CN101602741A - 作为γ-分泌酶抑制剂的取代的N-芳基磺酰基杂环胺 - Google Patents

作为γ-分泌酶抑制剂的取代的N-芳基磺酰基杂环胺 Download PDF

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Publication number
CN101602741A
CN101602741A CNA200910152119XA CN200910152119A CN101602741A CN 101602741 A CN101602741 A CN 101602741A CN A200910152119X A CNA200910152119X A CN A200910152119XA CN 200910152119 A CN200910152119 A CN 200910152119A CN 101602741 A CN101602741 A CN 101602741A
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CN
China
Prior art keywords
alkyl
aryl
alkylene
substituted
substituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA200910152119XA
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English (en)
Chinese (zh)
Inventor
H·B·乔西恩
J·W·克拉德
T·A·贝拉
R·徐
李虹美
D·比萨尼斯基
赵志强
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CN101602741A publication Critical patent/CN101602741A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CNA200910152119XA 2004-06-30 2005-06-28 作为γ-分泌酶抑制剂的取代的N-芳基磺酰基杂环胺 Pending CN101602741A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58401004P 2004-06-30 2004-06-30
US60/584010 2004-06-30

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800284229A Division CN101048393A (zh) 2004-06-30 2005-06-28 作为γ－分泌酶抑制剂的取代的N－芳基磺酰基杂环胺

Publications (1)

Publication Number Publication Date
CN101602741A true CN101602741A (zh) 2009-12-16

Family

ID=35783342

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA200910152119XA Pending CN101602741A (zh) 2004-06-30 2005-06-28 作为γ-分泌酶抑制剂的取代的N-芳基磺酰基杂环胺
CNA2005800284229A Pending CN101048393A (zh) 2004-06-30 2005-06-28 作为γ－分泌酶抑制剂的取代的N－芳基磺酰基杂环胺

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2005800284229A Pending CN101048393A (zh) 2004-06-30 2005-06-28 作为γ－分泌酶抑制剂的取代的N－芳基磺酰基杂环胺

Country Status (13)

Country Link
US (3) US7763613B2 (enExample)
EP (1) EP1789404B1 (enExample)
JP (1) JP2008505100A (enExample)
CN (2) CN101602741A (enExample)
AR (1) AR050994A1 (enExample)
AT (1) ATE461926T1 (enExample)
CA (1) CA2570183A1 (enExample)
DE (1) DE602005020156D1 (enExample)
ES (1) ES2341560T3 (enExample)
MX (1) MX2007000040A (enExample)
PE (1) PE20060481A1 (enExample)
TW (1) TWI297270B (enExample)
WO (1) WO2006004880A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109705052A (zh) * 2019-01-25 2019-05-03 苏州大学 一种制备1,4-二氢噁嗪的方法
CN119060034A (zh) * 2024-09-02 2024-12-03 上海信诺维生物医药有限公司 一种含吡喃取代的吗啉类化合物的制备方法

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MX2008009414A (es) 2006-01-20 2008-10-01 Schering Corp Arilsulfonas carbociclicas y heterociclicas como inhibidores de gamma secretasa.
JP2009526059A (ja) * 2006-02-07 2009-07-16 ワイス １１−ベータｈｓｄ１阻害剤
CA2649996A1 (en) 2006-04-26 2007-11-08 Merck Sharp & Dohme Limited Piperidines and related compounds for treatment of alzheimer's disease
DK2041181T3 (da) * 2006-06-08 2011-08-29 Helmholtz Zentrum Muenchen Specifikke proteaseinhibitorer og deres anvendelse i cancerterapi
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
EP2091948B1 (en) 2006-11-30 2012-04-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
CN101668525A (zh) 2007-03-01 2010-03-10 前体生物药物股份公司 谷氨酰胺酰环化酶抑制剂的新用途
US9656991B2 (en) 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
BRPI0817433A2 (pt) * 2007-10-19 2015-06-16 Janssen Pharmaceutica Nv Moduladores de gama-secretase piperidinila e piperazinila
ES2548913T3 (es) 2009-09-11 2015-10-21 Probiodrug Ag Derivados heterocíclicos como inhibidores de glutaminil ciclasa
US20110190269A1 (en) * 2010-02-01 2011-08-04 Karlheinz Baumann Gamma secretase modulators
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
CA2789440C (en) 2010-03-10 2020-03-24 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
JP5945532B2 (ja) 2010-04-21 2016-07-05 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
US8530670B2 (en) 2011-03-16 2013-09-10 Probiodrug Ag Inhibitors
AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
EP3461819B1 (en) 2017-09-29 2020-05-27 Probiodrug AG Inhibitors of glutaminyl cyclase

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JPH04247081A (ja) 1991-02-01 1992-09-03 Takeda Chem Ind Ltd ５員複素環酸アミド類
US5646167A (en) 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
WO1997028130A1 (en) * 1996-02-02 1997-08-07 Nippon Shinyaku Co., Ltd. Isoquinoline derivatives and drugs
EA200001144A1 (ru) * 1998-06-03 2001-10-22 Джи-Пи-Ай Эн-Ай-Эл Холдингз, Инк. Аза-гетероциклические соединения, применяемые для лечения неврологических расстройств и выпадения волос
IL144781A0 (en) 1999-02-26 2002-06-30 Merck & Co Inc Novel sulfonamide compounds and uses thereof
FR2802206B1 (fr) 1999-12-14 2005-04-22 Sod Conseils Rech Applic Derives de 4-aminopiperidine et leur utilisation en tant que medicament
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JP2001261657A (ja) * 2000-03-17 2001-09-26 Yamanouchi Pharmaceut Co Ltd シアノフェニル誘導体
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JP4247081B2 (ja) 2003-09-24 2009-04-02 三菱電機株式会社 レーザアニール装置のレーザビーム強度モニタ方法とレーザアニール装置
KR20070010144A (ko) 2004-04-05 2007-01-22 쉐링 코포레이션 신규한 감마 세크레타제 억제제
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MX2008009414A (es) 2006-01-20 2008-10-01 Schering Corp Arilsulfonas carbociclicas y heterociclicas como inhibidores de gamma secretasa.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109705052A (zh) * 2019-01-25 2019-05-03 苏州大学 一种制备1,4-二氢噁嗪的方法
CN119060034A (zh) * 2024-09-02 2024-12-03 上海信诺维生物医药有限公司 一种含吡喃取代的吗啉类化合物的制备方法

Also Published As

Publication number Publication date
US20060040936A1 (en) 2006-02-23
CN101048393A (zh) 2007-10-03
TWI297270B (en) 2008-06-01
AR050994A1 (es) 2006-12-13
JP2008505100A (ja) 2008-02-21
EP1789404A2 (en) 2007-05-30
CA2570183A1 (en) 2006-01-12
WO2006004880A3 (en) 2007-03-08
WO2006004880A2 (en) 2006-01-12
HK1099300A1 (en) 2007-08-10
ES2341560T3 (es) 2010-06-22
US20100087425A1 (en) 2010-04-08
TW200612928A (en) 2006-05-01
MX2007000040A (es) 2007-03-07
US7998958B2 (en) 2011-08-16
DE602005020156D1 (de) 2010-05-06
US20100093695A1 (en) 2010-04-15
US7763613B2 (en) 2010-07-27
EP1789404B1 (en) 2010-03-24
PE20060481A1 (es) 2006-06-19
ATE461926T1 (de) 2010-04-15

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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Open date: 20091216