JP2008505100A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008505100A5 JP2008505100A5 JP2007519415A JP2007519415A JP2008505100A5 JP 2008505100 A5 JP2008505100 A5 JP 2008505100A5 JP 2007519415 A JP2007519415 A JP 2007519415A JP 2007519415 A JP2007519415 A JP 2007519415A JP 2008505100 A5 JP2008505100 A5 JP 2008505100A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- alkylene
- substituted
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003118 aryl group Chemical group 0.000 claims 61
- 125000000217 alkyl group Chemical group 0.000 claims 56
- 150000001875 compounds Chemical class 0.000 claims 47
- 150000003839 salts Chemical class 0.000 claims 41
- 239000012453 solvate Substances 0.000 claims 41
- 125000001424 substituent group Chemical group 0.000 claims 39
- 125000001072 heteroaryl group Chemical group 0.000 claims 19
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 125000002947 alkylene group Chemical group 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 7
- 125000004350 aryl cycloalkyl group Chemical group 0.000 claims 5
- -1 2 -cyclopropyl Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000002993 cycloalkylene group Chemical group 0.000 claims 3
- 125000005349 heteroarylcycloalkyl group Chemical group 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims 2
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 2
- 125000005605 benzo group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 claims 1
- TVEXGJYMHHTVKP-UHFFFAOYSA-N 6-oxabicyclo[3.2.1]oct-3-en-7-one Chemical compound C1C2C(=O)OC1C=CC2 TVEXGJYMHHTVKP-UHFFFAOYSA-N 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 0 CCC[C@](COC[C@@]12)N1*(c1ccc(*)cc1)=C(C1)C21OC(N(CC1)CCN1C(C)(C)CO)=O Chemical compound CCC[C@](COC[C@@]12)N1*(c1ccc(*)cc1)=C(C1)C21OC(N(CC1)CCN1C(C)(C)CO)=O 0.000 description 10
- DIGDIWHKKJZMKG-YTQUADARSA-N CC(C)[C@H](COC[C@@H]1C2(CC2)OC(N(CC2)C[C@H]2O)=O)N1S(c(cc1)ccc1Cl)(=O)=O Chemical compound CC(C)[C@H](COC[C@@H]1C2(CC2)OC(N(CC2)C[C@H]2O)=O)N1S(c(cc1)ccc1Cl)(=O)=O DIGDIWHKKJZMKG-YTQUADARSA-N 0.000 description 1
- GHHUJPFVTHAWJJ-LEWJYISDSA-N CC(C)[C@H](COC[C@@H]1C2(CC2)OC(N2CCC(CO)CC2)=O)N1S(c(cc1)ccc1Cl)(=O)=O Chemical compound CC(C)[C@H](COC[C@@H]1C2(CC2)OC(N2CCC(CO)CC2)=O)N1S(c(cc1)ccc1Cl)(=O)=O GHHUJPFVTHAWJJ-LEWJYISDSA-N 0.000 description 1
- MVGOFZWJNQXPLL-LGJCEAAXSA-N CCC[C@H](COC[C@@H]12)N1C=C(C1)C21OC(N(CC1)CCC1(CC)OC)=O Chemical compound CCC[C@H](COC[C@@H]12)N1C=C(C1)C21OC(N(CC1)CCC1(CC)OC)=O MVGOFZWJNQXPLL-LGJCEAAXSA-N 0.000 description 1
- ZJTNMXKBOSGJPO-GLTZWUPFSA-N CCC[C@H](COC[C@@H]1C(C2)(/C2=C\C=O)OC(N2CCOCC2)=O)N1Sc(cc1)ccc1Cl Chemical compound CCC[C@H](COC[C@@H]1C(C2)(/C2=C\C=O)OC(N2CCOCC2)=O)N1Sc(cc1)ccc1Cl ZJTNMXKBOSGJPO-GLTZWUPFSA-N 0.000 description 1
- OCEIPUIMZWHBTM-YROPZMMGSA-N CCC[C@H](COC[C@@H]1C2(C=3C2)OC(N2[C@H](CO)CCC2)=O)N1S=3(c(cc1)ccc1Cl)=O Chemical compound CCC[C@H](COC[C@@H]1C2(C=3C2)OC(N2[C@H](CO)CCC2)=O)N1S=3(c(cc1)ccc1Cl)=O OCEIPUIMZWHBTM-YROPZMMGSA-N 0.000 description 1
- QXGBKHUOWLOVRK-RRPNLBNLSA-N CCc1cc(F)cc([C@H](COC[C@@H]2C3(CC3)OC(N(CC3)CCN3C(C)(C)CO)=O)N2S(c(cc2)ccc2Cl)(=O)=O)c1 Chemical compound CCc1cc(F)cc([C@H](COC[C@@H]2C3(CC3)OC(N(CC3)CCN3C(C)(C)CO)=O)N2S(c(cc2)ccc2Cl)(=O)=O)c1 QXGBKHUOWLOVRK-RRPNLBNLSA-N 0.000 description 1
- UANAZMMRKQNCKS-FDZRRXNVSA-N C[C@@H]([C@H]1C2CC2)OC[C@H](C2(CC2)OC[N+](CC2)(C[C@@H]2O)[O-])N1S(c(cc1)ccc1Cl)(=O)=O Chemical compound C[C@@H]([C@H]1C2CC2)OC[C@H](C2(CC2)OC[N+](CC2)(C[C@@H]2O)[O-])N1S(c(cc1)ccc1Cl)(=O)=O UANAZMMRKQNCKS-FDZRRXNVSA-N 0.000 description 1
- NXENLQIGYOVFMG-QGPMSJSTSA-N C[C@H](C(C)(C)OC[C@@H]1C2(CC2)OC(N(CC2)C[C@@H]2O)=O)N1S(c(cc1)ccc1Cl)(=O)=O Chemical compound C[C@H](C(C)(C)OC[C@@H]1C2(CC2)OC(N(CC2)C[C@@H]2O)=O)N1S(c(cc1)ccc1Cl)(=O)=O NXENLQIGYOVFMG-QGPMSJSTSA-N 0.000 description 1
- UBZIWDLPYNPRFW-RHLKJBLCSA-N C[C@H](C(C)(C)OC[C@@H]1C2(CC2)OC2OC2N(CC2)CCC2C(N)=O)N1S(c(cc1)ccc1Cl)(=O)=O Chemical compound C[C@H](C(C)(C)OC[C@@H]1C2(CC2)OC2OC2N(CC2)CCC2C(N)=O)N1S(c(cc1)ccc1Cl)(=O)=O UBZIWDLPYNPRFW-RHLKJBLCSA-N 0.000 description 1
- SWMAUZBTMLMXJB-AOYPEHQESA-N O=C(N(CC1)CCC1N1CCCCC1)OC1(CC1)[C@@H](COC[C@H]1CC2CC2)N1S(c(cc1)ccc1Cl)(=O)=O Chemical compound O=C(N(CC1)CCC1N1CCCCC1)OC1(CC1)[C@@H](COC[C@H]1CC2CC2)N1S(c(cc1)ccc1Cl)(=O)=O SWMAUZBTMLMXJB-AOYPEHQESA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58401004P | 2004-06-30 | 2004-06-30 | |
| PCT/US2005/023187 WO2006004880A2 (en) | 2004-06-30 | 2005-06-28 | Substituted n-arylsulfonylheterocyclic amines as gamma-secretase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008505100A JP2008505100A (ja) | 2008-02-21 |
| JP2008505100A5 true JP2008505100A5 (enExample) | 2008-08-07 |
Family
ID=35783342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007519415A Pending JP2008505100A (ja) | 2004-06-30 | 2005-06-28 | ガンマ−セクレターゼ阻害剤としての置換ｎ−アリールスルホニル複素環アミン |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7763613B2 (enExample) |
| EP (1) | EP1789404B1 (enExample) |
| JP (1) | JP2008505100A (enExample) |
| CN (2) | CN101602741A (enExample) |
| AR (1) | AR050994A1 (enExample) |
| AT (1) | ATE461926T1 (enExample) |
| CA (1) | CA2570183A1 (enExample) |
| DE (1) | DE602005020156D1 (enExample) |
| ES (1) | ES2341560T3 (enExample) |
| MX (1) | MX2007000040A (enExample) |
| PE (1) | PE20060481A1 (enExample) |
| TW (1) | TWI297270B (enExample) |
| WO (1) | WO2006004880A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008009414A (es) | 2006-01-20 | 2008-10-01 | Schering Corp | Arilsulfonas carbociclicas y heterociclicas como inhibidores de gamma secretasa. |
| JP2009526059A (ja) * | 2006-02-07 | 2009-07-16 | ワイス | １１−ベータｈｓｄ１阻害剤 |
| CA2649996A1 (en) | 2006-04-26 | 2007-11-08 | Merck Sharp & Dohme Limited | Piperidines and related compounds for treatment of alzheimer's disease |
| DK2041181T3 (da) * | 2006-06-08 | 2011-08-29 | Helmholtz Zentrum Muenchen | Specifikke proteaseinhibitorer og deres anvendelse i cancerterapi |
| WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| EP2091948B1 (en) | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| CN101668525A (zh) | 2007-03-01 | 2010-03-10 | 前体生物药物股份公司 | 谷氨酰胺酰环化酶抑制剂的新用途 |
| US9656991B2 (en) | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| BRPI0817433A2 (pt) * | 2007-10-19 | 2015-06-16 | Janssen Pharmaceutica Nv | Moduladores de gama-secretase piperidinila e piperazinila |
| ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
| US20110190269A1 (en) * | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| CA2789440C (en) | 2010-03-10 | 2020-03-24 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| JP5945532B2 (ja) | 2010-04-21 | 2016-07-05 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| AR091279A1 (es) | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
| EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| CN109705052B (zh) * | 2019-01-25 | 2020-12-08 | 苏州大学 | 一种制备1,4-二氢噁嗪的方法 |
| CN119060034A (zh) * | 2024-09-02 | 2024-12-03 | 上海信诺维生物医药有限公司 | 一种含吡喃取代的吗啉类化合物的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04247081A (ja) | 1991-02-01 | 1992-09-03 | Takeda Chem Ind Ltd | ５員複素環酸アミド類 |
| US5646167A (en) | 1993-01-06 | 1997-07-08 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamix acids |
| WO1997028130A1 (en) * | 1996-02-02 | 1997-08-07 | Nippon Shinyaku Co., Ltd. | Isoquinoline derivatives and drugs |
| EA200001144A1 (ru) * | 1998-06-03 | 2001-10-22 | Джи-Пи-Ай Эн-Ай-Эл Холдингз, Инк. | Аза-гетероциклические соединения, применяемые для лечения неврологических расстройств и выпадения волос |
| IL144781A0 (en) | 1999-02-26 | 2002-06-30 | Merck & Co Inc | Novel sulfonamide compounds and uses thereof |
| FR2802206B1 (fr) | 1999-12-14 | 2005-04-22 | Sod Conseils Rech Applic | Derives de 4-aminopiperidine et leur utilisation en tant que medicament |
| SE9904738D0 (sv) * | 1999-12-22 | 1999-12-22 | Astra Pharma Prod | Novel compounds |
| JP2001261657A (ja) * | 2000-03-17 | 2001-09-26 | Yamanouchi Pharmaceut Co Ltd | シアノフェニル誘導体 |
| AU2001254546A1 (en) | 2000-04-20 | 2001-11-07 | Nps Allelix Corp. | Aminopiperidines |
| US6589978B2 (en) | 2000-06-30 | 2003-07-08 | Hoffman-La Roche Inc. | 1-sulfonyl pyrrolidine derivatives |
| IL154363A0 (en) | 2000-09-25 | 2003-09-17 | Actelion Pharmaceuticals Ltd | Substituted amino-aza-cycloalkanes useful against malaria |
| EP1411944A1 (en) | 2001-08-03 | 2004-04-28 | Schering Corporation | Sulfonamide derivatives as gamma secretase inhibitors |
| PL372212A1 (en) | 2001-08-03 | 2005-07-11 | Schering Corporation | Novel gamma secretase inhibitors |
| US7256186B2 (en) | 2002-02-06 | 2007-08-14 | Schering Corporation | Gamma secretase inhibitors |
| US20040171614A1 (en) | 2002-02-06 | 2004-09-02 | Schering-Plough Corporation | Novel gamma secretase inhibitors |
| TW200302717A (en) | 2002-02-06 | 2003-08-16 | Schering Corp | Novel gamma secretase inhibitors |
| TW200510405A (en) | 2003-05-13 | 2005-03-16 | Schering Corp | Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors |
| JP4247081B2 (ja) | 2003-09-24 | 2009-04-02 | 三菱電機株式会社 | レーザアニール装置のレーザビーム強度モニタ方法とレーザアニール装置 |
| KR20070010144A (ko) | 2004-04-05 | 2007-01-22 | 쉐링 코포레이션 | 신규한 감마 세크레타제 억제제 |
| EP1758884A2 (en) * | 2004-05-20 | 2007-03-07 | Elan Pharmaceuticals, Inc. | N-cyclic sulfonamido inhibitors of gamma secretase |
| MX2008009414A (es) | 2006-01-20 | 2008-10-01 | Schering Corp | Arilsulfonas carbociclicas y heterociclicas como inhibidores de gamma secretasa. |
-
2005
- 2005-06-28 CN CNA200910152119XA patent/CN101602741A/zh active Pending
- 2005-06-28 CA CA002570183A patent/CA2570183A1/en not_active Abandoned
- 2005-06-28 WO PCT/US2005/023187 patent/WO2006004880A2/en not_active Ceased
- 2005-06-28 US US11/168,797 patent/US7763613B2/en not_active Expired - Fee Related
- 2005-06-28 AT AT05790194T patent/ATE461926T1/de not_active IP Right Cessation
- 2005-06-28 PE PE2005000751A patent/PE20060481A1/es not_active Application Discontinuation
- 2005-06-28 CN CNA2005800284229A patent/CN101048393A/zh active Pending
- 2005-06-28 DE DE602005020156T patent/DE602005020156D1/de not_active Expired - Lifetime
- 2005-06-28 MX MX2007000040A patent/MX2007000040A/es active IP Right Grant
- 2005-06-28 JP JP2007519415A patent/JP2008505100A/ja active Pending
- 2005-06-28 EP EP05790194A patent/EP1789404B1/en not_active Expired - Lifetime
- 2005-06-28 ES ES05790194T patent/ES2341560T3/es not_active Expired - Lifetime
- 2005-06-28 AR ARP050102662A patent/AR050994A1/es not_active Application Discontinuation
- 2005-06-29 TW TW094121770A patent/TWI297270B/zh not_active IP Right Cessation
-
2009
- 2009-12-08 US US12/633,311 patent/US7998958B2/en not_active Expired - Fee Related
- 2009-12-08 US US12/633,286 patent/US20100087425A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008505100A5 (enExample) | ||
| DK2989086T3 (en) | DERIVATIVES OF DOLASTATIN 10 AND AURISTATINES | |
| JP2006521336A5 (enExample) | ||
| JP2009535307A5 (enExample) | ||
| JP2010530881A5 (enExample) | ||
| JP2008526999A5 (enExample) | ||
| JP2007515432A5 (enExample) | ||
| CA3025227A1 (en) | 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides | |
| JP2007531742A5 (enExample) | ||
| JP2013521291A5 (enExample) | ||
| JP2008535903A5 (enExample) | ||
| RU2007105350A (ru) | 3-(гетероарилокси)-2-алкил-1-азабициклоалкильные производные, как лиганды альфа-7-nachr (никотиновых ацетилхолиновых рецепторов), предназначенные для лечения заболеваний центральной нервной системы | |
| JP6261011B2 (ja) | 眼疾患処置薬 | |
| JP2013532652A5 (enExample) | ||
| US20140275016A1 (en) | N-Acyl-N'-(pyridin-2-yl) Ureas and Analogs Exhibiting Anti-Cancer and Anti-Proliferative Activities | |
| JP6380777B2 (ja) | ＰＩ３Ｋ、ｍＴＯＲ阻害薬としての縮合キノリン化合物 | |
| AU2016379388A1 (en) | Methods of treating pulmonary diseases and disorders | |
| KR20220035031A (ko) | 오로라 키나아제 억제제 및 이의 용도 | |
| ES2688597T3 (es) | Compuesto de benzoxaborol tricíclico, método de preparación y uso del mismo | |
| JP2011519360A5 (enExample) | ||
| JP2009539943A5 (enExample) | ||
| WO2007096740A2 (en) | Novel cephalosporins | |
| RU2007102576A (ru) | Новые индаэолкарбоксамиды и их применение | |
| JP2010514734A5 (enExample) | ||
| WO2023022231A1 (ja) | ウイルス感染症を処置または予防するための可逆的共有結合阻害物質 |