JP2008508864A5 - - Google Patents
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- Publication number
- JP2008508864A5 JP2008508864A5 JP2007518205A JP2007518205A JP2008508864A5 JP 2008508864 A5 JP2008508864 A5 JP 2008508864A5 JP 2007518205 A JP2007518205 A JP 2007518205A JP 2007518205 A JP2007518205 A JP 2007518205A JP 2008508864 A5 JP2008508864 A5 JP 2008508864A5
- Authority
- JP
- Japan
- Prior art keywords
- chain variable
- variable region
- seq
- human
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 10
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 10
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 10
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 10
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 102000002227 Interferon Type I Human genes 0.000 claims 5
- 108010014726 Interferon Type I Proteins 0.000 claims 5
- 230000005856 abnormality Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000001404 mediated effect Effects 0.000 claims 4
- 102000007438 Interferon alpha-beta Receptor Human genes 0.000 claims 3
- 108010086140 Interferon alpha-beta Receptor Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000004071 biological effect Effects 0.000 claims 2
- 238000001516 cell proliferation assay Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 229940126619 mouse monoclonal antibody Drugs 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000030507 AIDS Diseases 0.000 claims 1
- 101710112752 Cytotoxin Proteins 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 241000699660 Mus musculus Species 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 108700019146 Transgenes Proteins 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 239000002619 cytotoxin Substances 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 229940127121 immunoconjugate Drugs 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000011830 transgenic mouse model Methods 0.000 claims 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims 1
- 108700026220 vif Genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58174704P | 2004-06-21 | 2004-06-21 | |
| US60/581,747 | 2004-06-21 | ||
| PCT/US2005/021951 WO2006002177A2 (en) | 2004-06-21 | 2005-06-20 | Interferon alpha receptor 1 antibodies and their uses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012217849A Division JP5899540B2 (ja) | 2004-06-21 | 2012-09-28 | インターフェロンアルファレセプター１抗体及びその使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008508864A JP2008508864A (ja) | 2008-03-27 |
| JP2008508864A5 true JP2008508864A5 (enExample) | 2008-08-07 |
| JP5160887B2 JP5160887B2 (ja) | 2013-03-13 |
Family
ID=35782299
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007518205A Expired - Lifetime JP5160887B2 (ja) | 2004-06-21 | 2005-06-20 | インターフェロンアルファレセプター１抗体及びその使用法 |
| JP2012217849A Expired - Lifetime JP5899540B2 (ja) | 2004-06-21 | 2012-09-28 | インターフェロンアルファレセプター１抗体及びその使用法 |
| JP2015135415A Pending JP2015172088A (ja) | 2004-06-21 | 2015-07-06 | インターフェロンアルファレセプター１抗体及びその使用法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012217849A Expired - Lifetime JP5899540B2 (ja) | 2004-06-21 | 2012-09-28 | インターフェロンアルファレセプター１抗体及びその使用法 |
| JP2015135415A Pending JP2015172088A (ja) | 2004-06-21 | 2015-07-06 | インターフェロンアルファレセプター１抗体及びその使用法 |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US7662381B2 (enExample) |
| EP (2) | EP1781705B1 (enExample) |
| JP (3) | JP5160887B2 (enExample) |
| KR (4) | KR101541658B1 (enExample) |
| CN (3) | CN102863532A (enExample) |
| AU (1) | AU2005258077C1 (enExample) |
| CA (1) | CA2570823C (enExample) |
| CY (2) | CY1115875T1 (enExample) |
| DK (2) | DK1781705T3 (enExample) |
| ES (2) | ES2526194T3 (enExample) |
| HU (1) | HUE035082T2 (enExample) |
| LT (1) | LT2662390T (enExample) |
| MX (1) | MX2007000023A (enExample) |
| PL (2) | PL2662390T3 (enExample) |
| PT (2) | PT1781705E (enExample) |
| RU (2) | RU2600884C2 (enExample) |
| SI (2) | SI1781705T1 (enExample) |
| WO (1) | WO2006002177A2 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1631312B1 (en) * | 2003-04-23 | 2008-09-10 | Medarex, Inc. | Compositions and methods for the therapy of inflammatory bowel disease |
| EP1781705B1 (en) | 2004-06-21 | 2014-10-08 | Medarex, L.L.C. | Interferon alpha receptor i antibodies and their uses |
| JPWO2006054748A1 (ja) * | 2004-11-22 | 2008-06-05 | Ｓｂｉバイオテック株式会社 | 腎炎の治療剤 |
| JP5215180B2 (ja) | 2005-06-20 | 2013-06-19 | メダレックス インコーポレーティッド | Ｃｄ１９抗体およびその使用法 |
| WO2007002543A2 (en) | 2005-06-23 | 2007-01-04 | Medimmune, Inc. | Antibody formulations having optimized aggregation and fragmentation profiles |
| WO2008048545A2 (en) | 2006-10-16 | 2008-04-24 | Medimmune, Llc. | Molecules with reduced half-lives, compositions and uses thereof |
| WO2008070135A2 (en) * | 2006-12-06 | 2008-06-12 | Medimmune, Llc. | Methods of treating systemic lupus erythematosus |
| CN101678100A (zh) | 2006-12-06 | 2010-03-24 | 米迪缪尼有限公司 | 治疗系统性红斑狼疮的方法 |
| CL2007003622A1 (es) * | 2006-12-13 | 2009-08-07 | Medarex Inc | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. |
| US7947274B2 (en) | 2007-01-04 | 2011-05-24 | Humabs, LLC. | Human cytomegalovirus neutralising antibodies and use thereof |
| GB0700133D0 (en) | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
| CN101909444B (zh) * | 2007-11-05 | 2013-09-18 | 米迪缪尼有限公司 | 硬皮病治疗方法 |
| HUE028958T2 (en) | 2008-02-08 | 2017-01-30 | Medimmune Llc | Anti-ifnar1 antibodies with reduced fc ligand affinity |
| EP2352759B1 (en) | 2008-07-16 | 2017-11-01 | Institute for Research in Biomedicine | Human cytomegalovirus neutralizing antibodies and use thereof |
| JP5475774B2 (ja) * | 2008-07-16 | 2014-04-16 | インスティテュート フォー リサーチ イン バイオメディシン | ヒトサイトメガロウイルス中和抗体およびその使用 |
| CN101580546B (zh) * | 2009-06-04 | 2011-09-14 | 中国疾病预防控制中心病毒病预防控制所 | 人源抗人干扰素α抗体及其应用 |
| ES2613055T3 (es) | 2009-09-03 | 2017-05-22 | Medimmune, Llc | Diagnóstico de interferón de tipo 1 |
| US9493570B2 (en) * | 2012-06-13 | 2016-11-15 | Medimmune, Llc | Fixed dosage regimens for anti-type I interferon receptor (IFNAR) antibodies |
| US20160003850A1 (en) * | 2013-02-26 | 2016-01-07 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN105358575B (zh) * | 2013-03-15 | 2020-09-22 | 詹森生物科技公司 | 干扰素α和ω抗体拮抗剂 |
| IL312865B2 (en) | 2013-09-11 | 2025-06-01 | Eagle Biologics Inc | Liquid protein formulations containing viscosity-lowering agents |
| WO2015061526A1 (en) * | 2013-10-25 | 2015-04-30 | Medimmune, Llc | Antibody purification |
| TWI713453B (zh) * | 2014-06-23 | 2020-12-21 | 美商健生生物科技公司 | 干擾素α及ω抗體拮抗劑 |
| RU2580301C1 (ru) * | 2015-04-21 | 2016-04-10 | Людмила Николаевна Хон | Способ лечения системной красной волчанки человека |
| US10329258B2 (en) | 2015-04-30 | 2019-06-25 | University Of Washington | CGAS in systemic lupus erythematosus (SLE) |
| RS64263B1 (sr) | 2015-08-19 | 2023-07-31 | Astrazeneca Ab | Stabilna anti-ifnar1 formulacija |
| MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
| CN108409862B (zh) | 2016-07-14 | 2021-07-13 | 中国科学院生物物理研究所 | I型干扰素受体抗体及其用途 |
| CN106243226B (zh) * | 2016-08-05 | 2019-02-12 | 北京智仁美博生物科技有限公司 | 抗人ifnar1的抗体及其用途 |
| WO2018136625A2 (en) * | 2017-01-20 | 2018-07-26 | Children's Medical Center Corporation | Compositions and methods for treating diseases characterized by reactive microglia mediated synapse loss |
| US20200031943A1 (en) | 2017-03-21 | 2020-01-30 | Austrianni Gmbh | Type 1 interferon receptor antagonists for use in methods of treating tuberculosis and other infectious diseases |
| TW201946654A (zh) | 2018-03-05 | 2019-12-16 | 比利時商健生藥品公司 | 抗ＰＨＦ－Ｔａｕ抗體及其用途 |
| JP7406254B2 (ja) * | 2018-06-01 | 2023-12-27 | アイエルシー セラピューティクス リミテッド | 疾患の治療に関する組成物および方法 |
| US11059897B2 (en) | 2018-09-18 | 2021-07-13 | I-Mab Biopharma Us Limited | Anti-IFNAR1 antibodies for treating autoimmune diseases |
| CN116333132A (zh) * | 2019-01-31 | 2023-06-27 | 广东旋玉健康生物科技有限公司 | 新型抗ifnar1抗体 |
| KR20210131354A (ko) | 2019-02-15 | 2021-11-02 | 아스트라제네카 아베 | I형 인터페론-매개 장애 |
| KR102766960B1 (ko) | 2019-11-11 | 2025-02-11 | 아스트라제네카 아베 | 전신성 홍반성 루푸스에서 i형 인터페론 억제 |
| CA3174858A1 (en) * | 2020-04-20 | 2021-10-28 | Juho JALKANEN | Treatment of diseases with clever-1 inhibition in combination with an interleukin inhibitor |
| AU2021279277A1 (en) | 2020-05-29 | 2023-02-02 | Astrazeneca Ab | Treatment of cardiometabolic disease with inhibitors of type I interferon signalling |
| TW202237647A (zh) | 2020-10-08 | 2022-10-01 | 瑞典商阿斯特捷利康公司 | 狼瘡發作之治療 |
| US20240327529A1 (en) | 2020-11-18 | 2024-10-03 | Astrazeneca Ab | Steroid sparing |
| LT4114465T (lt) | 2021-04-23 | 2023-11-10 | Astrazeneca Ab | Anti-ifnar1 dozavimo režimas, skirtas poodinei injekcijai |
| US20250002590A1 (en) | 2021-04-23 | 2025-01-02 | Astrazeneca Ab | Treatment of lupus nephritis with anti-type i inf receptor antibody anifrolumab |
| JP2024519196A (ja) * | 2021-04-23 | 2024-05-09 | アストラゼネカ・アクチエボラーグ | 皮膚エリテマトーデスの処置 |
| JP2024516886A (ja) | 2021-05-12 | 2024-04-17 | アストラゼネカ・アクチエボラーグ | 全身性エリテマトーデス患者における１型インターフェロン受容体阻害剤のステロイド節約 |
| CN113278071B (zh) * | 2021-05-27 | 2021-12-21 | 江苏荃信生物医药股份有限公司 | 抗人干扰素α受体1单克隆抗体及其应用 |
| CN113621063A (zh) * | 2021-08-02 | 2021-11-09 | 江苏荃信生物医药有限公司 | 降低单克隆抗体生产中宿主细胞蛋白含量的亲和纯化方法 |
| EP4377349A1 (en) | 2021-07-27 | 2024-06-05 | Astrazeneca AB | Treatment of lupus |
| CA3233069A1 (en) | 2021-10-04 | 2023-04-13 | Astrazeneca Ab | Treatment of lupus |
| CN119604764A (zh) | 2022-08-29 | 2025-03-11 | 江苏恒瑞医药股份有限公司 | 免疫调节剂的筛选和制备方法 |
| TW202411257A (zh) | 2022-08-29 | 2024-03-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 包含ｔａｃｉ多肽的融合蛋白及其用途 |
| CN120344259A (zh) * | 2022-10-13 | 2025-07-18 | 阿斯利康(瑞典)有限公司 | 狼疮的治疗 |
| CN121127499A (zh) | 2023-05-19 | 2025-12-12 | 阿斯利康(瑞典)有限公司 | 狼疮的治疗 |
| WO2025022280A1 (en) | 2023-07-21 | 2025-01-30 | Astrazeneca Ab | Treatment of neurodegenerative diseases |
| GB202315831D0 (en) | 2023-10-16 | 2023-11-29 | Astrazeneca Ab | Treatment of skin disease |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| GB202402824D0 (en) | 2024-02-28 | 2024-04-10 | Astrazeneca Ab | Treatment of chronic kidney disease |
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- 2005-06-20 KR KR1020127032569A patent/KR20130012258A/ko not_active Ceased
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- 2005-06-20 WO PCT/US2005/021951 patent/WO2006002177A2/en not_active Ceased
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