06-20 2022-06-21 Asahi Kasei Kabushiki Kaisha Hollow fiber membrane module and filtering method
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
US12071607B2 (en) * 2018-06-01 2024-08-27 Lonza Ltd. Midscale model for organic growth and phasing
GB201810772D0 (en) 2018-06-29 2018-08-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
JP7699537B2 (ja) 2018-08-31 2025-06-27 ジェンザイム・コーポレーション 無菌クロマトグラフィー樹脂および製造方法におけるその使用
GB201816871D0 (en) 2018-10-17 2018-11-28 Ge Healthcare Bio Sciences Ab A bioprocessing fluid sensor arrangement
DE102019100209B4 (de) 2019-01-07 2026-08-13 Sartorius Stedim Biotech Gmbh Verfahren zum Ausgleich von kurzfristigen Druck- oder Volumenschwankungen eines Mediums in einem kontinuierlich geführten biopharmazeutischen Prozess
JP2022520793A (ja) * 2019-02-15 2022-04-01 ジャスト－エヴォテック バイオロジックス、インコーポレイテッド 自動バイオ製造システム、施設、及びプロセス
CN111018968B (zh) * 2019-12-16 2021-07-27 兴盟生物医药(苏州)有限公司 一种通过超滤浓缩制备高浓度抗体制剂的方法
EP4036672B1 (en) 2021-01-29 2024-03-06 Tata Consultancy Services Limited Method to control a continuous bioprocessing
GB202109015D0 (en) * 2021-06-23 2021-08-04 Puridify Ltd A method for purifying a feed in a chromatography system
AR128770A1 (es) 2022-03-14 2024-06-12 Amgen Inc Procedimiento automatizado de llenado de fármacos
EP4501334A4 (en) * 2022-03-30 2025-07-16 Fujifilm Corp METHOD FOR THE MANUFACTURE OF A BIOPHARMACEUTICAL DRUG SUBSTANCE, SYSTEM FOR THE MANUFACTURE OF A BIOPHARMACEUTICAL DRUG SUBSTANCE, AND BIOPHARMACEUTICAL DRUG SUBSTANCE
EP4501335A4 (en) * 2022-03-30 2025-07-23 Fujifilm Corp METHOD FOR PRODUCING ACTIVE INGREDIENT OF BIOLOGICAL DRUG, SYSTEM FOR PRODUCING ACTIVE INGREDIENT OF BIOLOGICAL DRUG, AND ACTIVE INGREDIENT OF BIOLOGICAL DRUG
CN119968454A (zh) * 2022-09-28 2025-05-09 建新公司 用于生产生物产品的系统和装置及其使用方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5490937A (en) * 1990-09-17 1996-02-13 Genentech, Inc. Tangential flow filtration process and apparatus
US5616595A (en) * 1995-06-07 1997-04-01 Abbott Laboratories Process for recovering water insoluble compounds from a fermentation broth
US6350382B1 (en) * 2000-06-23 2002-02-26 Scilog, Inc. Enhancing filtration yields in tangential flow filtration
US20040139864A1 (en) * 2001-09-10 2004-07-22 Kopf Henry B. Method and apparatus for separation of milk, colostrum, and whey
US20040167320A1 (en) * 2003-02-24 2004-08-26 Couto Daniel E. Methods of tangential flow filtration and an apparatus therefore

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157113A (en) * 1987-08-10 1992-10-20 Miles Inc. Removal of nucleic acids from monoclonal antibody preparations
US5463029A (en) 1992-11-23 1995-10-31 Immunex Corporation Purification of fusion proteins comprising GM-CSF and IL-3
ES2264126T3 (es) * 1994-05-16 2006-12-16 MERCK & CO., INC. Vacunas contra el papilomavirus.
JP3566461B2 (ja) 1996-06-28 2004-09-15 ユニ・チャーム株式会社 使い捨ての体液吸収性物品
US7122344B2 (en) 1997-05-28 2006-10-17 Claragen, Inc. Methods for the production of purified recombinant human uteroglobin for the treatment of inflammatory and fibrotic conditions
DE19837391A1 (de) * 1997-08-22 1999-02-25 Hoffmann La Roche Immunologische Materialien und Verfahren zum Nachweis von Dihydropyrimidindehydrogenase
US6022477A (en) * 1997-11-14 2000-02-08 New Jersey Institute Of Technology Method and apparatus for isolation purification of biomolecules
US7820796B2 (en) 1998-03-12 2010-10-26 Genetics Institute, Llc. Methods for producing Factor VIII proteins
US6444223B1 (en) * 1999-05-28 2002-09-03 Alkermes Controlled Therapeutics, Inc. Method of producing submicron particles of a labile agent and use thereof
US6544424B1 (en) * 1999-12-03 2003-04-08 Refined Technology Company Fluid filtration system
WO2003004690A2 (en) * 2001-07-06 2003-01-16 454$m(3) CORPORATION Method for isolation of independent, parallel chemical micro-reactions using a porous filter
EP1451290B1 (en) * 2001-08-31 2011-01-05 Bayer Schering Pharma Aktiengesellschaft A unit and a process for carrying out high cell density fermentation
WO2003062374A2 (en) * 2001-11-09 2003-07-31 Entremed, Inc. Synthetic genes for malarial proteins and methods of use
CA2457262A1 (fr) * 2003-02-11 2004-08-11 Centre National En Electrochimie Et En Technologies Environnementales In C. Procede et dispositif pour la production de biomolecules en continu
US20050197496A1 (en) 2004-03-04 2005-09-08 Gtc Biotherapeutics, Inc. Methods of protein fractionation using high performance tangential flow filtration
CN102794109B (zh) 2004-09-30 2015-10-07 拜耳医药保健有限公司 用于集成连续生产生物分子的装置和方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5490937A (en) * 1990-09-17 1996-02-13 Genentech, Inc. Tangential flow filtration process and apparatus
US5616595A (en) * 1995-06-07 1997-04-01 Abbott Laboratories Process for recovering water insoluble compounds from a fermentation broth
US6350382B1 (en) * 2000-06-23 2002-02-26 Scilog, Inc. Enhancing filtration yields in tangential flow filtration
US20040139864A1 (en) * 2001-09-10 2004-07-22 Kopf Henry B. Method and apparatus for separation of milk, colostrum, and whey
US20040167320A1 (en) * 2003-02-24 2004-08-26 Couto Daniel E. Methods of tangential flow filtration and an apparatus therefore

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VOGEL JENS H; NGUYEN HUONG; WU PAUL; GIOVANNINI ROBERTO; SHACKLEFORD STEVE; KONSTANTINOV KONSTANTIN B: "Integration of isolation and continuous perfusion fermentation of recombinant biopharmaceuticals", DIVISION OF MEDICINAL CHEMISTRY SCIENTIFIC ABSTRACTS FOR THE 248TH NATIONAL MEETING AND EXPOSITION, AMERICAN CHEMICAL SOCIETY, US, vol. 227, no. Part 1, 1 March 2004 (2004-03-01), US, pages U122, XP009086770, ISSN: 0065-7727 *

Also Published As

Publication number Publication date
LT2550971T (lt) 2018-10-25
JP5579966B2 (ja) 2014-08-27
EP2550971A1 (en) 2013-01-30
IL217157A (en) 2015-04-30
ES2634323T3 (es) 2017-09-27
US20130345402A1 (en) 2013-12-26
SI2550971T1 (sl) 2017-08-31
US20080269468A1 (en) 2008-10-30
CN102794109A (zh) 2012-11-28
UA107937C2 (en) 2015-03-10
UA99249C2 (ru) 2012-08-10
CN101076347A (zh) 2007-11-21
NO341885B1 (no) 2018-02-12
US20130344585A1 (en) 2013-12-26
HRP20070097B1 (hr) 2018-03-23
IL217157A0 (en) 2012-01-31
RU2007115901A (ru) 2008-11-10
NO20171138A1 (no) 2007-06-27
CY1117699T1 (el) 2017-05-17
JP2012213772A (ja) 2012-11-08
US9045725B2 (en) 2015-06-02
KR101238798B1 (ko) 2013-03-04
EP1807101A4 (en) 2010-03-24
JP5762360B2 (ja) 2015-08-12
CN102794109B (zh) 2015-10-07
WO2006039588A2 (en) 2006-04-13
UA112529C2 (uk) 2016-09-26
KR101335936B1 (ko) 2013-12-03
IL217159A0 (en) 2012-01-31
IL217159A (en) 2015-04-30
CN101076347B (zh) 2012-09-26
IL205228A0 (en) 2011-07-31
IL217158A (en) 2016-06-30
HUE032538T2 (en) 2017-10-30
HUE027136T2 (en) 2016-08-29
US9133433B2 (en) 2015-09-15
KR20130003025A (ko) 2013-01-08
NZ554307A (en) 2011-06-30
IL181775A0 (en) 2007-07-04
IL205228A (en) 2015-09-24
RU2390526C2 (ru) 2010-05-27
NZ588616A (en) 2012-05-25
EP1807101B1 (en) 2016-04-13
WO2006039588A3 (en) 2007-05-18
PL1807101T3 (pl) 2016-11-30
BRPI0515849B1 (pt) 2019-07-30
DK1807101T3 (en) 2016-05-23
JP2008514237A (ja) 2008-05-08
ES2570006T3 (es) 2016-05-13
ZA200702578B (en) 2008-03-26
EP1807101A2 (en) 2007-07-18
HK1110519A1 (en) 2008-07-18
CA2579845C (en) 2014-11-18
AU2005292358A1 (en) 2006-04-13
DK2550971T3 (en) 2017-10-30
EP2550971B1 (en) 2016-11-09
IL217158A0 (en) 2012-01-31
HRP20070097A2 (hr) 2008-11-30
IL181775A (en) 2012-02-29
BRPI0515849A (pt) 2008-08-12
CA2579845A1 (en) 2006-04-13
KR20070092949A (ko) 2007-09-14
AU2005292358B2 (en) 2011-06-16
NO20072174L (no) 2007-06-27
PT2550971T (pt) 2017-10-02

Similar Documents

Publication Publication Date Title
NO341885B1 (no) Innretninger og fremgangsmåter for integrert, kontinuerlig fremstilling av biologiske molekyler
AU2005203413A1 (en) Improved liquid handling for filtration and preparative chromatography
AU2011203578B2 (en) Devices and methods for integrated continuous manufacturing of biological molecules
Matson Membrane bioseparations
Kumpalume et al. Chromatography: the high-resolution technique for protein separation
MX2007003782A (en) Devices and methods for integrated continuous manufacturing of biological molecules
HK1110519B (en) Devices and methods for integrated continuous manufacturing of biological molecules
Sartorius Membranes for Protein Isolation and Purification

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: BAYER HEALTHCARE LLC, US