JP2008505927A - ポリマー部分を含む多価ｖｌａ−４拮抗薬 - Google Patents

ポリマー部分を含む多価ｖｌａ−４拮抗薬 Download PDF

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JP2008505927A
JP2008505927A JP2007520561A JP2007520561A JP2008505927A JP 2008505927 A JP2008505927 A JP 2008505927A JP 2007520561 A JP2007520561 A JP 2007520561A JP 2007520561 A JP2007520561 A JP 2007520561A JP 2008505927 A JP2008505927 A JP 2008505927A
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substituted
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alkyl
compound
formula
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コンラディ、アンドレイ、ダブリュー．
プレイス、マイケル、エー．
セムコ、クリストファー、エム．
イェドノック、テオドール
スミス、ジェニファー、エル．
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イーラン ファーマスーティカルズ、インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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JP2007520561A 2004-07-08 2005-07-08 ポリマー部分を含む多価ｖｌａ−４拮抗薬 Pending JP2008505927A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58697504P 2004-07-08 2004-07-08
PCT/US2005/024369 WO2006010054A2 (en) 2004-07-08 2005-07-08 Multivalent vla-4 antagonists comprising polyethylene glycol moieties

Publications (1)

Publication Number Publication Date
JP2008505927A true JP2008505927A (ja) 2008-02-28

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JP2007520561A Pending JP2008505927A (ja) 2004-07-08 2005-07-08 ポリマー部分を含む多価ｖｌａ−４拮抗薬

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US (4) US7794700B2 (US07794700-20100914-C00204.png)
EP (4) EP2258399A3 (US07794700-20100914-C00204.png)
JP (1) JP2008505927A (US07794700-20100914-C00204.png)
KR (1) KR101273614B1 (US07794700-20100914-C00204.png)
CN (1) CN101035563B (US07794700-20100914-C00204.png)
AR (1) AR050425A1 (US07794700-20100914-C00204.png)
AU (1) AU2005265316B2 (US07794700-20100914-C00204.png)
BR (1) BRPI0513143A (US07794700-20100914-C00204.png)
CA (1) CA2573245C (US07794700-20100914-C00204.png)
EA (1) EA012433B1 (US07794700-20100914-C00204.png)
EC (1) ECSP077231A (US07794700-20100914-C00204.png)
HK (1) HK1111674A1 (US07794700-20100914-C00204.png)
IL (1) IL180558A0 (US07794700-20100914-C00204.png)
MA (1) MA28786B1 (US07794700-20100914-C00204.png)
MX (1) MX2007000228A (US07794700-20100914-C00204.png)
NO (1) NO20070216L (US07794700-20100914-C00204.png)
NZ (1) NZ588839A (US07794700-20100914-C00204.png)
TW (1) TWI418346B (US07794700-20100914-C00204.png)
WO (1) WO2006010054A2 (US07794700-20100914-C00204.png)
ZA (1) ZA200700238B (US07794700-20100914-C00204.png)

Cited By (4)

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JP2008540686A (ja) * 2005-05-20 2008-11-20 イーラン ファーマスーティカルズ、インコーポレイテッド Ｖｌａ−４アンタゴニストとしてのイミダゾロンフェニルアラニン誘導体
JP2009501246A (ja) * 2005-07-08 2009-01-15 イーラン ファーマスーティカルズ、インコーポレイテッド 治療用、農業用、及び食品用添加剤化合物のポリマー複合体の調製
JP2009510097A (ja) * 2005-09-29 2009-03-12 エラン ファーマシューティカルズ，インコーポレイテッド Ｖｌａ−４によって媒介される白血球接着を阻害するピリミジニルアミド化合物
JP2012197319A (ja) * 2005-09-29 2012-10-18 Elan Pharmaceuticals Inc Ｖｌａ−４によって媒介される白血球粘着を阻害するカルバメート化合物

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US6479492B1 (en) * 1999-01-22 2002-11-12 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
EP1706399A1 (en) * 2004-01-23 2006-10-04 Elan Pharmaceuticals, Inc. Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids
KR101273614B1 (ko) * 2004-07-08 2013-06-12 엘란 파마슈티칼스, 인크. 중합체 부분을 포함하는 다가 ｖｌａ―４ 길항제
CN101360736A (zh) * 2005-11-23 2009-02-04 阿斯利康(瑞典)有限公司 L-丙氨酸衍生物
EP1996559A1 (en) * 2006-02-27 2008-12-03 Elan Pharmaceuticals Inc. Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4
DK2676967T3 (da) 2006-02-28 2019-09-16 Biogen Ma Inc Fremgangsmåder til behandling af inflammatoriske og autoimmune sygdomme med natalizumab
EP2007392A4 (en) * 2006-02-28 2010-04-07 Elan Pharm Inc METHOD FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES WITH ALPHA-4-INHIBITABLE COMPOUNDS
MX2008011176A (es) 2006-03-03 2008-09-10 Elan Pharm Inc Metodos para tratar padecimientos inflamatorios y autoinmunes con natalizumab.
AU2007253717A1 (en) * 2006-05-22 2007-11-29 Elan Pharmaceuticals, Inc. Preparation of polymer conjugates of therapeutic, agricultural and food additive compounds
WO2007141473A1 (en) * 2006-06-09 2007-12-13 Astrazeneca Ab N-(benzoyl)-o- [2- (pyridin- 2 -ylamino) ethyl] -l-tyrosine derivatives and related compounds as a5b1 antagonists for the treatment of solid tumors
WO2008093065A1 (en) * 2007-01-29 2008-08-07 Astrazeneca Ab L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS
EP2124996A4 (en) 2007-02-20 2010-03-24 Merrimack Pharmaceuticals Inc METHODS OF TREATING MULTIPLE SCLEROSIS BY ADMINISTERING ALPHA-FETOPROTEIN COMBINED WITH INTEGRIN ANTAGONIST
WO2008125811A1 (en) * 2007-04-11 2008-10-23 Astrazeneca Ab N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS
WO2008153967A1 (en) * 2007-06-08 2008-12-18 Contec Therapeutics, Inc. Bk1 antagonist conjugates
EP2231185A4 (en) * 2007-12-07 2012-06-27 Elan Pharm Inc METHOD AND COMPOSITIONS FOR TREATING LIQUID TUMORS
EP2085407A1 (en) 2008-02-04 2009-08-05 Sahltech I Göteborg AB Treatment of idiopathic thrombocytopenic purpura
MX2011011326A (es) * 2009-04-27 2012-02-13 Elan Pharm Inc Antagonistas de piridinona de las integrinas alfa-4.
US20120258093A1 (en) * 2009-08-20 2012-10-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
US11287423B2 (en) 2010-01-11 2022-03-29 Biogen Ma Inc. Assay for JC virus antibodies
DK3339865T5 (da) 2010-01-11 2023-03-20 Biogen Ma Inc Assay for jc-virus-antistoffer
WO2011089214A1 (en) * 2010-01-22 2011-07-28 Ascendis Pharma As Carrier-linked carbamate prodrug linkers
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