JP2010500005A5 - - Google Patents
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- Publication number
- JP2010500005A5 JP2010500005A5 JP2009506826A JP2009506826A JP2010500005A5 JP 2010500005 A5 JP2010500005 A5 JP 2010500005A5 JP 2009506826 A JP2009506826 A JP 2009506826A JP 2009506826 A JP2009506826 A JP 2009506826A JP 2010500005 A5 JP2010500005 A5 JP 2010500005A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- chain variable
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 32
- 239000000427 antigen Substances 0.000 claims 14
- 102000036639 antigens Human genes 0.000 claims 14
- 108091007433 antigens Proteins 0.000 claims 14
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 claims 4
- 101710088580 Stromal cell-derived factor 1 Proteins 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000012997 experimental autoimmune encephalomyelitis Diseases 0.000 claims 1
- 230000001483 mobilizing effect Effects 0.000 claims 1
- 201000007914 proliferative diabetic retinopathy Diseases 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83700406P | 2006-08-11 | 2006-08-11 | |
| US60/837,004 | 2006-08-11 | ||
| PCT/JP2007/065991 WO2008018641A1 (en) | 2006-08-11 | 2007-08-10 | Monoclonal antibodies against stromal derived factor-1 (sdf-1) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010500005A JP2010500005A (ja) | 2010-01-07 |
| JP2010500005A5 true JP2010500005A5 (enExample) | 2010-08-19 |
| JP5244785B2 JP5244785B2 (ja) | 2013-07-24 |
Family
ID=39033152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009506826A Expired - Fee Related JP5244785B2 (ja) | 2006-08-11 | 2007-08-10 | ストローマ由来因子−１（ｓｄｆ−１）に対するモノクローナル抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8496931B2 (enExample) |
| EP (1) | EP2046834B9 (enExample) |
| JP (1) | JP5244785B2 (enExample) |
| ES (1) | ES2396220T3 (enExample) |
| TW (1) | TW200817437A (enExample) |
| WO (1) | WO2008018641A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008021263A2 (en) * | 2006-08-11 | 2008-02-21 | Medarex, Inc. | Methods of indentifying antibodies that bind oligomeric forms of chemokines and uses thereof |
| WO2009133939A1 (ja) | 2008-04-30 | 2009-11-05 | 株式会社ジェノミックス | 末梢循環への骨髄由来多能性幹細胞動員薬 |
| KR20110017371A (ko) | 2008-04-30 | 2011-02-21 | 가부시키가이샤 제노믹스 | 생체내 기능적 세포의 고효율 채취법 |
| KR20120135190A (ko) | 2009-10-28 | 2012-12-12 | 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 | 골수 간엽계 및/또는 다능성 줄기세포의 혈중 동원(動員)에 의한 조직 재생 촉진제 |
| US9308277B2 (en) * | 2010-02-25 | 2016-04-12 | Mesoblast International Sàrl | Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| DK2613789T3 (en) * | 2010-09-09 | 2018-07-23 | Noxxon Pharma Ag | SDF-1-binding nucleic acids and their use in cancer treatment |
| JP5843189B2 (ja) * | 2011-03-15 | 2016-01-13 | 国立大学法人名古屋大学 | Ｓｄｆ−１阻害剤を含有した軟骨組織再生用組成物 |
| CN103687946B (zh) | 2011-04-26 | 2017-05-03 | 吉诺米克斯股份有限公司 | 用于诱导组织再生的肽及其应用 |
| AU2012268078B2 (en) | 2011-06-07 | 2017-06-01 | Mesoblast International Sarl | Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived Factor-1 |
| PL2913058T3 (pl) | 2012-10-25 | 2018-04-30 | Genomix Co., Ltd. | Nowy sposób leczenia zawału mięśnia sercowego przy użyciu fragmentu HMGB1 |
| CN104955470B (zh) | 2012-10-25 | 2017-06-16 | 吉诺米克斯股份有限公司 | 利用了hmgb1片段的针对脊髄损伤的新型治疗方法 |
| CA2920377A1 (en) * | 2013-08-05 | 2015-02-12 | Cambridge Enterprise Limited | Inhibition of cxcr4 signaling in cancer immunotherapy |
| CN107207590A (zh) * | 2014-12-17 | 2017-09-26 | 癌症研究技术有限公司 | 抗cxcl12抗体分子及其用途 |
| EP3307778A1 (en) | 2015-06-12 | 2018-04-18 | Bristol-Myers Squibb Company | Treatment of cancer by combined blockade of the pd-1 and cxcr4 signaling pathways |
| US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| BR112019014921A2 (pt) | 2017-01-27 | 2020-03-31 | StemRIM Inc. | Agente terapêutico para miocardiopatia, infarto antigo do miocárdio e insuficiência cardíaca crônica |
| US11427634B2 (en) * | 2017-05-05 | 2022-08-30 | Vaccinex, Inc. | Human anti-semaphorin 4D antibody |
| US12421498B2 (en) | 2017-12-01 | 2025-09-23 | StemRIM Inc. | Ectodermal mesenchymal stem cells and method for producing same |
| JPWO2019107530A1 (ja) | 2017-12-01 | 2020-11-26 | 株式会社ステムリム | 炎症性腸疾患の治療薬 |
| WO2019156137A1 (ja) | 2018-02-08 | 2019-08-15 | 株式会社ステムリム | 乾癬の治療薬 |
| US12304933B2 (en) | 2018-10-05 | 2025-05-20 | StemRIM Inc. | Disease treatment drug based on mesenchymal-stem-cell mobilization |
| JP7743633B2 (ja) * | 2021-12-27 | 2025-09-24 | エピ バイオテック カンパニー リミテッド | Ｃｘｃｌ１２に対する抗体及びそれを含む脱毛治療用組成物 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
| EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
| US5476996A (en) | 1988-06-14 | 1995-12-19 | Lidak Pharmaceuticals | Human immune system in non-human animal |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| JP2989002B2 (ja) | 1988-12-22 | 1999-12-13 | キリン―アムジエン・インコーポレーテツド | 化学修飾顆粒球コロニー刺激因子 |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| ES2087997T3 (es) | 1990-01-12 | 1996-08-01 | Cell Genesys Inc | Generacion de anticuerpos xenogenicos. |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
| ATE463573T1 (de) | 1991-12-02 | 2010-04-15 | Medimmune Ltd | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| WO1993022332A2 (en) | 1992-04-24 | 1993-11-11 | Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| DE69833755T2 (de) | 1997-05-21 | 2006-12-28 | Biovation Ltd. | Verfahren zur herstellung von nicht-immunogenen proteinen |
| AU766675B2 (en) | 1998-03-30 | 2003-10-23 | Northwest Biotherapeutics, Inc. | Therapeutic and diagnostic applications based on the role of the CXCR-4 gene in tumorigenesis |
| NZ517202A (en) | 1999-08-24 | 2004-05-28 | Medarex Inc | Human CTLA-4 antibodies and their uses |
| JP3523245B1 (ja) | 2000-11-30 | 2004-04-26 | メダレックス，インコーポレーテッド | ヒト抗体作製用トランスジェニック染色体導入齧歯動物 |
| WO2002092780A2 (en) | 2001-05-17 | 2002-11-21 | Diversa Corporation | Novel antigen binding molecules for therapeutic, diagnostic, prophylactic, enzymatic, industrial, and agricultural applications, and methods for generating and screening thereof |
| US20040110226A1 (en) | 2002-03-01 | 2004-06-10 | Xencor | Antibody optimization |
| US7491389B2 (en) * | 2002-03-21 | 2009-02-17 | University Of Florida Reasearch Foundation, Inc. | Modulating angiogenesis |
| US20050002939A1 (en) * | 2002-12-23 | 2005-01-06 | Albert Zlotnik | Tumor killing/tumor regression using CXCR4 antagonists |
| WO2008021263A2 (en) * | 2006-08-11 | 2008-02-21 | Medarex, Inc. | Methods of indentifying antibodies that bind oligomeric forms of chemokines and uses thereof |
-
2007
- 2007-08-10 ES ES07792618T patent/ES2396220T3/es active Active
- 2007-08-10 US US12/377,015 patent/US8496931B2/en not_active Expired - Fee Related
- 2007-08-10 JP JP2009506826A patent/JP5244785B2/ja not_active Expired - Fee Related
- 2007-08-10 TW TW096129514A patent/TW200817437A/zh unknown
- 2007-08-10 WO PCT/JP2007/065991 patent/WO2008018641A1/en not_active Ceased
- 2007-08-10 EP EP07792618.6A patent/EP2046834B9/en not_active Not-in-force
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