|
US7528165B2
(en)
|
2001-12-13 |
2009-05-05 |
National Health Research Institutes |
Indole compounds
|
|
US7632955B2
(en)
|
2001-12-13 |
2009-12-15 |
National Health Research Institutes |
Indole compounds
|
|
CA2550361C
(en)
|
2003-12-19 |
2014-04-29 |
Prabha Ibrahim |
Compounds and methods for development of ret modulators
|
|
TWI372624B
(en)
*
|
2004-03-30 |
2012-09-21 |
Vertex Pharma |
Azaindoles useful as inhibitors of jak and other protein kinases
|
|
US7498342B2
(en)
*
|
2004-06-17 |
2009-03-03 |
Plexxikon, Inc. |
Compounds modulating c-kit activity
|
|
EP1781654A1
(en)
|
2004-07-27 |
2007-05-09 |
SGX Pharmaceuticals, Inc. |
Pyrrolo-pyridine kinase modulators
|
|
US7626021B2
(en)
*
|
2004-07-27 |
2009-12-01 |
Sgx Pharmaceuticals, Inc. |
Fused ring heterocycle kinase modulators
|
|
US7709645B2
(en)
*
|
2004-07-27 |
2010-05-04 |
Sgx Pharmaceuticals, Inc. |
Pyrrolo-pyridine kinase modulators
|
|
US7361764B2
(en)
|
2004-07-27 |
2008-04-22 |
Sgx Pharmaceuticals, Inc. |
Pyrrolo-pyridine kinase modulators
|
|
MX2007001126A
(es)
|
2004-07-27 |
2007-09-25 |
Sgx Pharmaceuticals Inc |
Moduladores de heterociclo cinasa de anillo fusionado.
|
|
EP1828180A4
(en)
*
|
2004-12-08 |
2010-09-15 |
Glaxosmithkline Llc |
1H-pyrrolo [2,3-BETA] PYRIDINE
|
|
US7456289B2
(en)
*
|
2004-12-31 |
2008-11-25 |
National Health Research Institutes |
Anti-tumor compounds
|
|
KR101411167B1
(ko)
|
2005-04-13 |
2014-06-23 |
아스텍스 테라퓨틱스 리미티드 |
하이드록시벤즈아미드 유도체 및 hsp90 억제제로서의이의 용도
|
|
AU2006272951A1
(en)
*
|
2005-05-17 |
2007-02-01 |
Plexxikon, Inc. |
Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
|
|
CN102206216B
(zh)
|
2005-06-22 |
2014-11-12 |
普莱希科公司 |
作为蛋白质激酶抑制剂的吡咯并[2,3-b]吡啶衍生物
|
|
US8119655B2
(en)
|
2005-10-07 |
2012-02-21 |
Takeda Pharmaceutical Company Limited |
Kinase inhibitors
|
|
CN102532133A
(zh)
|
2006-01-17 |
2012-07-04 |
沃泰克斯药物股份有限公司 |
适用作詹纳斯激酶抑制剂的吖吲哚类
|
|
US7754725B2
(en)
|
2006-03-01 |
2010-07-13 |
Astex Therapeutics Ltd. |
Dihydroxyphenyl isoindolymethanones
|
|
DE102006012617A1
(de)
*
|
2006-03-20 |
2007-09-27 |
Merck Patent Gmbh |
4-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate
|
|
MX2008014450A
(es)
*
|
2006-05-18 |
2009-03-09 |
Mannkind Corp |
Inhibidores de cinasa intracelular.
|
|
US20070286864A1
(en)
*
|
2006-06-09 |
2007-12-13 |
Buck Elizabeth A |
Combined treatment with an EGFR kinase inhibitor and an agent that sensitizes tumor cells to the effects of EGFR kinase inhibitors
|
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
US8198448B2
(en)
|
2006-07-14 |
2012-06-12 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
|
PE20080403A1
(es)
|
2006-07-14 |
2008-04-25 |
Amgen Inc |
Derivados heterociclicos fusionados y metodos de uso
|
|
US20080242694A1
(en)
*
|
2006-09-18 |
2008-10-02 |
D Sidocky Neil R |
Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith
|
|
SG158147A1
(en)
|
2006-10-09 |
2010-01-29 |
Takeda Pharmaceutical |
Kinase inhibitors
|
|
JO3598B1
(ar)
*
|
2006-10-10 |
2020-07-05 |
Infinity Discovery Inc |
الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
|
|
JP5528807B2
(ja)
|
2006-10-12 |
2014-06-25 |
アステックス、セラピューティックス、リミテッド |
複合薬剤
|
|
GB0620259D0
(en)
|
2006-10-12 |
2006-11-22 |
Astex Therapeutics Ltd |
Pharmaceutical compounds
|
|
WO2008044041A1
(en)
|
2006-10-12 |
2008-04-17 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
|
JP5518478B2
(ja)
|
2006-10-12 |
2014-06-11 |
アステックス、セラピューティックス、リミテッド |
医薬化合物
|
|
EP2073802A1
(en)
|
2006-10-12 |
2009-07-01 |
Astex Therapeutics Limited |
Pharmaceutical combinations
|
|
JP2010508363A
(ja)
*
|
2006-11-01 |
2010-03-18 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
ヤヌスキナーゼの阻害剤として有用な三環系ヘテロアリール化合物
|
|
WO2008060907A2
(en)
|
2006-11-10 |
2008-05-22 |
Bristol-Myers Squibb Company |
Pyrrolo-pyridine kinase inhibitors
|
|
ME02372B
(me)
*
|
2006-11-22 |
2016-06-20 |
Incyte Holdings Corp |
Imidazotriazini i imidazopiramidini kao inhibitori kinaze
|
|
WO2008063888A2
(en)
*
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
|
PE20081581A1
(es)
*
|
2006-12-21 |
2008-11-12 |
Plexxikon Inc |
COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
|
|
AU2007338754A1
(en)
|
2006-12-21 |
2008-07-03 |
Vertex Pharmaceuticals Incorporated |
5-cyan0-4- (pyrrolo [2, 3B] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
|
|
WO2008079909A1
(en)
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Pyrrolo [2,3-b] pyridines as kinase modulators
|
|
AU2007336811A1
(en)
*
|
2006-12-21 |
2008-07-03 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
AU2008210455A1
(en)
*
|
2007-01-31 |
2008-08-07 |
Vertex Pharmaceuticals Incorporated |
2-aminopyridine derivatives useful as kinase inhibitors
|
|
GB0702259D0
(en)
*
|
2007-02-06 |
2007-03-14 |
Eisai London Res Lab Ltd |
7-azaindole derivatives
|
|
GB0702265D0
(en)
*
|
2007-02-06 |
2007-03-14 |
Eisai London Res Lab Ltd |
7-Azaindole derivatives
|
|
WO2008124848A1
(en)
|
2007-04-10 |
2008-10-16 |
Sgx Pharmaceuticals, Inc. |
Fused ring heterocycle kinase modulators
|
|
US8263585B2
(en)
*
|
2007-05-04 |
2012-09-11 |
Novartis Ag |
Organic compounds
|
|
CA2688823A1
(en)
*
|
2007-05-21 |
2008-11-27 |
Sgx Pharmaceuticals, Inc. |
Heterocyclic kinase modulators
|
|
DE102007028515A1
(de)
*
|
2007-06-21 |
2008-12-24 |
Merck Patent Gmbh |
6-(Pyrrolopyridinyl)-pyrimidinyl-2-amin-derivate
|
|
EP2176216B1
(en)
*
|
2007-07-06 |
2012-04-25 |
Paratek Pharmaceuticals, Inc. |
Methods for synthesizing 9-substituted minocycline
|
|
JP2010533729A
(ja)
|
2007-07-17 |
2010-10-28 |
プレキシコン,インコーポレーテッド |
キナーゼ調節のための化合物と方法、及びそのための適応
|
|
ES2394126T3
(es)
*
|
2007-07-26 |
2013-01-22 |
Novartis Ag |
Derivados de pirimidina útiles para el tratamiento de estados inflamatorios o alérgicos
|
|
US8183245B2
(en)
*
|
2007-10-25 |
2012-05-22 |
Merck Sharp & Dohme Corp. |
Pyrazine substituted pyrrolopyridines as inhibitors of JAK and PDK1
|
|
US8598165B2
(en)
|
2007-11-26 |
2013-12-03 |
University Of Kansas |
Morpholines as selective inhibitors of cytochrome P450 2A13
|
|
US8268834B2
(en)
*
|
2008-03-19 |
2012-09-18 |
Novartis Ag |
Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
|
|
GB0806527D0
(en)
|
2008-04-11 |
2008-05-14 |
Astex Therapeutics Ltd |
Pharmaceutical compounds
|
|
WO2009143211A2
(en)
|
2008-05-21 |
2009-11-26 |
Incyte Corporation |
Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
|
|
US8569337B2
(en)
|
2008-07-23 |
2013-10-29 |
Vertex Pharmaceuticals Incorporated |
Tri-cyclic pyrazolopyridine kinase inhibitors
|
|
AU2009274023A1
(en)
|
2008-07-23 |
2010-01-28 |
Vertex Pharmaceuticals Incorporated |
Tri-cyclic pyrazolopyridine kinase inhibitors
|
|
ES2402087T3
(es)
|
2008-07-23 |
2013-04-26 |
Vertex Pharmaceuticals Incorporated |
Inhibidores de la pirazolopiridina quinasa
|
|
NZ590688A
(en)
|
2008-08-05 |
2012-09-28 |
Daiichi Sankyo Co Ltd |
imidazo[4,5-b]pyridin-2-one derivatives
|
|
EP2323659A4
(en)
*
|
2008-08-05 |
2012-03-14 |
Abbott Lab |
COMPOUNDS USEFUL AS INHIBITORS OF PROTEIN KINASES
|
|
MX2011001319A
(es)
*
|
2008-08-06 |
2011-04-05 |
Vertex Pharma |
Inhibidores de aminopiridina cinasa.
|
|
CA2744498C
(en)
|
2008-11-25 |
2017-10-24 |
University Of Rochester |
Mlk inhibitors and methods of use
|
|
CA3121743A1
(en)
*
|
2009-01-15 |
2010-07-22 |
Incyte Holdings Corporation |
Processes for preparing jak inhibitors and related intermediate compounds
|
|
FR2941948B1
(fr)
|
2009-02-12 |
2013-04-05 |
Nova Decision |
Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src
|
|
KR101739994B1
(ko)
|
2009-04-03 |
2017-05-25 |
에프. 호프만-라 로슈 아게 |
프로판-1-술폰산 {3-[5-(4-클로로-페닐)-1H-피롤로[2,3-b]피리딘-3-카르보닐]-2,4-디플루오로-페닐}-아미드 조성물 및 그의 용도
|
|
CA2760705A1
(en)
|
2009-05-06 |
2010-11-11 |
Vertex Pharmaceuticals Incorporated |
Pyrazolopyridines
|
|
RS57869B1
(sr)
|
2009-06-17 |
2018-12-31 |
Vertex Pharma |
Inhibitori replikacije virusa gripa
|
|
US8703808B2
(en)
|
2009-06-23 |
2014-04-22 |
Centre National De La Recherche Scientifique |
Use of derivatives of indoles for the treatment of cancer
|
|
EP2266562A1
(en)
*
|
2009-06-23 |
2010-12-29 |
Centre National de la Recherche Scientifique |
Use of derivatives of indoles for the treatment of cancer
|
|
US8329724B2
(en)
*
|
2009-08-03 |
2012-12-11 |
Hoffmann-La Roche Inc. |
Process for the manufacture of pharmaceutically active compounds
|
|
GB0918924D0
(en)
*
|
2009-10-28 |
2009-12-16 |
Vantia Ltd |
Azaindole derivatives
|
|
NZ599866A
(en)
|
2009-11-06 |
2014-09-26 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
EP3795573B1
(en)
|
2009-12-31 |
2022-07-06 |
Hutchison Medipharma Limited |
Certain triazolopyrazines, compositions thereof and methods of use therefor
|
|
WO2011094288A1
(en)
|
2010-01-27 |
2011-08-04 |
Vertex Pharmaceuticals Incorporated |
Pyrazolopyrazine kinase inhibitors
|
|
EP2528917B1
(en)
|
2010-01-27 |
2016-10-19 |
Vertex Pharmaceuticals Incorporated |
Pyrazolopyridines useful for the treatment of autoimmune, inflammatory or (hyper)proliferative diseases
|
|
MX2012008643A
(es)
|
2010-01-27 |
2013-02-26 |
Vertex Pharma |
Inhibidores de cinasas de pirazolopiridinas.
|
|
MX361692B
(es)
|
2010-02-03 |
2018-12-13 |
Infinity Pharmaceuticals Inc |
Inhibidores de amida hidrolasa de ácido graso.
|
|
CA2795422A1
(en)
*
|
2010-04-19 |
2011-10-27 |
Abbvie Inc. |
Pyrrolopyridine inhibitors of kinases
|
|
AU2011248175A1
(en)
*
|
2010-05-06 |
2012-10-25 |
Merck Sharp & Dohme Corp. |
Aza-Indole derivatives useful as modulators of FAAH
|
|
AU2011258465B2
(en)
|
2010-05-24 |
2016-12-15 |
University Of Rochester |
Bicyclic heteroaryl kinase inhibitors and methods of use
|
|
US8779150B2
(en)
*
|
2010-07-21 |
2014-07-15 |
Hoffmann-La Roche Inc. |
Processes for the manufacture of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide
|
|
AU2011343642A1
(en)
|
2010-12-16 |
2013-05-02 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of influenza viruses replication
|
|
KR101911972B1
(ko)
|
2011-02-07 |
2018-10-25 |
플렉시콘 인코퍼레이티드 |
키나제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증
|
|
TWI558702B
(zh)
|
2011-02-21 |
2016-11-21 |
普雷辛肯公司 |
醫藥活性物質的固態形式
|
|
WO2012135631A1
(en)
|
2011-03-30 |
2012-10-04 |
Arrien Pharmaeuticals Llc |
Substituted 5-(pyrazin-2-yl)-1h-pyrazolo [3, 4-b] pyridine and pyrazolo [3, 4-b] pyridine derivatives as protein kinase inhibitors
|
|
AU2012255275B2
(en)
|
2011-05-17 |
2016-01-28 |
Plexxikon Inc. |
Kinase modulation and indications therefor
|
|
UA118010C2
(uk)
|
2011-08-01 |
2018-11-12 |
Вертекс Фармасьютікалз Інкорпорейтед |
Інгібітори реплікації вірусів грипу
|
|
EP2763535B1
(en)
*
|
2011-10-03 |
2017-06-07 |
Merck Sharp & Dohme Corp. |
Azaindoles as janus kinase inhibitors
|
|
DE102011119127A1
(de)
|
2011-11-22 |
2013-05-23 |
Merck Patent Gmbh |
3-Cyanaryl-1H-pyrrolo[2.3-b]pyridin-Derivate
|
|
US9358235B2
(en)
|
2012-03-19 |
2016-06-07 |
Plexxikon Inc. |
Kinase modulation, and indications therefor
|
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
EP2925319B1
(en)
|
2012-11-30 |
2019-01-09 |
University Of Rochester |
Mixed lineage kinase inhibitors for hiv/aids therapies
|
|
US9260426B2
(en)
|
2012-12-14 |
2016-02-16 |
Arrien Pharmaceuticals Llc |
Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
|
|
US20140303121A1
(en)
|
2013-03-15 |
2014-10-09 |
Plexxikon Inc. |
Heterocyclic compounds and uses thereof
|
|
SG11201506687RA
(en)
|
2013-03-15 |
2015-09-29 |
Plexxikon Inc |
Heterocyclic compounds and uses thereof
|
|
US9206188B2
(en)
*
|
2013-04-18 |
2015-12-08 |
Arrien Pharmaceuticals Llc |
Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors
|
|
CN104119331B
(zh)
*
|
2013-04-26 |
2018-02-06 |
广东东阳光药业有限公司 |
烯基化合物及其使用方法和用途
|
|
GB2515785A
(en)
*
|
2013-07-03 |
2015-01-07 |
Redx Pharma Ltd |
Compounds
|
|
RS59144B1
(sr)
|
2013-11-13 |
2019-09-30 |
Vertex Pharma |
Inhibitori replikacije virusa influence
|
|
HRP20181272T1
(hr)
|
2013-11-13 |
2018-10-05 |
Vertex Pharmaceuticals Incorporated |
Postupci priprave inhibitora replikacije virusa influence
|
|
CA2973597A1
(en)
*
|
2015-01-23 |
2016-07-28 |
Confluence Life Sciences, Inc. |
Heterocyclic itk inhibitors for treating inflammation and cancer
|
|
KR101660863B1
(ko)
*
|
2015-04-03 |
2016-09-28 |
주식회사 녹십자 |
IKKε 및 TBK1 억제제로서의 7-아자인돌 또는 4,7-다이아자인돌 유도체 및 이를 포함하는 약학적 조성물
|
|
US10160755B2
(en)
*
|
2015-04-08 |
2018-12-25 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
JP6857617B2
(ja)
|
2015-05-13 |
2021-04-14 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
インフルエンザウイルスの複製の阻害剤
|
|
JP6704416B2
(ja)
|
2015-05-13 |
2020-06-03 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
インフルエンザウイルスの複製の阻害剤を調製する方法
|
|
WO2017094026A1
(en)
*
|
2015-11-30 |
2017-06-08 |
Council Of Scientific & Industrial Research |
3-pyrimidinyl pyrrolo [2,3-b] pyridine as new anticancer agents and the process for the preparation thereof
|
|
RU2018123825A
(ru)
*
|
2015-12-07 |
2020-01-15 |
Плексксикон Инк. |
Соединения и способы для модуляции киназ, и показания для этого
|
|
WO2018217766A1
(en)
|
2017-05-22 |
2018-11-29 |
Whitehead Institute For Biomedical Research |
Kcc2 expression enhancing compounds and uses thereof
|
|
US10428067B2
(en)
|
2017-06-07 |
2019-10-01 |
Plexxikon Inc. |
Compounds and methods for kinase modulation
|
|
CN107550905B
(zh)
*
|
2017-09-11 |
2020-07-17 |
浙江永宁药业股份有限公司 |
多取代吡咯并吡啶类化合物的药物用途及其制备方法
|
|
WO2019057660A1
(en)
*
|
2017-09-25 |
2019-03-28 |
Basf Se |
INDOLE AND AZAINDOLE COMPOUNDS HAVING 6-CHANNEL SUBSTITUTED ARYL AND HETEROARYL CYCLES AS AGROCHEMICAL FUNGICIDES
|
|
JP7675519B2
(ja)
|
2017-10-13 |
2025-05-13 |
オプナ バイオ ソシエテ アノニム |
キナーゼを調節するための化合物の固体形態
|
|
WO2019169306A1
(en)
*
|
2018-03-01 |
2019-09-06 |
The Trustees Of Columbia University In The City Of New York |
Compounds, compositions, and methods for suppressing toxic endoplasmic reticulum stress
|
|
TW202039483A
(zh)
*
|
2018-11-22 |
2020-11-01 |
英屬開曼群島商百濟神州有限公司 |
作為HPK1抑制劑的吡咯並[2,3-b]吡啶以及它們的用途
|
|
KR20220018475A
(ko)
*
|
2019-04-09 |
2022-02-15 |
플렉시콘 인코퍼레이티드 |
Ep300 또는 cbp 조절 및 이의 표시를 위한 응축 아진
|
|
TWI848141B
(zh)
|
2019-07-04 |
2024-07-11 |
英屬開曼群島商百濟神州有限公司 |
及其用途
|
|
TW202116771A
(zh)
|
2019-07-17 |
2021-05-01 |
英屬開曼群島商百濟神州有限公司 |
作為hpk1抑制劑之三環化合物及其用途
|
|
JP7564888B2
(ja)
*
|
2020-05-01 |
2024-10-09 |
ギリアード サイエンシーズ, インコーポレイテッド |
Cd73阻害性2,4-ジオキソピリミジン化合物
|
|
EP4225741A4
(en)
*
|
2020-10-05 |
2024-10-30 |
Enliven Inc. |
7-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES
|
|
WO2022243648A1
(fr)
*
|
2021-05-21 |
2022-11-24 |
Centre National De La Recherche Scientifique (Cnrs) |
Nouveaux derives azaindole en tant qu'agents antiviraux
|
|
WO2023245327A1
(en)
*
|
2022-06-20 |
2023-12-28 |
Biofront Ltd |
Multiple kinase degraders, compositions comprising the degrader, and methods of using the same
|
|
WO2023245329A1
(en)
*
|
2022-06-20 |
2023-12-28 |
Biofront Ltd |
Multi-kinase inhibitors, compositions thereof, and methods of using the same
|