JP2008505985A5 - - Google Patents

Info

Publication number

JP2008505985A5

JP2008505985A5 JP2007527553A JP2007527553A JP2008505985A5 JP 2008505985 A5 JP2008505985 A5 JP 2008505985A5 JP 2007527553 A JP2007527553 A JP 2007527553A JP 2007527553 A JP2007527553 A JP 2007527553A JP 2008505985 A5 JP2008505985 A5 JP 2008505985A5

Authority

JP

Japan

Prior art keywords

seq

polypeptide

virus

conjugate

reducing

Prior art date

2005-05-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 238000000034 method Methods 0.000 claims 23
• 229920001184 polypeptide Polymers 0.000 claims 15
• 102000004196 processed proteins & peptides Human genes 0.000 claims 15
• 108090000765 processed proteins & peptides Proteins 0.000 claims 15
• 241000700605 Viruses Species 0.000 claims 13
• 210000004027 cell Anatomy 0.000 claims 11
• 210000002966 serum Anatomy 0.000 claims 6
• 125000003275 alpha amino acid group Chemical group 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 5
• 238000004519 manufacturing process Methods 0.000 claims 4
• 210000003000 inclusion body Anatomy 0.000 claims 3
• 241000588724 Escherichia coli Species 0.000 claims 2
• 230000000840 anti-viral effect Effects 0.000 claims 2
• 230000001580 bacterial effect Effects 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 229930182817 methionine Natural products 0.000 claims 1
• 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 102000040430 polynucleotide Human genes 0.000 claims 1
• 108091033319 polynucleotide Proteins 0.000 claims 1
• 239000002157 polynucleotide Substances 0.000 claims 1
• 239000002689 soil Substances 0.000 claims 1
• 230000003381 solubilizing effect Effects 0.000 claims 1
• 230000003612 virological effect Effects 0.000 claims 1